32,281 results match your criteria sarcomas primary

Sarcomatous Meningioma: Diagnostic Pitfalls and the Utility of Molecular Testing.

J Neuropathol Exp Neurol 2021 Jun 12. Epub 2021 Jun 12.

Department of Pathology (C-HGL, PD, DAS, AP); Clinical Cancer Genomics Laboratory (PD), University of California, San Francisco, California, UUSA; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA (CG); Institute of Neuropathology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University, Düsseldorf, Germany (GR); Department of Pathology and Immunology, Washington University, St. Louis, Missouri, USA (SD); Department of Pathology, Sutter Medical Center, Sacramento (DC); Department of Neurological Surgery, University of California, San Francisco (AP), California, USA.

Anaplastic meningiomas can have a sarcomatous appearance on histology but true sarcomatous (metaplastic) differentiation is rare. These tumors follow an aggressive clinical course with recurrence and poor clinical outcomes. Due to significant overlap in morphology and immunohistochemical profiles, distinguishing between sarcomatous transformation of a meningioma and a true sarcoma can be challenging. Read More

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Usefulness of SS18-SSX antibody as a diagnostic marker for pulmonary metastatic synovial sarcoma.

Diagn Pathol 2021 Jun 14;16(1):54. Epub 2021 Jun 14.

Department of Laboratory Medicine, Shinshu University School of Medicine, Matsumoto, Japan.

Background: The novel SS18-SSX fusion-specific antibody is reported to have high sensitivity and specificity for the diagnosis of primary synovial sarcoma (SS), which often metastasizes to the lung. Thus far, no study has validated the diagnostic efficacy of SS18-SSX antibody for pulmonary metastatic SS. Therefore, we aimed to investigate the usefulness of the SS18-SSX antibody in the diagnosis of pulmonary metastatic SS. Read More

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Primary Extraosseous Ewing's Sarcoma of the Lung: Radiologic and Pathologic correlation.

Cureus 2021 May 4;13(5):e14830. Epub 2021 May 4.

Pathology, Osmangazi University Faculty of Medicine, Eskisehir, TUR.

Ewing's sarcoma (ES) is a rare and highly aggressive tumor belonging to a family of neoplasms of neuroectodermal origin, which primarily affects the bones or soft tissues. ES originating from lung parenchyma without chest wall involvement is extremely rare with less than 40 cases reported in the English literature. A 41-year-old man admitted to the thoracic surgery department presenting with intermittent non-productive cough, dyspnea, left-sided chest pain for two months for further evaluation and treatment with a preliminary diagnosis of pulmonary mass. Read More

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Adjuvant high-dose-rate interstitial brachytherapy for malignant peripheral nerve sheath tumor of the foot: a case report.

J Contemp Brachytherapy 2021 Jun 18;13(3):338-346. Epub 2021 May 18.

Department of Radiotherapy, IEO European Institute of Oncology IRCCS, Milan, Italy.

Soft tissue sarcomas of the foot are extremely rare and can therefore be misdiagnosed as benign diseases, and be prematurely removed with an unplanned excision. The standard treatment is a wide local excision with an addition of radiotherapy as an alternative to a radical resection (e.g. Read More

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Kaposi sarcoma of the adrenal gland: A report of two cases with a review of the literature.

J Cancer Res Ther 2021 Apr-Jun;17(2):606-608

Department of Pathology, Ibn Sina Teaching Hospital, Rabat, Morocco.

Kaposi sarcoma (KS) is a low-grade vascular neoplasm commonly involving mucocutaneous sites, while adrenal gland involvement is exceptional. The anaplastic variant is a rare entity characterized by marked cellular pleomorphism, increased mitosis, worse prognosis, and an increased metastatic potential. The diagnosis remains on histology and immunohistochemistry. Read More

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Understanding giant cell sarcoma of the head and neck: A population-based study.

Head Neck 2021 Jun 14. Epub 2021 Jun 14.

