12,346 results match your criteria sarcopenia


The Relationship Between Visceral Obesity and Post-operative Complications: A Meta-analysis.

J Surg Res 2021 Jun 12;267:71-81. Epub 2021 Jun 12.

Department of Surgery, University of Alberta, Edmonton, Canada. Electronic address:

Background: Body composition can have important influence on surgical outcome. There is substantial literature examining sarcopenia, however much less in known about the impact of fat. Visceral fat area (VFA) is a reliable measures of fat distribution that can be quantified with CT scan. Read More

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Are muscle parameters obtained by computed tomography associated with outcome after esophagectomy for cancer?

Clin Nutr 2021 May 1;40(6):3729-3740. Epub 2021 May 1.

Department of Intensive Care Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.

Background & Aims: Esophageal cancer patients often suffer from cancer-related malnutrition and, as a result, sarcopenia. Whether sarcopenia worsens the outcome after esophagectomy is unclear. Inconsistent study results are partly caused by varying cut-off values used for defining sarcopenia. Read More

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Pharmacokinetic study of Ninjin'yoeito: Absorption and brain distribution of Ninjin'yoeito ingredients in mice.

J Ethnopharmacol 2021 Jun 12:114332. Epub 2021 Jun 12.

Department of Cellular and Molecular Anatomy, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, Shizuoka, 431-3192, Japan; Preppers Co. Ltd., 1-23-17 Kitashinagawa, Shinagawa Ward, Tokyo, 140-0001, Japan; International Mass Imaging Center, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, Shizuoka, 431-3192, Japan; Department of Systems Molecular Anatomy, Institute for Medical Photonics Research, Preeminent Medical Photonics Education & Research Center, 1-20-1 Handayama, Higashi-ku, Hamamatsu, Shizuoka, 431-3192, Japan. Electronic address:

Ethnopharmacological Relevance: Ninjin'yoeito (NYT), a Japanese traditional Kampo medicine, has been reported to exert various clinical benefits such as relief from fatigue, malaise, anorexia, frailty, sarcopenia, and cognitive dysfunction. Recently, some review articles described the pharmacological effects of NYT and additionally indicated the possibility that multiple ingredients in NYT contribute to these effects. However, pharmacokinetic data on the ingredients are essential in addition to data on their pharmacological activities to accurately determine the active ingredients in NYT. Read More

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Combined exercise and nutrition intervention for spinal sarcopenia: A pilot study protocol.

Medicine (Baltimore) 2021 Jun;100(24):e26421

Department of Rehabilitation Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Republic of Korea.

Introduction: Spinal sarcopenia is a multifactorial disorder associated with the atrophy of and fatty changes to the paraspinal muscles. We previously developed the concept of spinal sarcopenia in community-dwelling older adults and investigated the association between conventional sarcopenic indices and spinal sarcopenia. However, interventional studies of spinal sarcopenia are lacking. Read More

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Sarcopenic obesity as a determinant of cardiovascular disease risk in older people-a systematic review.

Postgrad Med 2021 Jun 14. Epub 2021 Jun 14.

Department of Geriatric Medicine, Rotherham General Hospital, Moorgate Road, Rotherham S60 2UD, UK.

Background: Ageing is associated with body composition changes that include a reduction of muscle mass or sarcopenia and an increase in visceral obesity. Thus, ageing involves a muscle-fat imbalance with a shift towards more fat and less muscle. Therefore, sarcopenic obesity, defined as a combination of sarcopenia and obesity, is a global health phenomenon due to the increased ageing of the population combined with the increased epidemic of obesity. Read More

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A systematic review of the effectiveness of yoga on pain, physical function, and quality of life in older adults with chronic musculoskeletal conditions.

Musculoskeletal Care 2021 Jun 14. Epub 2021 Jun 14.

University of Salford, School of Health & Society Mary Seacole Building, Frederick Road Campus, UK.

Objectives: Exercise interventions suitable for older adults can help to slow and manage age-related conditions. This systematic review looks at age-related musculoskeletal conditions in a population with a mean age over 50 years, evaluating the effectiveness of yoga for pain, physical function, and quality of life.

