102,994 results match your criteria safety quality

Arterial Thrombosis in Patients with Antiphospholipid Syndrome: A Review and Meta-Analysis.

Semin Thromb Hemost 2021 May 10. Epub 2021 May 10.

Department of Medicine, Thrombosis and Atherosclerosis Research Institute, McMaster University, Hamilton, Ontario, Canada.

There is a scarcity of high-quality randomized controlled trials (RCTs) comparing antithrombotic regimens for secondary prevention of arterial thrombosis (AT) in antiphospholipid syndrome (APS). We reviewed different antithrombotic regimens used for this purpose. We searched for studies on management of AT in APS on PubMed and Web of Science. Read More

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Digital Biomarkers of Cognitive Frailty: The Value of Detailed Gait Assessment Beyond Gait Speed.

Gerontology 2021 May 10:1-10. Epub 2021 May 10.

Interdisciplinary Consortium on Advanced Motion Performance (iCAMP), Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA.

Background: Cognitive frailty (CF), defined as the simultaneous presence of cognitive impairment and physical frailty, is a clinical symptom in early-stage dementia with promise in assessing the risk of dementia. The purpose of this study was to use wearables to determine the most sensitive digital gait biomarkers to identify CF.

Methods: Of 121 older adults (age = 78. Read More

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Why is radiological protection different in medicine?

Eliseo Vano

J Radiol Prot 2021 May 10. Epub 2021 May 10.

Radiology Department, Universidad Complutense de Madrid, Madrid, SPAIN.

There are many aspects of radiological protection in medicine that are different than in other areas of activity using ionising radiations. In this paper, we present and justify some of these differences and highlight the reasons and benefits of this consideration for the medical field. It is important to understand the differences as we are all likely to be patients at some point in our lives and be exposed to ionising radiation for imaging procedures several times and, in some cases, for therapeutic indications. Read More

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Time-resolved fluorescent lateral flow strip for easy and rapid quality control of edible oil.

Food Chem 2021 Apr 6;357:129739. Epub 2021 Apr 6.

School Food and Biological Engineering, Hefei University of Technology, China. Electronic address:

Gutter oil is strictly prohibited from being reprocessed back to the catering and food industry. Extensive attention has been paid to rapid screening of gutter oil to guarantee the safety of edible oil. Capsaicin, a special component of condiments, has been adopted as the marker of gutter oil. Read More

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Oral immunization with recombinant Lactobacillus plantarum expressing Nudix hydrolase and 43 kDa proteins confers protection against Trichinella spiralis in BALB/c mice.

Acta Trop 2021 May 7:105947. Epub 2021 May 7.

College of Veterinary Medicine, Jilin Agricultural University, Changchun, China; Jilin Provincial Engineering Research Center of Animal Probiotics, Jilin Agricultural University, Changchun, China; Key Laboratory of animal production and product quality safety of Ministry of Education, Jilin Agricultural University, Changchun, China. Electronic address:

Trichinellosis is a significant food-borne zoonotic parasitic disease caused by parasite Trichinella. Given the side effects of anti-Trichinella drugs (e.g. Read More

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Analysis of Medical Device Alerts Issued by the Portuguese Medicines Agency: Scoping the Purpose of New Regulatory Recommendations.

Acta Med Port 2021 Mar 1;34(3):201-208. Epub 2021 Mar 1.

Departamento de Sócio-Farmácia. Faculdade de Farmácia. Universidade de Lisboa. Lisboa. Portugal.

Introduction: Medical devices are healthcare technologies with a significantly growing market worldwide. This study aims to analyze medical device alerts issued by the Portuguese Medicines Agency, INFARMED, I.P. Read More

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The efficacy of elobixibat as bowel preparation agent for colonoscopy: A prospective, randomized, multi-center study.

Dig Endosc 2021 May 10. Epub 2021 May 10.

Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, Japan.

Background And Aim: Elobixibat is a novel ileal bile acid transporter inhibitor. This study aimed to compare the efficacy, tolerability, and safety of the combination of elobixibat and 1 L of polyethylene glycol formulation containing ascorbic acid (PEG-Asc) solution versus the combination of sodium picosulfate and 1-L PEG-Asc solution as bowel preparation for colonoscopy.

