1,204,097 results match your criteria samples 34 μm


Lizard osteoderms - morphological characterisation, biomimetic design and manufacturing based on three species.

Bioinspir Biomim 2021 Sep 15. Epub 2021 Sep 15.

University College London, Mechanical Engineering, London, WC1E 6JE, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.

Osteoderms (OD) are mineralised dermal structures consisting mainly of calcium phosphate and collagen. The sheer diversity of OD morphologies and their distribution within the skin of lizards makes these reptiles an ideal group in which to study ODs. Nonetheless, our understanding of the structure, development, and function of lizard ODs remains limited. Read More

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September 2021

Seroepidemiological study of severe fever with thrombocytopenia syndrome in animals and humans in Okinawa, Japan.

Ticks Tick Borne Dis 2021 Sep 4;12(6):101821. Epub 2021 Sep 4.

Department of Child Medical Health and Development, Mie University Graduate School of Medicine, Mie, Japan; Department of Pediatrics, National Hospital Organization Mie National Hospital, 357 Osato-kubota, Tsu, Mie, Japan. Electronic address:

In Okinawa prefecture, Japan, the first case of severe fever with thrombocytopenia syndrome (SFTS) was confirmed in August 2016, and this case remains to be the only reported case of SFTS in Okinawa. The epidemiological investigation indicated that the patient had been infected on the main island of Okinawa, but source and route of infection were unknown. Therefore, to understand the possible source and route of SFTS virus (SFTSV) infection in Okinawa, we performed a seroepidemiological study of SFTSV among animals and dwellers in Okinawa and conducted a questionnaire survey to investigate risk factors for tick bites in Okinawa. Read More

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September 2021

An evaluation of interventions to improve outcomes for hospitalized patients in isolation: A systematic review.

Am J Infect Control 2021 Sep 12. Epub 2021 Sep 12.

School of Nursing and Midwifery, Centre for Quality and Patient Safety Research, Institute for Health Transformation, Deakin University, Burwood, Australia; Centre for Quality and Patient Safety Research-Alfred Health Partnership, Melbourne, Australia.

Background: Isolation is effective in preventing transmission of infectious disease. However, it has been shown to have negative effects including increased anxiety and poor physical outcomes.

Objectives: To summarize the effects of interventions to improve safety and outcomes for patients in isolation DESIGN: Systematic review (PROSPERO protocol registration-CD CRD42020222779). Read More

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September 2021

Real-Time SARS-CoV-2 Genotyping by High-Throughput Multiplex PCR Reveals the Epidemiology of the Variants of Concern in Qatar.

Int J Infect Dis 2021 Sep 12. Epub 2021 Sep 12.

Department of Pathology, Sidra Medicine, Doha, Qatar; Pathology and Laboratory Medicine, Weill Cornell Medicine-Qatar, Doha, Qatar.

Complementing whole genome sequencing strategies with high-throughput multiplex RT-qPCR genotyping allows for more comprehensive and real-time tracking of SARS-CoV-2 variants of concern. During the second and third waves of COVID-19 in Qatar, PCR genotyping, combined with Sanger sequencing of un-typeable samples, was employed to describe the epidemiology of the Alpha, Beta and Delta variants. A total of 9792 nasopharyngeal PCR-positive samples collected between April-June 2021 were successfully genotyped, revealing the importation and transmission dynamics of these three variants in Qatar. Read More

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September 2021

The exposome in practice: an exploratory panel study of biomarkers of air pollutant exposure in Chinese people aged 60-69 years (China BAPE Study).

Environ Int 2021 Sep 12;157:106866. Epub 2021 Sep 12.

