73 results match your criteria s Urological Management in Neurological Disease


Low-Intensity Electrostimulation Enhances Neuroregeneration and Improves Erectile Function in a Rat Model of Cavernous Nerve Injury.

J Sex Med 2022 05 11;19(5):686-696. Epub 2022 Mar 11.

Johns Hopkins School of Medicine, The James Buchanan Brady Urological Institute and Department of Urology, Baltimore, MD, USA. Electronic address:

Background: Neurogenic erectile dysfunction (ED) following radical prostatectomy (RP) is a frequent complication often leading to erectile tissue remodeling and permanent ED. Low-intensity electrostimulation (LIES) has been shown to enhance peripheral nerve regeneration, however, its application on cavernous nerves (CN) has never been investigated.

Aims: To investigate whether LIES enhances CN regeneration, improves erectile function (EF) recovery, and prevents corpora cavernosal remodeling after CN injury, which is a principal factor for ED following RP. Read More

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BoNT/A1 Secondary Failure for the Treatment of Neurogenic Detrusor Overactivity: An Ex Vivo Functional Study.

Toxins (Basel) 2022 01 21;14(2). Epub 2022 Jan 21.

Raymond-Poincaré Hospital, 92380 Garches, France.

Management of neurogenic detrusor overactivity (NDO) remains a clinical priority to improve patients' quality of life and prevent dramatic urological complications. Intradetrusor injection of onabotulinumtoxinA (BoNT/A1, botulinum neurotoxin A1) is approved as second therapeutic line in these patients, demonstrating a good efficacy. However, a loss of its efficacy over time has been described, with no clear understanding of the underlying mechanisms. Read More

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January 2022

Video-Urodynamic Characteristics and Predictors of Switching from Botulinum Neurotoxin a Injection to Augmentation Enterocystoplasty in Spinal Cord Injury Patients.

Toxins (Basel) 2022 01 10;14(1). Epub 2022 Jan 10.

Department of Urology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Tzu Chi University, Hualien 970374, Taiwan.

Botulinum neurotoxin type A (BoNT-A) injection and augmentation enterocystoplasty (AE) are alternative and effective management strategies for neurogenic detrusor overactivity (NDO) refractory to pharmacotherapy. A great majority of patients with spinal cord injury (SCI) may, however, prefer BoNT-A injections to AE, due to the less invasive characteristics. In this study we evaluated the influence of various video-urodynamic study (VUDS) parameters in SCI patients who continuously received repeat BoNT-A detrusor injections or switched to AE to improve their bladder conditions. Read More

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January 2022

Satisfaction with Detrusor OnabotulinumtoxinA Injections and Conversion to Other Bladder Management in Patients with Chronic Spinal Cord Injury.

Toxins (Basel) 2022 01 3;14(1). Epub 2022 Jan 3.

Department of Urology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Tzu Chi University, Hualien 97004, Taiwan.

This study investigated the satisfaction with continued detrusor Botox injections for urinary incontinence and conversion to other surgical procedures and bladder management procedures for neurogenic detrusor overactivity (NDO) in patients with chronic spinal cord injury (SCI). A total of 223 patients with chronic SCI underwent detrusor Botox 200U for urodynamically confirmed NDO and urinary incontinence. After initial detrusor Botox injections, patients opted to either continue detrusor Botox injections every six to nine months and on clean intermittent catheterization (CIC), switch to other bladder management procedures, or receive surgical procedures to improve their urinary incontinence, correct emergent complications, or have better voiding conditions without CIC. Read More

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January 2022

Assessment and Treatment of Nocturia in Neurological Disease in a Primary Care Setting: Systematic Review and Nominal Group Technique Consensus.

Eur Urol Focus 2022 Jan 12;8(1):33-41. Epub 2022 Jan 12.

Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK; Bristol Urological Institute, North Bristol NHS Trust, Bristol, UK. Electronic address:

Context: Neurological disease can affect the rate of urine production and bladder storage function, increasing nocturia severity, with additional risks if mobility or cognition is impaired.

Objective: To conduct a systematic review (SR) of nocturia in neurological diseases and achieve expert consensus for management in clinics without neurologist input.

Evidence Acquisition: Four databases were searched from January 2000 to April 2020. Read More

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January 2022

Association of Sleep Disorders with Nocturia: A Systematic Review and Nominal Group Technique Consensus on Primary Care Assessment and Treatment.