Methods: This multi-center, randomized, observer-blinded, non-inferiority study recruited 210 outpatients who were assigned to either the elobixibat plus 1-L PEG-Asc group (group A) or the sodium picosulfate plus 1-L PEG-Asc group (group B). Read More

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growth of ZIF-8 on gold nanoparticles/magnetic carbon nanotubes for the electrochemical detection of bisphenol A.

Anal Methods 2021 May 10. Epub 2021 May 10.

College of Chemistry and Chemical Engineering, Key Laboratory of Hunan Province for Water Environment and Agriculture Product Safety, Central South University, Changsha 410083, China.

We herein report a facile and scalable strategy for the fabrication of a metal-organic framework (MOF) based composite by in situ growing ZIF-8 on gold nanoparticle (AuNP) loaded magnetic carbon nanotubes (mCNTs). AuNPs were firstly loaded on PEI (polyethylenimine) modified mCNTs by electrostatic forces, and then AuNPs/mCNTs were encapsulated into the ZIF-8 frame through in situ self-assembling of zinc ions and 2-methylimidazole. The morphology, spectroscopy and structural properties of the AuNP/mCNT@ZIF-8 nanocomposites were systematically characterized. Read More

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Long-term outcome of 177Lu-PSMA-617 radioligand therapy in heavily pre-treated metastatic castration-resistant prostate cancer patients.

PLoS One 2021 10;16(5):e0251375. Epub 2021 May 10.

Department of Nuclear Medicine, Thyroid Clinic, AIIMS, Ansari Nagar, New Delhi, India.

Objective: Investigators have extensively explored the short-term safety and efficacy data on 177Lu-PSMA-617 radioligand therapy (RLT) in mCRPC patients. However, scarce literature is reported on the long-term outcome of these patients. The current goal of this study is focused on the long-term outcome of mCRPC patients treated with 177Lu-PSMA-617 RLT. Read More

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The potential of marine resources for retinal diseases: a systematic review of the molecular mechanisms.

Crit Rev Food Sci Nutr 2021 May 10:1-44. Epub 2021 May 10.

Department of Marine Biotechnology, Fraunhofer Research and Development Center for Marine and Cellular Biotechnology EMB, Lübeck, Germany.

We rely on vision more than on any other sense to obtain information about our environment. Hence, the loss or even impairment of vision profoundly affects our quality of life. Diet or food components have already demonstrated beneficial effects on the development of retinal diseases. Read More

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Microbial community and metabolic function analysis of cigar tobacco leaves during fermentation.

Microbiologyopen 2021 Feb;10(2):e1171

College of Tobacco Science, Henan Agricultural University, Zhengzhou, China.

Cigar tobacco leaves (CTLs) contain abundant bacteria and fungi that are vital to leaf quality during fermentation. In this study, artificial fermentation was used for the fermentation of CTLs since it was more controllable and efficient than natural aging. The bacterial and fungal community structure and composition in unfermented and fermented CTLs were determined to understand the effects of microbes on the characteristics of CTLs during artificial fermentation. Read More

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February 2021

The rationale for selenium supplementation in patients with autoimmune thyroiditis, according to the current state of knowledge.

Endokrynol Pol 2021 ;72(2):153-162

Department of Endocrinology, Metabolism, and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland.

Selenium (Se) supplements are commonly prescribed to autoimmune thyroiditis (AIT) patients by European endocrinologists, despite the lack of official guidelines. The majority of Europe is depleted of natural Se sources, and the daily population intake does not comply with recommended values. Optimal individual plasma Se concentration is reached when the selenoproteins (selenoprotein P, glutathione peroxidase) are fully saturated. Read More

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January 2021

Nutraceuticals and Behavioral Therapy for Headache.

Curr Neurol Neurosci Rep 2021 May 10;21(7):33. Epub 2021 May 10.

Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.