Methods: CENTRAL,CINAHL, Pubmed, PsycInfo, SCOPUS, Sports Discus, Web of Science Core Collection, and Google Scholar were searched. Read More

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Additive Value of Preoperative Sarcopenia and Lymphopenia for Prognosis Prediction in Localized Pancreatic Ductal Adenocarcinoma.

Front Oncol 2021 27;11:683289. Epub 2021 May 27.

Department of Medical Oncology, University Hospital of Besançon, Besançon, France.

Background: Surgical resection with adjuvant chemotherapy is the only treatment that can provide long term survival in localized pancreatic ductal adenocarcinoma (LPDAC). Notwithstanding, recurrence occurs in the vast majority of patients and a better stratification of preoperative therapies is required. This study aimed to investigate preoperative immunological and nutritional factors to predict relapse-free survival (RFS) in patients with LPDAC. Read More

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Explorations of Sarcopenia via a Dynamic Model.

Front Physiol 2021 28;12:670381. Epub 2021 May 28.

School of Sport Medicine and Physical Therapy, Beijing Sport University, Beijing, China.

The cause of sarcopenia has been observed over decades by clinical trials, which, however, are still insufficient to systematically unravel the enigma of how resistance exercise mediates skeletal muscle mass. Here, we proposed a minimal regulatory network and developed a dynamic model to rigorously investigate the mechanism of sarcopenia. Our model is consisted of eight ordinary differential equations and incorporates linear and Hill-function terms to describe positive and negative feedbacks between protein species, respectively. Read More

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Effects of Icelandic yogurt consumption and resistance training in healthy untrained older males.

Br J Nutr 2021 Jun 14:1-26. Epub 2021 Jun 14.

Department of Exercise Physiology, Ferdowsi University of Mashhad, Mashhad, Iran.

Due to the important roles of resistance training and protein consumption in the prevention and treatment of sarcopenia, we assessed the efficacy of post-exercise Icelandic yogurt consumption on lean mass, strength, and skeletal muscle regulatory factors in healthy untrained older males. Thirty healthy untrained older males (age = 68 ± 4 yr) were randomly assigned to Icelandic yogurt (IR; n =15, 18 g of protein) or an iso-energetic placebo (PR; n =15, 0 g protein) immediately following resistance training (3x/week) for eight weeks. Before and after training, lean mass, strength, and skeletal muscle regulatory factors (insulin-like growth factor-1 [IGF-1], transforming growth factor-beta 1 [TGF-β1], growth differentiation factor 15 [GDF15], Activin A, myostatin [MST], and follistatin [FST]) were assessed. Read More

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Is sarcopenia a predictive factor in colorectal cancer? Better understanding the status quo.

ANZ J Surg 2021 Jun;91(6):1317

Department of Physical and Rehabilitation Medicine, Hacettepe University Medical School, Ankara, Turkey.

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Diagnosing sarcopenia: functional perspectives and a new algorithm from the ISPRM special interest group on sarcopenia.

J Rehabil Med 2021 Jun 14. Epub 2021 Jun 14.

Physical and Rehabilitation Medicine, Hacettepe University Medical School, Ankara, Turkey. E-mail:

Sarcopenia is an important public health problem, characterized by age-related loss of muscle mass and muscle function. It is a precursor of physical frailty, mobility limitation, and premature death. Although muscle loss is mainly due to the loss of type II muscle fibres, progressive loss of motor neurones is thought to be the primary underlying factor. Read More

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Cross-Sectional Examination of Homocysteine Levels with Sarcopenia and Its Components in Memory Clinic Outpatients.

J Alzheimers Dis 2021 Jun 9. Epub 2021 Jun 9.

Center for Comprehensive Care and Research on Memory Disorders, National Center for Geriatrics and Gerontology, Obu, Japan.

Background: Homocysteine is a common risk factor for cognitive impairment and sarcopenia. However, very few studies have shown an association between sarcopenia and serum homocysteine levels after adjustment for cognitive function.

Objective: The purpose of this study was to investigate the relationship between homocysteine and sarcopenia in memory clinic patients. Read More

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Superiority of focused ion beam-scanning electron microscope tomography of cardiomyocytes over standard 2D analyses highlighted by unmasking mitochondrial heterogeneity.

J Cachexia Sarcopenia Muscle 2021 Jun 13. Epub 2021 Jun 13.

