127,706 results match your criteria scale population

Evidence of slow and variable choice-stepping reaction time in cancer survivors with chemotherapy-induced peripheral neuropathy.

Gait Posture 2021 Jul 21;89:178-185. Epub 2021 Jul 21.

Prince of Wales Clinical School, University of New South Wales, Kensington, Australia; Brain and Mind Centre, Faculty of Medicine and Health, The University of Sydney, Camperdown, New South Wales, Australia.

Background: Chemotherapy-induced peripheral neuropathy (CIPN) is reported to affect up to 70 % of cancer survivors. Despite evidence that CIPN-related impairments often translate into balance and mobility deficits, the effects on stepping and quality of gait, well-documented risk factors for falls, are unclear.

Aims: (i) Establish choice-stepping reaction time (CSRT) performance in survivors with CIPN compared to young and older healthy controls and people with Parkinson's disease; (ii) document walking stability; (iii) investigate relationships between stepping and gait data to objective and patient-reported outcomes. Read More

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Geographic differences in gut microbiota composition impact susceptibility to enteric infection.

Cell Rep 2021 Jul;36(4):109457

Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA. Electronic address:

Large-scale studies of human gut microbiomes have revealed broad differences in composition across geographically distinct populations. Yet, studies examining impacts of microbiome composition on various health outcomes typically focus on single populations, posing the question of whether compositional differences between populations translate into differences in susceptibility. Using germ-free mice humanized with microbiome samples from 30 donors representing three countries, we observe robust differences in susceptibility to Citrobacter rodentium, a model for enteropathogenic Escherichia coli infections, according to geographic origin. Read More

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Predicting the environmental suitability for onchocerciasis in Africa as an aid to elimination planning.

PLoS Negl Trop Dis 2021 Jul 28;15(7):e0008824. Epub 2021 Jul 28.

Department of Health Policy Planning and Management, University of Health and Allied Sciences, Ho, Ghana.

Recent evidence suggests that, in some foci, elimination of onchocerciasis from Africa may be feasible with mass drug administration (MDA) of ivermectin. To achieve continental elimination of transmission, mapping surveys will need to be conducted across all implementation units (IUs) for which endemicity status is currently unknown. Using boosted regression tree models with optimised hyperparameter selection, we estimated environmental suitability for onchocerciasis at the 5 × 5-km resolution across Africa. Read More

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The Effect of Immunosuppressant Therapy Adherence on the Comfort of Liver Transplant Recipients.

Gastroenterol Nurs 2021 Jul 27. Epub 2021 Jul 27.

Serdar Saritaş, PhD, is Associate Professor, Department of Surgical Nursing, Faculty of Nursing, Inonu University, Malatya, Turkey. Ahmet Özdemir, PhD, is Assistant Professor, Department of Nursing, Faculty of Health Sciences, Kahramanmaras Sutcu Imam University, Kahramanmaraş, Turkey.

Inadequate immunosuppressive therapy causes rejection, whereas an overdose may lead to infections or malignancy to affect a patient's life and comfort. This study used a descriptive correlational design to determine how compliance with immunosuppressive therapy affected the well-being of liver transplant patients. The study was conducted in the liver transplant unit of a university hospital with 103 patients who underwent liver transplant surgery. Read More

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Favipiravir and Hydroxychloroquine Combination Therapy in Patients with Moderate to Severe COVID-19 (FACCT Trial): An Open-Label, Multicenter, Randomized, Controlled Trial.

Infect Dis Ther 2021 Jul 28. Epub 2021 Jul 28.

College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.

Introduction: Antiviral drugs have shown limited effectiveness in treating patients with coronavirus disease 2019 (COVID-19). We aimed to assess the effects of a favipiravir and hydroxychloroquine combination on treating moderate-to-severe COVID-19 patients.

Methods: An investigator-initiated, multicenter, open-label, randomized trial at nine hospitals. Read More

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Safety and Acceptability of a Natural Language Artificial Intelligence Assistant to Deliver Clinical Follow-up to Cataract Surgery Patients: Proposal.

JMIR Res Protoc 2021 Jul 28;10(7):e27227. Epub 2021 Jul 28.

Centre for Health Technology, University of Plymouth, Plymouth, United Kingdom.

