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The Emotional Impact of the Operator in the Care of Patients With Mental Disorders during the Pandemic: Measure of Interventions on Compassion Fatigue and Burn-Out.

Psychiatr Danub 2021 Sep;33(Suppl 9):108-113

Mental Health Department, ASL TA, Via Piemonte, 51, 72022 Latiano, Italy,

Background: The continuation of the health emergency due to the management of COVID-19 is having a profound effect on all aspects of society, including mental health and physical health. This observational study examined practitioners of psychiatric rehabilitation and therapeutic communities, focusing on the emotional aspects of patient care, in particular the fatigue of compassion, empathy and lack of hope, aspects that could be directly linked to the burnout of health professionals, as found in other similar studies.

Method: In this study, self-administered scale data was collected in 87 healthcare professionals recruited from 3 different psychiatric rehabilitation communities. Read More

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September 2021

Effectiveness of Mindful Self-Compassion Training Supported by Online Peer Groups in China: A Pilot Study.

Altern Ther Health Med 2021 Sep 24. Epub 2021 Sep 24.

Context: Self-compassion training involves the cultivation of feelings of warmth and safety, presence, and interconnectedness. Mindful Self-Compassion (MSC) training in a group setting has been found to increase self-compassion, mindfulness, and emotional well-being.

Objective: The current study intended to examine the outcomes of live, online, videoconference-based MSC training with online peer-support for nonclinical populations in different cities in China. Read More

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September 2021

Cross-Cultural Adaptation and Validation of the Greek Version of the "Full Outline of Unresponsiveness Score": A Prospective Observational Clinimetric Study in Neurosurgical Patients.

Neurocrit Care 2021 Sep 23. Epub 2021 Sep 23.

Department of Neurosurgery, Hippokration General Hospital, Aristotle University School of Medicine, 49 Konstantinoupoleos Str., 54642, Thessaloniki, Greece.

Background: The Full Outline of Unresponsiveness (FOUR) score is a clinical instrument for the assessment of consciousness which is gradually gaining ground in clinical practice, as it incorporates more complete neurological information than the Glasgow Coma Scale (GCS). The main objectives of the current study were the following: (1) translate and cross-culturally adapt the FOUR score into Greek; (2) evaluate its clinimetric properties, including interrater reliability, internal consistency, and construct validity; and (3) evaluate the reliability of assessments among health care professionals with different levels of experience and training.

Methods: The FOUR score was initially translated into Greek. Read More

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September 2021

Neurophysiological and ultrasonographic comparative study of autonomous nervous system in patients suffering from fibromyalgia and generalized anxiety disorder.

Neurol Sci 2021 Sep 24. Epub 2021 Sep 24.

Second Department of Psychiatry, Medical School, National and Kapodistrian University of Athens, Attikon University General Hospital, Athens, Greece.

Background: Fibromyalgia (FM) and generalized anxiety disorder (GAD) share common clinical features: they both affect women more than men, their diagnosis is based solely on clinical criteria, and some of the symptoms such as anxiety, aches and muscle tension, sleep disorders, and cognitive dysfunction occur in both diseases. For both conditions, an underlying dysregulation of the autonomic nervous system (ANS) has been proposed.

Objective: The aims of this study were to investigate ANS dysfunction in FM and GAD and compare them with controls. Read More

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September 2021

Patient preferences in retinal drug delivery.

Sci Rep 2021 Sep 23;11(1):18996. Epub 2021 Sep 23.

Eugene and Marilyn Glick Eye Institute and Department of Ophthalmology, Indiana University School of Medicine, 1160 West Michigan Street, Indianapolis, IN, 46202, USA.

Retinal vascular diseases (RVDs) are often treated with intravitreally (IVT) injected drugs, with relatively low patient compliance and potential risks. Ongoing research explores alternative RVD treatments, including eye drops and oral tablets. This study surveyed RVD patients treated with IVT injections to establish factors influencing low compliance rates while gauging treatment delivery method preferences. Read More

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September 2021

Characteristics of patients with chronic hypoparathyroidism not adequately controlled with conventional treatment and management patterns in Spain.

