Endocrinology 2014 Aug 21;155(8):3017-24. Epub 2014 Mar 21.
Center for Pregnancy and Newborn Research (C.M.G., L.M., K.S.), Department of OB/GYN, University of Texas Health Science Center San Antonio, San Antonio, Texas 78229; School of Life Sciences (W.S.W., C.L.), Fudan University, Shanghai 200433, Peoples Republic of China; and Center for Reproductive Medicine (K.S.), Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200135, Peoples Republic of China.
Abundant evidence indicates a pivotal role of prostaglandin F2α (PGF2α) in human parturition. Both the fetal and maternal sides of the fetal membranes synthesize PGF2α. In addition to the synthesis of PGF2α from PGH2 by PGF synthase (PGFS), PGF2α can also be converted from PGE2 by carbonyl reductase 1 (CBR1). Read More