126,408 results match your criteria sars-cov-2 infection


SARS-CoV-2 uses a multipronged strategy to impede host protein synthesis.

Nature 2021 May 12. Epub 2021 May 12.

Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the ongoing coronavirus disease 19 pandemic. Coronaviruses developed varied mechanisms to repress host mRNA translation to allow the translation of viral mRNAs and concomitantly block the cellular innate immune response. Although different SARS-CoV-2 proteins are implicated in host expression shutoff, a comprehensive picture of the effects of SARS-CoV-2 infection on cellular gene expression is lacking. Read More

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The epidemiological impact of the NHS COVID-19 App.

Nature 2021 May 12. Epub 2021 May 12.

Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, Nuffield Department for Medicine, University of Oxford, Oxford, UK.

The COVID-19 pandemic has seen digital contact tracing emerge around the world to help prevent spread of the disease. A mobile phone app records proximity events between app users, and when a user tests positive for COVID-19, their recent contacts can be notified instantly. Theoretical evidence has supported this new public health intervention, but its epidemiological impact has remained uncertain. Read More

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Segmenting lung lesions of COVID-19 from CT images via pyramid pooling improved Unet.

Biomed Phys Eng Express 2021 May 12. Epub 2021 May 12.

Chongqing University, No.174 Shazhengjie, Chongqing, Sichuan, 400044, CHINA.

Segmenting lesion regions of Coronavirus Disease 2019 (COVID-19) from computed tomography (CT) images is a challenge owing to COVID-19 lesions characterized by high variation, low contrast between infection lesions and around normal tissues, and blurred boundaries of infections. Moreover, a shortage of available CT dataset hinders deep learning techniques applying to tackling COVID-19. To address these issues, we propose a deep learning-based approach known as PPM-Unet to segmenting COVID-19 lesions from CT images. Read More

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Changes in Physical Activity, Sleep, Mental Health, and Social Media Use During COVID-19 Lockdown Among Adolescent Girls: A Mixed-Methods Study.

J Phys Act Health 2021 May 11:1-9. Epub 2021 May 11.

Background: To suppress the transmission of coronavirus, many governments, including that of the island of Ireland, implemented a societal lockdown, which included school closures, limits on social gatherings, and time outdoors. This study aimed to evaluate changes in physical activity (PA), mental health, sleep, and social media use among adolescent girls during lockdown.

Methods: 281 female pupils (12-14 y) taking part in the ongoing Walking In Schools study on the island of Ireland self-reported PA, mental health, sleep, and social media use before (September-October 2019) and during lockdown (May-June 2020), via questionnaires. Read More

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Can coronavirus disease 2019 (COVID-19) trigger exacerbation of multiple sclerosis? A retrospective study.

Mult Scler Relat Disord 2021 Apr 11;52:102947. Epub 2021 Apr 11.

Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran; Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address:

The effect of coronavirus disease (COVID-19) on the risk of relapse in multiple sclerosis (MS) have been unknown. In this retrospective study of 41 relapsing-remitting MS patients, number of relapses in pre-defined at risk-period (ARP) was compared with the previous two years. During the previous two years, a total of 32 attacks was reported, which 5 (15. Read More

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Blood neutrophils from children with COVID-19 exhibit both inflammatory and anti-inflammatory markers.

EBioMedicine 2021 May 9;67:103357. Epub 2021 May 9.

División Infectología, Hospital General de Agudos Dr. Juan A. Fernández, Av. Cerviño 3356, CABA C1425, Argentina.

Background: Perhaps reflecting that children with COVID-19 rarely exhibit severe respiratory symptoms and often remain asymptomatic, little attention has been paid to explore the immune response in pediatric COVID-19. Here, we analyzed the phenotype and function of circulating neutrophils from children with COVID-19.

Methods: An observational study including 182 children with COVID-19, 21 children with multisystem inflammatory syndrome (MIS-C), and 40 healthy children was performed in Buenos Aires, Argentina. Read More

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Performance of the Abbott ID NOW rapid SARS-CoV-2 amplification assay in relation to nasopharyngeal viral RNA loads.

J Clin Virol 2021 Apr 24;140:104843. Epub 2021 Apr 24.

Department of Pathology, George Washington University School of Medicine and Health Sciences, United State; Department of Pathology and Laboratory Medicine, George Washington University Hospital, United States. Electronic address:

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Aptamer-based lateral flow assay on-site biosensors.

Biosens Bioelectron 2021 Apr 24;186:113279. Epub 2021 Apr 24.

