259 results match your criteria satellitosis

NCCN Guidelines® Insights: Melanoma: Cutaneous, Version 2.2021.

J Natl Compr Canc Netw 2021 Apr 1;19(4):364-376. Epub 2021 Apr 1.

32National Comprehensive Cancer Network.

Over the past few years, the NCCN Guidelines for Melanoma: Cutaneous have been expanded to include pathways for treatment of microscopic satellitosis (added in v2.2020), and the following Principles sections: Molecular Testing (added in v2.2019), Systemic Therapy Considerations (added in v2. Read More

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The Histogenetic Model of Melanoma in the Modern Era of Personalized Medicine.

Acta Dermatovenerol Croat 2020 Dec;28(7):236-237

Prof. Luca Roncati, MD, DMLS, PhD , Polyclinic Hospital, Largo del Pozzo 71 - 41124 , Modena (MO), Italy;

Malignant melanoma (M) can be defined, quite simply, as a malignant neoplasm derived from melanocytes; however, there is great histological and, consequently, clinical variability from case to case (1). In order to try to overcome this intrinsic difficulty, various classification systems have been proposed over the years; as part of this effort, the World Health Organization (WHO) introduced its famous classification about half a century ago (2). Currently, the International Classification of Diseases for Oncology (ICD-O), provided by the WHO International Agency for Research on Cancer (IARC), distinguishes the in situ forms from invasive ones, recognizing four main morphological subtypes: nodular M, superficial spreading M, lentigo maligna M, and acral lentiginous M (3). Read More

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December 2020

Clinicopathological, Genetic and Survival Advantages of Naevus-associated Melanomas: A Cohort Study.

Acta Derm Venereol 2021 Mar 31;101(3):adv00425. Epub 2021 Mar 31.

Department of Dermatology, Hospital Clinic of Barcelona, Barcelona, Spain.

Several studies have suggested that naevus-associated melanomas differ from de novo melanomas, being thinner and with less ulceration; however, the prognostic implication is unclear. The objective of this study was to describe clinicopathological, genetic and survival characteristics of de novo and naevus-associated melanomas in a cohort of primary invasive cutaneous melanomas over a 20-year period. Of the 2,227 patients included in the study, 509 (22. Read More

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Dissemination Patterns and Short-Term Management of Multifocal Rosette-Forming Glioneuronal Tumors.

World Neurosurg 2021 Feb 18;149:86-93. Epub 2021 Feb 18.

Department of Neurosurgery, Saint Louis University School of Medicine, St. Louis, Missouri, USA.

Background: Multifocal rosette-forming glioneuronal tumors (RGNTs) are challenging to manage. Gross total resection is often impossible, and data on adjunctive therapies are limited. We reviewed cases of multifocal RGNTs in the literature with special focus on dissemination patterns and management. Read More

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February 2021

Neurobiology of COVID-19: how can the virus affect the brain?

Braz J Psychiatry 2021 Feb 10. Epub 2021 Feb 10.

Laboratório de Fisiopatologia Experimental, Programa de Pós-Graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil.

Severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) causes the coronavirus disease 2019 (COVID-19), which has been declared a public health emergency of international interest, with confirmed cases in most countries. COVID-19 presents manifestations that can range from asymptomatic or mild infections up to severe manifestations that lead to hospitalization and death. A growing amount of evidence indicates that the virus may cause neuroinvasion. Read More

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February 2021

Detection of Tumor Multifocality in Resectable Intrahepatic Cholangiocarcinoma: Defining the Optimal Pre-operative Imaging Modality.

J Gastrointest Surg 2021 Feb 9. Epub 2021 Feb 9.

Department of Surgery, Division of Surgical Oncology, Oregon Heath & Science University (OHSU), 3181 SW Sam Jackson Park Rd, Mail Code: L-619, Portland, OR, 97239, USA.

Background: Multiple tumor foci (MTF) in intrahepatic cholangiocarcinoma (ICC), including satellitosis and true multifocality, is a known negative prognostic factor and can inform pre-operative decision-making. Lack of standardized pre-operative liver staging practices may contribute to undiagnosed MTF and poor outcomes. We sought to investigate the sensitivity of different cross-sectional imaging modalities for MTF at our institution. Read More

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February 2021

Glucose transporter Glut1 controls diffuse invasion phenotype with perineuronal satellitosis in diffuse glioma microenvironment.

