74 results match your criteria rutosides versus


The effect of EDTA and citric acid on biochemical processes and changes in phenolic compounds profile of okra (Abelmoschus esculentus L.) under mercury stress.

Ecotoxicol Environ Saf 2021 Jan 13;208:111607. Epub 2020 Nov 13.

University of Belgrade, Faculty of Agriculture, Department of Food Technology and Biochemistry, Belgrade, Serbia.

The present study aimed to explore the effect of synthetic and naturally occurring chelators, EDTA and citric acid (CA), respectively, on changes in physiological and biochemical factors including cell death, level of mercury ions accumulation, malondialdehyde (MDA) content, total phenol and total flavonoids, anthocyanins and DPPH free radical scavenging activity, in the leaves of okra (Abelmoschus esculentus L.) plants exposed to mercury stress. In addition, polyphenolic compounds profile was assessed by high-performance liquid chromatography. Read More

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January 2021

Supplementation with Whey Protein, Omega-3 Fatty Acids and Polyphenols Combined with Electrical Muscle Stimulation Increases Muscle Strength in Elderly Adults with Limited Mobility: A Randomized Controlled Trial.

Nutrients 2020 Jun 23;12(6). Epub 2020 Jun 23.

Laboratory of Applied Physiology, Graduate School of Human and Environmental Studies, Kyoto University, Kyoto 606-8501, Japan.

Age-related sarcopenia is a progressive and generalized skeletal muscle disorder associated with adverse outcomes. Herein, we evaluate the effects of a combination of electrical muscle stimulation (EMS) and a whey-based nutritional supplement (with or without polyphenols and fish oil-derived omega-3 fatty acids) on muscle function and size. Free-living elderly participants with mobility limitations were included in this study. Read More

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Impact of Rutin and Vitamin C combination on oxidative stress and glycemic control in patients with type 2 diabetes.

Clin Nutr ESPEN 2020 02 14;35:128-135. Epub 2019 Nov 14.

Clinical Pharmacy Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt. Electronic address:

Aim: This study aimed to investigate the effect of Vitamin C alone and in combination with Rutin on the glycemic control, insulin resistance, lipid profile and oxidative stress markers in patients with type 2 diabetes.

Methods: A prospective, randomized, controlled study conducted on 53 type 2 diabetes patients randomized into 3 groups; (group A) 20 received Rutin with vitamin C, (group B) 20receivedvitamin C and (group C)13 received antidiabetic treatment only. Fasting Blood Glucose (FBG), Hemoglobin A1c (HbA1c), fasting insulin, Malondialdehyde, Superoxide dismutase, Lipid profile and patients' quality of life (QOL) using SF-36 questionnaire were assessed in all patients at baseline and after 8 weeks. Read More

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February 2020

Natural substance rutin versus standard drug atorvastatin in a treatment of metabolic syndrome-like condition.

Saudi Pharm J 2019 Dec 11;27(8):1196-1202. Epub 2019 Oct 11.

Centre of Experimental Medicine, Institute of Experimental Pharmacology and Toxicology, Slovak Academy of Sciences, Dúbravská cesta 9, Bratislava, Slovakia.

Background: Metabolic syndrome is a cluster of metabolic risk factors. The clear causes of its development are not known yet and there is no comprehensive treatment of this disease. There is a trend to use natural substances in the treatment of various diseases, but their effects need to be well explored. Read More

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December 2019

Evaluation of potential herb-drug interactions between oseltamivir and commonly used anti-influenza Chinese medicinal herbs.

J Ethnopharmacol 2019 Oct 17;243:112097. Epub 2019 Jul 17.

School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region. Electronic address:

Ethnopharmacological Relevance: According to Traditional Chinese Medicine theory, influenza is categorized as a warm disease or Wen Bing. The Wen Bing formulas, such as Yin-Qiao-San and Sang-Ju-Yin, are still first-line herbal therapies in combating variant influenza virus. To continue our study on the pharmacokinetic and pharmacodynamic interactions between Wen Bing formulas and oseltamivir (OS), the first-line western drug for the treatment of influenza, further interactions between OS and the eight single herbs and their relevant marker components from Wen Bing formulas were investigated in the current study. Read More

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October 2019

Rutosides for treatment of post-thrombotic syndrome.

Cochrane Database Syst Rev 2018 11 8;11:CD005625. Epub 2018 Nov 8.

