65,136 results match your criteria salivary gland


Impact of anatomic site of distant metastasis on survival in salivary gland cancers.

Head Neck 2021 May 7. Epub 2021 May 7.

Department of Radiation Oncology, University of Illinois Hospital and Health Sciences System, Chicago, Illinois, USA.

Background: As exemplified in patients with adenoid cystic carcinoma (ACC), metastatic salivary gland cancers display heterogenous behavior. Although anatomic site of metastasis has been suggested to be prognostic for survival in this population, this is not adequately characterized in the current literature.

Methods: Using the National Cancer Database (NCDB), patients with newly diagnosed metastatic salivary gland cancers with distant metastasis to a single organ were identified. Read More

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Salivary glands in workers of Ruptitermes spp. (Blattaria, Isoptera, Termitidae, Apicotermitinae): a morphological and preoteomic approach.

Cell Tissue Res 2021 May 7. Epub 2021 May 7.

Centro de Estudos de Insetos Sociais-CEIS, Instituto de Biociências, Univ Estadual Paulista, UNESP, Campus Rio Claro, Avenida 24A, 1515, Bela Vista, Rio Claro, SP, 13506-900, Brazil.

Salivary glands are omnipresent in termites and occur in all developmental stages and castes. They function to produce, store, and secrete compounds, ranging from a feeding function to defensive mechanisms. Here, we provide a complete morphological overview of the salivary glands in the soldierless species Ruptitermes reconditus and R. Read More

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Sphingomyelinases in a journey to combat arthropod-borne pathogen transmission.

FEBS Lett 2021 May 7. Epub 2021 May 7.

Department of Biological Sciences, Old Dominion University, Norfolk, VA, USA.

Ixodes scapularis ticks feed on humans and other vertebrate hosts and transmit several pathogens of public health concern. Tick saliva is a complex mixture of bioactive proteins, lipids, and immunomodulators such as I. scapularis SMase (IsSMase)-like protein, an ortholog of dermonecrotoxin Sphingomyelinase D found in the venom of Loxosceles spp. Read More

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NR4A3 (NOR-1) Immunostaining Shows Better Performance than DOG1 Immunostaining in Acinic Cell Carcinoma of Salivary Gland: a Preliminary Study.

J Oral Maxillofac Res 2021 Jan-Mar;12(1):e4. Epub 2021 Mar 31.

Department of Diagnostic Sciences, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PennsylvaniaUnited States.

Objectives: Acinic cell carcinoma of salivary gland harbours recurrent and specific chromosomal rearrangement [t(4;9)(q13;q31)], resulting in the translocation of secretory calcium-binding phosphoprotein gene cluster at 4q13 to nuclear receptor subfamily 4 group a member 3 at 9q31. This upregulates the transcription factor nuclear receptor subfamily 4 group A member 3, which can be detected by immunohistochemistry. The purpose of this pilot study is to evaluate the performance of nuclear receptor subfamily 4 group A member 3 immunostaining on whole-slide acinic cell carcinoma tissue, in comparison with discovered on GIST-1 immunostaining. Read More

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Salivary gland cystadenocarcinoma: Rare neoplasm in buccal mucosa.

Oral Oncol 2021 May 3:105314. Epub 2021 May 3.

Clinical and Preventive Dentistry Department, School of Dentistry, Federal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil.

A 72-year-old female was referred for diagnosis of a lesion located in the right buccal mucosa, with duration unknown. At intraoral examination, the lesion appeared as a well-delimited, mobile, and submucosal nodule. A benign mesenchymal neoplasm was the main hypothesis of diagnosis. Read More

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Body Size and Tissue-Scaling Is Regulated by Motoneuron-Derived Activinß in Drosophila melanogaster.

Genetics 2019 Dec;213(4):1447-1464

Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota 55455.

Correct scaling of body and organ size is crucial for proper development, and the survival of all organisms. Perturbations in circulating hormones, including insulins and steroids, are largely responsible for changing body size in response to both genetic and environmental factors. Such perturbations typically produce adults whose organs and appendages scale proportionately with final size. Read More

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December 2019

Body Size and Tissue-Scaling Is Regulated by Motoneuron-Derived Activinß in Drosophila melanogaster.

Genetics 2019 Dec;213(4):1447-1464

Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota 55455.

Correct scaling of body and organ size is crucial for proper development, and the survival of all organisms. Perturbations in circulating hormones, including insulins and steroids, are largely responsible for changing body size in response to both genetic and environmental factors. Such perturbations typically produce adults whose organs and appendages scale proportionately with final size. Read More

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December 2019

Polymorphism and Divergence of Novel Gene Expression Patterns in Drosophila melanogaster.

