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A prospective randomized trial comparing accelerated concurrent chemoradiotherapy with conventional concurrent chemoradiotherapy in locally advanced carcinoma cervix (IIA-IVA).

J Cancer Res Ther 2021 Jul-Sep;17(4):1012-1016

Department of Radiation Oncology, Tertiary Cancer Centre, IGMC, Shimla, Himachal Pradesh, India.

Introduction: Cervical cancer ranks fourth in women worldwide. The management requires a multidisciplinary approach. Concomitant chemoradiotherapy with cisplatin, followed by brachytherapy, is the standard approach. Read More

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September 2021

Adolescent alcohol use in Estonia compared with Latvia, Lithuania, Finland and Sweden: results from cross-sectional surveys, 2003-2015.

BMJ Open 2021 Sep 15;11(9):e044889. Epub 2021 Sep 15.

Institute of Family Medicine and Public Health, University of Tartu, Tartu, Estonia.

Objectives: The aims of the study were (1) to describe trends in the prevalence of monthly alcohol use from 2003 to 2015 and (2) to analyse the associations between alcohol use and family-related and school-related factors, risk behaviours and perceived alcohol availability in Estonia compared with Latvia, Lithuania, Finland and Sweden.

Methods: The study used nationally representative data of 15-16-year-old adolescents from the European School Survey Project on Alcohol and Other Drugs. Data from Estonia, Latvia, Lithuania, Finland and Sweden collected in 2003, 2007, 2011 and 2015 were utilised (n=57 779). Read More

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September 2021

Trauma, alcohol and drugs misuse in car and motorcycle drivers: a prevalence study in a level one trauma center.

Updates Surg 2021 Sep 13. Epub 2021 Sep 13.

General Surgery and Trauma Team, ASST Niguarda, Piazza Ospedale Maggiore 3Milano, 20162, Milan, Italy.

Alcohol and drugs misuse represents an important social problem. There is no agreement about influence of ethanol and drugs on trauma severity and clinical course. The aim of this study was to investigate the impact of alcohol and drugs abuse on road related trauma managed to our Level I Trauma Center. Read More

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September 2021

Bedtime Routine Characteristics and Activities in Families with Young Children in the North of England.

Int J Environ Res Public Health 2021 Aug 26;18(17). Epub 2021 Aug 26.

Dental Health Unit, Division of Dentistry, The University of Manchester, Manchester M15 6SE, UK.

Bedtime routines have been shown to have significant associations with health, wellbeing and development outcomes for children and parents. Despite the importance of bedtime routines, most research has been carried out in the United States, with little information on bedtime routine characteristics and activities for families in other countries such as the United Kingdom and England in particular. Additionally, little is known about the possible effects of weekends vs. Read More

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Neighborhood Socioeconomic Deprivation and Youth Assault Injuries in Vancouver, Canada.

J Pediatr 2021 Sep 1. Epub 2021 Sep 1.

Department of Medicine, University of British Columbia, Vancouver, Canada; Centre for Clinical Epidemiology & Evaluation, Vancouver, Canada. Electronic address:

Objective: To examine the degree to which neighborhood socioeconomic deprivation influences youth assault injury risk.

Study Design: Population-based retrospective study of youth aged 10 to 24 years seeking emergency medical care between 2012 and 2019 at 14 hospitals in Vancouver, Canada. Neighborhood material and social deprivation were examined as independent predictors of assault injury, accounting for spatial autocorrelation and controlling for neighborhood drinking establishment density. Read More

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September 2021

Patterns of Missing Data with Ecological Momentary Assessment: Feasibility Report from a Pilot Study of People Who Use Drugs.

JMIR Form Res 2021 Aug 24. Epub 2021 Aug 24.

Department of Sociology, University of Nebraska-Lincoln, Lincoln, US.

Background: Ecological momentary assessment (EMA) is a set of research methods that capture events, feelings, and behaviors as they unfold in their "real world" setting. Capturing data "in the moment" reduces important sources of measurement error but also generates challenges for non-compliance (i.e. Read More

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Subtle differences in the pathogenicity of SARS-CoV-2 variants of concern B.1.1.7 and B.1.351 in rhesus macaques.

bioRxiv 2021 May 7. Epub 2021 May 7.

The emergence of several SARS-CoV-2 variants has caused global concerns about increased transmissibility, increased pathogenicity, and decreased efficacy of medical countermeasures. Animal models can be used to assess phenotypical changes in the absence of confounding factors that affect observed pathogenicity and transmissibility data in the human population. Here, we studied the pathogenicity of variants of concern (VOC) B. Read More

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National audit of seven-day working care in radiology.

