17,387 results match your criteria sars-cov-2 elderly


Clinical presentation and outcomes of COVID-19 in older hospitalised patients assessed by the record-based multidimensional prognostic index, a cross-sectional study.

Eur Geriatr Med 2021 Jun 12. Epub 2021 Jun 12.

Department of Geriatrics, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200, Aarhus, Denmark.

Purpose: Older people are the most frequently hospital admitted patients with COVID-19. We aimed to describe the clinical presentation of COVID-19 among frail and nonfrail older hospitalised patients and to evaluate the potential association between frailty and clinical course, decision of treatment level with outcomes change in functional capacity and survival.

Methods: We performed a multi-center, retrospective cross-sectional cohort study examining data on clinical presentation and frailty-related domains for hospitalised people aged 75 + years with a positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) test. Read More

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COVID-19 related cardiac complications - from clinical evidences to basic mechanisms. Opinion paper of the ESC Working Group on Cellular Biology of the Heart.

Cardiovasc Res 2021 Jun 12. Epub 2021 Jun 12.

Cardiology Chair, University of Pisa, and Pisa University Hospital, Pisa, Italy.

The pandemic of Coronavirus disease (COVID)-19 is a global threat, causing high mortality, especially in the elderly. The main symptoms and the primary cause of death are related to interstitial pneumonia. Viral entry also into myocardial cells mainly via the angiotensin converting enzyme type 2 (ACE2) receptor and excessive production of pro-inflammatory cytokines, however, also make the heart susceptible to injury. Read More

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The key role of the level of ACE2 gene expression in SARS-CoV-2 infection.

Aging (Albany NY) 2021 Jun 11;13. Epub 2021 Jun 11.

Department of Clinical Research and Innovation, Foch Hospital, Suresnes, France.

SARS-CoV-2 more readily affects the elderly, especially as they present co-morbidities. In the COVID-19 pathogeny, ACE2 appears to be the key cell receptor for SARS-CoV-2 to infect humans. The level of ACE2 gene expression influences the susceptibility of contracting SARS-CoV-2. Read More

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The presence of SARS-CoV-2 virus in semen samples of patients with COVID-19 pneumonia.

Andrologia 2021 Jun 11:e14145. Epub 2021 Jun 11.

Department of Urology, University of Mersin School of Medicine, Mersin, Turkey.

The SARS-CoV-2 set off a pandemic involving millions of people around the world. The topic of discussion is the possible viral detection in different body fluids than respiratory droplets. Therefore, we evaluated the possible presence of SARS-CoV-2 in semen and urine samples. Read More

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Community-level evidence for SARS-CoV-2 vaccine protection of unvaccinated individuals.

Nat Med 2021 Jun 10. Epub 2021 Jun 10.

Faculty of Biology, Technion-Israel Institute of Technology, Haifa, Israel.

Mass vaccination has the potential to curb the current COVID-19 pandemic by protecting individuals who have been vaccinated against the disease and possibly lowering the likelihood of transmission to individuals who have not been vaccinated. The high effectiveness of the widely administered BNT162b vaccine from Pfizer-BioNTech in preventing not only the disease but also infection with SARS-CoV-2 suggests a potential for a population-level effect, which is critical for disease eradication. However, this putative effect is difficult to observe, especially in light of highly fluctuating spatiotemporal epidemic dynamics. Read More

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Prevalence of COVID-19 in Iran: results of the first survey of the Iranian COVID-19 Serological Surveillance program.

Clin Microbiol Infect 2021 Jun 7. Epub 2021 Jun 7.

Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Objectives: This study aims to estimate the prevalence of COVID-19 in the general population of Iran.

Methods: The target population was all Iranian people aged six years and older in the country. A stratified random sampling design was used to select 28,314 subjects from among the individuals registered in the electronic health record systems used in primary health care in Iran. Read More

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Hospitalization of Adolescents Aged 12-17 Years with Laboratory-Confirmed COVID-19 - COVID-NET, 14 States, March 1, 2020-April 24, 2021.

MMWR Morb Mortal Wkly Rep 2021 Jun 11;70(23):851-857. Epub 2021 Jun 11.