Endocrinol Diabetes Nutr (Engl Ed) 2021 May 6;68(5):304-311. Epub 2021 Sep 6.

Shire Pharmaceuticals Ibérica SL, miembro del grupo empresarial Takeda, Madrid, Spain. Electronic address:

Background And Objective: The current guidelines on hypoparathyroidism offer a model for treating patients but do not cover real-world situations or patient diversity. Given the lack of data regarding hypoparathyroidism, a Delphi panel was convened in Spain to establish consensus in defining the characteristics of patients with chronic hypoparathyroidism not adequately controlled with conventional treatment, as well as to investigate patterns of management.

Material And Methods: A presentation matrix provided a framework for characterizing inadequately controlled chronic hypoparathyroidism, based on four predefined patient groups: group 1 (normal biochemical levels and the patient feeling well); group 2 (abnormal biochemical levels and the patient feeling well); group 3 (normal biochemical levels and the patient feeling unwell); and group 4 (abnormal biochemical levels and the patient feeling unwell). Read More

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Health-related quality of life for early-stage cervical cancer survivors after primary radical surgery followed by radiotherapy versus radical surgery alone.

J Obstet Gynaecol 2021 Sep 23:1-8. Epub 2021 Sep 23.

Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

This study compared the quality of life (QoL) of 265 stage IA2-IIA cervical cancer patients treated with radical surgery alone (group 1: 137 patients) versus those who underwent primary radical surgery followed by radiotherapy (group 2: 128 patients) and identified clinical characteristics that predict the poor quality of life. All participants completed quality of life questionnaires: EORTC QLQ-C30 and CMU cervical cancer QoL. For the EORTC QLQ-C30, the study groups were comparable regarding global health status/QoL scale and summary scores. Read More

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September 2021

[Motor rehabilitation of patients in the acute period of stroke using virtual reality technology].

Zh Nevrol Psikhiatr Im S S Korsakova 2021 ;121(8. Vyp. 2):71-75

Samara State Medical University, Samara, Russia.

Objective: To study an effect of adjuvant rehabilitation using implicit virtual reality on the dynamics of the motor function of the lower extremities in patients in the acute period of ischemic stroke.

Materials And Methods: The study was carried out to assess the effectiveness and safety of rehabilitation using virtual reality in 60 patients with lower central paresis in the acute period of ischemic stroke, lasting from 3 to 5 days. Patients of the study group additionally received rehabilitation using the hardware-software complex ReviVR, which allows to stimulate the patient's plantar surface by means of pneumo cuffs synchronously with the step of his animated body. Read More

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September 2021

Evaluation of Bowel Habits in Patients with Acne Vulgaris.

Int J Clin Pract 2021 Sep 23:e14903. Epub 2021 Sep 23.

Department of Family Medicine.

Purpose: To evaluate the bowel habits of patients with acne vulgaris METHOD: In this case control study, socio-demographic characteristics of the participants (age, gender, marital status, educational status, profession, economic status, smoking-alcohol habits, chronic diseases, previous operations, people they live with, diet) were questioned and the global acne grading scores of the patients were calculated. Bristol Stool Scale, Rome III IBS Criteria, International Physical Activity Questionnaire-Short Form, Hospital Anxiety Depression and KADF (dietary fiber information) scales were completed.

Results: The patient group consisted of 102 and the control group consisted of 104 participants. Read More

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September 2021

Listening and spoken language outcomes after 5 years of cochlear implant use for children born preterm and at term.

Dev Med Child Neurol 2021 Sep 22. Epub 2021 Sep 22.

National Hearing Implant and Research Centre, Beaumont Hospital, Dublin, Ireland.

Aim: To compare listening and spoken language outcomes after cochlear implantation for children born preterm and at term, and to examine patterns associated with additional disabilities or gestational age.

