1,179 results match your criteria satellite glial

β2 adrenergic receptor mediates noradrenergic action to induce CREB phosphorylation in satellite glial cells of dorsal root ganglia to regulate visceral hypersensitivity.

Pain 2021 Apr 30. Epub 2021 Apr 30.

Department of Physiology and Biophysics, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298-0551, USA.

Abstract: Sympathoneuronal outflow into dorsal root ganglia (DRG) is suggested to be involved in sympathetically maintained chronic pain, which is mediated by norepinephrine (NE) action on DRG cells. The present study combined in vitro and in vivo approaches to identify the cell types of DRG that received NE action and examined cell-type specific expression of adrenergic receptors (ARs) in DRG. Using DRG explants, we identified that NE acted on satellite glial cells (SGCs) to induce the phosphorylation of cAMP response element-binding (CREB). Read More

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Verification of neuroprotective effects of alpha-lipoic acid on chronic neuropathic pain in a chronic constriction injury rat model.

Open Life Sci 2021 12;16(1):222-228. Epub 2021 Mar 12.

Department of Neurosurgery, Hamamatsu University School of Medicine, Handayama, 1-20-1, Higashi-ku, Hamamatsu City, Shizuoka 431-3192, Japan.

Treatment of neuropathic pain is far from satisfactory. This study sought evidence of a neuroprotective effect of alpha-lipoic acid (ALA) to treat neuropathic pain in a chronic constriction injury (CCI) rat model. A total of 48 rats were randomly divided into sham, CCI, or CCI + ALA groups. Read More

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The α2δ-1-NMDAR1 interaction in the trigeminal ganglion contributes to orofacial ectopic pain following inferior alveolar nerve injury.

Brain Res Bull 2021 Jun 31;171:162-171. Epub 2021 Mar 31.

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China; Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China. Electronic address:

Orofacial ectopic pain can often arise following nerve injury. However, the exact mechanism responsible for orofacial ectopic pain induced by trigeminal nerve injury remains unknown. The α2δ-1 and glutamate N-methyl-d-aspartic acid receptor (NMDAR) interactions have been demonstrated to participate in neuropathic pain regulation in the spinal cord. Read More

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Purines in Pain as a Gliopathy.

Front Pharmacol 2021 10;12:649807. Epub 2021 Mar 10.

Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, Italy.

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The different mechanisms of peripheral and central TLR4 on chronic postsurgical pain in rats.

J Anat 2021 Mar 17. Epub 2021 Mar 17.

The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Chronic postsurgical pain (CPSP) is a common complication after surgery; however, the underlying mechanisms of CPSP are poorly understood. As one of the most important inflammatory pathways, the Toll-like receptor 4/nuclear factor-kappa B (TLR4/NF-κB) signaling pathway plays an important role in chronic pain. However, the precise role of the TLR4/NF-κB signaling pathway in CPSP remains unclear. Read More

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Cisplatin-induced activation and functional modulation of satellite glial cells lead to cytokine-mediated modulation of sensory neuron excitability.

Exp Neurol 2021 Mar 14;341:113695. Epub 2021 Mar 14.

Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Hospital Essen, Hufelandstr. 55, 45147 Essen, Germany.

Cisplatin plays an essential role in the treatment of various cancers. Cisplatin exhibits high efficacy, but it often leads to severe neurotoxic side effects, such as chemotherapy-induced polyneuropathy (CIPN). The pathophysiology of CIPN is not fully understood. Read More

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Activation of skeletal muscle-resident glial cells upon nerve injury.

JCI Insight 2021 Apr 8;6(7). Epub 2021 Apr 8.

IRCCS Fondazione Santa Lucia, Rome, Italy.

Here, we report on the identification of Itga7-expressing muscle-resident glial cells activated by loss of neuromuscular junction (NMJ) integrity. Gene expression analysis at the bulk and single-cell level revealed that these cells are distinct from Itga7-expressing muscle satellite cells. We show that a selective activation and expansion of Itga7+ glial cells occur in response to muscle nerve lesion. Read More

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How do neurons in sensory ganglia communicate with satellite glial cells?

