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Synthesis and biological evaluation of novel purinyl quinazolinone derivatives as PI3Kδ-specific inhibitors for the treatment of hematologic malignancies.

Bioorg Med Chem 2021 Jul 22;45:116312. Epub 2021 Jul 22.

School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi-do 16419, Republic of Korea. Electronic address:

Phosphatidylinositol 3-kinases (PI3Ks) mediate intracellular signal transduction. Aberrant PI3K signaling is associated with oncogenesis and disease progression in solid tumors and hematologic malignancies. Idelalisib (1), a first-in-class PI3Kδ inhibitor for the treatment of hematologic malignancies, was developed, but its sales were limited by black box warnings due to unexpected adverse effects. Read More

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Reactions to sales restrictions on flavored vape products or all vape products among young adults in the US.

Nicotine Tob Res 2021 Jul 31. Epub 2021 Jul 31.

Department of Prevention and Community Health, Milken Institute School of Public Health; George Washington Cancer Center, George Washington University, Washington, DC, USA.

Significance: Despite increases in e-cigarette sales restrictions, support for sales restrictions and perceived impact on young adult use are unclear.

Methods: We analyzed Feb-May 2020 data from a longitudinal study of 2,159 young adults (ages 18-34; Mage=24.75±4. Read More

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Viral-induced inflammatory coagulation disorders: Preparing for another epidemic.

Thromb Haemost 2021 Jul 30. Epub 2021 Jul 30.

Department of Gastroenterology, University College London Hospitals NHS Foundation Trust, London, United Kingdom of Great Britain and Northern Ireland.

A number of viral infectious diseases have emerged or reemerged from wildlife vectors that have generated serious threats to global health. Increased international traveling and commerce increase the risk of transmission of viral or other infectious diseases. In addition, recent climate changes accelerate the potential spread of domestic disease. Read More

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A methodologically sound survey of Chinese consumers' willingness to participate in courier, express, and parcel companies' green logistics.

PLoS One 2021 30;16(7):e0255532. Epub 2021 Jul 30.

Anhui Vocational College of Electronics and Information Technology, Bengbu, Anhui, China.

The environmental footprint of courier, express, and parcel (CEP) logistics is significant and growing, owing to increased e-commerce. Consumer willingness to participate in the green logistics of CEPs, however, has been understudied. This study addresses this knowledge gap by surveying 155 Chinese consumers about their willingness to participate in CEP green logistics. Read More

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Fabrication strategies and surface tuning of hierarchical gold nanostructures for electrochemical detection and removal of toxic pollutants.

J Hazard Mater 2021 Jul 14;420:126648. Epub 2021 Jul 14.

Core-Facility Center for Photochemistry & Nanomaterials, Department of Chemistry (BK21 FOUR), Research Institute of Natural Sciences, Gyeongsang National University, Jinju 52828, South Korea. Electronic address:

The intensive research on the synthesis and characterization of gold (Au) nanostructures has been extensively documented over the last decades. These investigations allow the researchers to understand the relationships between the intrinsic properties of Au nanostructures such as particle size, shape, morphology, and composition to synthesize the Au nano/hybrid nanostructures with novel physicochemical properties. By tuning the properties above, these nanostructures are extensively employed to detect and remove trace amounts of toxic pollutants from the environment. Read More

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Adolescent cannabinoid exposure modulates the vulnerability to cocaine-induced conditioned place preference and DNMT3a expression in the prefrontal cortex in Swiss mice.

Psychopharmacology (Berl) 2021 Jul 30. Epub 2021 Jul 30.

Department of Biomolecular Sciences, School of Pharmaceutical Sciences of Ribeirão Preto (FCFRP), University of São Paulo (USP), Café Av, s/n, Ribeirão Preto, SP, 14040-903, Brazil.

Rationale: Cannabis sativa is the most widely used drug by adolescents globally. The recreational use of synthetic cannabinoids by teenagers has also grown in recent years. Despite the wrong perception that exposure to these drugs does not cause harm, repeated exposure to cannabinoids at early stages of life compromises important maturation processes and brain development. Read More

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Life Cycle Greenhouse Gas Emissions for Last-Mile Parcel Delivery by Automated Vehicles and Robots.