Genetics 2020 Sep;216(1):79-93

One mechanism by which transcriptomes evolve is though tissue-specific gene expression. Cridland et al. measured gene expression in Drosophila melanogaster in five tissues: accessory gland, testis, larval salivary gland, head, and first. Read More

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September 2020

Congenital Parotid Fistula: Surgical Management in Two Infants and Review of Literature.

J Indian Assoc Pediatr Surg 2021 Jan-Feb;26(1):48-50. Epub 2021 Jan 11.

Department of Radiodiagnosis, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Congenital salivary gland fistulas are uncommon. They develop as a result of abnormalities of the first and second branchial arches. Operative and nonoperative methods of management have been described. Read More

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January 2021

Malignant tumours of the parotid gland: management of the neck (including the clinically negative neck) and a literature review.

Br J Oral Maxillofac Surg 2020 Aug 27. Epub 2020 Aug 27.

Department of Neurosciences, Reproductive and Odontostomatological Sciences, Federico II University of Naples, Naples, Italy.

Major salivary gland malignancies are rare, constituting 1%-3% of head-neck tumours. The surgical management of the clinically negative neck (cN0) does not have a univocal consensus yet. We have carried out a retrospective study on 119 cases of malignant parotid tumours that were surgically treated between January 1999 and January 2014. Read More

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Comparison of different methods for post-therapeutic dosimetry in [Lu]Lu-PSMA-617 radioligand therapy.

EJNMMI Phys 2021 May 5;8(1):40. Epub 2021 May 5.

Department of Nuclear Medicine, Saarland University-Medical Center, Kirrberger Str. Geb. 50, D-66421, Homburg, Germany.

Background: Dosimetry is of high importance for optimization of patient-individual PSMA-targeted radioligand therapy (PSMA-RLT). The aim of our study was to evaluate and compare the feasibility of different approaches of image-based absorbed dose estimation in terms of accuracy and effort in clinical routine.

Methods: Whole-body planar images and SPECT/CT images were acquired from 24 patients and 65 cycles at 24h, 48h, and ≥96h after administration of a mean activity of 6. Read More

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Ultrasound and electromyography & electrical stimulation-guided botulinum toxin injection of salivary glands for drooling: A case report with a description of the technique.

Turk J Phys Med Rehabil 2021 Mar 4;67(1):120-121. Epub 2021 Mar 4.

Department of Physical Medicine and Rehabilitation, Marmara University School of Medicine, Istanbul, Turkey.

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Muscarinic Receptors and BK Channels Are Affected by Lipid Raft Disruption of Salivary Gland Cells.

Int J Mol Sci 2021 Apr 30;22(9). Epub 2021 Apr 30.

Department of Physiology, Dental Research Institute, Seoul National University School of Dentistry, Seoul 03080, Korea.

Activity-dependent fluid secretion is the most important physiological function of salivary glands and is regulated via muscarinic receptor signaling. Lipid rafts are important for G-protein coupled receptor (GPCR) signaling and ion channels in plasma membranes. However, it is not well understood whether lipid raft disruption affects all membrane events or only specific functions in muscarinic receptor-mediated water secretion in salivary gland cells. Read More

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Multi-tissue single-cell analysis deconstructs the complex programs of mouse natural killer and type 1 innate lymphoid cells in tissues and circulation.

Immunity 2021 Apr 28. Epub 2021 Apr 28.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA. Electronic address:

Natural killer (NK) cells and type 1 innate lymphoid cells (ILC1s) are heterogenous innate lymphocytes broadly defined in mice as LinNK1.1NKp46 cells that express the transcription factor T-BET and produce interferon-γ. The ILC1 definition primarily stems from studies on liver and small intestinal populations. Read More

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How to perform shear wave elastography. Part I.

Med Ultrason 2021 May 4. Epub 2021 May 4.

Department Allgemeine Innere Medizin (DAIM), Kliniken Hirslanden Beau Site, Salem und Permancence, Bern, Switzerland.

We recently introduced a series of papers describing how to do certain techniques. This article is the first part of a review of shear wave elastography (SWE). It reports the principles and interpretation of the technique and describes how to optimize it. Read More

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The cAMP-phosphodiesterase 4 (PDE4) controls β-adrenoceptor- and CFTR-dependent saliva secretion in mice.

Biochem J 2021 May 4. Epub 2021 May 4.

University of South Alabama, Mobile, Alabama, United States.

