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Multiple-Session Subthreshold Micropulse Laser Therapy for Exudative Perifoveal Vascular Anomalous Complex: a case report.

Retin Cases Brief Rep 2021 Jul 16. Epub 2021 Jul 16.

Department of Ophthalmology, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu, South Korea.

Purpose: To report a case of exudative perifoveal vascular anomalous complex treated with a 532 nm subthreshold micropulse laser unresponsive to intravitreal injections.

Methods: A case report.

Results: A 65-year-old woman presented with blurred vision in left eye for 1 month. Read More

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Access to Postabortion Contraception: ACOG Committee Opinion, Number 833.

Authors:

Obstet Gynecol 2021 Aug;138(2):e91-e95

Abstract: All contraceptive methods are safe and effective when provided immediately after abortion procedures and when otherwise medically appropriate for a patient. Providing a contraceptive method immediately after an induced or spontaneous abortion can help individuals achieve their desired reproductive outcomes and minimize the burden of multiple appointments. Contraceptive counseling and methods should be made available to all patients who experience induced or spontaneous abortion, and the patient's right to decline or postpone this care should be respected. Read More

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Access to Postabortion Contraception: ACOG Committee Opinion Summary, Number 833.

Authors:

Obstet Gynecol 2021 Aug;138(2):324-325

Abstract: All contraceptive methods are safe and effective when provided immediately after abortion procedures and when otherwise medically appropriate for a patient. Providing a contraceptive method immediately after an induced or spontaneous abortion can help individuals achieve their desired reproductive outcomes and minimize the burden of multiple appointments. Contraceptive counseling and methods should be made available to all patients who experience induced or spontaneous abortion, and the patient's right to decline or postpone this care should be respected. Read More

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Ferric Citrate Dosing in Iron Deficiency Anemia in Nondialysis-Dependent Chronic Kidney Disease.

Am J Nephrol 2021 Jul 22:1-10. Epub 2021 Jul 22.

Akebia Therapeutics, Inc., Cambridge, Massachusetts, USA.

Introduction: Ferric citrate (FC) is indicated as an oral iron replacement for iron deficiency anemia in adult patients with chronic kidney disease (CKD) not on dialysis. The recommended starting dose is one 1-g tablet three times daily (TID). This study investigated long-term efficacy and safety of different FC dosing regimens for treating anemia in nondialysis-dependent CKD (NDD-CKD). Read More

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Direct in vivo reprogramming with non-viral sequential targeting nanoparticles promotes cardiac regeneration.

Biomaterials 2021 Jul 15;276:121028. Epub 2021 Jul 15.

Department of Cardiology, Zhongshan Hospital, Fudan University. Shanghai Institute of Cardiovascular Diseases, Shanghai, 20032, China; Institute of Biomedical Sciences, Fudan University, Shanghai, 20032, China. Electronic address:

microRNA-mediated direct cardiac reprogramming, directly converts fibroblasts into induced cardiomyocyte-like cells (iCMs), which holds great promise in cardiac regeneration therapy. However, effective approaches to deliver therapeutic microRNA into cardiac fibroblasts (CFs) to induce in vivo cardiac reprogramming remain to be explored. Herein, a non-viral biomimetic system to directly reprogram CFs for cardiac regeneration after myocardial injury was developed by coating FH peptide-modified neutrophil-mimicking membranes on mesoporous silicon nanoparticles (MSNs) loaded with microRNA1, 133, 208, and 499 (miR Combo). Read More

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Endovascular treatment of vertebro-vertebral arteriovenous fistula in neurofibromatosis type I: A report of two cases and literature review with a focus on endovascular treatment.

Clin Neurol Neurosurg 2021 Jul 14;207:106806. Epub 2021 Jul 14.

Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai, China. Electronic address:

Vertebro-Vertebral arteriovenous fistula (VV-AVF) associated with neurofibromatosis Type I (NF-1) is rare. We presented two female NF-1 patients with a diagnosis of VV-AVF treated with endovascular approach. The fistula was completely obliterated with balloon assisted embolization and covered stent separately and VA patency was preserved in both cases. Read More

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Combined transarterial embolization, and percutaneous sclerotherapy as treatment for refractory and non resectable aneurysmal bone cysts.

J Vasc Interv Radiol 2021 Jul 19. Epub 2021 Jul 19.

Clinic for Radiology, University Hospital Muenster, Muenster, Germany; Department of Radiology, University Hospital LMU Munich, Germany.