Background: Due to an aging population, the demand for many services is exceeding the capacity of the clinical workforce. As a result, staff are facing a crisis of burnout from being pressured to deliver high-volume workloads, driving increasing costs for providers. Artificial intelligence (AI), in the form of conversational agents, presents a possible opportunity to enable efficiency in the delivery of care. Read More

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Challenges of Estimating Accurate Prevalence of Arm Weakness Early After Stroke.

Neurorehabil Neural Repair 2021 Jul 28:15459683211028240. Epub 2021 Jul 28.

Department of Physical Therapy, 574564University of British Columbia, Vancouver, BC, Canada.

. Recent studies have reported lower statistics of upper limb (UL) weakness (48-57%) compared to widely cited values collected over 2 decades ago (70-80%). . Read More

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The influence of perceived discrimination in healthcare settings on psychological distress among a diverse sample of older Asian Americans.

Aging Ment Health 2021 Jul 28:1-8. Epub 2021 Jul 28.

Institute for Health, Health Care Policy and Aging Research, Rutgers University, New Brunswick, New Jersey, USA.

Objectives: The purpose of this study was to determine the relationship between discrimination in healthcare settings and psychological distress.

Method: This study utilized a retrospective cross-sectional study design. The dataset was obtained from 2015-2017 California Health Interview Survey (CHIS). Read More

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Rare Coding Variants Associated with Electrocardiographic Intervals Identify Monogenic Arrhythmia Susceptibility Genes: A Multi-ancestry Analysis.

Circ Genom Precis Med 2021 Jul 28. Epub 2021 Jul 28.

University of Maryland School of Medicine & Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD.

- Alterations in electrocardiographic (ECG) intervals are well-known markers for arrhythmia and sudden cardiac death (SCD) risk. While the genetics of arrhythmia syndromes have been studied, relations between ECG intervals and rare genetic variation at a population level are poorly understood. - Using a discovery sample of 29,000 individuals with whole-genome sequencing from TOPMed and replication in nearly 100,000 with whole-exome sequencing from the UK Biobank and MyCode, we examined associations between low-frequency and rare coding variants with 5 routinely measured ECG traits (RR, P-wave, PR, and QRS intervals and corrected QT interval [QTc]). Read More

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High-Throughput Multiplex SARS-CoV-2 IgG Microsphere Immunoassay for Dried Blood Spots: A Public Health Strategy for Enhanced Serosurvey Capacity.

Microbiol Spectr 2021 Jul 28:e0013421. Epub 2021 Jul 28.

Wadsworth Center, New York State Department of Healthgrid.238491.5, Albany, New York, USA.

Early in the pandemic when diagnostic testing was not widely available, serosurveys played an important role in estimating the prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in different populations. Dried blood spots (DBS), which can be collected in nonclinical settings, provide a minimally invasive alternative to serum for serosurveys. We developed a Luminex-based SARS-CoV-2 microsphere immunoassay (MIA) for DBS that detects IgG antibodies to nucleocapsid (N) and spike subunit 1 (S1) antigens. Read More

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Visuomotor Synchronization: Military Normative Performance.

Mil Med 2021 Jul 28. Epub 2021 Jul 28.

Brain Trauma Foundation, Palo Alto, CA 94301, USA.

Introduction: Cognitive processes such as perception and reasoning are preceded and dependent on attention. Because of the close overlap between neural circuits of attention and eye movement, attention may be objectively quantified with recording of eye movements during an attention-dependent task. Our previous work demonstrated that performance scores on a circular visual tracking task that requires dynamic synchronization of the gaze with the target motion can be impacted by concussion, sleep deprivation, and attention deficit/hyperactivity disorder. Read More

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Impact of abobotulinumtoxinA on the clinical features of cervical dystonia in routine practice.

Clin Park Relat Disord 2020 15;3:100063. Epub 2020 Jun 15.

Ipsen, 65 Quai Georges Gorse, 92100 Boulogne-Billancourt, France.

Introduction: The efficacy and safety of abobotulinumtoxinA in the management of cervical dystonia has been established in randomized, controlled trials that use a selected trial population. In this meta-analysis of observational data, we evaluated the real-life effectiveness of abobotulinumtoxinA as delivered in routine clinical practice.