BJR Open 2021 5;3(1):20200046. Epub 2021 Jul 5.

Department of Radiology, Eastbourne District General Hospital, Eastbourne, UK.

Objectives: To evaluate the extent to which our current provision of diagnostic and interventional radiology services matches existing clinical demand and future government proposals as set out in the Royal College of Radiologists published guidance on providing seven-day acute care.

Methods: In June 2018, all UK radiology department audit leads were sent a questionnaire designed to assess compliance for each standard of the Royal College of Radiologists published guidance on providing seven-day acute care.

Results: 135 hospitals (68%) responded. Read More

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Influence of weekday of admission and level of distress on length of hospital stay in patients with low back pain: a retrospective cohort study.

BMC Musculoskelet Disord 2021 Aug 5;22(1):656. Epub 2021 Aug 5.

Department of Internal Medicine, Winterthur Cantonal Hospital, Winterthur, Switzerland.

Background: Low back pain (LBP) is often a complex problem requiring interdisciplinary management to address patients' multidimensional needs. Providing inpatient care for patients with LBP in primary care hospitals is a challenge. In this setting, interdisciplinary LBP management is often unavailable during weekends. Read More

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Spatial analysis of female intentional homicides.

Rev Esc Enferm USP 2021 23;55:e03770. Epub 2021 Jul 23.

Fundação Joaquim Nabuco, Diretoria de Pesquisas Sociais, Recife, PE, Brasil.

Objective: To analyze the characteristics and spatial distribution of female intentional homicides, according to the regional health offices, in a state in the Northeast Region of Brazil.

Method: This is an ecological study that had the municipality and regional health offices as units of analysis and used data from the Brazilian Mortality Information System. Mortality rates were calculated and smoothed by the local empirical Bayesian method. Read More

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Intranasal ChAdOx1 nCoV-19/AZD1222 vaccination reduces viral shedding after SARS-CoV-2 D614G challenge in preclinical models.

Sci Transl Med 2021 08 27;13(607). Epub 2021 Jul 27.

Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.

ChAdOx1 nCoV-19/AZD1222 is an approved adenovirus-based vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) currently being deployed globally. Previous studies in rhesus macaques revealed that intramuscular vaccination with ChAdOx1 nCoV-19/AZD1222 provided protection against pneumonia but did not reduce shedding of SARS-CoV-2 from the upper respiratory tract. Here, we investigated whether intranasally administered ChAdOx1 nCoV-19 reduces detection of virus in nasal swabs after challenging vaccinated macaques and hamsters with SARS-CoV-2 carrying a D614G mutation in the spike protein. Read More

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Recovery from Acute SARS-CoV-2 Infection and Development of Anamnestic Immune Responses in T Cell-Depleted Rhesus Macaques.

mBio 2021 08 27;12(4):e0150321. Epub 2021 Jul 27.

Laboratory of Virology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseasesgrid.419681.3, National Institutes of Health, Hamilton, Montana, USA.

Severe coronavirus disease 2019 (COVID-19) has been associated with T cell lymphopenia, but no causal effect of T cell deficiency on disease severity has been established. To investigate the specific role of T cells in recovery from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, we studied rhesus macaques that were depleted of either CD4, CD8, or both T cell subsets prior to infection. Peak virus loads were similar in all groups, but the resolution of virus in the T cell-depleted animals was slightly delayed compared to that in controls. Read More

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"Saturday Night Seder" and the Affordances of Cultural Arts during COVID-19.

Contemp Jew 2021 Jul 20:1-20. Epub 2021 Jul 20.

Department of Academic Literacy and Linguistics, BMCC, City University of New York (CUNY), 199 Chambers St. Room N481, New York, NY 10025 USA.

Saturday Night Seder (SNS) was broadcast online on 11 April 2020 as a public celebration of Passover and as a benefit for the Centers for Disease Control and Prevention (CDC) Foundation. Part seder, part telethon, and part Broadway theatrical performance, SNS was the first online event to create a national Jewish communal gathering space in the context of coronavirus disease 2019 (COVID-19) and has since been viewed over 1.5 million times. Read More

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The chronobiology of migraine: a systematic review.

J Headache Pain 2021 Jul 19;22(1):76. Epub 2021 Jul 19.

Danish Headache Center, Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Valdemar Hansen Vej 5, DK-2600, Glostrup, Denmark.

Background: The paroxysmal nature of migraine is a hallmark of the disease. Some patients report increased attack frequency at certain seasons or towards the end of the week, while others experience diurnal variations of migraine attack onset. This systematic review investigates the chronobiology of migraine and its relation to the periodicity of attacks in existing literature to further understand the oscillating nature of migraine. Read More

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Weekend effect in extracorporeal membrane oxygenation therapy initiation: a nationwide cohort study in South Korea.