Purpose Of Review: Headache affects and disables at least 1 billion people worldwide. Patients and providers seek new therapies to relieve headache without the side effects and financial burden of current treatments. This narrative review highlights recent treatment advances in integrative headache medicine: nutraceuticals and behavioral therapies. Read More

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Patient-Reported Outcomes of Treatment of Opioid Dependence With Weekly and Monthly Subcutaneous Depot vs Daily Sublingual Buprenorphine: A Randomized Clinical Trial.

JAMA Netw Open 2021 May 3;4(5):e219041. Epub 2021 May 3.

Camurus, Lund, Sweden.

Importance: Patient-reported outcomes in the treatment of opioid dependence may differ between subcutaneously administered depot buprenorphine and daily sublingual buprenorphine.

Objective: To compare patient satisfaction between depot buprenorphine and sublingual buprenorphine in adult outpatients with opioid dependence.

Design, Setting, And Participants: This open-label, randomized clinical trial was conducted among adult patients with opioid dependence at 6 outpatient clinical sites in Australia from October 2018 to September 2019. Read More

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Cost-effectiveness calculators for health, well-being and safety promotion: a systematic review.

Eur J Public Health 2021 May 10. Epub 2021 May 10.

Department of Nursing Science, Faculty of Medicine, University of Turku, Turku, Finland.

Background: The health, well-being and safety of the general population are important goals for society, but forecasting outcomes and weighing up the costs and benefits of effective promotional programmes is challenging. This study aimed to identify and describe the cost-effectiveness calculators that analyze interventions that promote health, well-being and safety.

Methods: Our systematic review used the CINAHL, PsycINFO, SocINDEX, EconLit, PubMed and Scopus databases to identify peer-reviewed studies published in English between January 2010 and April 2020. Read More

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Non-invasive monitoring of red blood cells during cold storage using handheld Raman spectroscopy.

Transfusion 2021 May 10. Epub 2021 May 10.

Michael Smith Laboratories, The University of British Columbia, Vancouver, British Columbia, Canada.

Background: The current best practices allow for the red blood cells (RBCs) to be stored for prolonged periods in blood banks worldwide. However, due to the individual-related variability in donated blood and RBCs continual degradation within transfusion bags, the quality of stored blood varies considerably. There is currently no method for assessing the blood product quality without compromising the sterility of the unit. Read More

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Prevention schemes for future fresh agri-products (FAPs) supply chain: Mathematical model and experience of guaranteeing the supply of FAPs during the COVID-19 pandemic.

J Sci Food Agric 2021 May 10. Epub 2021 May 10.

College of Economics and Management, Hebei Agricultural University, Baoding, 071000, China.

Background: The COVID-19 outbreak caused short-term disruptions in the supply chain of fresh agricultural products (FAPs), which exposed the vulnerability of the existing FAPs supply chain. With the pandemic control being widely coordinated, the supply chain of FAPs was gradually optimized and improved. However, after the outbreak of COVID-19, how to achieve the effective supply of FAPs in future pandemics has become a key issue. Read More

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Nurses' experience of caring for people living with HIV: a focused ethnography.

Int Nurs Rev 2021 May 10. Epub 2021 May 10.

Department of Disaster Public Health, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Background: Healthcare providers have been found to have limited knowledge and skills in interacting with people living with HIV. These factors can adversely affect providers' practice, jeopardize their safety and compromise the care of the patients.

Aims: This study aimed to explore the experiences of Iranian nurses who were caring for patients with HIV. Read More

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Perioperative safety and short-term efficacy of functional minimally invasive esophagectomy.

J Int Med Res 2021 May;49(5):3000605211010081

Thoracic Surgery Department, Jining No. 1 People's Hospital, Jining, Shandong Province, China.

Background: Standard minimally invasive McKeown three-field esophagectomy (SMIE) results in high perioperative risk and poor postoperative quality of life owing to considerable surgical damage and numerous postoperative complications. We created a modified procedure, functional minimally invasive esophagectomy (FMIE), which preserves the azygos arch, bronchial artery, pulmonary branch of the vagus nerve, and the mediastinal pleura. Our aim was to evaluate the efficacy and safety of FMIE and to determine whether it has limited invasiveness. Read More

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Interdisciplinary Differences in Patient Safety Culture within a Teaching Hospital in a South East Asia.

