Arthritis Res Ther 2020 10 6;22(1):232. Epub 2020 Oct 6.
Institute of Immunology, Biomedical Sciences Research Center (BSRC), 'Alexander Fleming', 34 Alexander Fleming Street, 16672, Vari, Greece.
Background: The transmembrane-TNF transgenic mouse, TgA86, has been shown to develop spontaneously peripheral arthritis with signs of axial involvement. To assess similarity to human spondyloarthritis, we performed detailed characterization of the axial, peripheral, and comorbid pathologies of this model.
Methods: TgA86 bone pathologies were assessed at different ages using CT imaging of the spine, tail vertebrae, and hind limbs and characterized in detail by histopathological and immunohistochemical analysis. Read More