Eur Urol Focus 2022 Jan 10;8(1):42-51. Epub 2022 Jan 10.

Bristol Urological Institute, North Bristol NHS Trust, Bristol, UK; Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. Electronic address:

Context: Sleep disorders affect responsiveness to sensory information and can cause nocturnal polyuria and reduced sleep depth; hence, these are potentially influential in understanding the mechanism of nocturia.

Objective: To report the systematic review (SR) and expert consensus for primary care management of nocturia in sleep disorders.

Evidence Acquisition: Four databases were searched from January to April 2020. Read More

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January 2022

Lantox-The Chinese Botulinum Toxin Drug-Complete English Bibliography and Comprehensive Formalised Literature Review.

Toxins (Basel) 2021 05 22;13(6). Epub 2021 May 22.

Neurotoxin research Center of Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Tongji University School of Medicine, 389 Xincun Road, Shanghai 200065, China.

In 1997, lanbotulinumtoxinA (LAN) was introduced in China. It is now available in Asia, Latin America and Eastern Europe under various brand names including Hengli, Lantox, Prosigne, Lanzox, Redux, Liftox, HBTX-A and CBTX-A. The literature on LAN is mostly published in Chinese language, restricting its international accessibility. Read More

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The management of pediatric severe traumatic brain injury: Italian Guidelines.

Minerva Anestesiol 2021 05 12;87(5):567-579. Epub 2021 Jan 12.

Società Italiana di Pediatria (SIP), Rome, Italy.

Introduction: The aim of the work was to update the "Guidelines for the Management of Severe Traumatic Brain Injury" published in 2012, to reflect the new available evidence, and develop the Italian national guideline for the management of severe pediatric head injuries to reduce variation in practice and ensure optimal care to patients.

Evidence Acquisition: MEDLINE and EMBASE were searched from January 2009 to October 2017. Inclusion criteria were English language, pediatric populations (0-18 years) or mixed populations (pediatric/adult) with available age subgroup analyses. Read More

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Risk factors of papillary thyroid microcarcinoma that predispose patients to local recurrence.

PLoS One 2020 31;15(12):e0244930. Epub 2020 Dec 31.

Department of General, Minimally Invasive and Endocrine Surgery, Wroclaw Medical University, Wroclaw, Poland.

Background: Currently, less aggressive treatment or even active surveillance of papillary thyroid microcarcinoma (PTMC) is widely accepted and recommended as a therapeutic management option. However, there are some concerns about these approaches. We investigated whether there are any demographic, clinical and ultrasound characteristics of PTMC patients that are easy to obtain and clinically available before surgery to help clinicians make proper therapeutic decisions. Read More

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Lower urinary tract and bowel dysfunction in spinocerebellar ataxias.

Ann Clin Transl Neurol 2021 02 18;8(2):321-331. Epub 2020 Dec 18.

Department of Uro-Neurology, The National Hospital for Neurology and Neurosurgery, and UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, United Kingdom.

Background: Little information is available in spinocerebellar ataxias (SCAs) regarding pelvic organ symptoms. The aim of this study was to characterize the lower urinary tract (LUT) and bowel dysfunction in autosomal dominant spinocerebellar ataxias.

Methods: Patients with confirmed SCAs attending a tertiary care service were approached about LUT and bowel complaints, and completed validated questionnaires: urinary symptom profile (USP), Qualiveen-Short form, International Prostate Symptom Score, and Neurogenic Bowel Dysfunction Score. Read More

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February 2021

Anticholinergic drug use and risk of mortality for people with dementia in Northern Ireland.

Aging Ment Health 2021 08 19;25(8):1475-1482. Epub 2020 Oct 19.

Centre for Public Health, Institute for Clinical Sciences Block B, Queens University Belfast, Belfast, Northern Ireland.

Objective: Anticholinergic burden refers to the cumulative effect of medications which contain anticholinergic properties. We assessed how anticholinergic burden and different types of anticholinergic medications influence mortality rates among people with dementia in Northern Ireland. Our secondary aim was to determine what demographic characteristics predict the anticholinergic burden of people with dementia. Read More

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Neurogenic Bladder: Epidemiology, Diagnosis, and Management.

Semin Neurol 2020 10 16;40(5):569-579. Epub 2020 Oct 16.