Division of Epidemiology and Public Health, University of Nottingham, C120, Clinical Sciences Building - Ph2, City Hospital Campus, Hucknall Road, Nottingham, UK, NG5 1PB.

Background: Post-thrombotic syndrome (PTS) is a long-term complication of deep venous thrombosis (DVT) that is characterised by pain, swelling, and skin changes in the affected limb. One in three patients with DVT will develop post-thrombotic sequelae within five years. Rutosides are a group of compounds derived from horse chestnut (Aesculus hippocastanum), a traditional herbal remedy for treating oedema formation in chronic venous insufficiency (CVI). Read More

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November 2018

Rutosides for prevention of post-thrombotic syndrome.

Cochrane Database Syst Rev 2018 11 8;11:CD005626. Epub 2018 Nov 8.

Division of Epidemiology and Public Health, University of Nottingham, C120, Clinical Sciences Building - Ph2, City Hospital Campus, Hucknall Road, Nottingham, UK, NG5 1PB.

Background: Post-thrombotic syndrome (PTS) is a long-term complication of deep venous thrombosis (DVT) that is characterised by pain, swelling, and skin changes in the affected limb. One in three patients with DVT will develop post-thrombotic sequelae within five years. The current standard care for the prevention of PTS following DVT is elastic compression stockings. Read More

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November 2018

Global Liver Gene Expression Analysis on a Murine Hepatic Steatosis Model Treated with Mulberry ( L.) Leaf Powder.

Anticancer Res 2018 Jul;38(7):4305-4311

Faculty of Pharmaceutical Sciences, Hokkaido University of Science, Hokkaido, Japan

Background/aim: Mulberry (Morus alba L.) leaves (ML) contain many functional components, such as 1-deoxynojirimycin, flavonoids (rutin, quercetin, kaempferol). It is well known that 1-deoxynojirimycin functions to suppress increases in blood glucose level by α-glucosidase inhibitory activity. Read More

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Hybridity has a greater effect than paternal genome dosage on heterosis in sugar beet (Beta vulgaris).

BMC Plant Biol 2018 Jun 15;18(1):120. Epub 2018 Jun 15.

Genetics and Biotechnology Laboratory, Plant and AgriBioscience Research Centre (PABC), Ryan Institute, National University of Ireland Galway, University Road, Galway, H91 REW4, Ireland.

Background: The phenomenon of heterosis is critical to plant breeding and agricultural productivity. Heterosis occurs when F1 hybrid offspring display quantitative improvements in traits to levels that do not occur in the parents. Increasing the genome dosage (i. Read More

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Curcumin and Rutin Down-regulate Cyclooxygenase-2 and Reduce Tumor-associated Inflammation in HPV16-Transgenic Mice.

Anticancer Res 2018 03;38(3):1461-1466

Center for the Research and Technology of Agro-Environmental and Biological Sciences, University of Trás-os-Montes and Alto Douro, Vila Real, Portugal.

Aim: Cyclo-oxygenase-2 (COX2) plays a prominent role in carcinogenesis. This study addresses the effects of two nutraceutical compounds on the expression of COX2 and tumor-associated inflammation in human papillomavirus type 16 (HPV16)-transgenic mice.

Materials And Methods: Six-week-old FVB/n mice were supplemented with rutin or curcumin for 24 weeks: HPV16 no treatment, n=12; HPV16 no treatment, n=13; HPV16 rutin, n=12; HPV16 curcumin, n=13. Read More

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Analysis of Three Compounds in Flos Farfarae by Capillary Electrophoresis with Large-Volume Sample Stacking.

Int J Anal Chem 2017 5;2017:3813879. Epub 2017 Sep 5.

School of Pharmacy, Shanxi Medical University, Taiyuan 030001, China.

The aim of this study was to develop a method combining an online concentration and high-efficiency capillary electrophoresis separation to analyze and detect three compounds (rutin, hyperoside, and chlorogenic acid) in Flos Farfarae. In order to get good resolution and enrichment, several parameters such as the choice of running buffer, pH and concentration of the running buffer, organic modifier, temperature, and separation voltage were all investigated. The optimized conditions were obtained as follows: the buffer of 40 mM NaHP0-40 mM Borax-30% v/v methanol (pH 9. Read More

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September 2017

Phytochemical analysis, molecular docking and antiamnesic effects of methanolic extract of Silybum marianum (L.) Gaertn seeds in scopolamine induced memory impairment in mice.

