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Resilience and Work-Related Stress May Affect Depressive Symptoms in Nursing Professionals during the COVID-19 Pandemic Era.

Psychiatry Investig 2021 Apr 25;18(4):357-363. Epub 2021 Apr 25.

Department of Psychiatry, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Objective: We aimed to investigate the effect of nursing professionals' resilience on their mental health, work-related stress, and anxiety in response to the COVID-19 pandemic.

Methods: We conducted an online survey in the Asan Medical Center and Ulsan University Hospital, South Korea. We extracted data of 824 nursing professionals who consented to participate, including demographic variables and the Stress and Anxiety to Viral Epidemics-9 (SAVE-9), PHQ-9, GAD-7, and Brief Resilience Scale scores. Read More

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Validation of the Korean Version of the Anosognosia Questionnaire for Dementia.

Psychiatry Investig 2021 Apr 25;18(4):324-331. Epub 2021 Apr 25.

Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea.

Objective: Anosognosia is a common phenomenon in individuals with dementia. Anosognosia Questionnaire for dementia (AQ-D) is a well-known scale for evaluating anosognosia. This study aimed to establish a Korean version of the AQ-D (AQ-D-K) and to evaluate the reliability and validity of the AQ-D-K in patients with Alzheimer's disease (AD) dementia. Read More

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Detecting placebo and drug effects on Parkinson's disease symptoms by longitudinal item-score models.

CPT Pharmacometrics Syst Pharmacol 2021 Apr;10(4):309-317

Department of Pharmacy, Uppsala University, Uppsala, Sweden.

This study tested the hypothesis that analyzing longitudinal item scores of the Unified Parkinson's Disease Rating Scale could allow a smaller trial size and describe a drug's effect on symptom progression. Two historical studies of the dopaminergic drug ropinirole were analyzed: a cross-over formulation comparison trial in 161 patients with early-stage Parkinson's disease, and a 24-week, parallel-group, placebo-controlled efficacy trial in 393 patients with advanced-stage Parkinson's disease. We applied item response theory to estimate the patients' symptom severity and developed a longitudinal model using the symptom severity to describe the time course of the placebo response and the drug effect on the time course. Read More

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Antipsychotics are related to psychometric conversion to psychosis in ultra-high-risk youth.

Early Interv Psychiatry 2021 May 5. Epub 2021 May 5.

Programma2000 - Center for Early Detection and Intervention in Psychosis, Department of Mental Health, Niguarda Ca' Granda Hospital, Milan, Italy.

Background: The prescription of antipsychotics outside overt psychotic conditions remains controversial, especially in youth where it is relatively widespread. Furthermore, some studies seem to indicate that antipsychotic exposure in individuals at ultra-high-risk (UHR) for psychosis is associated with higher conversion rates. This study was set up to test whether the inter-current prescription of antipsychotics in UHR patients was related to the psychometric threshold for a diagnosis of psychosis. Read More

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Preliminary Report from the Pelvic Floor Disorders Consortium: Large Scale Data Collection through Quality Improvement Initiatives to Provide Data on Functional Outcomes Following Rectal Prolapse Repair.

Dis Colon Rectum 2021 Apr 26. Epub 2021 Apr 26.

Pelvic Floor Disorders Center, Section of Colon and Rectal Surgery, Massachusetts General Hospital, Boston, MA Department of Colorectal Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH Department of Surgery, The University of Chicago Medicine, Chicago, IL Department of Surgery, Mount Sinai School of Medicine, New York, NY Pelvic Floor Disorders Center, Section of Colon and Rectal Surgery, Massachusetts General Hospital, Boston, MA Division of Colorectal Surgery, University of Massachusetts-Baystate, Springfield, MA Department of General Surgery, Division of Colorectal Surgery, Stanford University Medical Center, Stanford, CA Pelvic Floor Disorders Center, Section of Colon and Rectal Surgery, Massachusetts General Hospital, Boston, MA.

Background: The surgical management of rectal prolapse is constantly evolving, yet numerous clinical trials and meta-analyses studying operative approaches have failed to make meaningful conclusions.

Objective: To report on preliminary data captured during a large-scale quality improvement initiative to measure and improve function in patients undergoing rectal prolapse repair.

Design: Retrospective analysis of prospectively collected surgical quality improvement data. Read More

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Using Natural Language Processing to Automatically Assess Feedback Quality: Findings From Three Surgical Residencies.

Acad Med 2021 May 4. Epub 2021 May 4.