China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China; Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China. Electronic address:

The exposome overhauls conventional environmental health impact research paradigms and provides a novel methodological framework that comprehensively addresses the complex, highly dynamic interplays of exogenous exposures, endogenous exposures, and modifiable factors in humans. Holistic assessments of the adverse health effects and systematic elucidation of the mechanisms underlying environmental exposures are major scientific challenges with widespread societal implications. However, to date, few studies have comprehensively and simultaneously measured airborne pollutant exposures and explored the associated biomarkers in susceptible healthy elderly subjects, potentially resulting in the suboptimal assessment and management of health risks. Read More

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September 2021

Safety and Immunogenicity of an Anti-Zika Virus DNA Vaccine.

N Engl J Med 2021 09;385(12):e35

From the Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania (P.T.), and Wistar Institute (K.M., E.L.R., S.B.K., F.I.Z., H.C., D.B.W.), Philadelphia, and Inovio Pharmaceuticals, Plymouth Meeting (S.W., A.S.K., J.B., M.B.) - all in Pennsylvania; GeneOne Life Science, Seoul, South Korea (C.C.R., Y.K.P., C.R., S.E.S., J.N.M.); Infectious Diseases Research Centre-Université Laval, Quebec, QC, Canada (T.R., S.T., G.P.K.); QPS-Miami Research Associates, Miami, (D.K.); and the Department of Medicine, Morristown Medical Center, Morristown, NJ (J.N.M.).

Background: Although Zika virus (ZIKV) infection is typically self-limiting, other associated complications such as congenital birth defects and the Guillain-Barré syndrome are well described. There are no approved vaccines against ZIKV infection.

Methods: In this phase 1, open-label clinical trial, we evaluated the safety and immunogenicity of a synthetic, consensus DNA vaccine (GLS-5700) encoding the ZIKV premembrane and envelope proteins in two groups of 20 participants each. Read More

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September 2021

CCL2 produced by pancreatic ductal adenocarcinoma is essential for the accumulation and activation of monocytic myeloid-derived suppressor cells.

Immun Inflamm Dis 2021 Sep 15. Epub 2021 Sep 15.

Department of Urology, School of Medicine, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China.

Introduction: The development of pancreatic ductal adenocarcinoma (PDAC) is closely tied with the immune system. C-C motif chemokine ligands (CCL) were proved to lead to immune recruitment and training. Thus, we reckoned CCL2 to be the kernel of immune suppression in PDAC tissues. Read More

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September 2021

Strategies to circumvent the solvent strength mismatch problem in on-line comprehensive two-dimensional liquid chromatography.

J Sep Sci 2021 Sep 15. Epub 2021 Sep 15.

Université de Lyon, Institut des sciences analytiques, UMR 5280 CNRS, 5 rue de la Doua, 69100 Villeurbanne, France.

On-line comprehensive two-dimensional liquid chromatography (LC x LC) is a powerful technique for the separation of highly complex samples. Due to the addition of a second dimension of separation, impressive peak capacities can be obtained within a reasonable analysis time compared to one-dimensional liquid chromatography (1D-LC). In on-line LC x LC, the separation power is maximized by selecting two separation dimensions as orthogonal as possible, which most often requires the combination of different mobile phases and stationary phases. Read More

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September 2021

Clinical Outcomes of Patients Taking First-generation EGFR-TKIs May Predict the Benefits Afforded by Osimertinib in EGFR T790M-mutant NSCLC Patients.

Int J Clin Pract 2021 Sep 15:e14877. Epub 2021 Sep 15.

Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China.

Background: Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) are widely used to treat patients with EGFR-mutated non-small cell lung cancers (NSCLCs). The association between the clinical outcomes of patients on first-line EGFR-TKIs and the efficacy of osimertinib as second-line treatment has not been previously assessed. This is our topic here. Read More

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September 2021

The effects of pre-emptive intravenous ibuprofen on the thiol/disulfide homeostasis and C-reactive protein level as the markers of oxidative stress and inflammation during gynecologic laparoscopy: A randomized clinical trial.

Int J Clin Pract 2021 Sep 15:e14872. Epub 2021 Sep 15.

