6,095 results match your criteria scales "usually"

RECOGNICER: A coarse-graining approach for identifying broad domains from ChIP-seq data.

Quant Biol 2020 Dec 19;8(4):359-368. Epub 2020 Nov 19.

Department of Physics, The George Washington University, Washington, DC 20052, USA.

Background: Histone modifications are major factors that define chromatin states and have functions in regulating gene expression in eukaryotic cells. Chromatin immunoprecipitation coupled with high-throughput sequencing (ChIP-seq) technique has been widely used for profiling the genome-wide distribution of chromatin-associating protein factors. Some histone modifications, such as H3K27me3 and H3K9me3, usually mark broad domains in the genome ranging from kilobases (kb) to megabases (Mb) long, resulting in diffuse patterns in the ChIP-seq data that are challenging for signal separation. Read More

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December 2020

Pancreatic Cancer Related Pain: Review of Pathophysiology and Intrathecal Drug Delivery Systems for Pain Management.

Gabriel Carvajal

Pain Physician 2021 Aug;24(5):E583-E594

Centro Nacional de Control del Dolor y Cuidados Paliativos Interventional Pain Management Unit, San José, Costa Rica.

Background: Pancreatic cancer (PC) is one of the most lethal cancers and is the eleventh most common cancer worldwide. This disease is characterized by an often-fatal evolution and a high burden of symptoms, particularly pain. Several studies have demonstrated that pancreatic cancer patients have a high prevalence of pain, with up to 82% of patients reporting pain, often requiring systemic strong opioids as mainstay treatment. Read More

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A Two-stage Density-aware Single Image Deraining Method.

IEEE Trans Image Process 2021 Jul 28;PP. Epub 2021 Jul 28.

Although advanced single image deraining methods have been proposed, one main challenge remains: the available methods usually perform well on specific rain patterns but can hardly deal with scenarios with dramatically different rain densities, especially when the impacts of rain streaks and the veiling effect caused by rain accumulation are heavily coupled. To tackle this challenge, we propose a two-stage density-aware single image deraining method with gated multi-scale feature fusion. In the first stage, a realistic physics model closer to real rain scenes is leveraged for initial deraining, and a network branch is also trained for rain density estimation to guide the subsequent refinement. Read More

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Interaction-Aware Spatio-Temporal Pyramid Attention Networks for Action Classification.

IEEE Trans Pattern Anal Mach Intell 2021 Jul 27;PP. Epub 2021 Jul 27.

For CNN-based visual action recognition, the accuracy may be increased if local key action regions are focused on. The task of self-attention is to focus on key features and ignore irrelevant information. So, self-attention is useful for action recognition. Read More

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Association of gastric emptying with postprandial appetite and satiety sensations in obesity.

Obesity (Silver Spring) 2021 Jul 27. Epub 2021 Jul 27.

Precision Medicine for Obesity Program, Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.

Objective: Satiety, defined as the duration of the sensation of fullness, is usually measured by validated visual analog scales (VAS) for appetite. Gastric function plays a key role in food intake regulation. However, the association between gastric emptying (GE) and VAS appetite is unknown. Read More

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At the tip of an iceberg: citizen science and active surveillance collaborating to broaden the known distribution of Aedes japonicus in Spain.

Parasit Vectors 2021 Jul 26;14(1):375. Epub 2021 Jul 26.

Centre de Recerca Ecològica i Aplicacions Forestals (CREAF), Cerdanyola del Vallès, Barcelona, Spain.

Background: Active surveillance aimed at the early detection of invasive mosquito species is usually focused on seaports and airports as points of entry, and along road networks as dispersion paths. In a number of cases, however, the first detections of colonizing populations are made by citizens, either because the species has already moved beyond the implemented active surveillance sites or because there is no surveillance in place. This was the case of the first detection in 2018 of the Asian bush mosquito, Aedes japonicus, in Asturias (northern Spain) by the citizen science platform Mosquito Alert. Read More

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Multiorgan segmentation from partially labeled datasets with conditional nnU-Net.

Comput Biol Med 2021 Jul 21;136:104658. Epub 2021 Jul 21.