E. Ötleş is Medical Scientist Training Program fellow, Department of Industrial and Operations Engineering, University of Michigan Medical School, Ann Arbor, Michigan. D. Kendrick is assistant professor, Department of Surgery, University of Minnesota Medical School, Minneapolis, Minnesota. Q.P. Solano is a third-year medical student, University of Michigan Medical School, Ann Arbor, Michigan. M. Schuller is senior project manager, Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan. S.L. Ahle is a resident, Department of Surgery, Yale School of Medicine, New Haven, Connecticut. M.H. Eskender is a resident, Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois. E. Carnes is research assistant, Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois. B.C. George is assistant professor and director, Center for Surgical Training and Research, Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan.

Purpose: Learning is markedly improved with high-quality feedback, yet assuring the quality of feedback is difficult to achieve at scale. Natural language processing (NLP) algorithms may be useful in this context as they can automatically classify large volumes of narrative data. However, it is unknown if NLP models can accurately evaluate surgical trainee feedback. Read More

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Efficacy of Selective Vidian Neurectomy for Allergic Rhinitis Combined with Chronic Rhinosinusitis.

ORL J Otorhinolaryngol Relat Spec 2021 May 5:1-8. Epub 2021 May 5.

Department of Otorhinolaryngology Head and Neck Surgery, XuanWu Hospital, Capital Medical University, Beijing, China.

Objective: The aim of this study was to investigate the efficacy of endoscopic selective vidian neurectomy in the treatment of severe persistent allergic rhinitis (AR) combined with chronic rhinosinusitis (CRS) with nasal polyps (ARwCRSwNP).

Methods: One hundred thirty patients with moderate to severe persistent ARwCRSwNP were enrolled at Xuanwu Hospital, Capital Medical University, from September 2015 to September 2017. Patients were divided into 2 groups. Read More

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Efficacy of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in the Adjuvant Setting for Patients with Resected Epidermal Growth Factor Receptor Mutant Non-Small Cell Lung Cancer: A Meta-Analysis with 11 Trials.

Oncol Res Treat 2021 May 5:1-9. Epub 2021 May 5.

Department of Thoracic Surgery, Hebei General Hospital, Shijiazhuang, China.

Background: Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have recently become the standard first-line therapy for advanced non-small cell lung cancer (NSCLC) patients harboring EGFR mutations. This study aimed to define the role of EGFR-TKI treatment in the adjuvant setting of patients with resected EGFR-mutant NSCLC.

Methods: Three online databases (PubMed, Embase, and the Cochrane Library) were used to conduct systematic research to search for studies published before June 1, 2020. Read More

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Interoceptive Sensibility, Alexithymia, and Emotion Regulation in Individuals Suffering from Fibromyalgia.

Psychopathology 2021 May 5:1-6. Epub 2021 May 5.

Institute of Clinical Psychology and Psychotherapy, University of Cologne, Cologne, Germany.

Introduction: People suffering from fibromyalgia syndrome report various difficulties in emotional processing, possibly resulting from changes in bodily perception (interoception). In our study, we investigated the relationships between interoceptive sensibility (IS) and two disease-relevant emotional components (alexithymia and emotion regulation) in fibromyalgia sufferers compared to healthy individuals.

Methods: Fifty-five fibromyalgia sufferers and 55 healthy individuals, matched with regard to age and gender, participated in our cross-sectional study. Read More

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Rural Stroke Surveillance and Establishment of Acute Stroke Care Pathway Using Frontline Health Workers in Rural Northwest India: The Ludhiana Experience.

Neuroepidemiology 2021 May 5:1-9. Epub 2021 May 5.

Department of Neurology, Christian Medical College and Hospital, Ludhiana, India.

Background And Purpose: The role of community health workers (CHWs) in stroke surveillance and in establishing the stroke care pathway has not been studied. The aim of the study was to evaluate the feasibility of using CHWs in the public health system to identify stroke patients for population-based stroke registration and to study the establishment of acute stroke care pathway in rural areas of Ludhiana, Punjab, Northwest India.

Methods: Two rural blocks in Ludhiana district, comprising 164 villages and a population of 259,778, were selected. Read More

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Evaluating the Effectiveness of a One-Week Multimodal Prevention Program for Slowing down and Stress Reduction Performed in a German Health Resort: Results of a Randomized Controlled Trial.

Complement Med Res 2021 May 5:1-11. Epub 2021 May 5.

Chair of Public Health and Health Services Research, Institute for Medical Information Processing, Biometry, and Epidemiology (IBE), Pettenkofer School of Public Health, Ludwig-Maximilians-Universität München, Munich, Germany.