Most COVID-19-associated hospitalizations occur in older adults, but severe disease that requires hospitalization occurs in all age groups, including adolescents aged 12-17 years (1). On May 10, 2021, the Food and Drug Administration expanded the Emergency Use Authorization for Pfizer-BioNTech COVID-19 vaccine to include persons aged 12-15 years, and CDC's Advisory Committee on Immunization Practices recommended it for this age group on May 12, 2021.* Before that time, COVID-19 vaccines had been available only to persons aged ≥16 years. Read More

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Incidence of Multisystem Inflammatory Syndrome in Children Among US Persons Infected With SARS-CoV-2.

JAMA Netw Open 2021 Jun 1;4(6):e2116420. Epub 2021 Jun 1.

Division of Hospital Medicine, Department of Pediatrics, Hackensack University Medical Center, Hackensack, New Jersey.

Importance: Multisystem inflammatory syndrome in children (MIS-C) is associated with recent or current SARS-CoV-2 infection. Information on MIS-C incidence is limited.

Objective: To estimate population-based MIS-C incidence per 1 000 000 person-months and to estimate MIS-C incidence per 1 000 000 SARS-CoV-2 infections in persons younger than 21 years. Read More

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Characteristics and outcomes of older patients with coronavirus disease 2019 in Japan.

Geriatr Gerontol Int 2021 Jun 9. Epub 2021 Jun 9.

Department of Social Medicine, Osaka University Graduate School of Medicine, Suita, Japan.

Aim: The epidemiological characteristics, in-hospital treatments and outcomes of coronavirus disease 2019 among older patients have not been fully evaluated in Japan.

Methods: In this retrospective observational study carried out in Osaka Prefecture, Japan, we enrolled patients aged ≥60 years with laboratory-confirmed coronavirus disease 2019 from January to November 2020. The main outcome was mortality during the observation period, based on the Infectious Diseases Control Law. Read More

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A nationwide analysis of population group differences in the COVID-19 epidemic in Israel, February 2020-February 2021.

Lancet Reg Health Eur 2021 Aug 5;7:100130. Epub 2021 Jun 5.

Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, 6139001, Israel.

Background: Social inequalities affect the COVID-19 burden and vaccine uptake. The aim of this study was to explore inequalities in the incidence and mortality rate of SARS-CoV-2 infection and vaccine uptake in various sociodemographic and population group strata in Israel.

Methods: We analysed nationwide publicly available, aggregated data on PCR-confirmed SARS-CoV-2 infections and COVID-19 deaths between March 2020 and February 2021, as well as the first three months of COVID-19 immunisation according to sociodemographics, including population group and residential socioeconomic status (SES). Read More

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Lifestyle and eating habits before and during COVID-19 quarantine in Brazil.

Public Health Nutr 2021 Jun 10:1-29. Epub 2021 Jun 10.

Department of Food Science, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.

Objective: To assess changes in daily habits, food choices, and lifestyle of adult Brazilians before and during the COVID-19 pandemic.

Design: This observational study was carried out with Brazilian adults through an online questionnaire five months after the social distance measures implementation. The McNemar, McNemar-Bowker, and Wilcoxon tests were used to investigate differences before and during the COVID pandemic period, adopting the statistical significance of p <0. Read More

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Is venous thromboembolism a predictable marker in older patients with COVID-19 infection? A single-center observational study.

J Infect Dev Ctries 2021 05 31;15(5):639-345. Epub 2021 May 31.

Clinica Medica Unit, Azienda Ospedaliero-Universitaria S. Anna, Ferrara, Italy.

Venous thromboembolism (VTE) represents an important clinical complication of patients with SARS-CoV-2 infection, and high plasma D-dimer levels could suggest a higher risk of hypercoagulability. We aimed to analyse if laboratory exams, risk assessment scores, comorbidity scores were useful in predicting the VTE in SARS-CoV-2 patients admitted in internal medicine (IM). We evaluated 49 older adults with suspected VTE analysing history and blood chemistry, besides we calculated the Padua Prediction Score, the modified early warning scoring (MEWS) and the modified Elixhauser index (mEI). Read More

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[Consensus of the Genetics Branch of the Chilean Society of Pediatrics on the prioritization of people with Down syndrome and rare diseases for vaccination against SARS-CoV-2].

