J Rheumatol 2021 Apr 15. Epub 2021 Apr 15.
Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark; Danish Hospital for Rheumatic Diseases, University Hospital of Southern Denmark, Soenderborg, Denmark; Department of Regional Health Research, University of Southern Denmark, Odense, Denmark; Department of Rheumatology, Lillebælt Hospital, Vejle, Denmark; Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark; Department of Radiology, Herlev and Gentofte Hospital, Copenhagen, Denmark. The source(s) of support in the form of grants or industrial support: The BIOSPA study was conducted without any financial support. The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors. The Danish Rheumatism Association supported MW with a PhD fellowship grant (R131- A5381). Address correspondence to Marie Wetterslev Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases Rigshospitalet, Glostrup Valdemar Hansen Vej 17 Email:
Objective: In axial spondyloarthritis (axSpA), sacroiliac joint (SIJ) erosion is often followed by fat metaplasia in an erosion cavity (backfill), and subsequently ankylosis. We aimed to combine Spondyloarthritis Research Consortium of Canada (SPARCC) SIJ Structural score for Erosion, Backfill and Ankylosis into 3 versions of a novel preliminary Composite axSpA MRI SIJ Structural Damage Score (CSDS) and test these.
Methods: Thirty-three axSpA patients followed for 5 years after initiation of tumor necrosis factor inhibitor had MRI of SIJs at baseline, and yearly thereafter. Read More