Background: Effective concepts are required to overcome the negative impact of daily stressful overwhelming. We investigated the effectiveness of a 1-week multimodal program for stress reduction.

Methods: We performed a randomized controlled trial including adults with above-average stress level. Read More

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Clinical characteristics of sleep apnea in middle-old and oldest-old inpatients: symptoms and comorbidities.

Sleep Med 2021 Apr 16;82:179-185. Epub 2021 Apr 16.

Sorbonne Université, CNRS, UMR 8256 Biological Adaptation and Aging, F-75005, Paris, France; Assistance Publique - Hôpitaux de Paris (AP-HP), DHU FAST, Functional Explorations and Sleep Investigation Unit for the Older Patients, Charles Foix Hospital, Pitié-Salpêtrière-Charles Foix Group, F-94200, Ivry-sur-Seine, France; Sorbonne Université, UFR Médecine, F-75013, Paris, France. Electronic address:

Background: Obstructive sleep apnea (OSA) is prevalent in older adults but still underdiagnosed for many reasons, such as underreported symptoms, non-specific ones because of the comorbidities and polypharmacy, or the social belief of sleep problems as normal with aging.

Objectives: To identify salient symptoms and comorbidities associated with OSA, diagnosed by nocturnal respiratory polygraphy in geriatric inpatients.

Method: We conducted a retrospective, cross-sectional study in a sample of 102 geriatric inpatients from a French Geriatric University Hospital. Read More

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Clinical competence and its association with self-efficacy and clinical learning environments among Chinese undergraduate nursing students.

Nurse Educ Pract 2021 Apr 16;53:103055. Epub 2021 Apr 16.

Alice Lee Centre for Nursing Studies, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address:

Evaluation and cultivation of clinical competence in undergraduate nursing students are essential in nursing education. Self-efficacy and good clinical learning environments are expected to have a positive influence on the clinical competence of undergraduate nursing students, but few studies have focused on the relationships among clinical competence, self-efficacy, and clinical learning environments. This study aimed to examine clinical competence and its association with self-efficacy and clinical learning environments among Chinese undergraduate nursing students. Read More

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Psychometric Evaluation of the Caregiver Version of the Child PTSD Symptom Scale in a Recently Immigrated, Spanish Speaking Population.

Psychiatry Res 2021 Apr 22;301:113954. Epub 2021 Apr 22.

University of Houston Department of Psychology, Houston, Texas, United States. Electronic address:

In recent years, there has been a large increase in the number of youth and families emigrating from Central America to the United States to escape extreme violence and crime victimization. As a result, the rate of trauma-exposure and trauma-related distress among this population is alarmingly high and necessitates representation of this population in psychological research, particularly related to trauma symptom measurement. The broad aim of the current study was to examine the psychometric performance of caregiver-reported data on one such instrument intended to measure youth trauma symptoms. Read More

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Emerging technologies for genetic modification of solventogenic clostridia: From tool to strategy development.

Bioresour Technol 2021 Apr 27;334:125222. Epub 2021 Apr 27.

Department of Biology, Shantou University, Shantou, Guangdong 515063, China; Guangdong Provincial Key Laboratory of Marine Biotechnology, Shantou University, Shantou, Guangdong 515063, China; Institute of Marine Sciences, Shantou University, Shantou, Guangdong 515063, China. Electronic address:

Solventogenic clostridia has been considered as one of the most potential microbial cell factories for biofuel production in the biorefinery industry. However, the inherent shortcomings of clostridia strains such as low productivity, by-products formation and toxic tolerance still strongly restrict the large-scale application. Therefore, concerns regarding the genetic modification of solventogenic clostridia have spurred interests into the development of modern gene-editing tools. Read More

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Association between metabolic syndrome and resting-state functional brain connectivity.

Neurobiol Aging 2021 Apr 1;104:1-9. Epub 2021 Apr 1.

Neuroimaging Research for Veterans Center (NeRVe), Geriatric Research Education and Clinical Center (GRECC), VA Boston Healthcare System, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.

The objective of this study is to examine whether metabolic syndrome (MetS), the clustering of 3 or more cardiovascular risk factors, disrupts the resting-state functional connectivity (FC) of the large-scale cortical brain networks. Resting-state functional magnetic resonance imaging data were collected from seventy-eight middle-aged and older adults living with and without MetS (27 MetS; 51 non-MetS). FC maps were derived from the time series of intrinsic activity in the large-scale brain networks by correlating the spatially averaged time series with all brain voxels using a whole-brain seed-based FC approach. Read More

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Associations of clinical frailty with severity of limb threat and outcomes in chronic limb-threatening ischaemia.