Department of Cardiology and Vascular Medicine, West German Heart and Vascular Center, Medical Faculty, University of Duisburg-Essen, Essen, Germany.

Background: Cardioprotection by preventing or repairing mitochondrial damage is an unmet therapeutic need. To understand the role of cardiomyocyte mitochondria in physiopathology, the reliable characterization of the mitochondrial morphology and compartment is pivotal. Previous studies mostly relied on two-dimensional (2D) routine transmission electron microscopy (TEM), thereby neglecting the real three-dimensional (3D) mitochondrial organization. Read More

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Significance of sarcopenia in children with end-stage liver disease undergoing liver transplantation.

Authors:
Eirini Kyrana

Pediatr Transplant 2021 Jun 13:e14038. Epub 2021 Jun 13.

Paediatric Liver, GI, and Nutrition Centre, King's College Hospital, London, UK.

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Corrigendum to 'Tangible dynamic changes in resilience, nutrition, and leisure activity of older patients with cardiovascular disease and possible sarcopenia: A longitudinal study' [Archives of Gerontology and Geriatrics AGG, Volume 91, July-August 2021, 104416].

Arch Gerontol Geriatr 2021 Jun 10;96:104456. Epub 2021 Jun 10.

Taipei Municipal Gan-Dau Hospital, Taipei, Taiwan, No.12, 225 Lane, Zhi-Sing Road, Taipei Taiwan, 11260, Taiwan, ROC.

Aim And Objectives: The purpose of this study was to explore the inter-relationships among resilience, nutrition, and leisure activity of older patients with cardiovascular disease and possible sarcopenia. Besides, the patterns of these three variables over a long-term follow-up was examine.

Material And Methods: Quantitative longitudinal study design was used in this study. Read More

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Nampt controls skeletal muscle development by maintaining Ca homeostasis and mitochondrial integrity.

Mol Metab 2021 Jun 10:101271. Epub 2021 Jun 10.

Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address:

Objective: NAD is a co-factor and substrate for enzymes maintaining energy homeostasis. Nicotinamide phosphoribosyltransferase (NAMPT) controls NAD synthesis, and in skeletal muscle, NAD is important for muscle integrity. However, the underlying molecular mechanisms by which NAD synthesis affects muscle health remain poorly understood. Read More

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Association between preoperative low muscle mass and psychological factors after surgery among patients with lumbar spinal stenosis: A longitudinal study.

J Clin Neurosci 2021 Jul 27;89:8-14. Epub 2021 Apr 27.

Rehabilitation Division, Tottori University Hospital, 36-1 Nishi-cho, Yonago, Tottori 683-8504, Japan; School of Health Science, Faculty of Medicine, Tottori University, 86 Nishi-cho, Yonago, Tottori 683-8503, Japan.

It remains controversial whether preoperative low muscle mass affects clinical outcomes after lumbar surgery. Previous studies evaluated outcomes such as pain, quality of life, and disability, but none investigated preoperative low muscle mass and psychological factors. The purpose of this study was to clarify the association between preoperative low muscle mass and postoperative psychological factors in lumbar spinal stenosis (LSS). Read More

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Assessment of functional sit-to-stand muscle power: Cross-sectional trajectories across the lifespan.

Exp Gerontol 2021 Jun 9;152:111448. Epub 2021 Jun 9.

Geriatric Research Unit, Geriatric Department, Bispebjerg University Hospital, Copenhagen, Denmark; Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet-Glostrup University Hospital, Copenhagen, Denmark; Geriatric Research Unit, Department of Internal Medicine, Herlev-Gentofte University Hospital, Copenhagen, Denmark. Electronic address:

Background: The 30-s sit-to-stand (STS) muscle power test is a valid test to assess muscle power in older people; however, whether it may be used to assess trajectories of lower-limb muscle power through the adult lifespan is not known. This study evaluated the pattern and time course of variations in relative, allometric and specific STS muscle power throughout the lifespan.

Methods: Subjects participating in the Copenhagen Sarcopenia Study (729 women and 576 men; aged 20 to 93 years) were included. Read More

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Utility of preoperative CT-based body metrics in relation to postoperative complications in pediatric liver transplant recipients.