Andes Pediatr 2021 Apr;92(2):309-315

Hospital Regional de Concepción, Chile.

In the framework of the vaccination campaign against the SARS-CoV-2 virus, the Chilean Ministry of Health requested advice from the Genetics Branch of the Chilean Society of Pediatrics, to define the level of prioritization for people with Down Syndrome . A panel of geneticists worked on the development of this consensus, in which not only patients with Down syndrome were included, but the search was extended to patients with other types of disabilities, in both pediatric and adult ages in or der to contribute to the development of public health measures against the COVID-19 pandemic. The consensus concludes that, given the prevalence of comorbidities associated with Down syndrome, the higher incidence of cases with severe COVID-19 in this population group and a higher mortality, individuals with trisomy 21 should be considered as a high-risk population, and therefore, vaccina tion against SARS-CoV-2 should have a high priority for all people with Down syndrome regardless of their age (except for the age limit established by the clinical trials of each vaccine), and should be preceded only by the groups of health personnel and adults aged > 60-65 years. Read More

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HEALTH STATUS AND LIFESTYLE HABITS OF VULNERABLE, COMMUNITY-DWELLING OLDER PEOPLE DURING THE COVID-19 LOCKDOWN.

J Frailty Aging 2021 ;10(3):286-289

Mónica Machón Sobrado, Instituto de Investigación Sanitaria Biodonostia, Paseo Doctor Beguiristian s/n, 20014 San Sebastián (Gipuzkoa), Spain, Tel. +34943006086; Fax: +34943006250; e-mail:

This study evaluated the health status and lifestyle habits of vulnerable, community-dwelling older adults during the first COVID-19 lockdown in Spain. A telephone assessment was carried out in 38 individuals (71% women), with a Barthel index ≥85 who were frail or had a high risk of falls. Data were compared with those from an assessment performed 9 months earlier. Read More

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Inflammation at the Crossroads: the Combined Effects of COVID-19, Ageing, and Air Pollution.

J Frailty Aging 2021 ;10(3):281-285

Dr. Sylvain Billet, Univ. Littoral Côte d'Opale, UR 4492, UCEIV, Maison de la Recherche en Environnement Industriel 2, 189A, Avenue Maurice Schumann, 59140 Dunkerque, France. Phone: +33-3 28 23 76 41, E-mail:

The global COVID-19 pandemic has highlighted different vulnerability profiles among individuals. With the highest mortality rate, the elderly are a very sensitive group. With regard to the main symptoms, a failure of the respiratory system, associated with deregulation of the immune system, has been observed. Read More

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Chronic non-communicable diseases and COVID-19: EPICOVID-19 Brazil results.

Rev Saude Publica 2021 2;55:38. Epub 2021 Jun 2.

Universidade Federal de Pelotas. Programa de Pós-Graduação em Epidemiologia. Pelotas, RS, Brasil.

Objective: Describing the prevalence of chronic diseases and associated socioeconomic and demographic factors, evaluating the patterns of social distancing and the antibodies prevalence against SARS-CoV-2 and COVID-19 symptoms in carriers and non-carriers of chronic diseases.

Methods: Data from 77,075 individuals aged 20 to 59 from three steps of the EPICOVID-19 Brazil (a nationwide serological survey conducted between May and June, 2021) were assessed. The presence of antibodies against SARS-CoV-2 was examined by rapid tests. Read More

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COVID-19 Medical-Religious Partnerships: Implementation of a Just-In-Time COVID-19 Training in Catholic Schools.

J Relig Health 2021 Jun 8. Epub 2021 Jun 8.

Johns Hopkins School of Education, Baltimore, MD, USA.

The concept of Just-In-Time Training (JITT) is to provide critical information specific to a public health crisis, allowing individuals to understand and respond to an urgent situation. The design of the JITT curriculum appropriate for school-aged children during the COVID-19 pandemic is vital, as every individual has a role to play in mitigating the spread of SARS-CoV-2. When working with various communities, considering culture and religion is essential, as aligning values and beliefs with the JITT curriculum's objectives may significantly change the community's behavior toward a public health crisis. Read More

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Incidence of SARS-CoV-2 infection according to baseline antibody status in staff and residents of 100 long-term care facilities (VIVALDI): a prospective cohort study.