Department of Otolaryngology - Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, New Jersey, USA.

Background: Giant cell sarcomas (GCS) are rare head and neck neoplasms.

Methods: The Surveillance, Epidemiology, and End Results (SEER) database was analyzed for all patients who have been diagnosed with GCS from 1973 to 2014.

Results: Four hundred and forty cases of GCS of the head and neck were identified. Read More

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MDCT evaluation of synchronous breast carcinoma and other solid malignancies.

Adel El-Badrawy

Breast Dis 2021 Jun 2. Epub 2021 Jun 2.

Radiology Department, Mansoura University Faculty of Medicine, Mansoura, Dakahlya, Egypt.

Background: Multiple primary malignancies are two or more malignancies in an individual without any relationship between the tumors. The development of improved diagnostic techniques, increased survival of cancer patients and the growing life expectancy have all contributed to the increased frequency of this phenomenon.

Objective: The aim of this study is to review the multidetector computed tomography (MDCT) findings of synchronous breast carcinoma and other solid malignancies. Read More

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[Primary liposarcomas of the digestive tract: Diversity of clinicopathological presentations and diagnostic challenges].

Ann Pathol 2021 Jun 10. Epub 2021 Jun 10.

Service d'anatomie et de cytologie pathologiques, CHU de Grenoble-Alpes, 38043 Grenoble, France; Univ Grenoble Alpes, Inserm, U1209, CNRS, UMR5309, Institute for Advanced Biosciences, 38700 Grenoble, France. Electronic address:

Sarcomas are rare tumours that represent less than 1% of all malignant tumours in adults. Liposarcomas are among the most common malignant mesenchymal tumours. They are preferentially located in the limbs and the retroperitoneum. Read More

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Aortic Angiosarcoma in Association with Endovascular Aneurysm Repair: Case Report and Review of the Literature.

Am J Case Rep 2021 Jun 12;22:e931740. Epub 2021 Jun 12.

Division of Clinical Pathology, Niigata University Faculty of Medicine, Niigata, Japan.

BACKGROUND Primary aortic sarcoma often poses diagnostic challenges for pathologists and clinicians because of a very low incidence and controversy over nomenclature and definition. We report a case of aortic angiosarcoma in association with a graft. We also conducted a clinicopathological review of cases of primary aortic sarcomas associated with implanted grafts. Read More

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Efficacy and safety of TAS-115, a novel oral multi-kinase inhibitor, in osteosarcoma: an expansion cohort of a phase I study.

Invest New Drugs 2021 Jun 12. Epub 2021 Jun 12.

Department of Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan.

Background osteosarcoma is a rare, primary malignant bone tumour with limited available treatments for advanced or recurrent disease, resulting in a poor prognosis for patients. TAS-115 is a novel tyrosine kinase inhibitor under investigation in a phase I study in patients with solid tumours. We report data of osteosarcoma patients in the expansion cohort of this ongoing study. Read More

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Primary neuroendocrine tumours of the heart: case report and literature review.

BMJ Case Rep 2021 Jun 11;14(6). Epub 2021 Jun 11.

Internal Medicine, University of Florida College of Medicine, Gainesville, Florida, USA.

Neuroendocrine tumours occur most frequently in the gastrointestinal tract, lungs, and pancreas. Primary malignant cardiac tumours are uncommon and are usually sarcomas, lymphomas, or, infrequently, mesotheliomas. Primary cardiac neuroendocrine carcinomas are exceedingly rare; only nine have been reported in the literature to date. Read More

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Distal Tibial Reconstruction in the Management of Primary Bone Tumors in Children and Adolescents.

Foot Ankle Int 2021 Jun 11:10711007211012690. Epub 2021 Jun 11.

Department of Oncology and Surgical Oncology for Children and Youth, Institute of Mother and Child, Warsaw, Poland.