Purpose: To evaluate safety and effectiveness of combined transarterial embolization and percutaneous sclerotherapy in treatment for refractory and non-resectable aneurysmal bone cysts (ABCs) as assessed by imaging and clinical outcomes.

Materials And Methods: This retrospective single center study included n=16 consecutive patients (f=9, m=7; age: median 17 (6-25) years) undergoing combined transarterial embolization (using ethylene vinyl alcohol) and percutaneous sclerotherapy (ethanol-gel and polidocanol) for refractory and non-resectable ABCs. Median follow-up was 27. Read More

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Promising potential of boron compounds against Glioblastoma: In Vitro antioxidant, anti-inflammatory and anticancer studies.

Neurochem Int 2021 Jul 19;149:105137. Epub 2021 Jul 19.

Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, SE1 9RT, UK; Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, SE-17121, Sweden. Electronic address:

Glioblastoma (GB) is the most common and aggressive primary malignant astrocytoma correlated with poor patient survival. There are no curative treatments for GB, and it becomes resistant to chemotherapy, radiation therapy, and immunotherapy. Resistance in GB cells is closely related to their states of redox imbalance, and the role of reactive oxygen species and its impact on cancer cell survival is still far from elucidation. Read More

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Stereotactic Electroencephalography Implantation Through Nonautologous Cranioplasty: Proof of Concept.

Oper Neurosurg (Hagerstown) 2021 Jul 22. Epub 2021 Jul 22.

Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

Background: Stereoelectroencephalography (SEEG) is an effective method to define the epileptogenic zone (EZ) in patients with medically intractable epilepsy. Typical placement requires passing and anchoring electrodes through native skull.

Objective: To describe the successful placement of SEEG electrodes in patients without native bone. Read More

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Tailored approach to the choice of long-term vascular access in breast cancer patients.

PLoS One 2021 22;16(7):e0255004. Epub 2021 Jul 22.

Division of Vascular and Transplantation Surgery, Department of Surgery, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea.

This study compared the possible options for vascular access in breast cancer patients by analyzing the complications of each method. We retrospectively evaluated the vascular access procedures for intravenous chemotherapy in breast cancer patients from 2016 to 2018. A total of 300 consecutive patients were included, 100 each who received peripherally inserted central catheters (PICCs), arm ports, and chest ports. Read More

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Use of 3D Navigation Versus Traditional Fluoroscopy for Posterior Pelvic Ring Fixation.

Orthopedics 2021 Jul-Aug;44(4):229-234. Epub 2021 Jul 1.

Unstable pelvic ring disruption is most commonly treated with closed reduction and percutaneous screw fixation. Traditional methods involve screw placement under fluoroscopic imaging, but with recent technologic advances, intraoperative 3D navigation can now be used to help with the insertion of sacroiliac screws. Various cadaver studies have shown that placement of sacroiliac screws under 3D navigation is more accurate than placement under traditional fluoroscopic guidance. Read More

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Design, Synthesis, and Biological Evaluation of Organic Nitrite (NO) Donors as Potential Anticerebral Ischemia Agents.

J Med Chem 2021 Jul 22. Epub 2021 Jul 22.

State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing 210009, P.R. China.

The treatment of ischemic stroke (IS) remains a big challenge in clinics, and it is urgently needed to develop novel, safe, and effective medicines against IS. Here, we report the design, synthesis, and biological evaluation of organic NO donors as potential agents for the treatment of IS. The representative compound was able to slowly generate low concentrations of NO by reaction with a thiol-containing nucleophile, and the NO was selectively converted into NO under ischemic/hypoxia conditions to protect primary rat neurons from oxygen-glucose deprivation and recovery (OGD/R)-induced cytotoxicity by enhancing the Nrf2 signaling and activating the NO/cGMP/PKG pathway. Read More

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Molecular Engineering of Hydrogels for Rapid Water Disinfection and Sustainable Solar Vapor Generation.

Adv Mater 2021 Jul 22:e2102994. Epub 2021 Jul 22.

Materials Science and Engineering Program and Department of Mechanical Engineering, The University of Texas at Austin, Austin, TX, 78712, USA.

Consumption of unsafe water is a major cause of morbidity and mortality in developing regions. Pasteurizing or boiling water to remove pathogens is energy-intensive and often impractical to off-grid communities. Therefore, low capital cost, rapid and energy-efficient water disinfection methods are urgently required to address global challenges of safe water access. Read More

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Pazopanib for severe bleeding and transfusion-dependent anemia in hereditary hemorrhagic telangiectasia.