Lancet Healthy Longev 2021 Jun 3;2(6):e362-e370. Epub 2021 Jun 3.

UCL Institute of Health Informatics, University College London, London, UK.

Background: SARS-CoV-2 infection represents a major challenge for long-term care facilities (LTCFs) and many residents and staff are seropositive following persistent outbreaks. We aimed to investigate the association between the SARS-CoV-2 antibody status at baseline and subsequent infection in this population.

Methods: We did a prospective cohort study of SARS-CoV-2 infection in staff (aged <65 years) and residents (aged >65 years) at 100 LTCFs in England between Oct 1, 2020, and Feb 1, 2021. Read More

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Testosterone target therapy: focus on immune response, controversies and clinical implications in patients with COVID-19 infection.

Ther Adv Endocrinol Metab 2021 22;12:20420188211010105. Epub 2021 Apr 22.

Department of Maternal-Infant and Urological Sciences, Prostate Cancer Unit, "Sapienza" Rome University, Policlinico Umberto I Hospital, Rome, Italy.

The pandemic acute respiratory syndrome coronavirus 2 (SARS-CoV-2) named COVID-19 is causing a severe health emergency, and an individual's hormonal milieu may play an important role in both susceptibility to infection and severity of clinical course. We analyzed the role of testosterone in the immune response, and we hypothesized possible mechanisms to explain the high incidence of COVID-19 infection and a worse clinical course in elderly male patients. Testosterone may impair the immune response, and this effect could explain the greater susceptibility of men to infection. Read More

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SARS-CoV-2 diagnosis: a single-centre experience.

J Med Life 2021 Mar-Apr;14(2):257-261

Department of Immunology and Immunology of Transplant, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.

The coronavirus disease 2019 (COVID-19) was declared a pandemic by the World Health Organization (WHO) on the 11 of March 2020. In Romania, there have been 983,217 confirmed cases and 24,386 deaths. We aim to show our experience at the Fundeni Clinical Institute in the diagnosis of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection in both patients and health care personnel. Read More

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ROLE OF THROMBODYNAMICS GLOBAL COAGULATION TEST IN IMPROVING TREATMENT RESULTS IN PATIENTS WITH CORONAVIRUS INFECTION AT A COVID-19 HOSPITAL.

Georgian Med News 2021 Apr(313):72-79

First Moscow State Medical University I.M. Sechenov (Sechenov University), Russian Federation.

The aim of the study was to evaluate the effectiveness of the global coagulation test of thrombodynamics for monitoring and correcting the hemostatic system and improving the results of complex treatment in patients with SARS-CoV-2 in the COVID hospital. From April 2020 to December 2020 on the basis of the University Clinical Hospital No. 4 of the First Moscow State Medical University named I. Read More

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Senolytics reduce coronavirus-related mortality in old mice.

Science 2021 Jun 8. Epub 2021 Jun 8.

Department of Laboratory Medicine and Pathology and Center of Immunology, University of Minnesota, Minneapolis, MN, USA.

The COVID-19 pandemic has revealed the pronounced vulnerability of the elderly and chronically-ill to SARS-CoV-2-induced morbidity and mortality. Cellular senescence contributes to inflammation, multiple chronic diseases, and age-related dysfunction, but effects on responses to viral infection are unclear. Here, we demonstrate that senescent cells (SnC) become hyper-inflammatory in response to pathogen-associated molecular patterns (PAMPs), including SARS-CoV-2 Spike protein-1, increasing expression of viral entry proteins and reducing anti-viral gene expression in non-SnCs through a paracrine mechanism. Read More

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Prevalence of elder abuse and victim-related risk factors during the COVID-19 pandemic in China.

BMC Public Health 2021 06 8;21(1):1096. Epub 2021 Jun 8.

Law School, Hunan University, Changsha, Hunan Province, P.R. China.

Background: With the accelerated aging of the Chinese population, elder abuse has become a serious social problem. As COVID-19 has had a very large impact on economic development and lifestyle in China, it has also affected elder abuse. The purpose of this study is to estimate the prevalence of elder abuse in China during the COVID-19 pandemic, and to identify changes in risk factors for elder abuse in the context of COVID-19. Read More

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Delayed Antibody and T-Cell Response to BNT162b2 Vaccination in the Elderly, Germany.