Background: Distal tibial primary bone tumors are rare, and options for limb salvage surgery are limited and challenging. Importantly, local control has shown to be crucial and necessary for cure, and radical surgery is one of the most important components of therapy for some bone sarcomas. We investigated the feasibility and functional and oncological outcomes of distal tibial reconstruction using endoprosthesis in children with malignant bone tumors. Read More

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Primary mediastinal germ cell tumours with high prevalence of somatic malignancy: An experience from a single tertiary care oncology centre.

Ann Diagn Pathol 2021 May 26;53:151763. Epub 2021 May 26.

Department of Thoracic Surgery, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, Maharashtra, India.

Background: Primary mediastinal germ tumours (PMGCT) constitute, a mere 3-4% of all germ cell tumours (GCT). Although they account for approximately 16% of mediastinal tumours in adults and 19-25% in children as per western literature, there is hardly any large series on PMGCT reported from the Indian subcontinent.

Design: We have retrospectively analysed clinicopathological features of 98 cases of PMGCT diagnosed over 10 years (2010-2019) from a tertiary-care oncology centre. Read More

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A unique case of adamantinoma-like Ewing sarcoma in the calcaneus, exhibiting prominent squamous differentiation and displaying EWSR1 gene rearrangement.

Skeletal Radiol 2021 Jun 10. Epub 2021 Jun 10.

Sparsh Orthopedic Oncology, Ahmedabad, Gujrat, India.

Adamantinoma-like Ewing sarcoma is uncommonly reported in the skeletal sites, including small bones of the feet.A 15-year-old girl presented with pain and swelling in her left foot, leading to difficulty in walking for 8 months. Plain radiograph revealed an ill-defined, lytic-sclerotic lesion without significant periosteal reaction in her left calcaneus. Read More

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Surgery in soft tissue sarcoma: the thin line between a surgical or more conservative approach.

Future Oncol 2021 Jun 10. Epub 2021 Jun 10.

Department of Surgery, IRCCS, Istituto Nazionale dei Tumori, Via Venezian 1, 20133, Milan, Italy.

Surgery is the primary treatment for localized, clinically resectable soft tissue sarcoma (STS). Chemotherapy and radiotherapy, administered in the pre- or post-operative settings, have important ancillary roles in the multimodal management of primary STS. Some sarcoma centers also employ locoregional therapies such as isolated limb perfusion and deep wave hyperthermia in multimodal therapy. Read More

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Primary Adrenal Malignant Rhabdoid Tumor in a 14-Year-Old Female: A Case Report and Literature Review.

Int J Surg Pathol 2021 Jun 9:10668969211024331. Epub 2021 Jun 9.

Children's Hospital Los Angeles, Los Angeles, CA, USA.

Malignant rhabdoid tumor (MRT) is a rare, SWItch/sucrose nonfermentable-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 ()-deficient, aggressive tumor, occurring predominantly in children below 3 years of age. Primary adrenal MRT is extremely rare, with only 3 cases reported in the literature. A previously healthy 14-year-old female presented with left upper quadrant/epigastric abdominal pain. Read More

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The 'other' bone sarcomas in Japan: a retrospective study of primary bone sarcomas other than osteosarcoma, Ewing sarcoma and chondrosarcoma, using data from the Bone Tumuor Registry in Japan.

Jpn J Clin Oncol 2021 Jun 9. Epub 2021 Jun 9.

The Department of Rare Cancer Center, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan.

Background: To date, no standard treatments for primary bone sarcomas other than those for osteosarcoma, Ewing sarcoma and chondrosarcoma have been developed.

Methods: The clinical characteristics and prognostic factors of 330 patients with primary bone sarcomas other than osteosarcoma, Ewing sarcoma and chondrosarcoma, listed in a nationwide tumour registry (Bone and Soft Tissue Tumor Registry in Japan) were investigated. The effects of adjuvant chemotherapy were determined by comparing the outcomes of patients with non-metastatic bone tumours who received surgery plus chemotherapy with those of patients who underwent surgery alone. Read More

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Clinical outcomes of endoprosthetic reconstruction for proximal femoral resection.