Saliva, while often taken for granted, is indispensable for oral health and overall well-being, as inferred from the significant impairments suffered by patients with salivary gland dysfunction. Here, we show that treatment with several structurally-distinct PAN-PDE4 inhibitors, but not a PDE3 inhibitor, induces saliva secretion in mice, indicating it is a class-effect of PDE4 inhibitors. In anesthetized mice, while neuronal regulations are suppressed, PDE4 inhibition potentiates a β-adrenoceptor-induced salivation, that is ablated by the β-blocker Propranolol and is absent in homozygous ΔF508-CFTR mice lacking functional CFTR. Read More

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Saliva and its potential in covid-19 cannot be ignored: a point of view.

Infect Control Hosp Epidemiol 2021 May 4:1-5. Epub 2021 May 4.

Associate professor, Conservative dentistry and endodontics, ESIC dental college, Rohini, Guru Gobind Singh Indraprastha

It has been demonstrated that salivary gland duct cells have similar receptors as ACE2-positive cells/keratin epithelial cells of the lung which have high potential to be infected by SARS-CoV 2 virus. The aerosols carrying virus have penetration into the healthy human body and lungs via inhalation through nose or mouth. Read More

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Inhibitory effect of HTLV-1 infection on the production of B-cell activating factors in established follicular dendritic cell-like cells.

Immun Inflamm Dis 2021 May 4. Epub 2021 May 4.

Division of Advanced Preventive Medical Sciences, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.

Introduction: The low frequency of ectopic germinal center in labial salivary glands of patients with human T-cell leukemia virus type 1 (HTLV-1) antibody-positive Sjögren's syndrome (SS) suggests that HTLV-1 has some effects on follicular dendritic cells (FDCs).

Methods: We used flow cytometry, immunofluorescence, and enzyme-linked immunosorbent assays (ELISAs) to investigate the direct effect of HTLV-1 on B-cell activating factors produced by established FDC like cells obtained from excised human tonsils. We then measured the serum B-cell activating factor (BAFF) and C-X-C motif ligand (CXCL) 13 concentrations of the HTLV-1-seropositive SS patients and the HTLV-1-seronegative SS patients by ELISA. Read More

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Accuracy, predictability and prognostic implications of fine needle aspiration biopsy for parotid gland tumors: A retrospective case series.

Clin Otolaryngol 2021 May 4. Epub 2021 May 4.

Department of Otolaryngology - Head and Neck Surgery, Rabin Medical Center, Petah Tikva, Israel.

Objective: To evaluate the precision and utility of Fine-needle aspiration (FNA) in differentiating between benign and malignant parotid tumors, and the implications of FNA results on management and outcomes.

Design: Retrospective case series.

Setting: Tertiary medical center. Read More

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Expression of p16 protein in pleomorphic adenoma and carcinoma ex pleomorphic adenoma proves diversity of tumour biology and predicts clinical course.

J Clin Pathol 2021 May 3. Epub 2021 May 3.

Department of Otolaryngology and Laryngological Oncology, Poznan University of Medical Sciences, Poznan, Poland.

Aims: The aim of the study is to correlate p16 expression with the clinical courses of pleomorphic adenoma (PA), its malignant transformation (CaexPA) and treatment outcomes.

Methods: Retrospective analysis (1998-2019) of 47 CaexPA, 148 PA and 22 normal salivary gland samples was performed. PAs were divided into two subsets: clinically 'slow' tumours characterised by stable size or slow growth; and 'fast' tumours with rapid growth rate. Read More

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Single-parenthood and health conditions among children receiving public assistance in Japan: a cohort study.

BMC Pediatr 2021 May 3;21(1):214. Epub 2021 May 3.

Department of Health and Social Behavior, Graduate School of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo, 113-0033, Japan.

Background: Children's healthy development is important. While governmental public assistance benefits financially troubled families, it cannot compensate for a lack of social support. Single-parenthood is a health risk factor for children owing to low-income-associated food insecurity and stress. Read More

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Salivary gland tissues and derived primary and metastatic neoplasms: unusual pitfalls in the work-up of sellar lesions. A systematic review.

J Endocrinol Invest 2021 May 3. Epub 2021 May 3.

Neuromed Institute, IRCCS, Pozzilli, IS, Italy.

Purpose: Salivary gland (SG) tissue and derived neoplasms may occur in the sellar region. As the current literature is mostly limited to case reports, the puzzling case of an inflammatory SG removed by transsphenoidal surgery (TS) and mimicking a prolactinoma prompted us to perform the first systematic review of these unusual conditions.

Methods: A systematic literature search was conducted according to the PRISMA guidelines. Read More

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Go Ask Your Patients! PSS-QoL Reported Perception of Dryness Correlates With Lacrimal and Salivary Flow in Primary Sjögren's Syndrome.