Environ Sci Technol 2021 Jul 30. Epub 2021 Jul 30.

Center for Sustainable Systems, School for Environment and Sustainability, University of Michigan, 440 Church Street, Ann Arbor, Michigan 48109, United States.

Increased E-commerce and demand for contactless delivery during the COVID-19 pandemic have fueled interest in robotic package delivery. We evaluate life cycle greenhouse gas (GHG) emissions for automated suburban ground delivery systems consisting of a vehicle (last-mile) and a robot (final-50-feet). Small and large cargo vans (125 and 350 cubic feet; V125 and V350) with an internal combustion engine (ICEV) and battery electric (BEV) powertrains were assessed for three delivery scenarios: (i) , human-driven vehicle with human delivery; (ii) , human-driven vehicle with robot delivery; and (iii) , connected automated vehicle (CAV) with robot delivery. Read More

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[Evaluation of drug myocardial toxicity and biological activity by real time xCELLigence analysis: a review].

Sheng Wu Gong Cheng Xue Bao 2021 Jul;37(7):2425-2434

Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094, China.

Realtime xCELLigence analysis (RTCA) is a new cell detection technology to continuously monitor, record and analyze a variety of information generated by cell activity. In drug research, it plays an important role in assessing myocardial toxicity and cell biological activity. Here, we first introduce the underlying mechanisms and characteristics of RTCA. Read More

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Knowledge, Attitude, and Practices of Tobacco Vendors toward Selling Tobacco Products to Young Children and Adolescents in Central Delhi.

Int J Clin Pediatr Dent 2021 Jan-Feb;14(1):97-99

Department of Pediatric Dentistry, Maulana Azad Institute of Dental Sciences, New Delhi, India.

Background: Tobacco consumption by youth is a serious public health problem. Regulation on tobacco sales has been given enough attention in our country, but very less information exists about the knowledge and attitude regarding tobacco laws by tobacco vendors.

Aim And Objective: To study the knowledge, attitude, and practices of tobacco vendors regarding the selling of tobacco to children and adolescents up to 18 years of age in the Central Delhi area. Read More

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Lipoprotein(a) and Benefit of PCSK9 Inhibition in Patients With Nominally Controlled LDL Cholesterol.

J Am Coll Cardiol 2021 Aug;78(5):421-433

Université de Paris, Assistance Publique-Hôpitaux de Paris, Hôpital Bichat, French Alliance for Cardiovascular Trials, and INSERM U1148, Paris, France; Imperial College, Royal Brompton Hospital, London, United Kingdom. Electronic address: https://twitter.com/gabrielsteg.

Background: Guidelines recommend nonstatin lipid-lowering agents in patients at very high risk for major adverse cardiovascular events (MACE) if low-density lipoprotein cholesterol (LDL-C) remains ≥70 mg/dL on maximum tolerated statin treatment. It is uncertain if this approach benefits patients with LDL-C near 70 mg/dL. Lipoprotein(a) levels may influence residual risk. Read More

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Can new energy vehicles help to achieve carbon neutrality targets?

J Environ Manage 2021 Jul 26;297:113348. Epub 2021 Jul 26.

School of Economics, Qingdao University, Qingdao, China. Electronic address:

In the reforms pertaining to the energy structure in the automotive industry, new energy vehicles (NEVs) have long been the focus of government attention, as an effective means to reduce air pollution. Therefore, this paper employs the rolling-window Granger causality test, in order to discuss the environmental benefits of new energy vehicles, so as to explore the active role of the transportation sector in reducing air pollution. By studying the interactions between NEVs and particulate matter (PM) from the time period spanning from 2013:M1 to 2020:M9, we have found that the positive influences from NEVs to PM ascertain that NEVs cannot be considered as an efficient measure to mitigate air pollution. Read More

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Dynamic estimation of future obsolete laptop flows and embedded critical raw materials: The case study of Greece.