Ann Vasc Surg 2021 May 2. Epub 2021 May 2.

Department of Cardiovascular Sciences, University of Leicester, UK; Leicester Vascular Institute, University Hospitals of Leicester NHS Trust, UK; National Institute for Health Research Leicester Biomedical Research Centre - The Glenfield Hospital, Leicester, UK.

Objective: Investigate the relationship of frailty and severity of chronic limb-threatening ischaemia (CLTI), and their comparative associations with one-year outcomes, in patients presenting to a vascular limb salvage (VaLS) clinic.

Methods: This retrospective cohort study utilised data collected from a prospectively maintained VaLS clinic database. Patients aged ≥50 presenting to the VaLS clinic with CLTI between February 2018 and April 2019 were included. Read More

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Laser in Glaucoma and Ocular Hypertension Trial (LIGHT) in China A Randomized Controlled Trial: Design and Baseline Characteristics.

Am J Ophthalmol 2021 May 2. Epub 2021 May 2.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Centre, Sun Yat-sen University, Guangzhou, PRC. Electronic address:

Purpose: To describe the baseline characteristics of a trial to evaluate whether selective laser trabeculoplasty (SLT), as a first-line treatment, provides superior economic and health-related quality of life outcomes to medical treatment in China.

Design: LiGHT China trial is an unmasked, single-center, pragmatic, Randomized controlled trial.

Methods: 771 previously undiagnosed patients with primary open angle glaucoma (POAG, 622 patients) or ocular hypertension (OHT, 149 patients) at Zhongshan Ophthalmic Center were recruited from March 2015 to January 2019. Read More

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Association between neurological outcome and poststroke comorbid mood and anxiety disorders: A real-life experience.

Brain Behav 2021 May 5:e02158. Epub 2021 May 5.

Univ. Bordeaux, CNRS, EPHE, INCIA, UMR 5287, Bordeaux, France.

Introduction: Poststroke depression (PSD) and anxiety (PSA) are prevalent and have a strong impact on functional outcome. Beside stroke severity, little is known on their clinical determinants. This study investigated the association between stroke mechanism, neurological poststroke complications and remaining vascular risk factors and the presence of comorbid PSD and PSA, termed poststroke emotional distress (PSED). Read More

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Iranian nurses' perception of the public image of nursing and its association with their quality of working life.

Nurs Open 2021 May 5. Epub 2021 May 5.

Department of Statistics and Epidemiology, School of Health, Tabriz University of Medical Sciences, Tabriz, Iran.

Aim: To investigate the association between the nurses' perception of the public image (PI) of nursing and the quality of nursing work life (QNWL).

Design: A descriptive correlational study.

Methods: 250 nurses of 12 hospitals affiliated with Tabriz University of Medical Sciences were sampled using a proportionate stratified sampling technique. Read More

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Comprehensive Interventions Including Vitamin D Effectively Reduce the Risk of Falls in Elderly Osteoporotic Patients.

Orthop Surg 2021 May 5. Epub 2021 May 5.

Department of Orthopaedics, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Objective: To evaluate the effects of different intervention measures to prevent falls in elderly osteoporotic patients.

Methods: A randomized controlled trial was conducted in our outpatient ward from August 2014 to September 2015. A total of 420 patients over 60 years of age were assigned to four groups. Read More

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Above-ground parts of white grapevine Vitis vinifera cv. Furmint share core members of the fungal microbiome.

Environ Microbiol Rep 2021 May 5. Epub 2021 May 5.

Department of Plant Anatomy, Institute of Biology, Eötvös Loránd University, Pázmány Péter sétány 1/C, Budapest, 1117, Hungary.

Grapevine (Vitis vinifera) is a reservoir of fungal endophytes that may affect its growth, health status and grape production. Although there is growing interest in comparing fungal communities of mainly red grape varieties across various factors using only high-throughput sequencing, the small-scale mycobiome variations in geographically close vineyards need further examination. We aimed to characterize the fungal microbiome of the above-ground tissues of V. Read More

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Longitudinal Monitoring of Cell Metabolism in Biopharmaceutical Production using Label-free Fluorescence Lifetime Imaging Microscopy.

Biotechnol J 2021 May 5:e2000629. Epub 2021 May 5.

GSK Center for Optical Molecular Imaging, University of Illinois at Urbana-Champaign, Urbana, IL, USA.