Method: Children were included if they underwent cochlear implantation in 2013 or 2014 and had complete 5-year follow-up data available. An analysis of assessment data recorded annually was conducted, including outcomes as measured by the Category of Auditory Performance (CAP), the Speech Intelligibility Rating, Second Edition (SIR 2) scale, and the British Picture Vocabulary Scales, Third Edition (BPVS-3). Read More

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September 2021

The Safety and Efficacy of Microbial Ecosystem Therapeutic-2 in People With Major Depression: Protocol for a Phase 2, Double-Blind, Placebo-Controlled Study.

JMIR Res Protoc 2021 Sep 22;10(9):e31439. Epub 2021 Sep 22.

Centre for Neuroscience Studies, Queen's University, Kingston, ON, Canada.

Background: The gut-brain axis is a bidirectional signaling pathway between the gastrointestinal tract and the brain; it is being studied because of its potential influence in mediating mood, anxiety, and other neuropsychiatric symptoms. Previous research examining the effects of gut microbiota on neuropsychiatric disorders suggests that gut repopulation treatments such as probiotics, microbe therapy, and fecal microbiota transplantation show promising results in treating symptoms of anxiety and depression. This study explores the use of an alternative gut repopulation treatment to fecal microbiota transplantation, known as Microbial Ecosystem Therapeutic (MET)-2, as an intervention against symptoms of depression. Read More

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September 2021

Comparing a Virtual Reality-Based Simulation App (VR-MRI) With a Standard Preparatory Manual and Child Life Program for Improving Success and Reducing Anxiety During Pediatric Medical Imaging: Randomized Clinical Trial.

J Med Internet Res 2021 Sep 22;23(9):e22942. Epub 2021 Sep 22.

Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.

Background: The experience of undergoing magnetic resonance imaging (MRI) can be anxiety provoking, particularly for pediatric patients and their families. Alternative methods to improve success and experiences without the use of sedation are needed.

Objective: This study aims to compare the effectiveness of a virtual reality (VR)-based simulation app (VR-MRI) with a standard preparatory manual (SPM) and a hospital-based Child Life Program (CLP) on success and anxiety during a simulated pediatric MRI scan. Read More

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September 2021

Altered attention network in paratroopers exposed to repetitive subconcussion: evidence based on behavioral and ERP results.

J Neurotrauma 2021 Sep 22. Epub 2021 Sep 22.

The General Hospital of Chinese PLA Central Theater Command, 627 Wuluo road,Wuhan, China, Wuhan, China, 430000;

Cognitive impairment caused by repetitive subconcussion has been received increasing attention in recent years. While the dysfunction of attention has been confirmed by neuropsychological research using scales, there is no event-related potentials (ERPs) research. Attention network (ANT) has been widely used to evaluate the three separate components of attention processing (alerting, orienting, and executive control). Read More

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September 2021

Comparison of kinesio taping and manual therapy in treatment of patients with bruxism using shear wave ultrasonography-a randomized clinical trial.

Int J Clin Pract 2021 Sep 21:e14902. Epub 2021 Sep 21.

Ankara University, Faculty of Dentistry, Ankara, Turkey.

Background: Bruxism is significantly associated with craniofacial pain, feeling of stiffness or fatigue of the jaw and neck pain. Various physiotherapeutic strategies are used in the treatment of bruxism; however, it is not clear which method leads to greater decrease in pain.

Objective: The aim of this study is to compare the effects of two physiotherapy methods (manual therapy (MT) and Kinesio taping with manual therapy (KTMT)) in patients with bruxism. Read More

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September 2021

Emotional Impact on Health Personnel, Medical Students, and General Population Samples During the COVID-19 Pandemic in Lima, Peru.

Rev Colomb Psiquiatr (Engl Ed) 2021 Jul-Sep;50(3):189-198

Department of Neuropsychiatry, Cayetano Heredia Hospital, San Martin de Porres, Lima, Peru.

Background: The aim of the study is to compare the emotional effects of COVID-19 among three different groups, namely: health personnel, medical students, and a sample of the general population.

