15 results match your criteria rstudio addition

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Magnetic resonance radiomics signatures for predicting poorly differentiated hepatocellular carcinoma: A SQUIRE-compliant study.

Medicine (Baltimore) 2021 May;100(19):e25838

Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Abstract: Radiomics contributes to the extraction of undetectable features with the naked eye from high-throughput quantitative images. In this study, 2 predictive models were constructed, which allowed recognition of poorly differentiated hepatocellular carcinoma (HCC). In addition, the effectiveness of the as-constructed signature was investigated in HCC patients. Read More

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Colorectal cancer of the young displays distinct features of aggressive tumor biology: A single-center cohort study.

World J Gastrointest Surg 2021 Feb;13(2):164-175

Department of Surgery and Transplantation, University Hospital Zurich, Zurich 8091, Switzerland.

Background: In recent years, a decrease in incidence and mortality of colorectal cancer (CRC) has been observed in developed nations, presumably through public disease awareness and increased screening efforts. However, a rising incidence of CRC in young patients below the age of 50 years has been reported in several studies.

Aim: To study tumor biology in CRC patients below 50 years of age. Read More

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February 2021

Predicting Radiotherapy Impact on Late Bladder Toxicity in Prostate Cancer Patients: An Observational Study.

Cancers (Basel) 2021 Jan 6;13(2). Epub 2021 Jan 6.

UOC Radioterapia Oncologica, Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia,Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Largo Agostino Gemelli 8, 00168 Roma, Italy.

Background And Purpose: The aim of our study was to elaborate a suitable model on bladder late toxicity in prostate cancer (PC) patients treated by radiotherapy with volumetric technique.

Materials And Methods: PC patients treated between September 2010 and April 2017 were included in the analysis. An observational study was performed collecting late toxicity data of any grade, according to RTOG and CTCAE 4. Read More

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January 2021

Active ingredients and mechanisms of Phellinus linteus (grown on Rosa multiflora) for alleviation of Type 2 diabetes mellitus through network pharmacology.

Gene 2021 Feb 26;768:145320. Epub 2020 Nov 26.

Department of Bio-Health Convergence, College of Biomedical Science, Kangwon National University, Chuncheon 24341, South Korea. Electronic address:

Phellinus linteus (mushroom) grown on Rosa multiflora ([email protected]), exposed beneficial effect and safety on Type 2 diabetes mellitus (T2DM) from Korean folk remedies. However, its active chemical constituents and mechanism(s) against T2DM have not been confirmed. Hence, we deciphered the active compounds and mechanism(s) of [email protected] against T2DM through network pharmacology. Read More

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February 2021

Interaction of CEND1 gene and life events in susceptibility to depressive symptoms in Chinese Han college students.

J Affect Disord 2021 01 24;278:570-575. Epub 2020 Sep 24.

Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China; Shanghai Key Laboratory of Psychotic Disorders, and Brain Science and Technology Research Center, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China. Electronic address:

Background: . The development of depressive symptoms (DSs) is a complex process caused by both genetic and environmental factors. CEND1 gene coordinates cell division, differentiation and maturation of neural precursor cells, which affects brain structure and function. Read More

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January 2021

Effect of three-dimensional porosity gradients of biomimetic coatings on their bonding strength and cell behavior.

J Biomed Mater Res A 2021 05 24;109(5):615-626. Epub 2020 Jul 24.

Department of Materials Science and Engineering, University of Connecticut, Storrs, Connecticut, USA.

Surface modification techniques are often used to enhance the properties of Ti-based materials as hard-tissue replacements. While the microstructure of the coating and the quality of the interface between the substrate and coating are essential to evaluate the reliability and applicability of the surface modification. In this study, both a hydroxyapatite (HA) coating and a collagen-hydroxyapatite (Col-HA) composite coating were deposited onto a Ti-6Al-4V substrate using a biomimetic coating process. Read More

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The Identification of Key Gene Expression Signature in Prostate Cancer.

Crit Rev Eukaryot Gene Expr 2020 ;30(2):153-168

Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Prostate cancer (PCa) is one of the most common malignancies affecting men's health worldwide. The aim of this study is to identify key genes and their regulatory networks and evaluate the usefulness of these genes on diagnosis of and prognosis for prostate cancer. The gene expression microarray dataset GSE55945 was downloaded for analysis. Read More

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Identification of the Active Constituents and Significant Pathways of Cangfu Daotan Decoction for the Treatment of PCOS Based on Network Pharmacology.

