79,677 results match your criteria salivary

Impact of tumor site on the prognosis of salivary gland neoplasms: a systematic review and meta-analysis.

Crit Rev Oncol Hematol 2021 May 12:103352. Epub 2021 May 12.

Brazilian Bioscience National Laboratory, Brazil Center of Research in Energy and Materials, Campinas, Brazil.

In numerous types of cancer, the primary tumor site can show a correlation with disease behavior and survival outcomes. In salivary gland tumors (SGTs) this association remains controversial. This study assessed the association between primary sites of SGTs and prognosis. Read More

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CTRP3 promotes TNF-α-induced apoptosis and barrier dysfunction in salivary epithelial cells.

Cell Signal 2021 May 12:110042. Epub 2021 May 12.

Department of Physiology and Pathophysiology, Peking University School of Basic Medical Sciences, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, and Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing, China. Electronic address:

Background: C1q/tumour necrosis factor-related protein 3 (CTRP3) plays important roles in metabolism and inflammatory responses in various cells and tissues. However, the expression and function of CTRP3 in salivary glands have not been explored.

Methods: The expression and distribution of CTRP3 were detected by western blot, polymerase chain reaction, immunohistochemical and immunofluorescence staining. Read More

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Intraductal Carcinoma of the Salivary Gland with NCOA4-RET: Expanding the Morphologic Spectrum and an Algorithmic Diagnostic Approach.

Hum Pathol 2021 May 12. Epub 2021 May 12.

Department of Pathology, Massachusetts General Hospital; Department of Otolaryngology, Massachusetts Eye and Ear; Department of Pathology, Harvard Medical School, Boston, MA, USA. Electronic address:

Following the publication of the 2017 WHO Classification of Head and Neck Tumours, there has been increasing interest in the classification of newly categorized intraductal carcinomas. Intraductal carcinoma (IC) is an indolent tumor, typically arising in the parotid gland, with an intact myoepithelial layer and a cystic, papillary, often cribriform architecture. Early studies of IC identified a heterogeneous group of molecular alterations driving neoplasia, and recent studies have defined three primary morphological/immunohistochemical variants, subsequently linking these morphologic variants with defined molecular signatures. Read More

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LMW cyclin E and its novel catalytic partner CDK5 are therapeutic targets and prognostic biomarkers in salivary gland cancers.

Oncogenesis 2021 May 14;10(5):40. Epub 2021 May 14.

Departments of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Salivary gland cancers (SGCs) are rare yet aggressive malignancies with significant histological heterogeneity, which has made prediction of prognosis and development of targeted therapies challenging. In majority of patients, local recurrence and/or distant metastasis are common and systemic treatments have minimal impact on survival. Therefore, identification of novel targets for treatment that can also be used as predictors of recurrence for multiple histological subtypes of SGCs is an area of unmet need. Read More

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Inhibition of DEC2 is necessary for exiting cell dormancy in salivary adenoid cystic carcinoma.

J Exp Clin Cancer Res 2021 May 14;40(1):169. Epub 2021 May 14.

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Oral Pathology, West China Hospital of Stomatology (Sichuan University), No.14, Sec. 3, Renminnan Road, Chengdu, 610041, China.

Background: Patients were prone to have poor prognosis once dormant tumor cells being reactivated. However, the molecular mechanism of tumor cell dormancy remains poorly understood. This study aimed to investigate the function of DEC2 in the dormancy of salivary adenoid cystic carcinoma (SACC) in vitro and vivo. Read More

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Histomorphometric and histochemical characteristics of the oesophagus of the greater mouse-eared Bat, Myotis myotis (Borkhausen, 1797).

Anat Histol Embryol 2021 May 14. Epub 2021 May 14.

Department of Basic Education, Faculty of Education, Trakya University, Edirne, Turkey.

The aim of this study was to examine the histomorphometric and histochemical structure of oesophagus of the wild-caught greater mouse-eared bat M. myotis. For this purpose, 10 specimens of oesophagus were collected and processed. Read More

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Unusual Case of a Caruncular Oncocytoma.

Am J Dermatopathol 2021 May 11. Epub 2021 May 11.

Virginia Tech Carilion School of Medicine, Roanoke, VA; Dermatology Section, Department of Internal Medicine, Virginia Tech Carilion School of Medicine, Roanoke, VA; Department of Basic Science Education, Virginia Tech Carilion School of Medicine, Roanoke, VA; and Oculofacial Plastic and Reconstructive Surgery, Vistar Eye Center, Roanoke, VA.

Abstract: Oncocytomas are benign neoplasms that are most often found in the salivary glands and kidneys. Ocular oncocytoma typically present as an asymptomatic dark blue papule on the lacrimal caruncle. Histologically, the tumor is composed of oncocytes, cells notable for eosinophilic cytoplasmic granules representing large quantities of dysfunctional mitochondria. Read More

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Tick-human interactions: from allergic klendusity to the α-Gal syndrome.