Waste Manag 2021 Jul 27;132:74-85. Epub 2021 Jul 27.

School of Environmental Engineering, Technical University of Crete, University Campus, 73100 Chania, Greece.

The coronavirus pandemic has turned school and university learning system from classroom-based to exclusively online all over the world. As this change is accompanied by a spike in demand of laptops, an excessive amount of obsolete devices will be witnessed in the near future. Laptops are the most valuable e-waste category containing a high content of numerous critical raw materials, thus their waste management is crucial. Read More

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Highly sensitive electrochemical immunosensor using a protein-polyvinylidene fluoride nanocomposite for human thyroglobulin.

Bioelectrochemistry 2021 Jul 16;142:107888. Epub 2021 Jul 16.

LABEL, Department of Chemistry, Federal University of Amazonas, Manaus, Amazonas 69067-005, Brazil. Electronic address:

The highly sensitive detection of serum thyroglobulin (Tg) is essential in the post-treatment follow-up of patients with differentiated thyroid cancer undergoing total or partial thyroidectomy and radioactive iodine ablation and requires sensitive, accurate and stable methods. This work proposes an electrochemical immunosensor for the detection of serum Tg antigen, making use of innovative nanocomposites including polyvinylidene fluoride (PVDF) microparticles coated with streptavidin (MP) and gold nanoparticles (AuNPs). The functionalized polymer matrices were characterized by UV-Vis, FTIR, XPS, SEM, dynamic light scattering, and free surface energy. Read More

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Goodbye Hippocrates?

Authors:
Michael Ashby

J Bioeth Inq 2021 Jul;18(2):195-198

Cancer, Chronic Disease and Sub-Acute Stream, Royal Hobart Hospital, Tasmanian Health Service, School of Medicine, University of Tasmania, Royal Hobart Hospital, Hobart, TAS, 7000, Australia.

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Disparities in antimicrobial consumption and resistance within a country: the case of beta-lactams in Argentina.

Rev Panam Salud Publica 2021 26;45:e76. Epub 2021 Jul 26.

National Administration of Drugs, Food and Technology Buenos Aires Argentina National Administration of Drugs, Food and Technology, Buenos Aires, Argentina.

Objective: To describe bacterial resistance and antimicrobial consumption ratio at the subnational level in Argentina during 2018, considering beta-lactams group as a case-study.

Methods: Antimicrobial consumption was expressed as defined daily doses (DDD)/1000 inhabitants. Resistance of and to beta-lactams was recorded. Read More

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Beedi Rollers' Perception toward Alternative Means of Livelihood amid Economic Benefits.

Indian J Community Med 2021 Apr-Jun;46(2):268-272. Epub 2021 May 29.

Department of Data Science, Prasanna School of Public Health, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Background: Beedi rolling is one of the principal occupations of women residing in coastal Karnataka. The beedi worker's welfare fund consists of a combination of schemes to improve the living conditions of beedi workers and their families. On the other hand, the government is introducing several anti-tobacco policies, which could lead to insecurity among beedi rollers about their future. Read More

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A multiplex PCR assay for six Aedini species, including Aedes albopictus.

Parasit Vectors 2021 Jul 28;14(1):380. Epub 2021 Jul 28.

School of Life Sciences, Kyungpook National University, Biology building 226, Daehak-ro 80, Daegu, Korea.

Background: Mosquitoes, as vectors of various human pathogens, are significant drivers of serious human illness. In particular, those species in the Aedini tribe, which typically transmit dengue virus, Chikungunya fever virus, and Zika virus, are increasing their range because of climate change and international commerce. In order to evaluate the risk of disease transmission, accurate mosquito species identification and monitoring are needed. Read More

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Waterborne outbreak in a rural area in Greece during the COVID-19 pandemic: contribution of community pharmacies.

Rural Remote Health 2021 Jul 28;21(3):6630. Epub 2021 Jul 28.