Methods: Meta-analysis of patient-level data for adult patients with cervical dystonia treated with abobotulinumtoxinA from three prospective, multicenter, observational studies (NCT01314365, NCT00833196 and NCT01753349). Read More

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A post hoc comparison of levodopa-carbidopa intestinal gel daytime monotherapy vs polytherapy safety and efficacy in patients with advanced Parkinson's disease: Results from 6 phase 3/3b open-label studies.

Clin Park Relat Disord 2020 11;2:25-34. Epub 2019 Dec 11.

Department of Neurology, Wake Forest School of Medicine, 475 Vine Street, Winston-Salem, NC 27101, USA.

Introduction: As Parkinson's disease (PD) progresses, the number/frequency of PD medications tend to increase, which is correlated with decreased patient compliance and suboptimal control of PD symptoms. We investigated efficacy and safety of levodopa-carbidopa intestinal gel (LCIG) daytime monotherapy (with or without nighttime oral levodopa-carbidopa) compared with polytherapy (LCIG with ≥1 adjunctive PD therapy) in advanced PD patients.

Methods: This post hoc descriptive study compared LCIG stable daytime monotherapy with LCIG stable polytherapy in all six phase 3/3b open-label studies from both US and international sites; because of study design variability, pooling data for comparison was not appropriate. Read More

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December 2019

A Geospatial Assessment of Flood Vulnerability Reduction by Freshwater Wetlands-A Benefit Indicators Approach.

Front Environ Sci 2019 May;7:1-54

University of Maryland Center for Environmental Science, Cambridge, MD, United States.

Flooding is among the most common and costly natural disasters in the United States. Flood impacts have been on the rise as flood mitigating habitats are lost, development places more people and infrastructure potentially at risk, and changing rainfall results in altered flood frequency. Across the nation, communities are recognizing the value of flood mitigating habitats and employing green infrastructure alternatives, including restoring some of those ecosystems, as a way to increase resilience. Read More

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Extracting scalar measures from functional data with applications to placebo response.

Stat Interface 2021 ;14(3):255-265

Department of Biostatistics, Columbia University, 722 W. 168th Street, 6th Floor, New York, NY 10032, USA.

In controlled and observational studies, outcome measures are often observed longitudinally. Such data are difficult to compare among units directly because there is no natural ordering of curves. This is relevant not only in clinical trials, where typically the goal is to evaluate the relative efficacy of treatments on average, but also in the growing and increasingly important area of personalized medicine, where treatment decisions are optimized with respect to a relevant patient outcome. Read More

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January 2021

Performance of the Hull Salford Cambridge Decision Rule (HSC DR) for early discharge of patients with findings on CT scan of the brain: a CENTER-TBI validation study.

Emerg Med J 2021 Jul 27. Epub 2021 Jul 27.

Centre for Urgent and Emergency Care Research (CURE), School of Health and Related Research (ScHARR). Emergency Department, Salford Royal Hospital, University of Sheffield and Salford Royal Hospital, Sheffield, UK.

Background: There is international variation in hospital admission practices for patients with mild traumatic brain injury (TBI) and injuries on CT scan. Only a small proportion of patients require neurosurgical intervention, while many guidelines recommend routine admission of all patients. We aim to validate the Hull Salford Cambridge Decision Rule (HSC DR) and the Brain Injury Guidelines (BIG) criteria to select low-risk patients for discharge from the emergency department. Read More

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The details are in the genome-wide SNPs: Fine scale evolution of the Malaysian weedy rice.

Plant Sci 2021 Sep 26;310:110985. Epub 2021 Jun 26.

School of Science, Monash University Malaysia, 46150 Bandar Sunway, Selangor, Malaysia; Monash University Malaysia Genomics Facility, Tropical Medicine and Biology Multidisciplinary Platform, 47500 Bandar Sunway, Selangor, Malaysia. Electronic address:

Weedy rice (Oryza spp.) is a major nuisance to rice farmers from all over the world. Although the emergence of weedy rice in East Malaysia on the island of Borneo is very recent, the threat to rice yield has reached an alarming stage. Read More

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September 2021

Validity of the Utrecht scale for evaluation of rehabilitation-participation restrictions scale in a hospital-based stroke population 3 months after stroke.

Top Stroke Rehabil 2021 Jul 27:1-11. Epub 2021 Jul 27.

Center of Excellence for Rehabilitation Medicine, UMC Utrecht Brain Center, University Medical Center Utrecht and De Hoogstraat Rehabilitation, Utrecht, The Netherlands.