Neurooncol Adv 2021 Jan-Dec;3(1):vdaa150. Epub 2020 Oct 30.

Department of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu, Japan.

Background: Gliomas typically escape surgical resection and recur due to their "diffuse invasion" phenotype, enabling them to infiltrate diffusely into the normal brain parenchyma. Over the past 80 years, studies have revealed 2 key features of the "diffuse invasion" phenotype, designated the Scherer's secondary structure, and include perineuronal satellitosis (PS) and perivascular satellitosis (PVS). However, the mechanisms are still unknown. Read More

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October 2020

Effects of Untreated Drinking Water at Three Indigenous Yaqui Towns in Mexico: Insights from a Murine Model.

Int J Environ Res Public Health 2021 01 19;18(2). Epub 2021 Jan 19.

Department of Biological Chemical Sciences, University of Sonora, Rosales and Encinas, Hermosillo 83000, Sonora, Mexico.

Background: Reports in a northwestern Mexico state linked arsenic (As) in drinking water to DNA damage in people from indigenous communities. However, this correlation remains under discussion due to unknown variables related to nutrition, customs, and the potential presence of other metal(oid)s.

Methods: To determine this association, we sampled water from three Yaqui towns (Cócorit, Vícam, and Pótam), and analyzed the metals by ICP-OES. Read More

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January 2021

Excitatory/Inhibitory Synaptic Ratios in Polymicrogyria and Down Syndrome Help Explain Epileptogenesis in Malformations.

Pediatr Neurol 2021 Mar 5;116:41-54. Epub 2020 Nov 5.

Department of Paediatrics, University of Calgary Cumming School of Medicine and Alberta Children's Hospital Research Institute (Owerko Centre), Calgary, Alberta, Canada; Department of Clinical Neurosciences, University of Calgary Cumming School of Medicine and Alberta Children's Hospital Research Institute (Owerko Centre), Calgary, Alberta, Canada.

Background: The ratio between excitatory (glutamatergic) and inhibitory (GABAergic) inputs into maturing individual cortical neurons influences their epileptic potential. Structural factors during development that alter synaptic inputs can be demonstrated neuropathologically. Increased mitochondrial activity identifies neurons with excessive discharge rates. Read More

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Disease Progression in Cutaneous Squamous Cell Carcinoma Patients With Satellitosis and In-transit Metastasis.

Anticancer Res 2021 Jan;41(1):289-295

Department of Radiation Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, U.S.A.

Background/aim: Satellitosis/in-transit metastasis (S-ITM) has prognostic value in melanoma and Merkel cell carcinoma, but is not incorporated into cutaneous squamous cell carcinoma (cSCC) staging.

Patients And Methods: From our IRB-approved registry, patients with high-risk cSCC, including patients with S-ITM, were identified. Univariate (UVA) and multivariate (MVA) analyses were performed to compare disease progression (DP) and overall survival (OS). Read More

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January 2021

, a Crosstalk between Neurons, Vascular Structures and Neoplastic Cells in Brain Tumours; Early Manifestation of Invasive Behaviour.

Cancers (Basel) 2020 Dec 11;12(12). Epub 2020 Dec 11.

Brain Tumour Research Centre, Institute of Biological and Biomedical Sciences (IBBS), School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2DT, UK.

The secondary structures of Scherer commonly known as perineuronal and perivascular satellitosis have been identified as a histopathological hallmark of diffuse, invasive, high-grade gliomas. They are recognised as perineuronal satellitosis when clusters of neoplastic glial cells surround neurons cell bodies and perivascular satellitosis when such tumour cells surround blood vessels infiltrating Virchow-Robin spaces. In this review, we provide an overview of emerging knowledge regarding how interactions between neurons and glioma cells can modulate tumour evolution and how neurons play a key role in glioma growth and progression, as well as the role of perivascular satellitosis into mechanisms of glioma cells spread. Read More

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December 2020

A clinical and histological comparison between acute cutaneous graft-versus-host disease and other maculopapular eruptions following hematopoietic stem cell transplantation: a retrospective cohort.