Directorate of Research, Studies and Documentation, National Public Health Organization, 3-5 Agrafon St, Athens 15123, Greece

Introduction: On 15 June 2020, the National Public Health Organization was informed about the identification of two cases of Escherichia coli Ο157 infection in a small town in the Peloponnese Region in Greece and we suspected an outbreak.

Methods: We asked the local pharmacist to assist us to verify the outbreak by providing the daily number of over-the-counter anti-diarrheal drugs sold from 20 May 2020 onwards. The pharmacist asked customers with gastroenteritis to submit stool samples at the local hospital. Read More

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In Situ Three-Dimensional Welded Nanofibrous Membranes for Robust Membrane Distillation of Concentrated Seawater.

Environ Sci Technol 2021 Jul 28. Epub 2021 Jul 28.

State Key Laboratory of Urban Water Resource and Environment (SKLUWRE), School of Environment, Harbin Institute of Technology, Harbin 150090, China.

Membrane distillation (MD) is a promising technology for treating the concentrated seawater discharged from the desalination process. Interconnected porous membranes, fabricated by additive manufacturing, have received significant attention for MD technology because of their excellent permeability. However, their poor hydrophobic durability induced by the deformation of pores constrains their water desalination performance. Read More

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Use of E-Cigarettes and Associated Factors among Youth in Thailand.

Asian Pac J Cancer Prev 2021 Jul 1;22(7):2199-2207. Epub 2021 Jul 1.

Department of Psychiatry, Faculty of Medicine Chulalongkorn University, Bangkok, Thailand.

Objective: The study explored e-cigarette use among youth and associated factors in Thailand.

Methods: This was a cross sectional study of 6,045 seventh grade students selected using a multistage design. Self-administered questionnaires relating to the socio-demographic characteristics, history of cigarette and e-cigarette uses, friends' and family's use of e-cigarettes, knowledge and perception of e-cigarette use, history of alcohol uses, and life assets were gathered. Read More

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Enhanced galectin-7 expression favors wound healing.

J Dermatol 2021 Jul 28. Epub 2021 Jul 28.

Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental (IBYME), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina.

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Qualitative perspectives of the North Carolina healthy food small retailer program among customers in participating stores located in food deserts.

BMC Public Health 2021 Jul 27;21(1):1459. Epub 2021 Jul 27.

Epidemiology & Community Health, University of Minnesota, 1300 South 2nd Street, WBOB Suite 300, Minneapolis, MN, 55454-1015, USA.

Background: The North Carolina Healthy Food Small Retailer Program (NC HFSRP) was established through a policy passed by the state legislature to provide funding for small food retailers located in food deserts with the goal of increasing access to and sales of healthy foods and beverages among local residents. The purpose of this study was to qualitatively examine perceptions of the NC HFSRP among store customers.

Methods: Qualitative interviews were conducted with 29 customers from five NC HFSRP stores in food deserts across eastern NC. Read More

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Opioid availability statistics from the International Narcotics Control Board do not reflect the medical use of opioids: comparison with sales data from Scandinavia.

Scand J Pain 2021 Jul 27. Epub 2021 Jul 27.

The NEPI Foundation and Unit of Health Care Analysis, Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.

Objectives: Opioid analgesics are essential in clinical practice, but their excessive use is associated with addiction risk. Increases in opioid prescription rates have fuelled an epidemic of opioid addiction in the USA, making statistics on medical opioid use a critical warning signal. A dramatic 150% increase in Swedish opioid access 2001-2013 was recently reported based on data from the International Narcotics Control Board (INCB; Berterame et al. Read More

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Design and synthesis of novel conformationally constrained 7,12-dihydrodibenzo[b,h][1,6] naphthyridine and 7H-Chromeno[3,2-c] quinoline derivatives as topoisomerase I inhibitors: In vitro screening, molecular docking and ADME predictions.

Bioorg Chem 2021 Jul 16;115:105174. Epub 2021 Jul 16.