Brain Res 2021 Jun 22;1760:147384. Epub 2021 Feb 22.

Laboratory of Experimental Surgery, Hadassah-Hebrew University Medical Center, Mount Scopus, Jerusalem 91240, Israel; Faculty of Medicine, Hebrew University of Jerusalem, Israel. Electronic address:

Neurons and satellite glial cells (SGCs) in sensory ganglia maintain bidirectional communications that are believed to be largely mediated by chemical messengers. Nerve injury leads to SGC activation, which was proposed to be mediated by nitric oxide (NO) released from active neurons, but evidence for this is lacking. Here we tested the idea that increased neuronal firing is a major factor in NO release. Read More

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Neuroinflammatory Process Involved in Different Preclinical Models of Chemotherapy-Induced Peripheral Neuropathy.

Front Immunol 2020 4;11:626687. Epub 2021 Feb 4.

Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

Peripheral neuropathies are characterized by nerves damage and axonal loss, and they could be classified in hereditary or acquired forms. Acquired peripheral neuropathies are associated with several causes, including toxic agent exposure, among which the antineoplastic compounds are responsible for the so called Chemotherapy-Induced Peripheral Neuropathy (CIPN). Several clinical features are related to the use of anticancer drugs which exert their action by affecting different mechanisms and structures of the peripheral nervous system: the axons (axonopathy) or the dorsal root ganglia (DRG) neurons cell body (neuronopathy/ganglionopathy). Read More

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February 2021

Functional P2X Receptors in the Auditory Nerve of Hearing Rodents Localize Exclusively to Peripheral Glia.

J Neurosci 2021 Mar 9;41(12):2615-2629. Epub 2021 Feb 9.

UCL Ear Institute, University College London, London WC1X 8EE, United Kingdom

P2X receptors (P2XRs) are associated with numerous pathophysiological mechanisms, and this promotes them as therapeutic targets for certain neurodegenerative conditions. However, the identity of P2XR-expressing cells in the nervous system remains contentious. Here, we examined P2XR functionality in auditory nerve cells from rodents of either sex, and determined their functional and anatomic expression pattern. Read More

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Axon-glia interactions in the ascending auditory system.

Dev Neurobiol 2021 Feb 9. Epub 2021 Feb 9.

Department of Otolaryngology - Head and Neck Surgery, Kresge Hearing Research Institute, University of Michigan, Ann Arbor, MI, USA.

The auditory system detects and encodes sound information with high precision to provide a high-fidelity representation of the environment and communication. In mammals, detection occurs in the peripheral sensory organ (the cochlea) containing specialized mechanosensory cells (hair cells) that initiate the conversion of sound-generated vibrations into action potentials in the auditory nerve. Neural activity in the auditory nerve encodes information regarding the intensity and frequency of sound stimuli, which is transmitted to the auditory cortex through the ascending neural pathways. Read More

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February 2021

Satellite Glial Cells and Astrocytes, a Comparative Review.

Neurochem Res 2021 Feb 1. Epub 2021 Feb 1.

Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M13 9PT, UK.

Astroglia are neural cells, heterogeneous in form and function, which act as supportive elements of the central nervous system; astrocytes contribute to all aspects of neural functions in health and disease. Through their highly ramified processes, astrocytes form close physical contacts with synapses and blood vessels, and are integrated into functional syncytia by gap junctions. Astrocytes interact among themselves and with other cells types (e. Read More

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February 2021

AAV Targeting of Glial Cell Types in the Central and Peripheral Nervous System and Relevance to Human Gene Therapy.

Front Mol Neurosci 2020 11;13:618020. Epub 2021 Jan 11.

Molecular Neurotherapeutics Group, Department of Pharmacology and Clinical Pharmacology, School of Medical Sciences, University of Auckland, Auckland, New Zealand.