Int J Clin Pract 2021 May 10:e14333. Epub 2021 May 10.

Department of Emergency Medicine, Faculty of Medicine, University of Malaya.

Background: Patient safety represents a global issue which leads to potentially avoidable morbidity and mortality. The healthcare providers perception and their role are utmost important in delivering quality care and patient safety. This study aimed to determine the interdisciplinary differences in patient safety culture in a tertiary university hospital. Read More

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Melatonin and the health of menopausal women: a systematic review.

J Pineal Res 2021 May 9:e12743. Epub 2021 May 9.

The Department of Family Medicine and Siaal Research Center for Family Practice and Primary Care, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Melatonin is involved in multiple changes, that characterize the aging and can potentially be a safe and effective treatment for menopausal women. The aim of this study was to carry out a systematic review of the medical literature on the health benefits of oral melatonin administration on menopausal women. The electronic databases PubMed, Scopus, and Web of Science were searched systematically on interventional studies that evaluated the association between oral melatonin administration and the health of menopausal women. Read More

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Surgical microdiscectomy versus transforaminal epidural steroid injection in patients with sciatica secondary to herniated lumbar disc (NERVES): a phase 3, multicentre, open-label, randomised controlled trial and economic evaluation.

Lancet Rheumatol 2021 May 18;3(5):e347-e356. Epub 2021 Mar 18.

Liverpool Clinical Trials Centre, University of Liverpool, Liverpool, UK.

Background: The optimal invasive treatment for sciatica secondary to herniated lumbar disc remains controversial, with a paucity of evidence for use of non-surgical treatments such as transforaminal epidural steroid injection (TFESI) over surgical microdiscectomy. We aimed to investigate the clinical and cost-effectiveness of these options for management of radicular pain secondary to herniated lumbar disc.

Methods: We did a pragmatic, multicentre, phase 3, open-label, randomised controlled trial at 11 spinal units across the UK. Read More

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Characterization of the complete mitochondrial genome of the Qiaoke sheep ().

Mitochondrial DNA B Resour 2021 Apr 26;6(4):1514-1515. Epub 2021 Apr 26.

Key Laboratory of Yak Breeding Engineering of Gansu Province, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou, China.

Qiaoke sheep () is a local sheep breed in Gansu province, China. It is a kind of Tibetan sheep that used for both meat and wool after long-term breeding. In this paper, the complete mitochondrial genome of Qiaoke sheep was sequenced. Read More

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Exosomal therapy-a new frontier in regenerative medicine.

Stem Cell Investig 2021 2;8. Epub 2021 Apr 2.

Department of Biotechnology, School of Engineering and Technology, Sharda University, Greater Noida, Uttar Pradesh, India.

The recent advances in translational and nanomedicine have paved the way for developing the targeted drug delivery system at a greater pace among global researchers. On par with these technologies, exosomes act as a potential portal for cell-free drug delivery systems as these are bestowed with the native characteristics of the parent cell of origin. Exosomes, called extracellular vesicles (EcVs), are present in almost all cells, tissues, and body fluids. Read More

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Tissue Depletion of Olaquindox and Its Six Metabolites in Pigs and Broilers: Identification of a Suitable Marker Residue.

Front Vet Sci 2021 23;8:638358. Epub 2021 Apr 23.

National Reference Laboratory of Veterinary Drug Residues (HZAU), Huazhong Agricultural University, Wuhan, China.

The depletion profiles of olaquindox and its six major metabolites, including O1 (-deoxyolaquindox), O2 (deoxyolaquindox), O3 (2-carboxamide-3-methylquinoxaline--oxide), O4 (2-carboxymethylaminocarbonyl-3-methylquinoxaline--oxide), O5 (2-carboxymethylaminocarbonyl-3-methylquinoxaline), and O6 [3-methyl-quinoxaline-2-carboxylic acid (MQCA)] were studied with a sensitive and accurate HPLC-UV method in pigs and broilers after oral administration of olaquindox at the rate of 50 mg kg feed for 14 consecutive days. Five medicated pigs and six medicated broilers and one control animal for each time point were anesthetized and killed at different time points (6 h and 1, 3, 7, and 14 days for pigs and 6 h and 1, 3, 5, and 7 days for broilers) after ingestion of the medicated feed ceased and samples of muscle, liver, kidney, and fat were collected. The samples were assayed using a liquid chromatographic method. Read More

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The effectiveness of axillary reverse mapping in preventing breast cancer-related lymphedema: a meta-analysis based on randomized controlled trials.