Front Med (Lausanne) 2021 15;8:660580. Epub 2021 Apr 15.

Department of Rheumatology and Immunology, Medical University of Graz, Graz, Austria.

The patient perspective is an essential outcome parameter in the quest for effective therapy in primary Sjögren's Syndrome (PSS). The EULAR Sjögren's Syndrome Patient Reported Index (ESSPRI) is recommended by EULAR to quantify patient's symptom burden and has been used in several clinical trials. Surprisingly, the patient's perception of dryness quantified with ESSPRI does not correlate with objective measures of salivary or lacrimal flow. Read More

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Necrotizing sialometaplasia-A self-limiting condition which poses a diagnostic dilemma.

Clin Case Rep 2021 Apr 18;9(4):2019-2022. Epub 2021 Feb 18.

Department of Oral Medicine and Radiology GDCRI Bangalore India.

Necrotizing sialometaplasia can make anyone very anxious about the lesion especially if they have habit of tobacco consumption. It requires a prompt diagnosis, counseling with assurance to patient and treatment. Read More

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Pharmacological Activities and Mechanisms of Hirudin and Its Derivatives - A Review.

Front Pharmacol 2021 16;12:660757. Epub 2021 Apr 16.

State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu, China.

Hirudin, an acidic polypeptide secreted by the salivary glands of (also known as "Shuizhi" in traditional Chinese medicine), is the strongest natural specific inhibitor of thrombin found so far. Hirudin has been demonstrated to possess potent anti-thrombotic effect in previous studies. Recently, increasing researches have focused on the anti-thrombotic activity of the derivatives of hirudin, mainly because these derivatives have stronger antithrombotic activity and lower bleeding risk. Read More

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Effectof Myd88 deficiency on gene expression profiling in salivary glands of female non-obese diabetic (NOD) mice.

J Oral Biosci 2021 Apr 29. Epub 2021 Apr 29.

Department of Oral Microbiology, Division of Oral Infection Health Sciences, Asahi University School of Dentistry, 1851 Hozumi, Mizuho, Gifu 501-0296, Japan. Electronic address:

Objectives: Sjögren's syndrome (SS) is a chronic autoimmune disease characterized by inflammatory lesions in the salivary and lacrimal glands, which are caused by distinct lymphocytic infiltrates. Female non-obese diabetic (NOD) mice spontaneously develop inflammatory lesions of the salivary glands with SS-like pathological features. Previous studies have shown that MyD88, a crucial adaptor protein that activates innate immune signaling, affects lymphocytic infiltration, but its detailed role remains unclear. Read More

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Oral manifestations of COVID-19 patients: An online survey of the Egyptian population.

Clin Exp Dent Res 2021 May 1. Epub 2021 May 1.

Faculty of Oral and Dental Medicine, Ahram Canadian University, Egypt.

Objectives: This pilot survey aims to study the oral manifestations associated with COVID-19 infection and report the prevalence of oral signs and symptoms in COVID-19 patients.

Materials And Methods: From May 15 to June 10, 2020, we used an online questionnaire containing the oral manifestations that are expected to be associated with the COVID-19 infection. Adults in our survey who have been diagnosed with COVID-19 positive were confirmed with reverse transcriptase PCR (RT-PCR), and isolated in various hospitals in Cairo, Egypt. Read More

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Mucoepidermoid carcinoma of the parotid gland: Twenty-year experience in treatment and outcomes.

Head Neck 2021 May 1. Epub 2021 May 1.

Department of Otolaryngology-Head and Neck Surgery, Mayo Clinic, Rochester, Minnesota, USA.

Background: Parotid gland mucoepidermoid carcinoma (MEC) has published five-year cancer-specific survival (CSS) rates of 77%-97%, with variance related to grade.

Methods: Patients receiving primary surgery for parotid gland MEC from 1995 to 2014 at a tertiary medical center underwent clinical review, histopathologic review, and cytogenetic analysis. Survival outcomes were evaluated. Read More

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Identification and characterization of primary cilia-positive salivary gland tumours exhibiting basaloid/myoepithelial differentiation.

J Pathol 2021 Apr 30. Epub 2021 Apr 30.

Department of Tumor Pathology, Hamamatsu University School of Medicine, Hamamatsu, Japan.

Primary cilia (PC) are non-motile, antenna-like structures on the cell surface. Many types of neoplasms exhibit PC loss, whereas in some neoplasms PC are retained and involved in tumourigenesis. To elucidate the PC status and characteristics of major salivary gland tumours (SGTs), we examined 100 major SGTs encompassing eight histopathological types by immunohistochemical analysis. Read More

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