Biochem J 2021 May;478(9):1783-1794

SaBio, Instituto de Investigación de Recursos Cinegéticos, IREC-CSIC-UCLM-JCCM, Ronda de Toledo s/n, 13005 Ciudad Real, Spain.

Ticks and the pathogens they transmit, including bacteria, viruses, protozoa, and helminths, constitute a growing burden for human and animal health worldwide. The ability of some animal species to acquire resistance to blood-feeding by ticks after a single or repeated infestation is known as acquired tick resistance (ATR). This resistance has been associated to tick-specific IgE response, the generation of skin-resident memory CD4+ T cells, basophil recruitment, histamine release, and epidermal hyperplasia. Read More

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Oncocytic Polyp in a Unicystic Mucoepidermoid Carcinoma of the Palate: A Unique Presentation.

Int J Surg Pathol 2021 May 14:10668969211018266. Epub 2021 May 14.

13123Tsurumi University Dental Hospital, Yokohama, Japan.

We report a palatal mucoepidermoid carcinoma (MEC) with unusual pathological features showing salivary duct cyst-like architecture, varied epithelial linings (excretory duct, mucous goblet cell, and apocrine epithelium phenotypes), scarce luminal tumor plaques, and a large intraluminal oncocytic polyp. To our knowledge, such a unicystic variant of MEC with pedicled oncocytic proliferation in the lumen is unprecedented in the literature. In this particular case, the microscopic diagnosis of MEC is problematic because of the large number of potential mimics. Read More

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Regenerative medicine for end-stage fibrosis and tissue loss in the upper aerodigestive tract: a twenty-first century review.

J Laryngol Otol 2021 May 14:1-13. Epub 2021 May 14.

Head and Neck Academic Department, Division of Surgery and Interventional Science, University College London.

Objective: This review assesses regenerative medicine of the upper aerodigestive tract during the first two decades of the twenty-first century, focusing on end-stage fibrosis and tissue loss in the upper airways, salivary system, oropharynx and tongue.

Method: PubMed, Embase, Google Scholar, Cochrane Library, Medline and clinicaltrials.org were searched from 2000 to 2019. Read More

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The 3D-Transition Study: Objectives, Methods, and Implementation of an Innovative Planned Missing Data Design.

Am J Epidemiol 2021 May 12. Epub 2021 May 12.

CHU Ste-Justine Research Centre, Montréal, Québec, Canada.

The prevalence of mental health problems represents a significant burden on school and community health resources as early as preschool. Reducing this burden requires a better understanding of the developmental mechanisms linking children's early vulnerabilities with mental health after the transition to formal schooling. The 3D-Transition study (2017-2021; ClinicalTrials. Read More

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Effects of acute heat stress on salivary metabolites in growing pigs: an analysis using nuclear magnetic resonance-based metabolomics profiling.

J Anim Sci Technol 2021 Mar 31;63(2):319-331. Epub 2021 Mar 31.

Animal Nutrition & Physiology Team, National Institute of Animal Science, Rural Development Administration, Wanju 55365, Korea.

Heat stress (HS) causes adverse impacts on pig production and health. A potential biomarker of HS is required to predict its occurrence and thereby better manage pigs under HS. Information about the saliva metabolome in heat-stressed pigs is limited. Read More

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Amylases: Biofilm Inducer or Biofilm Inhibitor?

Front Cell Infect Microbiol 2021 27;11:660048. Epub 2021 Apr 27.

Department of Biotechnology, Maulana Abul Kalam Azad University of Technology, Haringhata, India.

Biofilm is a syntrophic association of sessile groups of microbial cells that adhere to biotic and abiotic surfaces with the help of pili and extracellular polymeric substances (EPS). EPSs also prevent penetration of antimicrobials/antibiotics into the sessile groups of cells. Hence, methods and agents to avoid or remove biofilms are urgently needed. Read More

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MRI-Based Radiomics to Differentiate between Benign and Malignant Parotid Tumors With External Validation.

Front Oncol 2021 27;11:656918. Epub 2021 Apr 27.

Radiology and Diagnostic Imaging Department, IRCCS Regina Elena National Cancer Institute, Rome, Italy.

Background: The differentiation between benign and malignant parotid lesions is crucial to defining the treatment plan, which highly depends on the tumor histology. We aimed to evaluate the role of MRI-based radiomics using both T2-weighted (T2-w) images and Apparent Diffusion Coefficient (ADC) maps in the differentiation of parotid lesions, in order to develop predictive models with an external validation cohort.

Materials And Methods: A sample of 69 untreated parotid lesions was evaluated retrospectively, including 37 benign (of which 13 were Warthin's tumors) and 32 malignant tumors. Read More

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