Jpn J Clin Oncol 2021 Jun 8. Epub 2021 Jun 8.

Department of Orthopedic Surgery, Korea Cancer Center Hospital, Seoul, Korea.

Introduction: The proximal femur is a common site for primary sarcomas and metastatic lesions. Although the early results of tumor prostheses are promising, the long-term results of reconstruction are unknown. The purpose of this study is to evaluate the prognostic factors affecting prosthesis survival and complications after proximal femoral resection and reconstruction. Read More

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Sotorasib for Lung Cancers with p.G12C Mutation.

N Engl J Med 2021 Jun 4. Epub 2021 Jun 4.

From the University of Texas M.D. Anderson Cancer Center, Houston (F.S.), and U.S. Oncology Research, the Woodlands (A. Spira) - both in Texas; Memorial Sloan Kettering Cancer Center and Weill Cornell Medicine (B.T.L.) and Thoracic Medical Oncology, Perlmutter Cancer Center, New York University (V.V.), New York, and Roswell Park Cancer Institute, Buffalo (G.K.D.) - all in New York; the Queen Elizabeth Hospital and University of Adelaide, Woodville, SA, Australia (T.J.P.); Sarah Cannon Research Institute at HealthONE, Denver (G.S.F.); Department I of Internal Medicine, Center for Integrated Oncology, University Hospital Cologne, Cologne (J.W.), the West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Essen (M.S.), and the German Cancer Consortium, Heidelberg (M.S.) - all in Germany; the Early Phase Trials and Sarcoma Units, Bergonie Cancer Institute, Bordeaux (A.I.), and Gustave Roussy Institute, Villejuif (F.B., B.B.) - both in France; Fox Chase Cancer Center, Philadelphia (H.B.); Kanagawa Cancer Center, Yokohama (T.K.), and the Division of Thoracic Oncology, Shizuoka Cancer Center, Shizuoka (T.T.) - both in Japan; the Department of Medical Oncology and Hematology, University Hospital Zurich, Zurich, Switzerland (A.C.-F.); Princess Margaret Cancer Centre, University Health Network, Toronto (A. Sacher); Virginia Cancer Specialists, Fairfax (A. Spira); Johns Hopkins School of Medicine, Johns Hopkins University, Baltimore (A. Spira); Winship Cancer Institute of Emory University, Atlanta (S.S.R.); Amgen, Thousand Oaks, CA (A. Anderson, A. Ang, Q.T., O.M., H.H., G.N., G.F.); and the Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis (R.G.).

Background: Sotorasib showed anticancer activity in patients with p.G12C-mutated advanced solid tumors in a phase 1 study, and particularly promising anticancer activity was observed in a subgroup of patients with non-small-cell lung cancer (NSCLC).

Methods: In a single-group, phase 2 trial, we investigated the activity of sotorasib, administered orally at a dose of 960 mg once daily, in patients with p. Read More

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Primary Intracranial Leiomyosarcoma Secondary to Glioblastoma: Case Report and Literature Review.

Front Oncol 2021 20;11:642683. Epub 2021 May 20.

Department of Neurosurgery, First Hospital of Jilin University, Changchun, China.

Background: Leiomyosarcoma is a highly malignant soft-tissue sarcoma with a poor prognosis. In recent years, treatment for leiomyosarcoma has not shown much progress. Primary intracranial leiomyosarcoma (PILMS) is a much rarer type of neoplasm, which occurs more frequently in immunocompromised patients. Read More

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Primary renal NUT carcinoma identified by next-generation sequencing: a case report and literature review.

Int J Clin Exp Pathol 2021 15;14(5):662-669. Epub 2021 May 15.

Department of Medical, OrigiMed Shanghai, China.

Background: NUT carcinoma is a rare aggressive squamous cell carcinoma subtype genetically characterized by rearrangements. NUT carcinoma can be easily misdiagnosed as an undifferentiated carcinoma or Ewing sarcoma due to its primitive differentiation.