University of Health Sciences, Kartal Dr. Lütfi Kırdar City Hospital, The Department of Anesthesiology and Reanimation, Istanbul, Turkey.

Aims: In this study, we aimed to investigate the anti-inflammatory and antioxidant effects of intravenous ibuprofen by using the C-reactive protein level and thiol/disulfide homeostasis as the oxidative stress marker.

Materials And Methods: This study was conducted on 70 patients aged between 30 and 65 who were scheduled for elective laparoscopic hysterectomy. The patients were divided into two groups to receive either preemptive 800mg of intravenous ibuprofen plus 1000 mg of intravenous paracetamol (Group IP) or only 1000 mg of intravenous paracetamol as a control group (Group P). Read More

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September 2021

COVID-19 among children seeking primary paediatric care with signs of an acute infection.

Acta Paediatr 2021 Sep 15. Epub 2021 Sep 15.

Institute of Medical Virology, Goethe University, Frankfurt, Germany.

Aim: It can be challenging to distinguish COVID-19 in children from other common infections. We set out to determine the rate at which children consulting a primary care paediatrician with an acute infection are infected with SARS-CoV-2, and to compare distinct findings.

Method: In seven out-patient clinics, children 0 to 13 years with any new respiratory or gastrointestinal symptoms and presumed infection, were invited to be tested for SARS-CoV-2. Read More

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September 2021

Diversity and antibiotic resistance profiles of Listeria monocytogenes serogroups in different food products from Transylvania Region, Central Romania.

J Food Prot 2021 Sep 15. Epub 2021 Sep 15.

Banat University of Agricultural Sciences and Veterinary Medicine ROMANIA Timasoara.

The aim of this study was to assess the presence and antimicrobial susceptibility profile of the molecularly serogrouped Listeria monocytogenes isolates in different animal origin food products, collected from a county situated in the historical region of Transylvania, Central Romania. A total of 7.7% (17/221) of the screened samples were positive for L. Read More

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September 2021

Risk assessment of pesticide residues in Chinese litchis.

J Food Prot 2021 Sep 15. Epub 2021 Sep 15.

CHINA.

The presence of pesticide residues in fruit has been of extensive concern worldwide. In this paper, pesticide residues in litchi samples in China and their dietary exposure risks were evaluated. Fifty-seven pesticides in 150 litchi samples were measured by GC and UPLC/MS-MS. Read More

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September 2021

Infection Dynamics of Batrachochytrium dendrobatidis In Two Frog Species Inhabiting Quito'S Metropolitan Guangüiltagua Park, Ecuador.

J Wildl Dis 2021 Sep 15. Epub 2021 Sep 15.

Escuela de Medicina Veterinaria, Facultad de Ciencias de la Salud, Universidad de Las Américas, Vía Nayón S/N, Quito 170124, Ecuador.

Batrachochytrium dendrobatidis (Bd) infection is one of the principal causes of amphibian declines worldwide. The presence of Bd has been determined in Gastrotheca riobambae tadpoles that inhabit ponds in Quito's Metropolitan Guangüiltagua Park, Ecuador. This study sought to determine whether these tadpoles are infected and to determine the presence of chytridiomycosis in another frog species, Pristimantis unistrigatus, which also inhabits the park and has different reproductive biology and distinct behavioral habits. Read More

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September 2021

Intrinsic defect structures of polycrystalline CaKFeAs superconductors.

Phys Chem Chem Phys 2021 Sep 15;23(35):19827-19833. Epub 2021 Sep 15.

Research Institute for Advanced Electronics and Photonics, National Institute of Advanced Industrial Science and Technology (AIST), 1-1-1 Central 2, Umezono, Tsukuba, Ibaraki, 305-8568, Japan.