Department of Chemistry, S. S. G. M. College, Kopargaon 423601, Maharashtra, India. Electronic address:

Novel non-camptothecin (non-CPT) class of conformationally constrained, hitherto unknown 7,12-dihydrodibenzo[b,h][1,6] naphthyridine and 7H-Chromeno[3,2-c] quinoline derivatives have been designed, synthesized and evaluated for anti-cancer activity. In vitro anti-proliferation evaluation against human cancer cell lines (A549 and MCF-7) exhibited significant cytotoxicity. Among the derivatives (8-24), 8 (IC 0. Read More

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TSMiner: a novel framework for generating time-specific gene regulatory networks from time-series expression profiles.

Nucleic Acids Res 2021 Jul 27. Epub 2021 Jul 27.

State Key Laboratory of Proteomics, Beijing Institute of Lifeomics, National Center for Protein Sciences (Beijing), Beijing 102206, P.R. China.

Time-series gene expression profiles are the primary source of information on complicated biological processes; however, capturing dynamic regulatory events from such data is challenging. Herein, we present a novel analytic tool, time-series miner (TSMiner), that can construct time-specific regulatory networks from time-series expression profiles using two groups of genes: (i) genes encoding transcription factors (TFs) that are activated or repressed at a specific time and (ii) genes associated with biological pathways showing significant mutual interactions with these TFs. Compared with existing methods, TSMiner demonstrated superior sensitivity and accuracy. Read More

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Online alcohol sales and home delivery: An international policy review and systematic literature review.

Health Policy 2021 Jul 18. Epub 2021 Jul 18.

School of Population Health, University of New South Wales, Sydney, Australia.

Background: Online alcohol sales are experiencing rapid growth in many places, accelerated by the COVID-19 pandemic, prompting new laws and regulations. There are no comprehensive and systematic analyses of the laws or their effectiveness.

Objective: To summarise international policies governing online alcohol sale and delivery, including changes occurring with COVID-19, and examine available evidence of retailer compliance with such policies. Read More

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A manless adultery: the story of Bassa as related in a Marcus Valerius Martialis' epigram.

Hormones (Athens) 2021 Jul 23. Epub 2021 Jul 23.

Division of Endocrinology, Department of Internal Medicine, University of Patras School of Health Sciences, Patras, Greece.

During the Golden Age of the Roman Empire, Rome was transformed into a magnificent city where architecture, the arts, and commerce flourished. An inconceivable amount of wealth was accumulated by a handful of noble families, while the masses starved. In such a context, moral values inevitably decline, while sexual mores are liberalized and ever more veer towards salacity. Read More

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Legalization as more effective control? Parallels between the end of alcohol prohibition (1927) and the legalization of cannabis (2018) in Ontario, Canada.

Int J Drug Policy 2021 Jul 23;97:103367. Epub 2021 Jul 23.

Centre for Alcohol Policy Research, La Trobe University, Plenty Road, Bundoora, Melbourne, Victoria, Australia, VIC 3086; Centre for Social Research on Alcohol and Drugs, Department of Public Health Sciences, Stockholm University, Stockholm, Sweden, SE-106 91.

Background: In the 1920s, eight of nine Canadian provinces legalized alcohol sales, ending prohibition in favor of government control. Much has been written about the rise and fall of Prohibition in North America, but there is little work examining these events in the light of current drug policy debates. This paper attempts to fill some of these gaps. Read More

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ABC-SPH risk score for in-hospital mortality in COVID-19 patients: development, external validation and comparison with other available scores.

Int J Infect Dis 2021 Jul 23. Epub 2021 Jul 23.

Infectious Diseases Physician, Hospital Eduardo de Menezes, R. Dr. Cristiano Rezende, 2213 - Bonsucesso, Belo Horizonte, Brazil. Electronic address:

Objectives: The majority of available scores to assess mortality risk of coronavirus disease 19 (COVID-19) patients in the emergency department have high risk of bias. Therefore, our aim was to develop and validate a score at hospital admission for predicting in-hospital mortality in COVID-19 patients, and to compare this score with other existing ones.

Methods: Consecutive patients (≥18 years) with confirmed COVID-19 admitted to the participating hospitals were included. Read More

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