Ann Transl Med 2021 May;9(9):742

Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea.

Background: Extracorporeal membrane oxygenation (ECMO) therapy requires close monitoring and optimal management after initiation. However, it remains unclear whether the day of the week of ECMO initiation affects patient outcomes. We aimed to investigate whether the initiation of ECMO therapy during a weekend was associated with increased mortality risk. Read More

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Prevalence and Correlates of Illicit Drug Use among Norwegian Nightlife Patrons.

Subst Use Misuse 2021 12;56(11):1697-1706. Epub 2021 Jul 12.

Section of Drug Abuse Research, Department of Forensic Sciences, Oslo University Hospital, Oslo, Norway.

Background: Nightclubs and bars are recreational settings with extensive availability and consumption of alcohol and recreational drugs.

Objectives: This study aims to determine the proportion of nightclub patrons in Norway that tested positive for illicit drugs, moreover, we examined the correlation between positive test results and demographic and substance use characteristics.

Methods: Patrons were recruited outside nightclubs on Friday and Saturday nights between 10:00 pm and 04:00 am. Read More

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Chemotherapy with gemcitabine for unresectable intrahepatic cholangiocarcinoma in a patient undergoing maintenance hemodialysis.

Clin J Gastroenterol 2021 Oct 9;14(5):1511-1516. Epub 2021 Jul 9.

Department of Gastroenterology, Teikyo University Mizonokuchi Hospital, Kawasaki, Japan.

A 56-year-old man with chronic renal failure due to diabetic nephropathy had received maintenance dialysis (every 4 h, three times/week). A hypoechoic tumor measuring 67 × 50 mm in the right lobe of the liver was discovered following routine abdominal ultrasonography. Dynamic computed tomography showed a low-density liver tumor, enlarged hilar lymph node, and a small nodule on the dorsal side of the lower lobe of the left lung. Read More

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October 2021

Day-to-day pattern of work and leisure time physical behaviours: are low socioeconomic status adults couch potatoes or work warriors?

BMC Public Health 2021 07 7;21(1):1342. Epub 2021 Jul 7.

National Research Centre for the Working Environment, Copenhagen, Denmark.

Background: Most studies on day-to-day patterns of physical behaviours (i.e. physical activities and sedentary behaviour) are based on adults with high socioeconomic status (SES) and without differentiating between work and leisure time. Read More

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Drinking location moderates the association between social group size and alcohol consumption among young adults: An event-level study.

Drug Alcohol Rev 2021 Jul 7. Epub 2021 Jul 7.

Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA.

Introduction: Previous studies have demonstrated relationships between social and environmental characteristics of the drinking context and alcohol use. However, the use of event-level data to investigate individual and joint relationships between such characteristics and alcohol use remains a gap in the literature. This study aimed to examine associations between drinking context (location and social group size) and alcohol consumption, and estimate the relationship between the interaction of context and alcohol consumption. Read More

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Saturday night vasculitis, an uncommon presentation but not an original name.

Pediatr Dermatol 2021 05;38(3):731

Hospital Universitario Central de Asturias, UGC Medicina Interna, Unidad de Enfermedades Autoinmunes Sistémicas, Oviedo, Spain.

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Weekend and evening planned colonoscopy activity: a safe and effective way to meet demands.

Endosc Int Open 2021 Jul 17;9(7):E1026-E1031. Epub 2021 Jun 17.

Endoscopy unit, Sheffield Teaching Hospitals, University of Sheffield, Sheffield, UK.

Colonoscopy is the "gold standard" investigation for assessment of the large bowel that detects and prevents colorectal cancer, as well as non-neoplastic conditions. The Joint Advisory Group (JAG) on Gastrointestinal Endoscopy recommends monitoring key performance indicators such as cecal intubation rate (CIR) and adenoma detection rate (ADR). We aimed to investigate the quality of colonoscopies carried out during evening and Saturday lists in our unit and compare them against JAG standards of quality for colonoscopies. Read More

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Is the weekend effect true in acute stroke patients at tertiary stroke center?

J Neurol Sci 2021 08 24;427:117557. Epub 2021 Jun 24.

Department of Neurology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. Electronic address:

Background: There is contradicting evidence on the outcome of emergency patients treated during weekends versus weekdays. We studied if outcome of ischemic stroke patients receiving intravenous thrombolysis (IVT) differs according to the treatment time.

Methods: Our retrospective study included consecutive patients receiving IVT within 4. Read More

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Medication Error During the Day and Night Shift on Weekdays and Weekends: A Single Teaching Hospital Experience in Riyadh, Saudi Arabia.