Methods: 375 participants were recruited for this study, of which 125 were medical students (preclinical studies, 59; clinical studies, 66), 125 were health personnel (COVID-19 frontline personnel, 59; personnel not related with COVID-19, 66), and 125 belonged to the general population. The PHQ-9, GAD-7, and CPDI scales were used to assess the emotional impact. Read More

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December 2020

Maternal FADS2 single nucleotide polymorphism modified the impact of prenatal docosahexaenoic acid (DHA) supplementation on child neurodevelopment at 5 years: Follow-up of a randomized clinical trial.

Clin Nutr 2021 Sep 11;40(10):5339-5345. Epub 2021 Sep 11.

Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA. Electronic address:

Background: Variability in the FADS2 gene, which codifies the Delta-6 Desaturases and modulates the conversion of essential n-3 and n-6 fatty acids into long-chain polyunsaturated fatty acids, might modify the impact of prenatal supplementation with n-3 docosahexaenoic acid (DHA) on neurodevelopment.

Objective: To assess if maternal FADS2 single nucleotide polymorphisms (SNPs) modified the effect of prenatal DHA on offspring development at 5 years.

Design: We conducted a post-hoc interaction analysis of the POSGRAD randomized controlled trial (NCT00646360) of prenatal supplementation with algal-DHA where 1094 pregnant women originally randomized to 400 mg/day of preformed algal DHA or a placebo from gestation week 18-22 through delivery. Read More

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September 2021

Cervical disc arthroplasty for Klippel-Feil syndrome.

Clin Neurol Neurosurg 2021 Sep 3;209:106934. Epub 2021 Sep 3.

Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan; School of Medicine, National Yang-Ming Chiao-Tung University, Taipei, Taiwan. Electronic address:

Objective: Klippel-Feil syndrome (KFS) is a congenital musculoskeletal condition characterized by improper segmentation of the cervical spine. This study aimed to evaluate outcomes of KFS patients who underwent cervical disc arthroplasty (CDA).

Methods: Consecutive patients who underwent anterior cervical surgery were retrospectively reviewed. Read More

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September 2021

Validation and reliability of the Dutch version of the EORTC QLQ-NMIBC24 Questionnaire Module for patients with non-muscle-invasive bladder cancer.

J Patient Rep Outcomes 2021 Sep 20;5(1):96. Epub 2021 Sep 20.

Department for Health Evidence, Radboud Institute for Health Sciences, Radboud University Medical Center, PO Box 9101, 6500 HB, Nijmegen, The Netherlands.

Background: The European Organisation for Research and Treatment of Cancer (EORTC) quality of life questionnaire for non-muscle invasive bladder cancer (QLQ-NMIBC24) has been available and applied for some years now, but has yet to undergo a full comprehensive psychometric evaluation. The aim of this study was to investigate the psychometric properties of the Dutch version of the EORTC QLQ-NMIBC24 questionnaire in patients with low, intermediate and high risk NMIBC.

Methods: We included patients newly diagnosed with NMIBC participating in the multicenter, population-based prospective cohort studies UroLife or BlaZIB. Read More

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September 2021

Single-Incision Versus Conventional Laparoscopic Appendectomy: A Multi-Center Randomized Controlled Trial (SCAR trial).

Int J Surg Protoc 2021 30;25(1):201-208. Epub 2021 Aug 30.

Department of Surgery, Daegu Catholic University Medical Center, Catholic University of Daegu School of Medicine, Daegu, KR.

Introduction: Although single-incision laparoscopic appendectomy (SILA) was introduced decades ago, it is still considered a difficult technique to perform compared to conventional laparoscopic appendectomy (CLA). In addition, controversy about the benefits of SILA compared to CLA abound and no definite criteria for choosing SILA over CLA in patients with appendicitis currently exist. Therefore, we have planned a multi-center randomized controlled trial to compare SILA with CLA in terms of cosmetic satisfaction and pain reduction. Read More

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Comparison of the Effects of Haloperidol and Dexmedetomidine on Delirium and Agitation in Patients with a Traumatic Brain Injury Admitted to the Intensive Care Unit.

Anesth Pain Med 2021 Jun 27;11(3):e113802. Epub 2021 Jul 27.

Payame Noor University, Tehran, Iran.