Int J Dermatol 2021 Jan 29;60(1):60-69. Epub 2020 Sep 29.

Division of Dermatology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Background: Prompt management of acute graft-versus-host disease (GVHD) may prevent its morbidity and mortality. Maculopapular (MP) eruption is a presenting sign of acute GVHD, but differentiation from other causes of MP rash is challenging.

Methods: A retrospective study was conducted among patients developing MP eruptions after allogeneic hematopoietic stem cell transplantation. Read More

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January 2021

Putative Malignant Pleural Mesothelioma in situ (MPMIS) with Sequential Acquisition of Genomic Alterations on Fluorescence in situ Hybridization (FISH) Examination.

Acta Cytol 2021 19;65(1):99-104. Epub 2020 Aug 19.

Department of Pathology, Institute of Medical Genetics and Pathology, University Hospital of Basel, University of Basel, Basel, Switzerland,

Malignant pleural mesothelioma (MPM) is a rare and deadly disease. A precursor in situ lesion, malignant pleural mesothelioma in situ (MPMIS), has recently been proposed. On cytological examination, the distinction between reactive and malignant mesothelial cells is often challenging, and sometimes even impossible without ancillary methods. Read More

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January 2021


J Wildl Dis 2020 10;56(4):873-883

US Geological Survey, National Wildlife Health Center, 6006 Schroeder Road, Madison, Wisconsin 53711, USA.

Before 2001, all serosurveys for morbilliviruses in sea otters (Enhydra lutris) in California, Washington, and Alaska, US, documented a 0% seroprevalence. The first published serologic detections of morbillivirus in sea otters occurred in 2001-02 in live-captured Washington sea otters, with a documented 80% seroprevalence. We conducted a retrospective study of sea otter cases from 1989 to 2010 compiled at the US Geological Survey, National Wildlife Health Center to identify cases of morbilliviral disease in Washington sea otters and to characterize the disease using immunohistochemistry, reverse transcription (RT)-PCR, genetic sequencing, virus isolation, and serology. Read More

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October 2020

Myelopathy and Reactive Microgliosis and Astrogliosis in Equine Back Pain.

J Equine Vet Sci 2020 07 9;90:103019. Epub 2020 Apr 9.

Department of Veterinary Laboratory Diagnosis, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.

Equine chronic back pain (CBP) has been linked to different pathologic processes, which directly or indirectly involve spinal structures. Thus, making diagnosis and management very challenging with most horses with the condition recommended for early retirement from athletic activity. This study described the spinal cord lesions and the development of reactive microgliosis and astrocytosis in the spinal cords of horse with CBP. Read More

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Rapid response of hyperkeratotic erythema multiforme to oclacitinib in two dogs.

Vet Dermatol 2020 Aug 19;31(4):330-e86. Epub 2020 Apr 19.

Department of Clinical Sciences, College of Veterinary Medicine, NC State University, 1060 William Moore Drive, Raleigh, NC, 27607, USA.

Background: Hyperkeratotic erythema multiforme (HKEM) is a clinically distinct dermatosis and poorly characterized syndrome, comprised of hyperkeratotic plaques with variable symmetry and apoptosis similar to "classic" erosive canine EM. Hyperkeratotic EM has a protracted clinical course and, although treatments with glucocorticoids, azathioprine and/or ciclosporin have been tried, rates of remission are low.

Objectives: To describe successful treatment of HKEM in two dogs using oclacitinib. Read More

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A spindle cell squamous cell carcinoma on the cheek presenting with in-transit metastases and a satellite lesion.

Eui-Tae Lee

Arch Craniofac Surg 2020 Feb 20;21(1):58-63. Epub 2020 Feb 20.

Department of Plastic and Reconstructive Surgery, Chungbuk National University College of Medicine, Cheongju, Korea.

Spindle cell squamous cell carcinoma (SpSCC) is a biphasic tumor composed of squamous cell epithelial and spindle cell mesenchymal components, both of which are malignant. Cutaneous SpSCC can cause diagnostic and therapeutic difficulties because of its rarity, heterogeneity, morphological similarity to other cutaneous spindle cell neoplasms, and uncertain pathogenesis and prognosis, particularly when the squamous cell carcinoma component is minimal or missing. Intransit metastasis and satellite lesion (satellitosis) constitute a spectrum of non-nodal regional metastases. Read More

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February 2020

Molecular characterization and diagnostic investigations of rabies encephalitis in camels (Camelus dromedaries) in Oman: a retrospective study.