Case Presentation: We report a case of renal-derived NUT carcinoma diagnosed as a malignant small round-cell tumor resembling Ewing sarcoma/primitive neuroectodermal tumor where the diagnosis was revised to NUT carcinoma with a characteristic NUTM1 rearrangement based on next-generation sequencing (NGS). Read More

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Primary mobile vertebral column sarcomas: Prognostic factors vary by histologic subtypes.

J Surg Oncol 2021 Jun 6. Epub 2021 Jun 6.

Department of Orthopaedic Surgery, University of California-Davis, Sacramento, California, USA.

Background: Primary sarcomas originating from the mobile spine portends a particularly sinister outcome. Rarity of the disease process has resulted in inconsistent data due to small sample size and heterogeneity in patient selection and analytics.

Methods: Surveillance, Epidemiology and End Result (SEER) database from 1975 to 2017 was queried to report incidence and survival data in 712 patients in the United States. Read More

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The preoperative localisation of small parathyroid adenomas improves when adding Tc-99m-Sestamibi SPECT to multiphase contrast-enhanced CT.

Insights Imaging 2021 Jun 5;12(1):72. Epub 2021 Jun 5.

Department of Oncology-Pathology, Karolinska Institute, SLL, 17177, Stockholm, Sweden.

Objectives: To investigate the incremental value of Sestamibi SPECT combined with a non-enhanced and contrast-enhanced CT, using SPECT/CT, for the preoperative localisation of small parathyroid adenomas (PTA).

Methods: Retrospectively, 147 patients surgically cured from primary hyperparathyroidism, as verified by biochemistry 6 months postoperatively, were included. All patients had preoperatively undergone a dual time Technetium-Sestamibi SPECT (S) with multiphase CT including native (N), arterial (A) and venous (V) phases. Read More

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Is bipolar hemiarthroplasty an appropriate type of hip articulation following proximal femoral or total femoral resections for musculoskeletal malignancies?

Arch Orthop Trauma Surg 2021 Jun 6. Epub 2021 Jun 6.

Department of Orthopaedics and Traumatology, Marmara University Pendik Training and Research Hospital, 34890, Pendik, İstanbul, Turkey.

Background: Different approaches are applied for reconstruction in patients with a musculoskeletal malignancy which require a proximal femoral or total femoral resection. We aimed to evaluate the treatment outcomes of patients who underwent a proximal femoral or total femoral resection due to bone and soft tissue tumors and had an endoprosthetic reconstruction by a bipolar hemiarthroplasty type of hip articulation.

Methods: We retrospectively identified 133 patients who underwent a proximal femoral or total femoral endoprosthetic replacement after resection of a bone or soft tissue malignancy. Read More

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Oncological and Functional Outcomes in Joint-sparing Resections of the Proximal Femur for Malignant Primary Bone Tumors.

J Pediatr Orthop 2021 Jun 7. Epub 2021 Jun 7.

Department of Orthopaedic Surgery, Boston Children's Hospital Department of Orthopaedic Surgery, Massachusetts General Hospital Section of Orthopaedic Oncology, Division of Orthopaedic Surgery, Lahey Hospital and Medical Center, Burlington Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center, Boston, MA Department of Orthopaedic Surgery, Tripler Army Medical Center, Honolulu, HI Heart and Vascular Center, Dartmouth-Hitchcock Medical Center, Lebanon, NH Allegheny Orthopaedic Associates, Pittsburgh, PA.

Background: Joint-sparing resections (JSR) of the proximal femur allow for preservation of the proximal femoral growth plate and native hip joint, but whether this offers fewer complications or better function and longevity of the reconstruction remains unknown. In this study, we compared the functional outcomes of pediatric patients with bone sarcomas undergoing JSR of the proximal femur with intercalary allograft (ICA) reconstruction to those undergoing proximal femoral resections (PFR) with allograft-prosthetic composite (APC) reconstructions.