J Ethnopharmacol 2018 Jan 24;210:198-208. Epub 2017 Aug 24.

Department of Botany, University of Malakand, Chakdara, Dir (Lower), 18800 KP, Pakistan. Electronic address:

Ethnopharmacological Relevance: Silybum marianum (L.) Gaertn and its main component silymarin have been extensively studied and have been found effective in various neurological disorders.

Aims Of The Study: The aim of the current study is to identify phytoconstituents in the methanolic extract (Me. Read More

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January 2018

Aegle marmelos differentially affects hepatic markers of glycolysis, insulin signalling pathway, hypoxia, and inflammation in HepG2 cells grown in fructose versus glucose-rich environment.

Mol Cell Biochem 2018 Jan 1;438(1-2):1-16. Epub 2017 Aug 1.

Department of Pharmacology, Delhi Institute of Pharmaceutical Sciences and Research (DIPSAR), Pushp Vihar, Sector-3, MB Road, New Delhi, 110017, India.

Fructose consumption is responsible for the onset of insulin resistance (IR), and metabolic syndrome. It possesses no functional utility in body and its detrimental effects on hepatic metabolic milieu are beyond those produced by glucose. The need of the hour is to identify fructose-induced IR as an unique pathological state to be managed differentially. Read More

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January 2018

A comparative study on the radioprotective potential of the polyphenolic glycoconjugates from medicinal plants of Rosaceae and Asteraceae families versus their aglycones.

J Photochem Photobiol B 2017 Jun 26;171:50-57. Epub 2017 Apr 26.

Department of General Biochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland. Electronic address:

Radioprotective potential of the polyphenolic glycoconjugates, isolated from flowers of Sanguisorba officinalis L. (So) and Erigeron canadensis L. (Ec), and from leaves of Fragaria vesca L. Read More

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Cholesterol-Lowering Activity of Tartary Buckwheat Protein.

J Agric Food Chem 2017 Mar 24;65(9):1900-1906. Epub 2017 Feb 24.

Food & Nutritional Sciences Programme, School of Life Sciences, The Chinese University of Hong Kong , Shatin, New Territories, Hong Kong, China.

Previous research has shown that Tartary buckwheat flour is capable of reducing plasma cholesterol. The present study was to examine the effect of rutin and Tartary buckwheat protein on plasma total cholesterol (TC) in hypercholesterolemia hamsters. In the first animal experiment, 40 male hamsters were divided into four groups fed either the control diet or one of the three experimental diets containing 8. Read More

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Industrial processing versus home processing of tomato sauce: Effects on phenolics, flavonoids and in vitro bioaccessibility of antioxidants.

Food Chem 2017 Apr 29;220:51-58. Epub 2016 Sep 29.

Faculty of Chemical and Metallurgical Engineering, Food Engineering Department, Istanbul Technical University, Maslak, 34469 Istanbul, Turkey. Electronic address:

The effect of industrial and home processing, in vitro gastrointestinal digestion, individual phenolic content, and antioxidant capacity of tomato into tomato sauce were investigated. Industrial processing of tomato fruit into sauce had an overall positive effect on the total antioxidant capacity (∼1.2-fold higher) compared to tomato fruit whereas home processing of tomato fruit into sauce led to a decrease in these values. Read More

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In Vitro Antioxidant versus Metal Ion Chelating Properties of Flavonoids: A Structure-Activity Investigation.

PLoS One 2016 27;11(10):e0165575. Epub 2016 Oct 27.

Laboratory of Bioorganic and Medicinal Chemistry, UMR 7509 CNRS, ECPM, 25 rue Becquerel, 67200 Strasbourg, France.

Natural flavonoids such as quercetin, (+)catechin and rutin as well as four methoxylated derivatives of quercetin used as models were investigated to elucidate their impact on the oxidant and antioxidant status of human red blood cells (RBCs). The impact of these compounds against metal toxicity was studied as well as their antiradical activities with DPPH assay. Antihemolytic experiments were conducted on quercetin, (+)catechin and rutin with excess of Fe, Cu and Zn (400 μM), and the oxidant (malondialdehyde, carbonyl proteins) and antioxidant (reduced glutathione, catalase activity) markers were evaluated. Read More

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Purified rutin and rutin-rich asparagus attenuates disease severity and tissue damage following dextran sodium sulfate-induced colitis.

Mol Nutr Food Res 2016 11 5;60(11):2396-2412. Epub 2016 Aug 5.