Trop Anim Health Prod 2020 Jul 2;52(4):2163-2168. Epub 2020 Mar 2.

Animal Health Research Center, Directorate General of Agriculture and Livestock Research, Ministry of Agriculture and Fisheries, Muscat, Sultanate of Oman.

The accurate and early diagnosis of rabies is critical for undertaking public health measures in animals. The aim of the current study was to identify the molecular characterization of the circulating rabies virus (RABV) among camels (Camelus dromedaries) in Oman and to evaluate the efficacy of the histopathology and reverse transcription polymerase chain reaction (RT-PCR) as diagnostic tools of acute rabies encephalitis in camels in comparison with direct fluorescent antibody test (dFAT). Of the forty-five brain samples from suspected camels submitted to the Animal Health Research Center in Oman (2009-2013), 22 cases were positive by dFAT and RT-PCR. Read More

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Blue nevus with satellitosis: a case report in a pregnant patient.

G Ital Dermatol Venereol 2020 Feb 5. Epub 2020 Feb 5.

Department of Dermatology and Venereology, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.

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February 2020

Are apoptosis-determining techniques useful to establish an early diagnosis of acute graft-vs-host disease in pediatric patients under treatment with multiple drugs?

J Cutan Pathol 2020 Jun 25;47(6):517-523. Epub 2020 Feb 25.

Department of Dermatology, National Institute of Pediatrics, Mexico City, Mexico.

Background: There are no pathognomonic histopathological features to distinguish acute graft-vs-host disease (aGVHD) from skin drug reactions (SDRs) in pediatric patients with multiple drug regimens that have received blood transfusions and/or transplants. We aimed to determine if the addition of apoptosis markers is helpful to distinguish aGVHD from SDRs in these patients.

Methods: Skin biopsy specimens from patients with a clinical diagnosis of aGVHD or SDRs were evaluated for the presence of apoptotic bodies, satellitosis, interface damage, vasculitis, and inflammatory infiltrate on H&E stain. Read More

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Factors Affecting Local and Intra Hepatic Distant Recurrence After Surgery for Hcc: An Alternative Perspective on Microvascular Invasion and Satellitosis - A Western European Multicentre Study.

J Gastrointest Surg 2021 Jan 21;25(1):104-111. Epub 2020 Jan 21.

Department of Surgery, School of Medicine and Surgery, University of Milan-Bicocca, Milan, Italy.

Background: Few studies have focused on risk factors which may predict an intrahepatic local recurrence (LR) on the surgical edge rather than a distant recurrence (DR) in other liver segments after surgery for hepatocarcinoma (HCC). The purpose of this study was to assess the risk factors for both patterns of recurrence.

Methods: An international, multicentre, retrospective study was conducted by collecting data on all consecutive patients with a first diagnosis of HCC who were treated between 2010 and 2017. Read More

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January 2021

Erythema Multiforme Major in a Dog Treated with Intravenous Human Immunoglobulin and Immunosuppressive Therapy.

J Am Anim Hosp Assoc 2020 Mar/Apr;56(2):133-138. Epub 2020 Jan 21.

From the Department of Veterinary Clinical Sciences (S.J.R., V.M.B., M.C.W.), and Department of Pathobiological Sciences (I.M.L.), School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana.

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November 2020

Hans Joachim Scherer and His Impact on the Diagnostic, Clinical, and Modern Research Aspects of Glial Tumors.

Cureus 2019 Nov 13;11(11):e6148. Epub 2019 Nov 13.

General and Clinical Pathology, Forensic Medicine and Deontology, Medical University of Varna, Varna, BGR.