School of Mechanical Engineering, Tianjin University, Tianjin, 300350, China. Electronic address:

Accurate and robust multiorgan abdominal CT segmentation plays a significant role in numerous clinical applications, such as therapy treatment planning and treatment delivery. Almost all existing segmentation networks rely on fully annotated data with strong supervision. However, annotating fully annotated multiorgan data in CT images is both laborious and time-consuming. Read More

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An Approximation for Metal-Oxide Sensor Calibration for Air Quality Monitoring Using Multivariable Statistical Analysis.

Sensors (Basel) 2021 Jul 13;21(14). Epub 2021 Jul 13.

Department of Automation Engineering, Electronics and Computer Architecture and Networks, University of Cádiz, 11519 Cádiz, Spain.

Good air quality is essential for both human beings and the environment in general. The three most harmful air pollutants are nitrogen dioxide (NO), ozone (O) and particulate matter. Due to the high cost of monitoring stations, few examples of this type of infrastructure exist, and the use of low-cost sensors could help in air quality monitoring. Read More

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Nested versus Independent Sampling: Solving the Mystery of Contradictory Species-Area Relationships.

Am Nat 2021 Aug 14;198(2):268-277. Epub 2021 Jun 14.

AbstractSpecies-area relationships (SARs) describe how the number of species increases with the size of the area surveyed. They usually take the form of a power law on regional spatial scales. A metareview of empirical data has shown that the exponent of the power law is larger on average when the areas are sampled in a nested manner, compared with sampling of isolated areas such as islands or nature reserves of different sizes. Read More

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Recording fine-scale movement of ground beetles by two methods: Potentials and methodological pitfalls.

Ecol Evol 2021 Jul 16;11(13):8562-8572. Epub 2021 May 16.

MTA-ELTE-MTM Ecology Research Group Biological Institute, Eötvös Loránd University Budapest Hungary.

Movement trajectories are usually recorded as a sequence of discrete movement events described by two parameters: step length (distance) and turning angle (bearing). One of the most widespread methods to record the geocoordinates of each step is by a GPS device. Such devices have limited suitability for recording fine movements of species with low dispersal ability including flightless carabid beetles at small spatio-temporal scales. Read More

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A comparative analysis of the modified Rankin Scale, Karnofsky Performance Status and Kurtzke expanded disability status scale in the perioperative management of patients with brainstem cavernous malformations.

Clin Neurol Neurosurg 2021 Jun 25;207:106785. Epub 2021 Jun 25.

Department of Neurosurgery, Kyoto Prefectural University Graduate School of Medicine Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan.

Background: The neurological conditions of brainstem cerebral cavernous malformation (BCM) patients are usually ascertained using Karnofsky Performance Status (KPS) or the modified Rankin scale (mRS). However, these scales do not reflect slight changes in brainstem function, because neither KPS nor mRS includes brainstem symptoms such as worsening of swallowing or diplopia. The main problem when managing the BCM patients is that we can neither systematically record neurological changes nor conduct clinical outcome investigations of BCM due to the lack of an adequately detailed assessment system. Read More

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Prognostic value of patient-reported quality of life for survival in oesophagogastric cancer: analysis from the population-based POCOP study.

Gastric Cancer 2021 Jul 12. Epub 2021 Jul 12.

Department of Medical Oncology, Amsterdam UMC, University of Amsterdam, Cancer Center Amsterdam, Office D3-312, PO Box 22660, 1100DD, Amsterdam, The Netherlands.

Background: Accumulating evidence of trials demonstrates that patient-reported health-related quality of life (HRQoL) at diagnosis is prognostic for overall survival (OS) in oesophagogastric cancer. However, real-world data are lacking. Moreover, differences in disease stages and tumour-specific symptoms are usually not taken into consideration. Read More

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Prevalence of freezing of gait in Parkinson's disease: a systematic review and meta-analysis.

J Neurol 2021 Jul 8. Epub 2021 Jul 8.

Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background: Freezing of gait (FOG) is considered one of the most disturbing and least understood symptoms in Parkinson's disease (PD). The reported prevalence rates of FOG in PD vary widely, ranging from 5 to 85.9%. Read More

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[Quality of life and disease activity assessment in juvenile idiopathic arthritis].