We investigated the defect structures of polycrystalline CaKFeAs (CaK1144) superconductors by scanning transmission electron microscopy (STEM). The STEM studies revealed the presence of a one-layer CaFeAs (∼1 nm size) defect along the -plane, as observed in single crystalline CaK1144. Step-like CaFeAs defects are also observed. Read More

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September 2021

Air separation via two-step solar thermochemical cycles based on SrFeO and (Ba,La)SrFeO perovskite reduction/oxidation reactions to produce N: rate limiting mechanism(s) determination.

Phys Chem Chem Phys 2021 Sep 15;23(35):19280-19288. Epub 2021 Sep 15.

George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia, 30332-0405, USA.

Two-step solar thermochemical cycles based on reversible reactions of SrFeO and (Ba,La)SrFeO perovskites were considered for air separation. The cycle steps encompass (1) the thermal reduction of SrFeO or (Ba,La)SrFeO perovskites driven by concentrated solar irradiation and (2) oxidation in air to remove O and produce N. Rate limiting mechanisms were examined for both reactions using a combination of isothermal and non-isothermal thermogravimetry for temperature-swings between 673 and 1373 K, heating rates of 10, 20, and 50 K min, and O pressure-swings between 20% O/Ar and 100% Ar at atmospheric pressure. Read More

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September 2021

Principal component analysis of alpha-helix deformations in transmembrane proteins.

PLoS One 2021 15;16(9):e0257318. Epub 2021 Sep 15.

Department of Bioengineering, McGill University, Montreal, Quebec, Canada.

α-helices are deformable secondary structural components regularly observed in protein folds. The overall flexibility of an α-helix can be resolved into constituent physical deformations such as bending in two orthogonal planes and twisting along the principal axis. We used Principal Component Analysis to identify and quantify the contribution of each of these dominant deformation modes in transmembrane α-helices, extramembrane α-helices, and α-helices in soluble proteins. Read More

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September 2021

Resilient SARS-CoV-2 diagnostics workflows including viral heat inactivation.

PLoS One 2021 15;16(9):e0256813. Epub 2021 Sep 15.

King's College London Diagnostics Team at Guy's Campus, London, United Kingdom.

There is a worldwide need for reagents to perform SARS-CoV-2 detection. Some laboratories have implemented kit-free protocols, but many others do not have the capacity to develop these and/or perform manual processing. We provide multiple workflows for SARS-CoV-2 nucleic acid detection in clinical samples by comparing several commercially available RNA extraction methods: QIAamp Viral RNA Mini Kit (QIAgen), RNAdvance Blood/Viral (Beckman) and Mag-Bind Viral DNA/RNA 96 Kit (Omega Bio-tek). Read More

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September 2021

Structured illumination microscopy for simultaneous imaging of achiral and chiral domains.

Opt Lett 2021 Sep;46(18):4546-4549

We propose double structured illumination microscopy (SIM) method, which enables simultaneous imaging of achiral and chiral domains at sub-wavelength resolution. In double SIM, the illumination field is spatially structured both in the intensity and optical chirality so that moiré effects can be concurrently generated on the achiral and chiral fluorescent domains of a sample. This allows for down-modulating the high spatial frequency of both domains at the same time and thus provides sub-wavelength details after image reconstruction. Read More

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September 2021

Association between biofilm-production and antibiotic resistance in Escherichia coli isolates: A laboratory-based case study and a literature review.

Acta Microbiol Immunol Hung 2021 Sep 14. Epub 2021 Sep 14.

6Department of Medical Microbiology, Albert Szent-Györgyi Health Center and Faculty of Medicine, University of Szeged, Semmelweis utca 6., 6725 Szeged, Hungary.

Bacteria can enhance their survival by attaching to inanimate surfaces or tissues, and presenting as multicellular communities encased in a protective extracellular matrix called biofilm. There has been pronounced interest in assessing the relationship between the antibiotic resistant phenotype and biofilm-production in clinically-relevant pathogens. The aim of the present paper was to provide additional experimental results on the topic, testing the biofilm-forming capacity of Escherichia coli isolates using in vitro methods in the context of their antibiotic resistance in the form of a laboratory case study, in addition to provide a comprehensive review of the subject. Read More

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September 2021

Acousto-Pi: An Opto-Acoustofluidic System using Surface Acoustic Waves controlled with Open Source Electronics for Integrated In-Field Diagnostics.