Liver Transpl 2021 Jun 12. Epub 2021 Jun 12.

Department of Radiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Background: Computed tomography (CT) derived body metrics such as skeletal muscle index (SMI), psoas muscle index (PMI), and subcutaneous fat index (ScFI) are measurable components of sarcopenia, frailty, and nutrition. While these body metrics are advocated in adults for predicting postoperative outcomes after liver transplantation (LT), little is known about the value in pediatric populations. This study assessed the relation between preoperative CT-based body metrics and postoperative short-term outcomes in pediatric LT recipients. Read More

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Impact of skeletal muscle mass in patients with recurrent gastric cancer.

World J Surg Oncol 2021 Jun 11;19(1):170. Epub 2021 Jun 11.

Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine, 36-1 Nishi-cho, Yonago, 683-8504, Japan.

Background: We retrospectively examined the relationship among skeletal muscle mass index (SMI), prognosis, and chemotherapy side effects in patients with recurrent gastric cancer (RGC).

Methods: Sixty-seven patients who developed recurrence after undergoing curative gastrectomy for gastric cancer at Tottori University Hospital and received palliative chemotherapy were included in this study. Pretreatment computed tomography was performed to measure the skeletal muscle mass (SMM) and cross-sectional SMM at the third lumbar vertebra. Read More

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Proteomic Characterization of Senescent Laryngeal Adductor and Plantaris Hindlimb Muscles.

Laryngoscope 2021 Jun 11. Epub 2021 Jun 11.

Department of Otolaryngology-Head and Neck Surgery, New York University Grossman School of Medicine, New York, New York, U.S.A.

Objectives: The goals of this study were to 1) compare global protein expression in muscles of the larynx and hindlimb and 2) investigate differences in protein expression between aged and nonaged muscle using label-free global proteomic profiling methods.

Methods: Liquid chromatography-mass spectrometry (LC-MS/MS) analysis was performed on thyroarytenoid intrinsic laryngeal muscle and plantaris hindlimb muscle from 10 F344xBN F1 male rats (5 old and 5 young). Protein expression was compared and pathway enrichment analysis performed for each muscle type (larynx and limb) and age group (old and young muscle). Read More

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Identification of novel pleiotropic gene for bone mineral density and lean mass using the cFDR method.

Ann Hum Genet 2021 Jun 11. Epub 2021 Jun 11.

Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan, China.

Bone mineral density (BMD) and whole-body lean mass (WBLM) are two important phenotypes of osteoporosis and sarcopenia. Previous studies have shown that BMD and lean mass were phenotypically and genetically correlated. To identify the novel common genetic factors shared between BMD and WBLM, we performed the conditional false discovery rate (cFDR) analysis using summary data of the genome-wide association study of femoral neck BMD (n = 53,236) and WBLM (n = 38,292) from the Genetic Factors for Osteoporosis Consortium (GEFOS). Read More

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Survival motor neuron deficiency slows myoblast fusion through reduced myomaker and myomixer expression.

J Cachexia Sarcopenia Muscle 2021 Jun 11. Epub 2021 Jun 11.

Department of Anatomy, Physiology, and Genetics, Uniformed Services University of the Health Sciences, F. Edward Hébert School of Medicine, Bethesda, MD, USA.

Background: Spinal muscular atrophy is an inherited neurodegenerative disease caused by insufficient levels of the survival motor neuron (SMN) protein. Recently approved treatments aimed at increasing SMN protein levels have dramatically improved patient survival and have altered the disease landscape. While restoring SMN levels slows motor neuron loss, many patients continue to have smaller muscles and do not achieve normal motor milestones. Read More

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Clinical and prognostic role of sarcopenia in elderly patients with classical Hodgkin lymphoma: a multicentre experience.

J Cachexia Sarcopenia Muscle 2021 Jun 11. Epub 2021 Jun 11.

Division of Hematology, ASST Spedali Civili, Brescia, Italy.

Background: Elderly classical Hodgkin lymphoma (cHL) (ecHL) is a rare disease with dismal prognosis and no standard treatment. Fitness-based approaches may help design appropriate treatments. Sarcopenia has been associated with an increased risk of treatment-related toxicities and worse survival in various solid tumours, but its impact in ecHL is unknown. Read More

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Screening for Sarcopenia (Physical Frailty) in the COVID-19 Era.