Chinese hamster ovary (CHO) cells are routinely used in the biopharmaceutical industry for production of therapeutic monoclonal antibodies (mAbs). Although multiple offline and time-consuming measurements of spent media composition and cell viability assays are used to monitor the status of culture in biopharmaceutical manufacturing, the day-to-day changes in the cellular microenvironment need further in-depth characterization. In this study, two-photon fluorescence lifetime imaging microscopy (2P-FLIM) was used as a tool to directly probe into the health of CHO cells in a bioreactor, exploiting the autofluorescence of intracellular nicotinamide adenine dinucleotide phosphate (NAD(P)H), an enzymatic cofactor that determines the redox state of the cells. Read More

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Application of Enhanced Recovery after Surgical Treatment of the Occipitocervical Region.

Orthop Surg 2021 May 5. Epub 2021 May 5.

Department of Orthopaedic Surgery, Eastern Hospital, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, China.

Objective: The concept of enhanced recovery after surgery (ERAS) has been proposed to provide guidance for the improved postoperative rehabilitation of patients with occipitocervical region disease (ORD).

Methods: This study retrospectively investigated 208 consecutive patients (116 men and 92 women) ranging in age from 22 to 76 years with ORD between July 2014 and June 2017 in our medical center, who were divided into three groups that received different preoperative, intraoperative, and postoperative management plans: traditional group (n = 73), ameliorated group (n = 70), and ERAS group (n = 65). We compiled a range of data relating to demographics and postoperative changes in hemoglobin and albumin, surgery duration, intraoperative blood loss, number of postoperative hospitalization days and expenses, readmission rates, and visual analog scale pain symptoms. Read More

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Zinc attenuates ferroptosis and promotes functional recovery in contusion spinal cord injury by activating Nrf2/GPX4 defense pathway.

CNS Neurosci Ther 2021 May 5. Epub 2021 May 5.

Department of Orthopedics, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China.

Aim: Spinal cord injury (SCI) involves multiple pathological processes. Ferroptosis has been shown to play a critical role in the injury process. We wanted to explore whether zinc can inhibit ferroptosis, reduce inflammation, and then exert a neuroprotective effect. Read More

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Validation of Oxford Cognitive Screen: Executive Function (OCS-EF), a tablet-based executive function assessment tool amongst adolescent females in rural South Africa.

Int J Psychol 2021 May 5. Epub 2021 May 5.

Department of Psychiatry, University of Oxford, Oxford, UK.

Short, reliable, easily administered executive function (EF) assessment tools are needed to measure EF in low- and middle-income countries, particularly in sub-Saharan Africa given the prevalence of human immunodeficiency virus (HIV)-associated neurocognitive disorder. We administered Oxford Cognitive Screen-Executive Function (OCS-EF) to 932 rural South African females (mean age 19.7 years). Read More

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Absorbable Hemostatic Pack Effect After Primary Incisor Extraction: A Pilot Study and Introduction of a Novel Scale to Assess Post-Operative Bleeding.

J Clin Pediatr Dent 2021 Apr;45(2):67-73

Objectives: This pilot study compared hemostatic pack (HP) application with no intervention following extraction of maxillary primary incisors in healthy children for effect on bleeding time and influence of patient or tooth variables utilizing a novel scale for assessment of bleeding following extraction.

Study Design: A novel scale was created to assess bleeding after extraction. This scale was utilized in a randomized, split mouth study of healthy children ages 2-7 years old requiring extraction of at least 2 primary maxillary incisors under general anesthesia. Read More

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Age and frailty are independently associated with increased COVID-19 mortality and increased care needs in survivors: results of an international multi-centre study.

Carly Welch

Age Ageing 2021 May;50(3):617-630

Introduction: Increased mortality has been demonstrated in older adults with coronavirus disease 2019 (COVID-19), but the effect of frailty has been unclear.

Methods: This multi-centre cohort study involved patients aged 18 years and older hospitalised with COVID-19, using routinely collected data. We used Cox regression analysis to assess the impact of age, frailty and delirium on the risk of inpatient mortality, adjusting for sex, illness severity, inflammation and co-morbidities. Read More

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Frailty is associated with in-hospital mortality in older hospitalised COVID-19 patients in the Netherlands: the COVID-OLD study.

Age Ageing 2021 May;50(3):631-640

Department of Internal Medicine, Haga Teaching Hospital, The Hague, the Netherlands.

Background: During the first wave of the coronavirus disease 2019 (COVID-19) pandemic, older patients had an increased risk of hospitalisation and death. Reports on the association of frailty with poor outcome have been conflicting.

Objective: The aim of the present study was to investigate the independent association between frailty and in-hospital mortality in older hospitalised COVID-19 patients in the Netherlands. Read More

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