Different glial cell types are found throughout the central (CNS) and peripheral nervous system (PNS), where they have important functions. These cell types are also involved in nervous system pathology, playing roles in neurodegenerative disease and following trauma in the brain and spinal cord (astrocytes, microglia, oligodendrocytes), nerve degeneration and development of pain in peripheral nerves (Schwann cells, satellite cells), retinal diseases (Müller glia) and gut dysbiosis (enteric glia). These cell type have all been proposed as potential targets for treating these conditions. Read More

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January 2021

Astragalin Alleviates Neuropathic Pain by Suppressing P2X4-Mediated Signaling in the Dorsal Root Ganglia of Rats.

Front Neurosci 2020 11;14:570831. Epub 2021 Jan 11.

Department of Physiology, Medical School of Nanchang University, Nanchang, China.

Neurologic damage often leads to neuropathic pain, for which there are no effective treatments owing to its complex pathogenesis. The purinergic receptor P2X4 is closely associated with neuropathic pain. Astragalin (AST), a compound that is used in traditional Chinese medicine, has protective effects against allergic dermatitis and neuronal injury, but its mechanism of action is not well understood. Read More

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January 2021

Catestatin enhances ATP-induced activation of glial cells mediated by purinergic receptor P2X.

J Recept Signal Transduct Res 2021 Jan 27:1-9. Epub 2021 Jan 27.

Department of Physiology, Basic Medical College of Nanchang University, Nanchang, P.R. China.

The activation of glial cells and its possible mechanism play an extremely important role in understanding the pathophysiological process of some clinical diseases, and catestatin (CST) is involved in regulating this activation. In this project, we found that CST could enhance the activation of satellite glial cells (SGCs) and microglial cells and that the expression of P2X was increased; the co-expression of the P2X receptor with glial fibrillary acidic protein (GFAP) and the P2X receptor with CD11b was also increased significantly in glial cells of the ATP + CST group, and TNF-α and IL-1β also showed a rising trend; the expression of phosphorylated ERK1/2 was also increased in the ATP + CST group. In summary, we conclude that CST could enhance ATP-induced activation of SGCs and microglial cells mediated by the P2X receptor and that the ERK1/2 signaling pathway may be involved in this activation process. Read More

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January 2021

Involvement of substance P, osteopontin and satellite glial cells on photobiomodulation-induced antinociceptive effect in an experimental model of dentin hypersensitivity.

Lasers Med Sci 2021 Jan 15. Epub 2021 Jan 15.

Department of Anatomy, Laboratory of Neuromodulation of Experimental Pain, University of São Paulo, Av Lineu Prestes 2415, ICB III, São Paulo, 05508-000, Brazil.

The aim of this work was to investigate the involvement of substance P (SP), osteopontin (OPN), and satellite glial cells (SGC) on photobiomodulation-induced (PBM) antinociceptive effect in an experimental model of dentin hypersensitivity (DH). Rats ingested isotonic drink (ID, pH 2.87) for 45 consecutive days and after this period received PBM irradiation at λ660 nm or λ808 nm (1 J, 3. Read More

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January 2021

Single-cell transcriptomic profiling of satellite glial cells in stellate ganglia reveals developmental and functional axial dynamics.

Glia 2021 May 12;69(5):1281-1291. Epub 2021 Jan 12.

UCLA Neurocardiology Research Center of Excellence, Los Angeles, California, USA.

Stellate ganglion neurons, important mediators of cardiopulmonary neurotransmission, are surrounded by satellite glial cells (SGCs), which are essential for the function, maintenance, and development of neurons. However, it remains unknown whether SGCs in adult sympathetic ganglia exhibit any functional diversity, and what role this plays in modulating neurotransmission. We performed single-cell RNA sequencing of mouse stellate ganglia (n = 8 animals), focusing on SGCs (n = 11,595 cells). Read More

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The application of bone marrow mesenchymal stem cells and biomaterials in skeletal muscle regeneration.

Regen Ther 2020 Dec 28;15:285-294. Epub 2020 Nov 28.

State Key Laboratory of Oral Disease, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, PR China.