Int J Endocrinol 2021 21;2021:5563960. Epub 2021 May 21.

Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan.

Although the numbers of aged populations have risen considerably in the last few decades, the current coronavirus disease 2019 (COVID-19) has revealed an extensive vulnerability among these populations. Sarcopenia is an age-related disorder that increases hospitalization, dependencies, and mortality in older adults. It starts to develop in midlife or even earlier as a result of unbalanced diet/poor nutrition and low levels of physical activity, in addition to chronic disorders such as obesity and diabetes mellitus. Read More

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Short-term glucocorticoid excess blunts abaloparatide-induced increase in femoral bone mass and strength in mice.

Sci Rep 2021 Jun 10;11(1):12258. Epub 2021 Jun 10.

Department of Biomedicine, Health, Aarhus University, Wilhelm Meyers Allé 3, 8000, Aarhus C, Denmark.

Glucocorticoids (GCs), such as prednisolone, are widely used to treat inflammatory diseases. Continuously long-term or high dose treatment with GCs is one of the most common causes of secondary osteoporosis and is associated with sarcopenia and increased risk of debilitating osteoporotic fragility fractures. Abaloparatide (ABL) is a potent parathyroid hormone-related peptide analog, which can increase bone mineral density (aBMD), improve trabecular microarchitecture, and increase bone strength. Read More

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Differential response of oxidative and glycolytic skeletal muscle fibers to mesterolone.

Sci Rep 2021 Jun 10;11(1):12301. Epub 2021 Jun 10.

Department of Anatomy, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.

Oxidative and glycolytic muscle fibers differ in their ultrastructure, metabolism, and responses to physiological stimuli and pathological insults. We examined whether these fibers respond differentially to exogenous anabolic androgenic steroids (AASs) by comparing morphological and histological changes between the oxidative anterior latissimus dorsi (ALD) and glycolytic pectoralis major (PM) fibers in adult avian muscles. Adult female White Leghorn chickens (Gallus gallus) were randomly divided into five groups: a vehicle control and four mesterolone treatment groups (4, 8, 12, and 16 mg/kg). Read More

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Low preoperative skeletal muscle density is predictive for negative postoperative outcomes in older women with ovarian cancer.

Gynecol Oncol 2021 Jun 7. Epub 2021 Jun 7.

Leiden University Medical Center, Leiden University, Department of Medical Oncology, Albinusdreef 2, 2333 ZA, Leiden, the Netherlands.

Objective: To determine the predictive value of lumbar skeletal muscle mass and density for postoperative outcomes in older women with advanced stage ovarian cancer.

Methods: A multicenter, retrospective cohort study was performed in women ≥ 70 years old receiving surgery for primary, advanced stage ovarian cancer. Skeletal muscle mass and density were assessed in axial CT slices on level L3. Read More

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The role of SARC-F scale in predicting progression risk of COVID-19 in elderly patients: a prospective cohort study in Wuhan.

BMC Geriatr 2021 06 10;21(1):355. Epub 2021 Jun 10.

Global Health Research Center, Duke Kunshan University, Suzhou, Jiangsu Province, China.

Background: Since the outbreak of COVID-19, it has been documented that old age and underlying illnesses are associated with poor prognosis among COVID-19 patients. However, it is unknown whether sarcopenia, a common geriatric syndrome, is associated with poor prognosis among older COVID-19 patients. The aim of our prospective cohort study is to investigate the association between sarcopenia risk and severe disease among COVID-19 patients aged ≥60 years. Read More

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Gender differences in multifidus fatty infiltration and sarcopenia and association with preoperative pain and functional disability in patients with lumbar spinal stenosis.

Spine J 2021 Jun 7. Epub 2021 Jun 7.

Spine Surgery Unit, Neurosurgical Department, Tel Aviv Medical Center, Tel Aviv, Israel. Electronic address:

Background: In patients with lumbar spinal stenosis, female gender has been associated with higher pain and functional disability. Sarcopenia and multifidus atrophy have also been associated with symptomatic severity.

Purpose: The purpose of this study was to determine if gender differences in sarcopenia and multifidus atrophy are associated with gender disparities in disease symptomatology. Read More

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