School of Information and Communication Engineering, University of Electronic Science and Technology of China, Chengdu, 611731, China. Electronic address:

The lateral flow assay (LFA) is a widely used paper-based on-site biosensor that can detect target analytes and obtain test results in several minutes. Generally, antibodies are utilized as the biorecognition molecules in the LFA. However, antibodies selected using an in vivo process not only may risk killing the animal hosts and causing errors between different batches but also their range is restricted by the refrigerated conditions used to store them. Read More

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How the European In Vitro Diagnostic Regulation could negatively impact the European response to the next pandemic: an urgent call for action before May 2022.

Clin Microbiol Infect 2021 May 9. Epub 2021 May 9.

Clinical Department of Laboratory Medicine and National Reference Center for Respiratory Pathogens, University Hospitals Leuven, Leuven, Belgium; Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.

The Corona Virus Disease 2019 (COVID-19) pandemic has demonstrated that the ability for laboratories to quickly set up and implement labdeveloped tests (LDTs) is essential to respond to an emerging health crisis. The Regulation on in vitro diagnostic medical devices (IVDR) could, however, profoundly impact our ability to respond to a future pandemic since the IVDR could significant restrict the use of LDTs. We address using the example of the current pandemic a number of LDT implementing issues problems which should be addressed. Read More

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A bibliometric study of COVID-19 research in Web of Science.

Pharmacol Res 2021 May 9:105664. Epub 2021 May 9.

Institute of Endocrine and Metabolic Diseases, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China. Electronic address:

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Development of potent and selective inhibitors targeting the papain-like protease of SARS-CoV-2.

Cell Chem Biol 2021 Apr 27. Epub 2021 Apr 27.

Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China. Electronic address:

The COVID-19 pandemic has been disastrous to society and effective drugs are urgently needed. The papain-like protease domain (PLpro) of SARS-CoV-2 (SCoV2) is indispensable for viral replication and represents a putative target for pharmacological intervention. In this work, we describe the development of a potent and selective SCoV2 PLpro inhibitor, 19. Read More

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Erythroid precursors and progenitors suppress adaptive immunity and get invaded by SARS-CoV-2.

Stem Cell Reports 2021 May;16(5):1165-1181

School of Dentistry, Division of Foundational Sciences, University of Alberta, Edmonton, T6G2E1, AB, Canada; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, T6G2E1, AB, Canada; Li Ka Shing Institute of Virology, University of Alberta, Edmonton, T6G2E1, AB, Canada; Department of Medical Oncology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, T6G2E1, AB, Canada. Electronic address:

SARS-CoV-2 infection is associated with lower blood oxygen levels, even in patients without hypoxia requiring hospitalization. This discordance illustrates the need for a more unifying explanation as to whether SARS-CoV-2 directly or indirectly affects erythropoiesis. Here, we show significantly enriched CD71 erythroid precursors/progenitors in the blood circulation of COVID-19 patients. Read More

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SARS-CoV-2 targets glial cells in human cortical organoids.

Stem Cell Reports 2021 May;16(5):1156-1164

Department of Biology, University of Texas at San Antonio, San Antonio, TX 78249, USA; Brain Health Consortium, University of Texas at San Antonio, San Antonio, TX 78249, USA. Electronic address:

Coronavirus disease 2019 (COVID-19) patients have manifested a variety of neurological complications, and there is still much to reveal regarding the neurotropism of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Human stem cell-derived brain organoids offer a valuable in vitro approach to study the cellular effects of SARS-CoV-2 on the brain. Here we used human embryonic stem cell-derived cortical organoids to investigate whether SARS-CoV-2 could infect brain tissue in vitro and found that cortical organoids could be infected at low viral titers and within 6 h. Read More

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Glass hybrid (glass ionomer) versus composite for non-carious cervical lesions: Survival, restoration quality and costs in randomized controlled trial after 3 years.

J Dent 2021 May 9:103689. Epub 2021 May 9.

Department of Operative and Preventive Dentistry, Charité - Universitätsmedizin Berlin, Germany.

Objective: This study compared survival, restoration quality and costs of glass hybrid (GH; EQUIA Forte Fil/EQUIA Forte Coat) and resin composite restorations (RC; OptiBond FL/Filtek Supreme XTE) of sclerotic non-carious cervical lesions.

Methods: This is a cluster-randomized trial (ClinicalTrials.gov: NCT02631161). Read More

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Possible Human-to-Dog Transmission of SARS-CoV-2, Italy, 2020.

Emerg Infect Dis 2021 May 12;27(7). Epub 2021 May 12.