Background: Patients under mechanical ventilation in the Intensive Care Unit (ICU) have a higher risk of delirium. To date, the ideal sedative combination for delirium treatment in terms of cost and side effects has not been determined.

Objectives: This study was designed to compare the effects of haloperidol and dexmedetomidine on delirium in trauma patients under mechanical ventilation in the ICU. Read More

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Therapeutic Effects of Intra-articular Botulinum Neurotoxin Versus Physical Therapy in Knee Osteoarthritis.

Anesth Pain Med 2021 Jun 8;11(3):e112789. Epub 2021 Jul 8.

Shahid Beheshti Universities of Medical Sciences, Tehran, Iran.

Background: Knee osteoarthritis (KOA) is the most common cause of chronic knee pain, and disability and different modalities have been used to improve pain and function. Botulinum toxin intra-articular injection is proposed to manage resistant joint pains.

Objectives: This study was carried out to compare therapeutic effects of intra-articular botulinum neurotoxin (BTX) versus physical therapy (PT) in KOA. Read More

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Discomfort, pain and fatigue levels of 160 cyclists after a kinematic bike-fitting method: an experimental study.

BMJ Open Sport Exerc Med 2021 30;7(3):e001096. Epub 2021 Aug 30.

Curso de Graduação em Fisioterapia, Universidade do Sul de Santa Catarina, Palhoca, Santa Catarina, Brazil.

Objective: To analyse rider's subjective responses after a standardised bicycle ergonomic adjustment method.

Methods: Experimental study of 160 healthy, amateur mountain bikers analysed previously and 30 days after a bike-fitting session. The main outcome measures were subjective comfort level (Feeling Scale, FEEL), fatigue (OMINI Scale) and pain (Visual Analogue Scale, VAS). Read More

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A Treatment-Response Comparison Study of Resting-State Functional Magnetic Resonance Imaging Between Standard Treatment of SSRI and Standard Treatment of SSRI Plus Non-dominant Hand-Writing Task in Patients With Major Depressive Disorder.

Front Psychiatry 2021 3;12:698954. Epub 2021 Sep 3.

Bezmialem Vakıf University, Department of Radiology, School of Medicine, Istanbul, Turkey.

Researches have recently shifted from functional/structural imaging studies to functional connectivity (FC) studies in major depressive disorder (MDD). We aimed to compare treatment response of two treatment groups before and after treatment, in terms of both with psychiatric evaluation scales and resting-state functional connectivity (RSFC) changes in order to objectively demonstrate the possible contribution of the non-dominant hand-writing exercise (NHE) effect on depression treatment. A total of 26 patients who were right-handed women with similar sociodemographic characteristics were enrolled. Read More

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September 2021

Self-rated impulsivity in healthy individuals, substance use disorder and ADHD: psychometric properties of the Swedish Barratt impulsiveness scale.

BMC Psychiatry 2021 Sep 18;21(1):458. Epub 2021 Sep 18.

Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet & Stockholm Health Care Services, Norra Stationsgatan 69, floor 7, 113 64, Stockholm, Sweden.

Background: Impulsivity is associated with several psychiatric disorders, including substance use disorders (SUD) and attention deficit hyperactivity disorder (ADHD). A widely used questionnaire to assess impulsivity is the Barratt Impulsiveness Scale (BIS), and the aim of the current study was to evaluate the psychometric properties of the Swedish version of the BIS (swe-BIS).

Methods: The original BIS was translated to Swedish and back-translated by an authorized translator. Read More

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September 2021

Assessment of reliability and validity of the adapted Persian version of the Spinal Appearance Questionnaire in adolescents with idiopathic scoliosis.

Spine Deform 2021 Sep 17. Epub 2021 Sep 17.

Department of Rehabilitation, Faculty of Allied Medicine, Kerman University of Medical Sciences, Medical University Campus, Haft-Bagh Highway, Kerman, Iran.

Purpose: This study investigates the reliability and validity of the adapted Persian version of the Spinal Appearance Questionnaire (P-SAQ).