The historical descriptions of glial tumors are often poorly understood and interpreted. The gross and histological depictions of glial tumors are often credited to Virchow, and while the first true histological description is truly his, gross descriptions can be traced back to the beginning of the 1800s, with their classification and histogenesis attributed to Percival Bailey and Harvey Cushing. Without any question, the most prominent and under-credited researcher in the field of glioma pathobiology was the German neuropathologist Hans Joachim Scherer. Read More

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November 2019

Neuropathology mediated through caspase dependent extrinsic pathway in goat kids naturally infected with PPRV.

Microb Pathog 2020 Mar 23;140:103949. Epub 2019 Dec 23.

Division of Pathology, ICAR-Indian Veterinary Research Institute (IVRI), Izatnagar, India.

Peste des petits ruminant (PPR), a highly contagious viral disease of small ruminants, is characterized by erosive stomatitis and pneumo-enteritis. However, its neurovirulence potential as observed with other morbilliviruses has not been fully investigated. The present study describes the neuropathological alterations induced by PPR virus through apoptotic pathway. Read More

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Revisiting multifocal breast cancer: a clonality study of ductal carcinoma using whole exome sequencing.

Hum Pathol 2019 12 6;94:71-77. Epub 2019 Nov 6.

New York University Medical Center. Electronic address:

Multifocal breast cancer (MFBC), ductal type, has been hypothesized to arise by one of two mechanisms: either through intramammary/intralymphatic spread from a single index tumor (MBC-1), or as multiple independent tumors with each focus carrying its corresponding ductal carcinoma in-situ (MBC-2). In order to improve our understanding of MFBC pathogenesis, we employed laser capture microdissection coupled with whole-exome sequencing to study clonal origin in MFBC. We selected three cases of MBC-1 (C1 to C3) and MBC-2 (C4 to C6) and analyzed three foci from each case. Read More

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December 2019

[Pyogenic granuloma with satellitosis].

Hautarzt 2020 Mar;71(3):219-222

Klinik für Dermatologie, Allergologie und Phlebologie, Klinikum Bremerhaven Reinkenheide, Postbrookstr. 103, 27574, Bremerhaven, Deutschland.

A 16-year-old female developed a satellite-like recurrence of a pyogenic granuloma on her thorax 2 weeks after complete excision. Treatment with a pulsed dye laser led to a complete resolution. BRAF and RAS mutations detected in the pyogenic granuloma are considered major driver mutations. Read More

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Factors associated with sentinel lymph node status and prognostic role of completion lymph node dissection for thick melanoma.

Eur J Surg Oncol 2020 02 2;46(2):263-271. Epub 2019 Oct 2.

Dermatology Department, Instituto Valenciano de Oncología, Valencia, Spain.

Introduction: Sentinel lymph node (SLN) biopsy is useful for the prognostic stratification of patients with thick melanoma. Identifying which variables are associated with SLN involvement and establishing risk in different subgroups of patients could be useful for guiding the indication of SLN biopsy. The value of complete lymph node dissection (CLND) in patients with a positive SLN biopsy is currently under debate. Read More

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February 2020

Polymorphous Low-Grade Neuroepithelial Tumor of the Young: A Case Report with Genomic Findings.

World Neurosurg 2019 Dec 11;132:347-355. Epub 2019 Sep 11.

Department of Pathology, Medical College of Georgia at Augusta University, Augusta, Georgia, USA. Electronic address:

Background: Polymorphous low-grade neuroepithelial tumor of the young (PLNTY) is a recently recognized epileptogenic neuroepithelial tumor. Despite its distinctiveness, its polymorphous histology and the nature of its oligodendrocyte-like cells remain unclear.

Case Description: A 30-year-old, right-handed man was diagnosed with intractable epilepsy since 22 years of age. Read More

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December 2019

[MRI in a dog with confirmed pseudorabies infection].

Tierarztl Prax Ausg K Kleintiere Heimtiere 2019 Aug 21;47(4):272-281. Epub 2019 Aug 21.

Tierklinik Dresdner Heide, Dresden.

We describe the magnetic resonance imaging (MRI) examination in a dog with confirmed suid herpesvirus 1 (SHV-1) infection and compare the findings to the results of the histopathologic examination. A 5-year-old female German Hunting Terrier used for hunting displayed severe pruritus and fever 7 days after contact with a wild boar. Two days after the onset of the first disease symptoms, the dog was presented with seizures and hyperthermia. Read More

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