Skeletal muscle injuries have bothered doctors and caused great burdens to the public medical insurance system for a long time. Once injured, skeletal muscles usually go through the processes of inflammation, repairing and remodeling. If repairing and remodeling stages are out of balance, scars will be formed to replace injured skeletal muscles. Read More

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December 2020

Chronic Tear Deficiency Sensitizes Transient Receptor Potential Vanilloid 1-Mediated Responses in Corneal Sensory Nerves.

Front Cell Neurosci 2020 23;14:598678. Epub 2020 Dec 23.

Department of Pharmacology, School of Medicine, Kanazawa Medical University, Uchinada, Japan.

Chronic tear deficiency enhances the excitability of corneal cold-sensitive nerves that detect ocular dryness, which can lead to discomfort in patients with dry eye disease (DED). However, changes in corneal nerve excitations through the polymodal nociceptor "transient receptor potential vanilloid 1" (TRPV1) and the potential link between this receptor and symptoms of DED remain unclear. In this study, we examined the firing properties of corneal cold-sensitive nerves expressing TRPV1 and possible contributions of chronic tear deficiency to corneal nerve excitability by TRPV1 activation. Read More

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December 2020

Satellite Glial Cells Give Rise to Nociceptive Sensory Neurons.

Stem Cell Rev Rep 2021 Jan 3. Epub 2021 Jan 3.

Department of Cell Biology, Medical College of Soochow University, Suzhou, 215123, China.

Dorsal root ganglia (DRG) sensory neurons can transmit information about noxious stimulus to cerebral cortex via spinal cord, and play an important role in the pain pathway. Alterations of the pain pathway lead to CIPA (congenital insensitivity to pain with anhidrosis) or chronic pain. Accumulating evidence demonstrates that nerve damage leads to the regeneration of neurons in DRG, which may contribute to pain modulation in feedback. Read More

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January 2021

From astrocytes to satellite glial cells and back: A 25 year-long journey through the purinergic modulation of glial functions in pain and more.

Stefania Ceruti

Biochem Pharmacol 2021 May 28;187:114397. Epub 2020 Dec 28.

Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, via Balzaretti, 9, 20133 Milan, Italy. Electronic address:

Fundamental progresses have been made in pain research with a comprehensive understanding of the neuronal pathways which convey painful sensations from the periphery and viscera to the central nervous system and of the descending modulating pathways. Nevertheless, many patients still suffer from various painful conditions, which are often associated to other primary pathologies, and get no or poor relief from available painkillers. Thus, the interest of many researchers has concentrated on new and promising cellular targets and biochemical pathways. Read More

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Novel theory about radiosurgery's action mechanisms on trigeminal ganglion for idiopathic trigeminal neuralgia: Role of the satellite glial cells.

Surg Neurol Int 2020 4;11:412. Epub 2020 Dec 4.

Department of Radiation Oncologist Radiation Oncology, Centro Diagnostico Docente Las Mercedes, Caracas, Miranda, Venezuela.

Background: There are many theories about the cause of trigeminal neuralgia (TN). None of them satisfactorily explains how demyelination alone through the ephaptic mechanism can contribute to the development of the TN crisis. The main characteristic of TN pain is its dynamic nature, which is difficult to explain based only on anatomical findings. Read More

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December 2020

Morphological and functional characteristics of satellite glial cells in the peripheral nervous system.

Folia Morphol (Warsz) 2020 Dec 17. Epub 2020 Dec 17.

Institute of Histology and Embryology, Faculty of Medicine, University of Belgrade, Serbia.

Satellite glial cells are specialized cells that form a functional perineuronal sheath around sensory ganglion neurons. There are a large number of studies that reveal the morphological and functional characteristics of these cells. Satellite glial cells have been studied both in intact ganglions and in tissue cultures, using light and transmission electron microscopy, immunohistochemical and other methods. Read More

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December 2020

Investigation of Neuroprotective Effects of Erythropoietin on Chronic Neuropathic Pain in a Chronic Constriction Injury Rat Model.

J Pain Res 2020 30;13:3147-3155. Epub 2020 Nov 30.

Department of Orthopedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, People's Republic of China.