Emerg Infect Dis 2021 Jun 8;27(8). Epub 2021 Jun 8.

We detected delayed and reduced antibody and T-cell responses after BNT162b2 vaccination in 71 elderly persons (median age 81 years) compared with 123 healthcare workers (median age 34 years) in Germany. These data emphasize that nonpharmaceutical interventions for coronavirus disease remain crucial and that additional immunizations for the elderly might become necessary. Read More

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Lessons learnt during the COVID-19 pandemic: Why Australian schools should be prioritised to stay open.

J Paediatr Child Health 2021 Jun 8. Epub 2021 Jun 8.

Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia.

In 2020, school and early childhood educational centre (ECEC) closures affected over 1.5 billion school-aged children globally as part of the COVID-19 pandemic response. Attendance at school and access to ECEC is critical to a child's learning, well-being and health. Read More

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Self-identified Race and COVID-19-Associated Acute Kidney Injury and Inflammation: a Retrospective Cohort Study of Hospitalized Inner-City COVID-19 Patients.

J Gen Intern Med 2021 Jun 7. Epub 2021 Jun 7.

Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Background: Black individuals have been disproportionately affected by the coronavirus disease 2019 (COVID-19). However, it remains unclear whether there are any biological factors that predispose Black patients to COVID-19-related morbidity and mortality.

Objective: To compare in-hospital morbidity, mortality, and inflammatory marker levels between Black and White hospitalized COVID-19 patients. Read More

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COVID-19: A Comprehensive Analysis of the Pandemic's Effect on an Emergency Department.

Disaster Med Public Health Prep 2021 Jun 8:1-13. Epub 2021 Jun 8.

Professor of Emergency Medicine, Department of Emergency Medicine, Life Lion EMS, Penn State Health Milton S. Hershey Medical Center, 500 University Drive, Hershey, PA 17033,

Objective: COVID-19 (caused by SARS-CoV-2) is a historic pandemic severely impacting health care. This study examines its early effect on a busy academic emergency department.

Methods: A retrospective analysis of patients from an academic tertiary care Level I trauma, cardiac and stroke center's emergency department seeing an average of 54,000 adults and 21,000 pediatric patients per year. Read More

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Pathogenesis-based preexposure prophylaxis associated with a low risk of SARS-CoV-2 infection in healthcare workers at a designated COVID-19 hospital: a pilot study.

BMC Infect Dis 2021 Jun 7;21(1):536. Epub 2021 Jun 7.

North-Western State Medical University named after I.I. Mechnikov of Ministry of Health of Russian Federation, 41 Kirochnaya str, 191015, St. Petersburg, Russia.

Background: At present, no agents are known to be effective at preventing COVID-19. Based on current knowledge of the pathogenesis of this disease, we suggest that SARS-CoV-2 infection might be attenuated by directly maintaining innate pulmonary redox, metabolic and dilation functions using well-tolerated medications that are known to serve these functions, specifically, a low-dose aerosolized combination of glutathione, inosine and potassium.

Methods: From June 1 to July 10, 2020, we conducted a pilot, prospective, open-label, single-arm, single-center study to evaluate the safety and efficacy of preexposure prophylaxis (PrEP) with aerosolized combination medication (ACM) on the incidence of SARS-CoV-2 positivity in 99 healthcare workers (HCWs) at a hospital designated for treating COVID-19 patients. Read More

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Impact of the COVID-19 pandemic on migraine in Japan: a multicentre cross-sectional study.

J Headache Pain 2021 Jun 7;22(1):53. Epub 2021 Jun 7.

Department of Neurology, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Shimotsuga, 321-0293, Tochigi, Japan.

Objectives: To assess the impacts of social situation changes due to the coronavirus disease 2019 (COVID-19) pandemic on headache-related disability and other symptoms in patients with migraine in Japan.

Methods: We conducted a multicentre, cross-sectional study including 659 outpatients with migraine diagnosed by headache specialists. The participants were asked about the impacts of the first wave of the COVID-19 pandemic on headache-related disability, headache days, headache intensity, stress, physical activity, hospital access and their work and home lives. Read More

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