Methods: The stages of cross-cultural adaptation were conducted according to an internationally accepted guidelines. Reliability of the P-SAQ was measured by evaluating internal consistency and test-retest reproducibility using Cronbach's α and intraclass correlation coefficient (ICC). Read More

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September 2021

Health Literacy, Education, and Internal Consistency of Psychological Scales.

Health Lit Res Pract 2021 Jul 15;5(3):e245-e255. Epub 2021 Sep 15.

Background: Measurement error might lead to biased estimates, causing ineffective interventions and service delivery. Identifying measurement error of health-related instruments helps develop accurate assessment of health-related constructs.

Objective: We compared the internal consistency of eight psychological scales used in health research in groups with adequate versus limited health literacy and in groups with higher versus lower education. Read More

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Long-Term Quality of Life of Acute Promyelocytic Leukemia Patients Treated with Arsenic Trioxide versus Chemotherapy.

Blood Adv 2021 Sep 16. Epub 2021 Sep 16.

"Sapienza" University, Roma, Italy.

The main objective of this study was to compare the long-term health-related quality of life of patients with acute promyelocytic leukemia (APL) treated with all-trans retinoic acid (ATRA) plus arsenic trioxide (ATO) versus ATRA plus standard chemotherapy. Patients previously enrolled in the randomized controlled trial APL0406 were considered eligible for this follow-up study. The following patient-reported outcome measures were used: the EORTC QLQ-C30, the EORTC QLQ-CIPN20 and the SF-36. Read More

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September 2021

Osseous Genioplasty: Prevention of Witch's Chin Deformity with No-Degloving Technique.

Plast Reconstr Surg 2021 Sep 16. Epub 2021 Sep 16.

From the Division of Plastic and Reconstructive Surgery, Zucker School of Medicine at Hofstra/Northwell; Division of Plastic and Reconstructive Surgery, Temple University; and Division of Plastic and Reconstructive Surgery, University of California, Los Angeles.

Background: Osseous genioplasty is a powerful procedure that can correct chin dysmorphology; however, traditional techniques may result in chin ptosis or a "witch's chin" deformity. Iatrogenic chin ptosis is thought to be caused by excessive degloving of soft tissue with a failure to reattach the mentalis muscle. In the authors' study, they compared the "no-degloving" technique (using a 90-degree plate with lag-screw fixation) to the "traditional" technique, for minimization of chin ptosis. Read More

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September 2021

Feasibility, Reliability, and Validity of the Turkish Version of the Esophageal-Atresia-Quality-of-Life Questionnaires to Assess Condition-Specific Quality of Life in Children and Adolescents Born with Esophageal Atresia.

Turk J Gastroenterol 2021 Aug;32(8):640-650

Department of Pediatric Surgery, The Queen Silva Children's Hospital, Gothenburg, Sweden;Department of Pediatrics, University of Gothenburg, Institute of Clinical Sciences, Sweden.

Background: This study reports the feasibility, validity and reliability of the Turkish versions of the Esophageal-Atresia-Quality-of-Life (EA-QOL) questionnaires, which were originally developed in Sweden and Germany.

Methods: After translation from Swedish to Turkish and cognitive debriefings, 51 families of children aged 2 to 7 years (parent-report, 17-items) and 54 families of children 8 to 17 years (child and parent-report, 24-items) responded to the EA-QOL questionnaires and a validated generic HRQOL-instrument (PedsQL4.0). Read More

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Clinical and Structural Results of Rotator Cuff Repair Compared With Rotator Cuff Debridement in Arthroscopic Treatment of Calcifying Tendinitis of the Shoulder.

Am J Sports Med 2021 Sep 16:3635465211037690. Epub 2021 Sep 16.

Department of Orthopaedic Surgery, Saarland University, Homburg (Saar), Germany.

Background: Arthroscopic treatment of calcifying tendinitis of the shoulder reveals good to excellent results. However, whether the tendon needs to be repaired after removal of the calcific deposit or simply debrided remains unclear.

Purpose: To evaluate the structural and clinical results after arthroscopic calcific deposit removal with additional rotator cuff repair or rotator cuff debridement. Read More

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September 2021