Introduction: Neuropathic pain is pretty common in modern society, and the treatment effect is far from satisfactory. This study aimed to find evidence of the neuroprotective effect of erythropoietin (EPO) in the treatment of neuropathic pain in a rat model of chronic constriction injury (CCI).

Methods: A total of 30 rats were randomly divided into sham operation group, CCI group, or CCI+EPO group. Read More

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November 2020

Satellite glia as a critical component of diabetic neuropathy: Role of lipocalin-2 and pyruvate dehydrogenase kinase-2 axis in the dorsal root ganglion.

Glia 2021 Apr 29;69(4):971-996. Epub 2020 Nov 29.

Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.

Diabetic peripheral neuropathy (DPN) is a common complication of uncontrolled diabetes. The pathogenesis of DPN is associated with chronic inflammation in dorsal root ganglion (DRG), eventually causing structural and functional changes. Studies on DPN have primarily focused on neuronal component, and there is limited knowledge about the role of satellite glial cells (SGCs), although they completely enclose neuronal soma in DRG. Read More

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In vitro priming response in dorsal root ganglia partially mimics injury-driven pre-conditioning response and reprograms neurons for enhanced outgrowth.

Mol Cell Neurosci 2021 01 25;110:103573. Epub 2020 Nov 25.

Division of Neurology, Department of Medicine, and the Neuroscience and Mental Health Institute, University of Alberta, Edmonton, Alberta, Canada. Electronic address:

Peripheral nerve injuries have the potential to bring about long-term disabilities in individuals. The major issue in repairing nerve injuries is the poor growth rate of axons. Although several molecules have been identified as potential candidates for improving axon growth, their potential translation into clinical practice is preliminary and largely unexplored. Read More

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January 2021

Satellite Glial Cells of the Dorsal Root Ganglion: A New "Guest/Physiopathological Target" in ALS.

Front Aging Neurosci 2020 9;12:595751. Epub 2020 Nov 9.

"Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas" (CIBERNED), Madrid, Spain.

Amyotrophic lateral sclerosis (ALS) might not only be circumscribed to the motor system but also involves other neuronal systems including sensory abnormalities. In line with this notion, we aimed to assess the pathophysiology of sensory disturbances in the SOD1 mouse model of ALS, focusing on the satellite glial cells (SGCs) at the dorsal root ganglion (DRG) as a new potential target of the disease. The presence of sensory disturbances was evaluated using von Frey, hot plate, and hot water tail immersion tests at 75 days old, which represented the motor-pre-symptomatic stage. Read More

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November 2020

A novel hypothesis on metal dyshomeostasis and mitochondrial dysfunction in amyotrophic lateral sclerosis: Potential pathogenetic mechanism and therapeutic implications.

Eur J Pharmacol 2021 Feb 19;892:173737. Epub 2020 Nov 19.

Center for Pharma-Food Research (CPFR), Division of Pharmaceutical Sciences, Graduate School of Integrative Pharmaceutical and Nutritional Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, 422-8526, Japan.

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by motor dysfunctions resulting from the loss of upper (UMNs) and lower (LMNs) motor neurons. While ALS symptoms are coincidental with pathological changes in LMNs and UMNs, the causal relationship between the two is unclear. For example, research on the extra-motor symptoms associated with this condition suggests that an imbalance of metals, including copper, zinc, iron, and manganese, is initially induced in the sensory ganglia due to a malfunction of metal binding proteins and transporters. Read More

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February 2021

Large-Scale Convergence of Receptor Cell Arrays Onto Afferent Terminal Arbors in the Lorenzinian Electroreceptors of .

Front Neuroanat 2020 19;14:50. Epub 2020 Oct 19.

Department of Biological Sciences, Ohio University, Athens, OH, United States.

Certain sensory receptors contain many transducers, converging onto few afferents. Convergence creates star-topology neural networks, of iterative parallel organization, that may yield special functional properties. We quantitated large-scale convergence in electroreceptors on the rostrum of preadult paddlefish, (Acipenseriforme vertebrates), and analyzed the afferent terminal branching underlying the convergence. Read More

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October 2020