Department of Plant Agriculture, University of Guelph, Guelph, ON, Canada.

Scope: This study investigated the effects of cooked whole asparagus (ASP) versus its equivalent level of purified flavonoid glycoside, rutin (RUT), on dextran sodium sulfate (DSS)-induced colitis and subsequent colitis recovery in mice.

Methods And Results: C57BL/6 male mice were fed an AIN-93G basal diet (BD), or BD supplemented with 2% cooked ASP or 0.025% RUT for 2 wks prior to and during colitis induction with 2% DSS in water for 7 days, followed by 5 days colitis recovery. Read More

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November 2016

Interventions for varicose veins and leg oedema in pregnancy.

Cochrane Database Syst Rev 2015 Oct 19(10):CD001066. Epub 2015 Oct 19.

School of Nursing, Midwifery and Social Work, The University of Manchester, Jean McFarlane Building, Oxford Road, Manchester, UK, M13 9PL.

Background: Pregnancy is presumed to be a major contributory factor in the increased incidence of varicose veins in women, which can in turn lead to venous insufficiency and leg oedema. The most common symptom of varicose veins and oedema is the substantial pain experienced, as well as night cramps, numbness, tingling, the legs may feel heavy, achy, and possibly be unsightly. Treatments for varicose veins are usually divided into three main groups: surgery, pharmacological and non-pharmacological treatments. Read More

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October 2015

Selenium and rutin alone or in combination do not have stronger protective effects than their separate effects against cadmium-induced renal damage.

Pharm Biol 2016 10;54(5):896-904. Epub 2015 Oct 10.

b Department of Chemical Sciences , Redeemer's University , Ede , Nigeria.

Context: Selenium (Se) and rutin (RUT) are antioxidants that protect against tissue damage.

Objective: In this study, the separate and combine protective effects of RUT and Se against cadmium (Cd)-induced renal damage were evaluated in rats.

Materials And Methods: Wistar rats were treated by gavage to RUT (30 mg/kg) or Se (0. Read More

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December 2016

Rutosides for treatment of post-thrombotic syndrome.

Cochrane Database Syst Rev 2015 Sep 16(9):CD005625. Epub 2015 Sep 16.

Centre for Population Health Sciences, University of Edinburgh, Medical Buildings, Teviot Place, Edinburgh, UK, EH8 9AG.

Background: Post-thrombotic syndrome (PTS) is a long-term complication of deep venous thrombosis (DVT) that is characterised by pain, swelling, and skin changes in the affected limb. One in three patients with DVT will develop post-thrombotic sequelae within five years. Rutosides are a group of compounds derived from horse chestnut (Aesculus hippocastanum), a traditional herbal remedy for treating oedema formation in chronic venous insufficiency (CVI). Read More

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September 2015

Rutosides for prevention of post-thrombotic syndrome.

Cochrane Database Syst Rev 2015 Sep 16(9):CD005626. Epub 2015 Sep 16.

Centre for Population Health Sciences, University of Edinburgh, Medical Buildings, Teviot Place, Edinburgh, UK, EH8 9AG.

Background: Post-thrombotic syndrome (PTS) is a long-term complication of deep venous thrombosis (DVT) that is characterised by pain, swelling, and skin changes in the affected limb. One in three patients with DVT will develop post-thrombotic sequelae within five years. The current standard care for the prevention of PTS following DVT is elastic compression stockings. Read More

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September 2015

Rutin antinociception involves opioidergic mechanism and descending modulation of ventrolateral periaqueductal grey matter in rats.

Eur J Pain 2016 Feb 27;20(2):274-83. Epub 2015 Apr 27.

Laboratorio de Neurofarmacología de Productos Naturales de la Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Mexico.

Background: Rutin is a bioflavonoid found in fruits, vegetables and plants used in traditional medicine to alleviate pain. However, rutin's scientific evidence for the modulation of pain and its mechanism of action is lacking. It is well known that the periaqueductal grey matter (PAG) contains opioidergic neural circuits involved in the modulation of descending nociception. Read More

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February 2016

Characterization of the Canine Anthracycline-Metabolizing Enzyme Carbonyl Reductase 1 (cbr1) and the Functional Isoform cbr1 V218.

Drug Metab Dispos 2015 Jul 27;43(7):922-7. Epub 2015 Apr 27.

Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, The State University of New York at Buffalo, Buffalo, New York

The anthracyclines doxorubicin and daunorubicin are used in the treatment of various human and canine cancers, but anthracycline-related cardiotoxicity limits their clinical utility. The formation of anthracycline C-13 alcohol metabolites (e.g. Read More

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Elucidating the specificity of non-heparin-based conformational activators of antithrombin for factor Xa inhibition.

J Nat Sci Biol Med 2014 Jan;5(1):36-42

Department of Bio-Sciences, Protein Conformation and Enzymology Lab, New Delhi, India.

Introduction: Antithrombin, the principal inhibitor of coagulation proteases, requires allosteric activation by its physiological cofactor, heparin or heparin sulfate to achieve physiologically permissible rates. This forms the basis of heparin's use as a clinical anticoagulant. However, heparin therapy is beset with severe complications, giving rise to the need to search new non-heparin activators of antithrombin, devoid of these complications and with favorable safety profiles. Read More

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January 2014

Induction of PGF2α synthesis by cortisol through GR dependent induction of CBR1 in human amnion fibroblasts.

Endocrinology 2014 Aug 21;155(8):3017-24. Epub 2014 Mar 21.

Center for Pregnancy and Newborn Research (C.M.G., L.M., K.S.), Department of OB/GYN, University of Texas Health Science Center San Antonio, San Antonio, Texas 78229; School of Life Sciences (W.S.W., C.L.), Fudan University, Shanghai 200433, Peoples Republic of China; and Center for Reproductive Medicine (K.S.), Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200135, Peoples Republic of China.

Abundant evidence indicates a pivotal role of prostaglandin F2α (PGF2α) in human parturition. Both the fetal and maternal sides of the fetal membranes synthesize PGF2α. In addition to the synthesis of PGF2α from PGH2 by PGF synthase (PGFS), PGF2α can also be converted from PGE2 by carbonyl reductase 1 (CBR1). Read More

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Electrochemical versus spectrophotometric assessment of antioxidant activity of hop (Humulus lupulus L.) products and individual compounds.

J Agric Food Chem 2013 Sep 12;61(38):9089-96. Epub 2013 Sep 12.

Institute of General and Physical Chemistry, University of Belgrade , P.O. Box 45, 11158 Belgrade 118, Serbia.

Antioxidant (AO) activity of extracts of hop cones (Serbian domestic varieties) and commercial hop products (Saaz, Spalter, Spalter select, and Magnum pellets) was determined by parallel application of recently developed direct current (DC) polarographic and widely used DPPH assay. Correlations between 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) scavenging and total phenolics (TPC) determined by the Folin-Ciocalteu assay (FC) (0.99), and between H2O2 scavenging (HPS) and humulone content (H) determined by conductometric method (0. Read More

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September 2013

Light gazpachos contain higher phytochemical levels than conventional gazpachos.

Food Sci Technol Int 2013 Aug 31;19(4):377-85. Epub 2013 May 31.

Nutrition and Food Science Department, University of Barcelona, Barcelona, Spain.

Light gazpachos in comparison with conventional alternatives are interesting because of their low percentage of fat and high content of bioactive compounds that are beneficial for human health. An hybrid quadrupole time-of-flight mass spectrometer was used to identify those metabolites that have the greatest impact on the overall metabolic profile in light gazpachos as compared to conventional alternatives. Individual polyphenols were quantified using liquid chromatography-electrospray ionization tandem mass spectrometry. Read More

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Rutosides for prevention of post-thrombotic syndrome.

Cochrane Database Syst Rev 2013 Apr 30(4):CD005626. Epub 2013 Apr 30.

Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK.

Background: Post-thrombotic syndrome (PTS) is a long-term complication of deep venous thrombosis (DVT) that is characterised by pain, swelling, and skin changes in the affected limb. One in three patients with DVT will develop post-thrombotic sequelae within five years. The current standard care for the prevention of PTS following DVT is elastic compression stockings. Read More

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Rutosides for treatment of post-thrombotic syndrome.

Cochrane Database Syst Rev 2013 Apr 30(4):CD005625. Epub 2013 Apr 30.

Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK.

Background: Post-thrombotic syndrome (PTS) is a long-term complication of deep venous thrombosis (DVT) that is characterised by pain, swelling, and skin changes in the affected limb. One in three patients with DVT will develop post-thrombotic sequelae within five years. Rutosides are a group of compounds derived from horse chestnut (Aesculus hippocastanum), a traditional herbal remedy for treating oedema formation in chronic venous insufficiency (CVI). Read More

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