IEEE Trans Ultrason Ferroelectr Freq Control 2021 Sep 15;PP. Epub 2021 Sep 15.

Surface acoustic wave (SAW) devices are increasingly applied in life science, biology, and point-of-care applications due to their combined acoustofluidic sensing and actuating properties. Despite the advances in this field, there remain significant gaps in interfacing hardware and control strategies to facilitate system integration with high performance and low cost. In this work, we present a versatile, and digitally controlled acoustofluidic platform by demonstrating key functions for biological assays such as droplet transportation and mixing using a closed-loop feedback control with image recognition. Read More

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September 2021

Evaluation of biocidal properties of biodegradable nanofiber filters and their use in face masks.

Environ Technol 2021 Sep 15:1-23. Epub 2021 Sep 15.

Federal University of Technology - Paraná, Av. Dos Pioneiros, 3131, Londrina - PR, 86036-370, Brazil.

Due to the recent coronavirus-2019 pandemic, several studies have emerged looking for new materials, especially with biocidal characteristics. Thus, the present research investigates the antibacterial properties of biodegradable cellulose acetate (CA) / cetylpyridinium bromide (CPB) electrospun nanofibers, their aerosol filtration, and the possible use as a filter media of surgical face masks. To achieve this goal, samples of these nanofibers were produced over a nonwoven substrate, using three different volumes of polymeric solution (0. Read More

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September 2021

Dynamic Change in Oral Microbiota of Children With Cleft Lip and Palate After Alveolar Bone Grafting.

Cleft Palate Craniofac J 2021 Sep 15:10556656211044396. Epub 2021 Sep 15.

159460Peking University School and Hospital of Stomatology, Beijing, P.R. China.

To investigate the longitudinal influence of alveolar bone grafting on the oral microbiota of children with cleft lip and palate (CLP).

Twenty-eight children with nonsyndromic CLP were recruited and underwent secondary alveolar bone grafting at the first time. Unstimulated saliva and plaque samples were collected from the subjects preoperatively and at 2 days, 1 month, and 3 months postoperatively. Read More

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September 2021

Distinct assembly processes and determinants of soil microbial communities between farmland and grassland in arid and semiarid areas.

Appl Environ Microbiol 2021 Sep 15:AEM0101021. Epub 2021 Sep 15.

State Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil Science, Chinese Academy of Sciences, Nanjing 210008, China.

It is critical to identify the assembly processes and determinants of soil microbial communities to better predict soil microbial responses to environmental change in arid and semiarid areas. Here, soils from 16 grassland-only, 9 paired grassland and farmland, and 16 farmland-only sites were collected across the central Inner Mongolia Plateau covering a steep environmental gradient. Through analyzing the paired samples, we discovered that land uses had strong effects on soil microbial communities, but weak effects on their assembly processes. Read More

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September 2021

Comparing immunoassays for SARS-Coronavirus-2 antibody detection in patients with and without laboratory-confirmed SARS-Coronavirus-2 infection.

J Clin Microbiol 2021 Sep 15:JCM0138121. Epub 2021 Sep 15.

Clinical Virology, Laboratory Medicine, University Hospital Basel, Basel, Switzerland.