Rev Med Inst Mex Seguro Soc 2021 Jun 14;59(2):133-140. Epub 2021 Jun 14.

Instituto Mexicano del Seguro Social, Centro Médico Nacional "Manuel Ávila Camacho", Hospital de Especialidades, Dirección General. Puebla, Puebla, México.

Background: Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatological disease in children. It is a multisystemic, dynamic pathophysiology of unknown cause and genetically heterogeneous.

Objective: To compare the quality of life and illness' activity in patients with juvenile idiopathic arthritis, from urban, suburban and rural areas. Read More

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Bioactive Compounds of Nutraceutical Value from Fishery and Aquaculture Discards.

Foods 2021 Jun 28;10(7). Epub 2021 Jun 28.

Stazione Zoologica Anton Dohrn, Department of Marine Biotechnology, Villa Dohrn, Punta San Pietro, 80077 Naples, Italy.

Seafood by-products, produced by a range of different organisms, such as fishes, shellfishes, squids, and bivalves, are usually discarded as wastes, despite their possible use for innovative formulations of functional foods. Considering that "wastes" of industrial processing represent up to 75% of the whole organisms, the loss of profit may be coupled with the loss of ecological sustainability, due to the scarce recycling of natural resources. Fish head, viscera, skin, bones, scales, as well as exoskeletons, pens, ink, and clam shells can be considered as useful wastes, in various weight percentages, according to the considered species and taxa. Read More

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Getting to the Heart of Left-Right Asymmetry: Contributions from the Zebrafish Model.

J Cardiovasc Dev Dis 2021 Jun 4;8(6). Epub 2021 Jun 4.

Department of Physiology, The University of Melbourne, Parkville, VIC 3010, Australia.

The heart is laterally asymmetric. Not only is it positioned on the left side of the body but the organ itself is asymmetric. This patterning occurs across scales: at the organism level, through left-right axis patterning; at the organ level, where the heart itself exhibits left-right asymmetry; at the cellular level, where gene expression, deposition of matrix and proteins and cell behaviour are asymmetric; and at the molecular level, with chirality of molecules. Read More

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Bionic Birdlike Imaging Using a Multi-Hyperuniform LED Array.

Sensors (Basel) 2021 Jun 14;21(12). Epub 2021 Jun 14.

School of Instrumentation and Optoelectronic Engineering, Beihang University, Beijing 100191, China.

Digital cameras obtain color information of the scene using a chromatic filter, usually a Bayer filter, overlaid on a pixelated detector. However, the periodic arrangement of both the filter array and the detector array introduces frequency aliasing in sampling and color misregistration during demosaicking process which causes degradation of image quality. Inspired by the biological structure of the avian retinas, we developed a chromatic LED array which has a geometric arrangement of multi-hyperuniformity, which exhibits an irregularity on small-length scales but a quasi-uniformity on large scales, to suppress frequency aliasing and color misregistration in full color image retrieval. Read More

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Challenging response latencies in faking detection: The case of few items and no warnings.

Behav Res Methods 2021 Jun 25. Epub 2021 Jun 25.

Department of Psychology, Queen's University, Kingston, Canada.

AbstractFaking detection is an ongoing challenge in psychological assessment. A notable approach for detecting fakers involves the inspection of response latencies and is based on the congruence model of faking. According to this model, respondents who fake good will provide favorable responses (i. Read More

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Peripheral adenopathies in children - an attempt of clinical morphological profile.

Rom J Morphol Embryol 2020 Oct-Dec;61(4):1193-1212

Departments of Pathology, Carol Davila University of Medicine and Pharmacy, and Fundeni Clinical Institute, Bucharest, Romania;

Aim: The authors have proposed to assess peripheral adenopathies in a series of hospitalized children in order to identify and define clinical and morphological profiles of different types of lymph node (LN) diseases.

Materials And Methods: The studied group consisted of 58 patients less than 18 years of age. The investigation algorithm included: gender, age, site, involvement, side, extension and histopathological (HP) type of LN lesions. Read More

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Methanotrophic denitrification in wastewater treatment: microbial aspects and engineering strategies.