Gland Surg 2021 Apr;10(4):1447-1459

Department of Breast Disease, Henan Breast Cancer Center, The affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, China.

Background: Here, we carried out an extensive meta-analysis to investigate the effectiveness of the use of axillary reverse mapping (ARM) during axillary lymph node dissection (ALND) in preventing breast cancer-related lymphedema (BCRL).

Methods: Database searches to identify relevant randomized controlled trials (RCTs) were performed of MEDLINE (PubMed), Web of Science, Embase, and the Cochrane Library. Eligible articles with a publication date from database establishment to December 2020 were retrieved by combining keywords including: "breast cancer", "breast carcinoma", "breast neoplasm", "axillary reverse mapping", "axillary lymph node dissection", "lymphatic arm drainage", and "lymphedema". Read More

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Stone removing efficiency and safety comparison between single use ureteroscope and reusable ureteroscope: a systematic review and meta-analysis.

Transl Androl Urol 2021 Apr;10(4):1627-1636

Department of Urology, Institute of Urology (Laboratory of Reconstructive Urology), West China Hospital, Sichuan University, Chengdu, China.

Background: Urologists are gradually beginning to use single-use ureteroscopes (sufURSs), despite a lack of high-level evidence as to their efficacy and safety. This systematic review was registered on PROSPERO (no. CRD42020181808). Read More

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Barriers and Facilitators to Bikeshare Programs: A Qualitative Study in an Urban Environment.

J Transp Health 2021 Jun 4;21. Epub 2021 Apr 4.

Division of Pulmonary and Sleep Medicine, Department of Pediatrics, School of Medicine, The University of Alabama at Birmingham, 1600 7th Avenue South, Lowder 620, Birmingham, AL, 35233, USA.

Introduction: Bikeshare programs have emerged across the US to promote bicycling as an active mode of transportation that could potentially improve health and quality of life. However, bikeshare usage is low in some settings. The purpose of this qualitative study is to explore barriers and facilitators of bikeshare use and to identify potential strategies to increase participation in urban environments. Read More

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Identification and characterization of alkaline phosphatase gene in PCC7806.

3 Biotech 2021 May 16;11(5):218. Epub 2021 Apr 16.

School of Life Sciences, Nanjing Normal University, Nanjing, 210023 China.

PhoX is an extracellular alkaline phosphatase that is widely found in cyanobacteria and plays an important role in the conversion of extracellular organophosphorus into soluble inorganic phosphorus. However, the gene has not yet been experimentally confirmed to exist in bloom-forming species. In this study, we identified a putative gene (GenBank accession no. Read More

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Efficacy and Safety of Orally Administered Acotiamide Extended-Release Tablets Among Functional Dyspepsia-Postprandial Distress Syndrome Patients: A Randomized, Double-Blind, Multicenter Study.

Cureus 2021 Apr 8;13(4):e14361. Epub 2021 Apr 8.

Clinical Development and Medical Affairs, Hetero Labs Limited, Hyderabad, IND.

Background: Acotiamide, is the world's first-in-class, prokinetic drug and world's first approved treatment for postprandial distress syndrome (PDS) symptoms of functional dyspepsia (FD). An extended-release (ER) formulation of this drug product, developed first-time in the world has been evaluated in phase 3, a comparative trial to explore the efficacy and safety in patients with FD-PDS.

Methods: In this study, 219 patients with FD-PDS aged 18-65 years were randomized (1:1) to receive either acotiamide ER 300 mg once daily or acotiamide 100 mg three times daily for four weeks. Read More

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