Methods: We retrospectively reviewed all patients undergoing JSR with ICA reconstruction and PFR with APC reconstructions between 1995 and 2013 at a tertiary pediatric referral center. Read More

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Quality of life in patients with BRAF-mutant melanoma receiving the combination encorafenib plus binimetinib: Results from a multicentre, open-label, randomised, phase III study (COLUMBUS).

Eur J Cancer 2021 Jun 3;152:116-128. Epub 2021 Jun 3.

Massachusetts General Hospital, Boston, MA, USA.

Background: In COLUMBUS, treatment with encorafenib plus binimetinib in patients with advanced BRAF-mutant melanoma showed improved progression-free and overall survival with favourable tolerability compared to vemurafenib treatment. Here, results on health-related quality of life (HRQoL) are presented.

Methods: COLUMBUS was a two-part, open-label, randomised, phase III study in patients with BRAF-mutant melanoma. Read More

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Unique hybrid double apposing flap in a Z-plasty technique to reconstruct major perianal defect resulting from chondyloma acuminatum resection - Case report.

Adnan G Gelidan

Int J Surg Case Rep 2021 May 21;83:106002. Epub 2021 May 21.

Department of Surgery, King Khalid University Hospital, King Saud University, Saudi Arabia.

Perianal area is anatomically challenging location to reconstruct after wide extensive local excision especially when preserving the anus anatomy anal sphincter continence is a requirement. That is the case in many benign locally aggressive conditions, due to high risk of suture line disruption, wound dehiscence, and wound infection. Many surgical options like primary closure, loco reginal flaps, distant or pedicled flaps, or even free flaps are available for such reconstruction. Read More

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Epithelioid hemangioendothelioma, an ultra-rare cancer: a consensus paper from the community of experts.

ESMO Open 2021 Jun 2;6(3):100170. Epub 2021 Jun 2.

Department of Medical Oncology, Leiden University Medical Center, Leiden, The Netherlands.

Epithelioid hemangioendothelioma (EHE) is an ultra-rare, translocated, vascular sarcoma. EHE clinical behavior is variable, ranging from that of a low-grade malignancy to that of a high-grade sarcoma and it is marked by a high propensity for systemic involvement. No active systemic agents are currently approved specifically for EHE, which is typically refractory to the antitumor drugs used in sarcomas. Read More

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Preoperative stereotactic ablative body radiotherapy with postoperative conventional irradiation of soft tissue sarcomas: protocol overview with a preliminary safety report.

Radiother Oncol 2021 Jun 2. Epub 2021 Jun 2.

Department of Radiation Oncology & Nuclear Medicine, N.N. Petrov National Medical Research Center of Oncology, St. Petersburg 197758, Russia. Electronic address:

Preoperative radiotherapy in patients with soft tissue sarcomas is characterized by important advantages: high precision of dose delivery, reduction of tumour volume and implantation potential, induction of immunologic response. Postoperative irradiation is associated with a reduced risk of complication, and a comprehensive radiotherapy planning in accordance with the pathologic report. Combination of pre- and postoperative irradiation gives the opportunity to use the best of both methods. Read More

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Skull Base Primary Ewing Sarcoma: A Radiological Experience of a Rare Disease in an Atypical Location.

Am J Case Rep 2021 Jun 5;22:e930384. Epub 2021 Jun 5.

Department of Radiology, School of Medical Sciences, University of Science Malaysia, Kota Bharu, Malaysia.

BACKGROUND Ewing sarcoma and primitive neuroectodermal tumor are rare tumors grouped under the spectrum of the Ewing sarcoma family of tumors. These highly malignant tumors involve the bones and commonly occur in children. Ewing sarcoma of the skull bone accounts for only 1% of all Ewing sarcomas, with primary skull base Ewing sarcoma occurring in less than 1% of cases. Read More

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