Commercially available SARS-CoV-2-directed antibody assays may assist in diagnosing past exposure to SARS-CoV-2 antigens. We cross-compared eight immunoassays detecting antibodies against SARS-CoV-2 nucleocapsid(N)- or spike(S)-antigens in three cohorts consisting of 859 samples from 622 patients: (#1)EDI™-Novel-Coronavirus-COVID19, Epitope; (#2)RecomWell-SARS-CoV-2, Mikrogen; (#3)COVID19-ELISA, VirCell; (#4)Elecsys-Anti-SARS-CoV-2-N, Roche; (#5)LIAISON®-SARS-CoV-2-S1/S2, Diasorin; (#6)Anti-SARS-CoV-2-ELISA, EuroImmun; (#7)Elecsys-Anti-SARS-CoV-2-S, Roche; and (#8)LIAISON®-SARS-CoV-2-TrimericS, Diasorin. In cross-sectional Cohort-1 (68 sera from 38 patients with documented SARS-CoV-2 infection), agreement between assays #1 to #6 ranged from 75% to 93%, whereby discordance mostly resulted from N-based assays #1 to #4. Read More

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September 2021

First Report of Post-Harvest Gray Mold on Hyacinth bean () Caused by in Korea.

Plant Dis 2021 Sep 15. Epub 2021 Sep 15.

National Academy of Agricultural Science, Crop Protection Division, National Institute of Agricultural Sciences, Rural Development Administration, Wanju 55365, Korea, Wanju, Korea (the Republic of), 55365;

Hyacinth bean ( L.) is a highly proteineous legume under the family . It is native to Africa, cultivated throughout the world, and recently introduced vegetable in Korea. Read More

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September 2021

Leaf spot caused by Colletotrichum fructicola on star anise (Illicium verum) in China.

Plant Dis 2021 Sep 15. Epub 2021 Sep 15.

University of Guelph, Environmental Sciences, 50 Stone Road East, Guelph, Ontario, Canada, N1G2W1;

Star anise (Illicium verum) has been cultivated for centuries in southern China, and its fruit is an important seasoning spice, and can be used as a medicine (Wang et al. 2011). It is grown mainly in Guangxi, Guangdong, Guizhou, and Yunnan provinces, in China. Read More

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September 2021

Reversible Click Chemistry Tag for Universal Proteome Sample Preparation for Top-Down and Bottom-Up Analysis.

J Proteome Res 2021 Sep 15. Epub 2021 Sep 15.

Impact Proteomics, LLC., Pittsburgh, Pennsylvania 15206, United States.

Successful proteome analysis requires reliable sample preparation beginning with protein solubilization and ending with a sample free of contaminants, ready for downstream analysis. Most proteome sample preparation technologies utilize precipitation or filter-based separation, both of which have significant disadvantages. None of the current technologies are able to prepare both intact proteins or digested peptides. Read More

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September 2021

Fecal Metabolomics and Network Pharmacology Reveal the Correlations between Constipation and Depression.

J Proteome Res 2021 Sep 15. Epub 2021 Sep 15.

Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China.

Constipation and depression are tightly related and often co-occur and coexist in clinic. Yet, the relationships and the underlying mechanisms are still unclear. Fecal metabolomics and network pharmacology were, for the first time, applied to investigate the potential correlations from multiple levels including classic behaviors, metabolomics, and gene targets. Read More

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September 2021

Bioavailability of Aflatoxins in Cultured Fish and Animal Livers Using an Dialyzability Approach.

J Agric Food Chem 2021 Sep 15. Epub 2021 Sep 15.

Trace Element, Spectroscopy and Speciation Group (GETEE), Strategic Grouping in Materials (AEMAT), Department of Analytical Chemistry, Nutrition and Bromatology, Faculty of Chemistry, Universidade de Santiago de Compostela, Avenida das Ciencias, s/n, 15782 Santiago de Compostela, Spain.

The objective of the present study was to investigate the bioavailability of aflatoxins (AFs) from fish, and chicken and rabbit livers using an dialyzability approach. Ultrahigh-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) was used to assess the aflatoxin content in samples, as well as in dialyzate and residue fractions after the procedure. A vortex-assisted dispersive liquid-liquid microextraction (VALLME) technique was used for preconcentrating AFs before determination. Read More

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September 2021