Angiogenesis 2021 Jul 22. Epub 2021 Jul 22.

Division of Hematology, Massachusetts General Hospital, Zero Emerson Pl Suite 118, Office 112, Boston, MA, 02114, USA.

Hereditary hemorrhagic telangiectasia (HHT) is a rare angiogenic disorder causing chronic gastrointestinal bleeding, epistaxis, and severe anemia. Pazopanib is an oral multi-kinase angiogenesis inhibitor with promise to treat bleeding in HHT. We analyzed outcomes of HHT patients with the most severe bleeding causing RBC transfusion dependence treated on a predefined institutional pazopanib treatment pathway (with data collected retrospectively). Read More

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Microvascular decompression as a second step treatment for trigeminal neuralgia in patients with failed two-isocentre gamma knife radiosurgery.

Neurosurg Rev 2021 Jul 22. Epub 2021 Jul 22.

Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue No.1277, Wuhan, 430022, People's Republic of China.

Objective: Subsequent microvascular decompression (MVD) might be affected by the previous two-isocentre gamma knife radiosurgery (GKS) due to the tissue changes caused by its higher dose radiation and larger treatment volume. This study aimed to evaluate the safety and efficacy of MVD as a second step treatment after two-isocentre GKS.

Methods: Between December 2016 and May 2019, data from 19 consecutive trigeminal neuralgia (TN) patients who experienced MVD after failed two-isocentre GKS were collected. Read More

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Urgent surgery for COVID-19-positive pediatric patient.

JA Clin Rep 2021 Jul 22;7(1):57. Epub 2021 Jul 22.

Department of Anesthesiology and Critical Care Medicine, Children's Hospital Los Angeles, University of Southern California, 4650 Sunset Blvd, Los Angeles, CA, 90027, USA.

Background: We present a case of COVID-19-positive pediatric patient for urgent urological surgery by spinal anesthesia to avoid aerosolizing procedure.

Case Presentation: A 12-year-old, COVID-19-positive boy presented for urgent wound incision and drainage at the circumcision site. Our anesthetic plan consisted of spinal anesthesia with sedation. Read More

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The Development of Frontal and Sphenoid Sinuses After Full-House Endoscopic Sinus Surgery in a Child.

J Craniofac Surg 2021 Jul 20. Epub 2021 Jul 20.

Department of Otolaryngology, Tohoku Kosai Hospital, Sendai, Miyagi, Japan.

Abstract: Although endoscopic sinus surgery (ESS) is a standard procedure for adults and is considered a safe and effective procedure in children as well, some uncertainty remains when it comes to children, especially with regard to the future facial and sinus development. Overall, limited ESS does not affect sinus development, and extended ESS does not affect facial features. However, whether or not full-house ESS affects the sinus development, especially the frontal and sphenoid sinuses, remains unclear. Read More

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Population pharmacokinetics of infliximab in children with juvenile idiopathic arthritis.

Ther Drug Monit 2021 Jul 19. Epub 2021 Jul 19.

Department of pediatric immunology, rheumatology and infectious diseases, Emma Children's Hospital, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands and Zaans Medical Center, Zaandam, the Netherlands Department of pediatric immunology, rheumatology and infectious diseases, Emma Children's Hospital, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands Hospital Pharmacy, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands.

Background: The recommended infliximab (IFX) dose in (pediatric) rheumatology practice is 3-6 mg/kg every 4-8 weeks. Higher dosage regimens (>10 mg/kg) of IFX are effective and safe. To optimize IFX treatment in juvenile idiopathic arthritis (JIA) patients, therapeutic drug monitoring (TDM) might be beneficial. Read More

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Intention to get vaccinated against COVID-19 among the general population in France: Associated factors and gender disparities.

Hum Vaccin Immunother 2021 Jul 22:1-12. Epub 2021 Jul 22.

Southeastern Health Regional Observatory (ORS Paca), Faculté De Médecine, Marseille Cedex 5, France.

As the coronavirus disease 2019 (COVID-19) spreads across the world, the rapid distribution of an effective vaccine and its acceptability among the population constitute priorities for health authorities. This study aimed to document attitudes of the general population toward a future vaccine against COVID-19. We used the national COCONEL surveys conducted during the lockdown to identify factors associated with vaccine refusal, in the whole population, and separately among men and women. Read More

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Bexagliflozin for type 2 Diabetes: an overview of the data.