We detected severe acute respiratory syndrome coronavirus 2 in an otherwise healthy poodle living with 4 family members who had coronavirus disease. We observed antibodies in serum samples taken from the dog, indicating seroconversion. Full-length genome sequencing showed that the canine and human viruses were identical, suggesting human-to-animal transmission. Read More

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Industry Sectors Highly Affected by Worksite Outbreaks of Coronavirus Disease, Los Angeles County, California, USA, March 19-September 30, 2020.

Emerg Infect Dis 2021 May 12;27(7). Epub 2021 May 12.

Worksites with on-site operations have experienced coronavirus disease (COVID-19) outbreaks. We analyzed data for 698 nonresidential, nonhealthcare worksite COVID-19 outbreaks investigated in Los Angeles County, California, USA, during March 19, 2020‒September 30, 2020, by using North American Industry Classification System sectors and subsectors. Nearly 60% of these outbreaks occurred in 3 sectors: manufacturing (n = 184, 26. Read More

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COVID-19 Surveillance for Local Decision Making : An Academic, School District, and Public Health Collaboration.

Public Health Rep 2021 May 12:333549211018203. Epub 2021 May 12.

443323 Franklin County Public Health, Columbus, OH, USA.

Objective: Data-informed decision making is valued among school districts, but challenges remain for local health departments to provide data, especially during a pandemic. We describe the rapid planning and deployment of a school-based COVID-19 surveillance system in a metropolitan US county.

Methods: In 2020, we used several data sources to construct disease- and school-based indicators for COVID-19 surveillance in Franklin County, an urban county in central Ohio. Read More

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Electroconvulsive Therapy Is an Essential Procedure.

Am J Psychiatry 2021 May;178(5):381-382

Department of Psychiatry, University of Michigan, Ann Arbor (Maixner); Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C. (Weiner); Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore (Reti); Department of Psychiatry and Behavioral Sciences, Emory School of Medicine, Atlanta (Hermida, McDonald); Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas (Husain); National Network of Depression Centers, Ann Arbor, Mich. (Larsen).

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Plasma Therapy to Prevent Severe Covid-19 in Older Adults. Reply.

N Engl J Med 2021 May 12. Epub 2021 May 12.

Fundación INFANT, Buenos Aires, Argentina

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Plasma Therapy to Prevent Severe Covid-19 in Older Adults.

N Engl J Med 2021 May 12. Epub 2021 May 12.

Hospital Aleman de Buenos Aires, Buenos Aires, Argentina.

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Plasma Therapy to Prevent Severe Covid-19 in Older Adults.

N Engl J Med 2021 May 12. Epub 2021 May 12.

Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil.

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More on SARS-CoV-2 Infection after Vaccination in Health Care Workers.

N Engl J Med 2021 May 12. Epub 2021 May 12.

Fondazione Policlinico Universitario Agostino Gemelli, Rome, Italy.

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The Covid-19 Infodemic - Applying the Epidemiologic Model to Counter Misinformation.

N Engl J Med 2021 May 12. Epub 2021 May 12.

From the Division of General Internal Medicine, Weill Cornell Medical College, New York (D.S.); Critica, Bronx, NY (D.S., J.G.), and the Annenberg Public Policy Center, University of Pennsylvania, Philadelphia (K.H.J.).

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Efficacy and safety of Xiyanping injection in the treatment of COVID-19: A multicenter, prospective, open-label and randomized controlled trial.

Phytother Res 2021 May 12. Epub 2021 May 12.

Department of Respiratory Diseases, The Second Affiliated Hospital of Nanchang University, Nanchang, China.

Xiyanping (XYP) is a Chinese herbal medicine used in the clinic to treat respiratory infection and pneumonia. Recent evidence identified XYP as a potential inhibitor of severe acute respiratory syndrome coronavirus 2, implying XYP as a possible treatment for the coronavirus disease 2019 (COVID-19). Here, we conducted a prospective, multicenter, open-label and randomized controlled trial to evaluate the safety and effectiveness of XYP injection in patients with mild to moderate COVID-19. Read More

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Differences in risk perception, knowledge and protective behaviour regarding COVID-19 by education level among women and men in Germany. Results from the COVID-19 Snapshot Monitoring (COSMO) study.

PLoS One 2021 12;16(5):e0251694. Epub 2021 May 12.

Robert Koch Institute, Berlin, Germany.

The main strategy for combatting SARS-CoV-2 infections in 2020 consisted of behavioural regulations including contact reduction, maintaining distance, hand hygiene, and mask wearing. COVID-19-related risk perception and knowledge may influence protective behaviour, and education could be an important determinant. The current study investigated differences by education level in risk perception, knowledge and protective behaviour regarding COVID-19 in Germany, exploring the development of the pandemic over time. Read More

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