The Utrecht Scale for Evaluation of Rehabilitation-Participation Restrictions scale (USER--R) is a promising patient-reported outcome measure, but has currently not been validated in a hospital-based stroke population. To examine psychometric properties of the USER--R in a hospital-based stroke population 3 months after stroke onset. Cross-sectional study including 359 individuals with stroke recruited through 6 Dutch hospitals. Read More

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Patient-Reported Outcomes and Patient-Reported Experience of Patients With Atrial Fibrillation in the IMPACT-AF Clinical Trial.

J Am Heart Assoc 2021 Jul 28:e019783. Epub 2021 Jul 28.

Department of Health Research Methods, Evidence and Impact McMaster University Hamilton ON Canada.

Background The IMPACT-AF (Integrated Management Program Advancing Community Treatment of Atrial Fibrillation) trial is a prospective, randomized, cluster design trial comparing atrial fibrillation management with a computerized clinical decision support system with usual care (control) in the primary care setting of Nova Scotia, Canada. The objective of this analysis was to assess and compare patient-reported health-related quality of life and patient-reported experience with atrial fibrillation care between clinical decision support and control groups. Methods and Results Health-related quality of life was measured using the EuroQol 5-dimensional 5-level scale, whereas patient-reported experience was assessed using a self-administered satisfaction questionnaire, both assessed at baseline and 12 months. Read More

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Questionnaires used in complex trauma intervention evaluations and consideration of their utility for autistic adults with mild intellectual disability: A systematic review.

Res Dev Disabil 2021 Jul 24;117:104039. Epub 2021 Jul 24.

Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, NE1 4LP, United Kingdom.

Introduction: Research suggests some trauma symptoms e.g. avoidance are difficult to recognise in autistic people with intellectual disability while arousal/emotional and interpersonal difficulties may be useful signals. Read More

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The psychological impact of Gestational Trophoblastic Disease: a prospective observational multicentre cohort study.

BJOG 2021 Jul 27. Epub 2021 Jul 27.

Radboud University Medical Centre, Department of Medical Oncology, Nijmegen, the Netherlands.

Objective: To evaluate the short-term psychological consequences of Gestational Trophoblastic Disease (GTD).

Design: A prospective observational multicentre cohort study.

Setting: Nationwide in the Netherlands POPULATION: GTD patients. Read More

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Bipolar symptoms, somatic burden and functioning in older-age bipolar disorder: Analyses from the Global Aging & Geriatric Experiments in Bipolar Disorder Database project.

Bipolar Disord 2021 Jul 27. Epub 2021 Jul 27.

Department of Psychiatry, University of California San Diego, and Desert-Pacific Mental Illness Research Education and Clinical Center, VA San Diego Healthcare System, San Diego, CA, USA.

Objective: Literature on older-age bipolar disorder (OABD) is limited. This first-ever analysis of the Global Aging & Geriatric Experiments in Bipolar Disorder Database (GAGE-BD) investigated associations among age, BD symptoms, comorbidity, and functioning.

Methods: This analysis used harmonized, baseline, cross-sectional data from 19 international studies (N = 1377). Read More

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Sleeping through a pandemic: impact of COVID-19 related restrictions on narcolepsy and idiopathic hypersomnia.

J Clin Sleep Med 2021 Jul 27. Epub 2021 Jul 27.

Sleep Disorders Unit, University Hospital Pitié-Salpêtrière, APHP-Sorbonne, Paris, France.

Study Objectives: To assess the impact of COVID-19 related restrictions on narcolepsy type 1 (NT2), narcolepsy type 2 (NT2), and idiopathic hypersomnia (IH).

Methods: Participants with NT1, NT2 and IH followed in a university hospital completed an online 78-question survey assessing demographic, clinical and occupational features of the population during the first COVID-19 related lockdown.

Results: The 219 /851 (25. Read More

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Higher Habitual Flavonoid Intakes Are Associated With A Lower Incidence Of Diabetes.

J Nutr 2021 Jul 27. Epub 2021 Jul 27.

Institute for Nutrition Research, School of Medical and Health Sciences, Edith Cowan University, Perth, Australia.

Background: Higher flavonoid intakes are hypothesised to confer protection against type 2 diabetes mellitus.