Expert Opin Pharmacother 2021 Jul 22. Epub 2021 Jul 22.

Dobney Hypertension Centre, School of Medicine - Royal Perth Hospital Unit, Royal Perth Hospital Research Foundation, Faculty of Medicine, Dentistry & Health Sciences, The University of Western Australia, Perth Australia.

Introduction: Sodium-glucose cotransporter-2 (SGLT2) inhibitors are a relatively novel glucose-lowering drugs (GLDs) which additionally promote weight loss and blood pressure reduction amongst other beneficial effects.

Areas Covered: This review reflects on the extra-glycaemic effects of SGLT2 inhibitors and their impact on important clinical endpoints, and provides an overview of data relating to a newer member of the SGLT2 inhibitor class, bexagliflozin.

Expert Opinion: SGLT2 inhibitors, while consolidating glycaemic control as adjunctive therapy, indisputably effect cardio-renal benefits in the T2D population which is prevalently afflicted by heightened cardiovascular risk profiles and a disproportionately increased incidence of unfavourable cardiovascular and renal clinical outcomes. Read More

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Exploring epigenetic and microRNA approaches for γ-globin gene regulation.

Exp Biol Med (Maywood) 2021 Jul 22:15353702211028195. Epub 2021 Jul 22.

Department of Pediatrics, Division of Hematology/Oncology, Augusta University, Augusta, GA 30912, USA.

Therapeutic interventions aimed at inducing fetal hemoglobin and reducing the concentration of sickle hemoglobin is an effective approach to ameliorating acute and chronic complications of sickle cell disease, exemplified by the long-term use of hydroxyurea. However, there remains an unmet need for the development of additional safe and effective drugs for single agent or combination therapy for individuals with β-hemoglobinopathies. Regulation of the γ-globin to β-globin switch is achieved by chromatin remodeling at the locus on chromosome 11 and interactions of major DNA binding proteins, such as KLF1 and BCL11A in the proximal promoters of the globin genes. Read More

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Impact of Systemic versus Intratympanic Dexamethasone Administration on the Perilymph Proteome.

J Proteome Res 2021 Jul 22. Epub 2021 Jul 22.

Department of Otolaryngology-Head and Neck Surgery, Columbia University Vagelos College of Physicians and Surgeons, New York, New York 10032, United States.

Glucocorticoids are the first-line treatment for sensorineural hearing loss, but little is known about the mechanism of their protective effect or the impact of route of administration. The recent development of hollow microneedles enables safe and reliable sampling of perilymph for proteomic analysis. Using these microneedles, we investigate the effect of intratympanic (IT) versus intraperitoneal (IP) dexamethasone administration on guinea pig perilymph proteome. Read More

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Photothermal-Enhanced Fenton-like Catalytic Activity of Oxygen-Deficient Nanotitania for Efficient and Safe Tooth Whitening.

ACS Appl Mater Interfaces 2021 Jul 22. Epub 2021 Jul 22.

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Engineering Research Center of Oral Translational Medicine, Ministry of Education & National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.

The growing demand for charming smiles has led to the popularization of tooth bleaching procedures. Current tooth bleaching products with high-concentration hydrogen peroxide (HP, 30-40%) are effective but detrimental due to the increased risk of enamel destruction, tooth sensitivity, and gingival irritation. Herein, we reported a less-destructive and efficient tooth whitening strategy with a low-concentration HP, which was realized by the remarkably enhanced Fenton-like catalytic activity of oxygen-deficient TiO (TiO). Read More

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Acquired Perforating Dermatosis Induced by PD-1 Inhibitor: A Case Report.

Am J Dermatopathol 2021 Jul 20. Epub 2021 Jul 20.

Department of Dermatology, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China; Department of Dermatology, Affiliated Hospital of Chengde Medical College; Department of Biology, Providence College, Providence, RI; and Ackerman Academy of Dermatopathology, New York, NY.

Abstract: Acquired perforating dermatoses (APDs) are a group of diverse skin disorders in patients with systemic disease, most commonly chronic renal failure and diabetes mellitus. APD induced by medication has seldom been reported. Anti-PD-1 monoclonal antibody has recently been used as a broad-spectrum, effective, durable, and relatively safe antitumor therapy for various malignancies. Read More

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Early cardiac rehabilitation for acute decompensated heart failure safely improves physical function (PEARL study): a randomized controlled trial.