Department of Uro-Neurology, The National Hospital for Neurology and Neurosurgery and UCL Queen Square Institute of Neurology, London, United Kingdom.

Lower urinary tract dysfunction is a common sequel of neurological disease resulting in symptoms that significantly impacts quality of life. The site of the neurological lesion and its nature influence the pattern of dysfunction. The risk for developing upper urinary tract damage and renal failure is considerably lower in patients with slowly progressive nontraumatic neurological disorders, compared with those with spinal cord injury or spina bifida. Read More

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October 2020

Self-Reported Urological Hospitalizations or Emergency Room Visits in a Contemporary Spinal Cord Injury Cohort.

J Urol 2021 02 9;205(2):477-482. Epub 2020 Oct 9.

Professor of Urology, University of Michigan, Ann Arbor, Michigan.

Purpose: Individuals with spinal cord injuries frequently use urgent and emergent medical care. We hypothesized that urological causes are a primary driver of hospitalizations/emergency room visits in a contemporary spinal cord injury cohort.

Materials And Methods: The Neurogenic Bladder Research Group spinal cord injury registry is a prospective cohort study evaluating neurogenic bladder related quality of life after traumatic spinal cord injury. Read More

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February 2021

Urodynamics tests for the diagnosis and management of bladder outlet obstruction in men: the UPSTREAM non-inferiority RCT.

Health Technol Assess 2020 09;24(42):1-122

Bristol Urological Institute, Southmead Hospital, Bristol, UK.

Background: Lower urinary tract symptoms (LUTS) in men may indicate bladder outlet obstruction (BOO) or weakness, known as detrusor underactivity (DU). Severe bothersome LUTS are a common indication for surgery. The diagnostic tests may include urodynamics (UDS) to confirm whether BOO or DU is the cause, potentially reducing the number of people receiving (inappropriate) surgery. Read More

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September 2020

Assessment of patients with lower urinary tract symptoms where an undiagnosed neurological disease is suspected: A report from an International Continence Society consensus working group.

Neurourol Urodyn 2020 11 4;39(8):2535-2543. Epub 2020 Aug 4.

Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol Urological Institute, Bristol, UK.

Aim: Lower urinary tract symptoms (LUTS) are a common urological referral, which sometimes can have a neurological basis in a patient with no formally diagnosed neurological disease ("occult neurology"). Early identification and specialist input is needed to avoid bad LUTS outcomes, and to initiate suitable neurological management.

Methods: The International Continence Society established a neurological working group to consider: Which neurological conditions may include LUTS as an early feature? What diagnostic evaluations should be undertaken in the LUTS clinic? A shortlist of conditions was drawn up by expert consensus and discussed at the annual congress of the International Neurourology Society. Read More

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November 2020

Voiding conditions, renal and bowel function in a cohort of adults with spina bifida.

Neurourol Urodyn 2020 08 12;39(6):1796-1802. Epub 2020 Jun 12.

Rehab Station Stockholm, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.

Aim: To map voiding patterns, degree of continence, use of drugs for voiding disorders, kidney function and surgical interventions but also the bowel function in a near-total regional cohort of adults with spina bifida aged more than or equal to 18 years.

Methods: All individuals more than or equal to 18 years of age with spina bifida registered at a regional outpatient clinic (n = 219) were invited to participate, of which 196 persons were included. Bladder and bowel function were assessed according to questions used by the Nordic Spinal Cord Injury Registry by structured interviews and questionnaires in combination with review of patient charts including kidney function. Read More

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Xerogenic Medications as a Predictor for Dental Health Intervention in People with Dementia.

J Alzheimers Dis 2020 ;75(4):1263-1271

Department of Dental Medicine, Karolinska Institutet, Stockholm, Sweden.

Background: Older adults with dementia often have poor oral health. Chronic use of xerogenic medications may contribute to adverse dental outcomes.

Objective: To investigate the impact of xerogenic medication classes on the predicted risk for dental interventions in people with dementia. Read More

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Outcome of Different Approaches to Reduce Urinary Tract Infection in Patients With Spinal Cord Lesions: A Systematic Review.

Am J Phys Med Rehabil 2020 11;99(11):1056-1066

From the Department of Physical Medicine and Rehabilitation, Chung Shan Medical University Hospital, Taichung City, Taiwan (S-CC, SZ, S-JT); and Department of Physical Medicine and Rehabilitation, School of Medicine, Chung Shan Medical University, Taichung City, Taiwan (S-CC, S-JT).