Crit Rev Biotechnol 2021 Jun 22:1-17. Epub 2021 Jun 22.

Department of Hydraulics and Sanitation, São Carlos School of Engineering (EESC), University of São Paulo (USP), São Carlos, Brazil.

Anaerobic technologies are consolidated for sewage treatment and are the core processes for mining marketable products from waste streams. However, anaerobic effluents are supersaturated with methane, which represents a liability regarding greenhouse gas emissions. Meanwhile, anaerobic technologies are not capable of nitrogen removal, which is required to ensure environmental protection. Read More

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Improving the Effectiveness of Psychological Interventions for Depression and Anxiety in Cardiac Rehabilitation: PATHWAY-A Single-Blind, Parallel, Randomized, Controlled Trial of Group Metacognitive Therapy.

Circulation 2021 Jul 21;144(1):23-33. Epub 2021 Jun 21.

Department of Health Sciences, University of Liverpool, United Kingdom (P.F.).

Background: Depression and anxiety in cardiovascular disease are significant, contributing to poor prognosis. Unfortunately, current psychological treatments offer mixed, usually small improvements in these symptoms. The present trial tested for the first time the effects of group metacognitive therapy (MCT; 6 sessions) on anxiety and depressive symptoms when delivered alongside cardiac rehabilitation (CR). Read More

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[Self-assessment of healthcare workers regarding the management of trans people in a university hospital].

Prog Urol 2021 Jun 16. Epub 2021 Jun 16.

Université de Rennes, urologie, CHU Rennes, Rennes, France.

Introduction: Trans people face more barriers when seeking healthcare than the cisgender population probably due to a lack of knowledge, education and comfort of healthcare workers. The purpose of this study was to assess the knowledge and comfort felt by healthcare professionals in managing trans people in a French university hospital.

Methods: A self-questionnaire was emailed to healthcare professionals working in departments usually involved in the care of trans people in a French university hospital "not specialized" in medical and surgical gender transition. Read More

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eDNA sampled from stream networks correlates with camera trap detection rates of terrestrial mammals.

Sci Rep 2021 Jun 15;11(1):11362. Epub 2021 Jun 15.

World Wildlife Fund, Wildlife Conservation Team, Washington, DC, USA.

Biodiversity monitoring delivers vital information to those making conservation decisions. Comprehensively measuring terrestrial biodiversity usually requires costly methods that can rarely be deployed at large spatial scales over multiple time periods, limiting conservation efficiency. Here we investigated the capacity of environmental DNA (eDNA) from stream water samples to survey terrestrial mammal diversity at multiple spatial scales within a large catchment. Read More

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Uncovering transmission patterns of COVID-19 outbreaks: A region-wide comprehensive retrospective study in Hong Kong.

EClinicalMedicine 2021 Jun 6;36:100929. Epub 2021 Jun 6.

Department of Computer Science, Hong Kong Baptist University, Hong Kong Special Administrative Region, People's Republic of China.

Background: Given the dynamism and heterogeneity of COVID-19 transmission patterns, determining the most effective yet timely strategies for specific regions remains a severe challenge for public health decision-makers.

Methods: In this work, we proposed a spatiotemporal connectivity analysis method for discovering transmission patterns across geographic locations and age-groups throughout different COVID-19 outbreak phases. First, we constructed the transmission networks of the confirmed cases during different phases by considering the spatiotemporal connectivity of any two cases. Read More

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Unmodified cellulose filter paper, a sustainable and affordable sorbent for the isolation of biogenic amines from beer samples.

J Chromatogr A 2021 Aug 28;1651:462297. Epub 2021 May 28.

Affordable and Sustainable Sample Preparation (AS2P) Research group. Departamento de Química Analítica, Instituto Universitario de Investigación en Química Fina y Nanoquímica IUNAN, Universidad de Córdoba, Campus de Rabanales, Edificio Marie Curie, Córdoba E-14071, Spain.