Objective: We aimed to 1) investigate associations between flavonoid intakes and diabetes, 2) examine the mediating impact of body fat, and 3) identify subpopulations that may receive the greatest benefit from higher flavonoid intakes in participants of the Danish Diet, Cancer, and Health Study followed-up for 23 years.

Design: Cross-sectional associations between baseline flavonoid intake, estimated using food frequency questionnaires and the Phenol Explorer database, and body fat estimated by bioelectrical impedance, were assessed using multivariable-adjusted linear regression models. Read More

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Temporal Expression Pattern of Hemoxygenase-1 Expression and Its Association with Vasospasm and Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage.

Neurocrit Care 2021 Jul 26. Epub 2021 Jul 26.

Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Background: Red blood cell-induced cerebral inflammation and toxicity has been shown to be attenuated by induction of the heme-catalyzing enzyme, hemoxygenase-1 (HO-1), in animal models of subarachnoid hemorrhage (SAH). Although inflammatory mechanisms leading to secondary neuronal injury in SAH are becoming increasingly well understood, markers of cerebral inflammation have so far not been implemented in clinical prediction models of SAH.

Methods: In this biomarker observational study, HO-1 messenger ribonucleic acid (mRNA) expression levels were determined in cerebrospinal fluid (CSF) and blood of 66 patients with aneurysmal SAH on days 1, 7, and 14 after the SAH event. Read More

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High Seroprevalence of Anti-SARS-CoV-2 Antibodies Among Ethiopian Healthcare Workers.

Res Sq 2021 Jul 19. Epub 2021 Jul 19.

COVID-19 pandemic has a devastating impact on the economies and health care system of sub-Saharan Africa. Healthcare workers (HWs), the main actors of the health system, are at higher-risk because of their occupation. Serology-based estimates of SARS-CoV-2 infection among HWs represent a measure of HWs’ exposure to the virus and a guide to the prevalence of SARS-CoV-2 in the community. Read More

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Commuting in metapopulation epidemic modeling.

Sci Rep 2021 Jul 26;11(1):15198. Epub 2021 Jul 26.

Soreq Nuclear Research Center, Yavne, 81800, Israel.

The COVID-19 pandemic led authorities all over the world to imposing travel restrictions both on a national and on an international scale. Understanding the effect of such restrictions requires analysis of the role of commuting and calls for a metapopulation modeling that incorporates both local, intra-community infection and population exchange between different locations. Standard metapopulation models are formulated as markovian processes, and as such they do not label individuals according to their original location. Read More

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Influence of road salt thawing peaks on the inflow composition and activated sludge properties in municipal wastewater treatment.

Water Sci Technol 2021 Jul;84(2):314-322

Institute for Water Quality and Resource Management, TU Wien, Karlsplatz 13/226, 1040 Vienna, Austria.

Operational data over 2 years from three large Austrian wastewater treatment plants (WWTPs) with design capacities of 4 million, 950,000 and 110,000 population equivalent (PE) were examined. Salt peaks, due to thawing road salt were detected and quantified by electrical conductivity, temperature and chloride measurement in the inflow of the WWTPs. Daily NaCl inflow loads up to 1,147 t/d and PE-specific loads of 0. Read More

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50 years of design and operation of large wastewater treatment plant conferences. A history of innovation and development.

Water Sci Technol 2021 Jul;84(2):263-273

Institute of Water Quality and Resource Management, TU Wien, Vienna, Austria.

Large wastewater treatment plants (>50,000 population equivalents) treat more than 80% of the wastewater treated on a global scale, today it might be even >90%. They therefore provide the most relevant contribution to water protection from urban and industrial wastewater. This was already the case in 1971 when academics realised that progress in the scientific community alone will not succeed in a rapid transfer of research results to practitioners in design and operation of these plants. Read More

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Implementation of the programme to prevent falls in older people: a process evaluation protocol.

BMJ Open 2021 Jul 26;11(7):e048395. Epub 2021 Jul 26.

Falls, Balance and Injury Research Centre, Neuroscience Research Australia, Randwick, New South Wales, Australia

Introduction: One in three people aged 65 years and over fall each year. The health, economic and personal impact of falls will grow substantially in the coming years due to population ageing. Developing and implementing cost-effective strategies to prevent falls and mobility problems among older people is therefore an urgent public health challenge. Read More

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