Neurogenic bladder disorders are common among patients with spinal cord lesions, which often result in upper and lower urinary tract complications. Urinary tract infection has remained the most frequent type of infection in this population. Our aim is to review systematically the literature on the outcome of different intervention methods to reduce urinary tract infection incidence. Read More

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November 2020

Management of urethrocutaneous fistulae complicating sacral and perineal pressure ulcer in neurourological patients: A national multicenter study from the French-speaking Neuro-urology Study Group and the Neuro-urology committee of the French Association of Urology.

Neurourol Urodyn 2019 08 29;38(6):1713-1720. Epub 2019 May 29.

Department of Urology, Pitié-Salpêtrière Academic Hospital, Assistance Publique-Hôpitaux de Paris, Médecine Sorbonne Université, Paris, France.

Purpose: To describe the epidemiologic characteristics of urethrocutaneous fistulae (UCF) in sacro-perineal pressure ulcer (SPPU) in neurourological patients and to assess outcomes after surgical urinary diversion.

Materials And Methods: Through the French-speaking Neurourology Study Group and Association of Urology network, a retrospective multicenter study in nine major urology and physical medicine and rehabilitation (PMR) units was conducted. All patients with SPPU associated with UCF between 2000 and 2016 were included. Read More

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Lumbosacral spinal cord epidural stimulation improves voiding function after human spinal cord injury.

Sci Rep 2018 06 6;8(1):8688. Epub 2018 Jun 6.

Kentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY, USA.

Deficits in urologic function after spinal cord injury (SCI) manifest both as a failure to store and empty, greatly impacting daily life. While current management strategies are necessary for urological maintenance, they oftentimes are associated with life-long side effects. Our objective was to investigate the efficacy of spinal cord epidural stimulation (scES) as a promising therapy to improve bladder control after SCI. Read More

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Evaluating a telehealth intervention for urinalysis monitoring in children with neurogenic bladder.

J Child Health Care 2019 03 27;23(1):45-62. Epub 2018 May 27.

3 School of Nursing, University of Northern British Columbia, British Columbia, Canada.

Telehealth as a community-monitoring project within children's urology care is an innovative development. There is limited evidence of the inclusion of staff and parents in the early-stage development and later adoption of telehealth initiatives within routine urological nursing care or families' management of their child's bladder. The aim was to explore the experiences of key stakeholders (parents, clinicians, and technical experts) of the proof of concept telehealth intervention in terms of remote community-based urinalysis monitoring by parents of their child's urine. Read More

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The International Society for the Study of Women's Sexual Health Process of Care for Management of Hypoactive Sexual Desire Disorder in Women.

Mayo Clin Proc 2018 04 12;93(4):467-487. Epub 2018 Mar 12.

Department of Family Medicine, SUNY Downstate Medical Center, Brooklyn, NY.

The International Society for the Study of Women's Sexual Health process of care (POC) for management of hypoactive sexual desire disorder (HSDD) algorithm was developed to provide evidence-based guidelines for diagnosis and treatment of HSDD in women by health care professionals. Affecting 10% of adult females, HSDD is associated with negative emotional and psychological states and medical conditions including depression. The algorithm was developed using a modified Delphi method to reach consensus among the 17 international panelists representing multiple disciplines. Read More

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Neurogenic bladder findings in patients with Congenital Zika Syndrome: A novel condition.

PLoS One 2018 1;13(3):e0193514. Epub 2018 Mar 1.

Department of Neonatology, Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira (IFF/FIOCRUZ), Rio de Janeiro, Rio de Janeiro, Brazil.

Introduction: Congenital Zika Syndrome (CZS) has been associated with microcephaly and other central nervous system abnormalities including areas that have been implicated in the control of the lower urinary tract. As such, this descriptive case series has aimed to investigate whether CZS is linked with neurogenic bladder. Identifying such an association is paramount in the effort to recognize CZS complications that have putative treatment options that could mitigate the impact of CZS in infected children. Read More

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Natural history of post-void residual urine volume over 5 years in community-dwelling older men: The Concord Health and Ageing in Men Project.