Eur J Phys Rehabil Med 2021 Jul 22. Epub 2021 Jul 22.

Department of Cardiology and Geriatrics, Kochi Medical School, Kochi University, Kochi, Japan.

Background: Improvements in the Short Physical Performance Battery (SPPB) rather than exercise tolerance reportedly lead to favorable prognosis in elderly patients with acute decompensated heart failure (ADHF). However, about 50% of heart failure shows heart failure with preserved ejection fraction, safe and effective interventions to improve SPPB for these types remain unclear. In addition, although a standard cardiac rehabilitation (CR) program for heart failure is widely used in Japan, whether this is sufficient to improve SPPB in elderly patients with ADHF remains unclear. Read More

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Gastric peroral endoscopic myotomy (GPOEM) for severe gastroparesis after lung transplantation: a promising minimally invasive option.

Clin Transplant 2021 Jul 21. Epub 2021 Jul 21.

Aix-Marseille Université, APHM, Department of Gastroenterology, Hôpital Nord, Marseille, France.

Background: After lung transplantation (LT), gastroparesis is frequent, occurring in 25% to 63% of cases and leading to pulmonary infections. In refractory disease, classical management has demonstrated limited efficacy. G-POEM is a recently developed safe and effective procedure that has been performed here on 5 patients with severe post-LT gastroparesis. Read More

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Interferential Electrical Stimulation Efficacy in the Management of Lower Urinary Tract Dysfunction in Children: A Review of the Literature.

Urol J 2021 Jul 22. Epub 2021 Jul 22.

Pediatric Urology and Regenerative Medicine Research Center, Pediatric Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.

Background: Lower urinary tract dysfunction (LUTD) is the most common problem of the referral children to the pediatric urology clinics. If this condition does not treat early in life, it will be a lifelong problem. During recent decades, electrical stimulation therapy has been expanded and extensively used for the treatment of LUTD in both adults and children. Read More

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Outpatient Initiation of Sotalol in Patients with Atrial Fibrillation: Utility of Cardiac Implantable Electronic Devices for Therapy Monitoring.

Am J Cardiovasc Drugs 2021 Jul 22. Epub 2021 Jul 22.

Cardiovascular and Heart Rhythm Consultants, 30 West 60th Street, Suite 1U, New York, NY, 10023, USA.

Background: Antiarrhythmic drugs are often used in the management of patients with atrial fibrillation (AF). Sotalol is conventionally initiated in the inpatient setting for monitoring efficacy and adverse effects, including QTc interval prolongation and torsades de pointes (TdP) proarrhythmia.

Objective: We aimed to evaluate the efficacy and safety of outpatient initiation of sotalol for the treatment of AF in a select group of patients with cardiac implantable electronic devices (CIEDs): permanent pacemakers (PPMs), implantable cardioverter defibrillators (ICDs), and implantable loop recorders (ILRs) capable of continuous rhythm monitoring remotely. Read More

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The place of vericiguat in the landscape of treatment for heart failure with reduced ejection fraction.

Heart Fail Rev 2021 Jul 21. Epub 2021 Jul 21.

Institute of Life Sciences, Scuola Superiore Sant'Anna, Piazza Martiri della Libertà 33, Pisa, Italy.

The significant morbidity and mortality associated with heart failure with reduced (HFrEF) or preserved ejection fraction (HFpEF) justify the search for novel therapeutic agents. The nitric oxide (NO)-soluble guanylate cyclase (sGC)-cyclic guanosine monophosphate (cGMP) pathway plays an important role in the regulation of cardiovascular function. This pathway is disrupted in HF resulting in decreased protection against myocardial injury. Read More

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Pharmacokinetics and Biologic Activity of Apixaban in Healthy Dogs.

Front Vet Sci 2021 5;8:702821. Epub 2021 Jul 5.

Department of Clinical Sciences, Cornell University College of Veterinary Medicine, Ithaca, NY, United States.

Thrombosis is common in critically ill dogs and causes considerable morbidity and mortality. The direct factor Xa inhibitor apixaban is safe, efficacious, and convenient in humans. This study aimed to determine the pharmacokinetics (PK), bioactivity, protein binding, and bioavailability of apixaban following intravenous (IV) and oral (PO) administration to healthy dogs. Read More

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