Risk Manag Healthc Policy 2021 21;14:2571-2578. Epub 2021 Jun 21.

Department of Pharmacy Services, King Saud University Medical City, Riyadh, Saudi Arabia.

Background: The association between medication error incidence and time (day shift vs night shift) have not been extensively studied in Saudi Arabia, this study aimed to answer this question: is there a relationship between medication error incidence and time of the day (day shifts vs night shifts) on weekdays and weekends?.

Objective: To identify whether medication errors and their sub-categories are significantly different between day shifts, night shifts, during weekdays and weekends.

Methods: A retrospective analysis of medication errors reported by health-care practitioners from January 2018 to December 2019 through the Electronic-Occurrence Variance Reporting System (E-OVR) of a university teaching hospital in Riyadh, Saudi Arabia. Read More

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Risk factors leading to COVID-19 cases in a Sydney restaurant.

Aust N Z J Public Health 2021 Jun 28. Epub 2021 Jun 28.

South Eastern Sydney Local Health District, South Eastern Sydney Public Health Unit, New South Wales.

Objective: To explore the factors associated with the transmission of SARS-CoV-2 to patrons of a restaurant.

Methods: A retrospective cohort design was undertaken, with spatial examination and genomic sequencing of cases. The cohort included all patrons who attended the restaurant on Saturday 25 July 2020. Read More

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Size does matter: An exploration of the relationship between licensed venue capacity and on-premise assaults.

Alcohol Clin Exp Res 2021 06 22;45(6):1298-1303. Epub 2021 Jun 22.

School of Psychology, Deakin University, Geelong, Vic., Australia.

Aims: Venue capacity has been proposed as a factor associated with increased number of violent incidents on-premises, though no specific research has demonstrated this association, and instead has tended to focus on the relationship between crowding and aggression. The aim of current paper is to investigate the association between venue capacity and the number of violent incidents on-premises.

Methods: Venue capacity data (the maximum capacity listed on the liquor license) were obtained for all venues in central Melbourne from 2010 until 2016. Read More

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Assessing the Association Between Social Gatherings and COVID-19 Risk Using Birthdays.

JAMA Intern Med 2021 08;181(8):1090-1099

Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts.

Importance: Many policies designed to stop the spread of COVID-19 address formal gatherings, such as workplaces and dining locations. Informal social gatherings are a potentially important mode of SARS-CoV-2 transmission, but studying their role in transmission is challenged by data and methodological limitations; birthdays offer an opportunity to empirically quantify the potential role of small social gatherings in COVID-19 spread.

Objective: To assess the association between social gatherings and SARS-CoV-2 transmission by studying whether COVID-19 rates increase after birthdays in a household. Read More

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Estimation of the probability of daily fluctuations of incidence of COVID-19 according to official data.

PeerJ 2021 4;9:e11049. Epub 2021 Jun 4.

Department of Medical Informatics and Statistics, I.M. Sechenov First Moscow State Medical University, Moscow, Russia.

When studying the dynamics of morbidity and mortality, one should not limit ourselves to analyzing general trends. Interesting information can be obtained from the analysis of deviations in morbidity and mortality from the general dynamics. Comparison of the cases of morbidity or death for adjacent time intervals allows us to find out whether the changes in conditions were for short periods of time and whether the cases of morbidity or death were independent. Read More

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Big Data-Enabled Analysis of Factors Affecting Patient Waiting Time in the Nephrology Department of a Large Tertiary Hospital.

J Healthc Eng 2021 27;2021:5555029. Epub 2021 May 27.

Outpatient Department, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.

The length of waiting time has become an important indicator of the efficiency of medical services and the quality of medical care. Lengthy waiting times for patients will inevitably affect their mood and reduce satisfaction. For patients who are in urgent need of hospitalization, delayed admission often leads to exacerbation of the patient's condition and may threaten the patient's life. Read More

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Spatial and temporal variations of faecal indicator bacteria in Lake Bunyonyi, South-Western Uganda.

SN Appl Sci 2021 10;3(7):697. Epub 2021 Jun 10.

Department of Aquatic Sciences and Fisheries, University of Dar Es Salaam, P.O. Box 35064, Dar es Salaam, Tanzania.

Microbial water quality serves to indicate health risks associated with the consumption of contaminated water. Nevertheless, little is known about the microbiological characteristics of water in Lake Bunyonyi. This study was therefore undertaken to examine the spatial and temporal variations of faecal indicator bacteria (FIB) in relation to physicochemical parameters in Lake Bunyonyi. Read More

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