Neurourol Urodyn 2018 03 20;37(3):1068-1073. Epub 2017 Sep 20.

Centre for Education and Research on Ageing and Ageing and Alzheimer's Institute, Concord Hospital, University of Sydney, New South Wales, Australia.

Aims: To describe the natural history of post-void residual urine volume (PVR) in community-dwelling older men.

Methods: The Concord Health and Ageing in Men Project involves a representative sample of community-dwelling men aged 70 and older in a defined geographic area of Sydney, Australia. PVR were measured at baseline and 2-year and 5-year follow-up. Read More

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The validation of the Dutch SF-Qualiveen, a questionnaire on urinary-specific quality of life, in spinal cord injury patients.

BMC Urol 2017 Sep 19;17(1):88. Epub 2017 Sep 19.

Department of Urology, Erasmus MC, Wijtemaweg 80, Room Na 1724, 3015, CN, Rotterdam, The Netherlands.

Background: Optimizing the patients' quality of life is one of the main goals in the urological management of spinal cord injury (SCI) patients. In this study we validated the Dutch SF-Qualiveen, a short questionnaire that measures the urinary-specific quality of life, in SCI patients. No such measure is yet available for this patient group. Read More

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September 2017

The utility of stem cells in pediatric urinary bladder regeneration.

Pediatr Res 2018 01 8;83(1-2):258-266. Epub 2017 Nov 8.

Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.

Pediatric patients with a neurogenic urinary bladder, caused by developmental abnormalities including spina bifida, exhibit chronic urological problems. Surgical management in the form of enterocystoplasty is used to enlarge the bladder, but is associated with significant clinical complications. Thus, alternative methods to enterocystoplasty have been explored through the incorporation of stem cells with tissue engineering strategies. Read More

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January 2018

Probiotics for preventing urinary tract infection in people with neuropathic bladder.

Cochrane Database Syst Rev 2017 09 8;9:CD010723. Epub 2017 Sep 8.

Spinal Medicine Department, Prince of Wales Hospital, Level 2, High Street Entrance, Randwick, NSW, Australia, 2031.

Background: Neuropathic or neurogenic bladder describes a process of dysfunctional voiding as the result of injury in the brain, spinal cord or nerves innervating the bladder. People with neuropathic bladder, such as from spinal cord injury (SCI), are at significant risk of morbidity from urinary tract infections (UTI). Effective methods to prevent UTI in people with SCI have been sought for many years. Read More

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September 2017

Neurogenic bowel dysfunction: Clinical management recommendations of the Neurologic Incontinence Committee of the Fifth International Consultation on Incontinence 2013.

Neurourol Urodyn 2018 01 22;37(1):46-53. Epub 2017 Jun 22.

St. Mark's Hospital, London, UK.

Background: Evidence-based guidelines for the management of neurological disease and lower bowel dysfunction have been produced by the International Consultations on Incontinence (ICI). These are comprehensive guidelines, and were developed to have world-wide relevance.

Aims: To update clinical management of neurogenic bowel dysfunction from the recommendations of the 4th ICI, 2009. Read More

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January 2018

A Targeted Self-Management Approach for Reducing Stroke Risk Factors in African American Men Who Have Had a Stroke or Transient Ischemic Attack.

Am J Health Promot 2018 02 6;32(2):282-293. Epub 2017 Mar 6.

9 Department of Neurology, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA.

Purpose: This study compared a novel self-management (TargetEd MAnageMent Intervention [TEAM]) versus treatment as usual (TAU) to reduce stroke risk in African American (AA) men.

Design: Six-month prospective randomized controlled trial with outcomes evaluated at baseline, 3 months, and 6 months.

Setting: Academic health center. Read More

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February 2018

Design and Methodological Considerations of the Centers for Disease Control and Prevention Urologic and Renal Protocol for the Newborn and Young Child with Spina Bifida.

J Urol 2016 12 27;196(6):1728-1734. Epub 2016 Jul 27.

Department of Urology, University of Alabama-Birmingham, Birmingham, Alabama.

Purpose: Care of children with spina bifida has significantly advanced in the last half century, resulting in gains in longevity and quality of life for affected children and caregivers. Bladder dysfunction is the norm in patients with spina bifida and may result in infection, renal scarring and chronic kidney disease. However, the optimal urological management for spina bifida related bladder dysfunction is unknown. Read More

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December 2016