While current trends in Green Analytical Chemistry aim at reducing or simplifying sample treatment, food usually comprises complex matrices where direct analysis is not possible in most cases. In this context, sample treatment plays a pivotal role. Biogenic amines are naturally formed in many foodstuffs due to the action of microorganisms, while their presence has been associated with adverse health effects. Read More

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Multicomponent density models for body composition: Review of the dual energy X-ray absorptiometry volume approach.

Obes Rev 2021 Aug 7;22(8):e13274. Epub 2021 Jun 7.

Cancer Center, University of Hawaii Cancer Center, Honolulu, HI, USA.

Accurate and precise body composition estimates, notably of total body adiposity, are a vital component of in vivo physiology and metabolic studies. The reference against which other body composition approaches are usually validated or calibrated is the family of methods referred to as multicomponent "body density" models. These models quantify three to six components by combining measurements of body mass, body volume, total body water, and osseous mineral mass. Read More

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Clinician Use of Primary Care Research Reports.

J Am Board Fam Med 2021 May-Jun;34(3):648-660

From the University of Washington, Seattle (WRP, AY); Monash University, Melbourne, Victoria, Australia, (ES, GMR); Bond University, Robina, Queensland, Australia (PG); Radboud Institute of Health Sciences, Radboud University, Nijmegen, The Netherlands (TOH, CvW); University of Toronto, Toronto, Ontario, Canada (AO); Australia National University, Canberra, ACT, Australia (CvW).

Purpose: To assess how primary care practitioners use reports of general health care (GHC) and primary care (PC) research and how well reports deliver what they need to inform clinical practice.

Methods: International, interprofessional online survey, 2019, of primary care clinicians who see patients at least half time. Respondents used frequency scales to report how often they access both GHC and PC research and how frequently reports meet needs. Read More

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Cross-scale monitoring of habitat suitability changes using satellite time series and ecological niche models.

Sci Total Environ 2021 Aug 20;784:147172. Epub 2021 Apr 20.

CICGE - Centro de Investigação em Ciências Geo-Espaciais, Faculdade de Ciências, Universidade do Porto, Observatório Astronómico "Prof. Manuel de Barros", Alameda do Monte da Virgem, 4430-146 Vila Nova de Gaia, Portugal. Electronic address:

One of the biggest challenges to deal with the global crisis of biodiversity loss is the lack of efficient and viable monitoring systems across scales. Unlike traditional in situ biodiversity monitoring, a usually costly and time-consuming enterprise, satellite remote sensing (SRS) data offer a technically feasible and sustainable in time solution. Here, we devise a cost-effective and upgradeable spatiotemporal framework for monitoring the species-specific habitat availability changes across scales by trend analysis of habitat suitability index (HSI) derived from ecological niche models (ENMs; Maxent) and using time series of SRS data (MODIS). Read More

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Benthic estuarine communities' contribution to bioturbation under the experimental effect of marine heatwaves.

Sci Rep 2021 Jun 1;11(1):11422. Epub 2021 Jun 1.

CIIMAR - Interdisciplinary Centre of Marine and Environmental Research, Novo Edifício Do Terminal de Cruzeiros Do Porto de Leixões, Avenida General Norton de Matos S/N, 4450-208, Matosinhos, Portugal.

Marine heatwaves are increasing worldwide, with several negative impacts on biological communities and ecosystems. This 24-day study tested heatwaves' effect with distinct duration and recovery periods on benthic estuarine communities' diversity and contribution to ecosystem functioning experimentally. The communities were obtained from a temperate estuary, usually subjected to high daily thermal amplitudes. Read More

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Trends in the Hydrogen-Deuterium Exchange at the Carbon Centers. Preparation of Internal Standards for Quantitative Analysis by LC-MS.

Molecules 2021 May 18;26(10). Epub 2021 May 18.

Faculty of Chemistry, University of Wrocław, F. Joliot-Curie 14, 50-383 Wrocław, Poland.

The application of internal standards in quantitative and qualitative bioanalysis is a commonly used procedure. They are usually isotopically labeled analogs of the analyte, used in quantitative LC-MS analysis. Usually, H, C, N and O isotopes are used. Read More

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