Evid Based Complement Alternat Med 2020 21;2020:4086864. Epub 2020 Feb 21.

Department of Reproduction, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Zhangjiagang, Suzhou, Jiangsu, China.

Background: Polycystic ovary syndrome (PCOS) is the most common female endocrine disease. Cangfu Daotan Decoction (CDD) can effectively relieve the clinical symptoms of PCOS patients.

Methods: To explore the active ingredients and related pathways of CDD for treating PCOS, a network pharmacology-based analysis was carried out. Read More

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February 2020

Cardiovascular Risk in Women Deprived of Freedom from a Public Prison in Mato Grosso, Brazil.

High Blood Press Cardiovasc Prev 2020 Apr 7;27(2):139-150. Epub 2020 Mar 7.

Postgraduate Program in Collective Health, Federal University of Mato Grosso, Cuiabá, MT, Brazil.

Introduction: Cardiovascular diseases occur worldwide and have progressively affected the female sex, without distinction of life context; however, the prison environment may intensify the risk of developing them.

Aim: To evaluate the cardiovascular risk in women deprived of freedom from a public prison in Mato Grosso, Brazil.

Methods: This is a quantitative, cross-sectional and analytical study performed with all incarcerated women from the prison institution in the second half of the years 2016, 2017 and 2018, through a structured questionnaire and statistical analysis through the RStudio. Read More

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Regression Models Predicting the Number of Deaths from the New Coronavirus Infection.

Sovrem Tekhnologii Med 2020 ;12(2):6-11

Professor, Head of Department of Epidemiology, Microbiology and Evidence-Based Medicine, Privolozhsky Research Medical University, 10/1 Minin and Pozharsky Square, Nizhny Novgorod, 603005, Russia.

Predicting the development of epidemic infection caused by the COVID-19 coronavirus is a matter of the utmost urgency for health care and effective anti-epidemic measures. Given the rapidly changing initial information and the ambiguous quality of data coming from various sources, it is important to quickly optimize the existing prognostic models by using more sophisticated algorithms. is to test the originally developed mathematical algorithms for predicting the development of the COVID-19 epidemic process. Read More

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January 2020

Dietary Determinants of Metabolic Syndrome Parameters Differ by Gender in College Students.

Nutrients 2019 Nov 27;11(12). Epub 2019 Nov 27.

Department of Exercise and Nutrition Sciences, Weber State University, Ogden, UT 84408-2801, USA.

MyPlate is a guidance system for healthier eating choices. In this cross-sectional study, we investigated the influence of MyPlate food group consumption and exercise on metabolic syndrome (MetS) parameters in college students. Participant ( = 462) blood was analyzed using Cholestech for triglycerides (TG), glucose, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C). Read More

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November 2019

pwrEWAS: a user-friendly tool for comprehensive power estimation for epigenome wide association studies (EWAS).

BMC Bioinformatics 2019 Apr 29;20(1):218. Epub 2019 Apr 29.

Department of Biostatistics & Data Science, University of Kansas Medical Center, Kansas City, KS, USA.

Background: When designing an epigenome-wide association study (EWAS) to investigate the relationship between DNA methylation (DNAm) and some exposure(s) or phenotype(s), it is critically important to assess the sample size needed to detect a hypothesized difference with adequate statistical power. However, the complex and nuanced nature of DNAm data makes direct assessment of statistical power challenging. To circumvent these challenges and to address the outstanding need for a user-friendly interface for EWAS power evaluation, we have developed pwrEWAS. Read More

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Evaluating Google, Twitter, and Wikipedia as Tools for Influenza Surveillance Using Bayesian Change Point Analysis: A Comparative Analysis.

JMIR Public Health Surveill 2016 Oct 20;2(2):e161. Epub 2016 Oct 20.

College of Public Health and Health Professions, Department of Epidemiology, University of Florida, Gainesville, FL, United States.

Background: Traditional influenza surveillance relies on influenza-like illness (ILI) syndrome that is reported by health care providers. It primarily captures individuals who seek medical care and misses those who do not. Recently, Web-based data sources have been studied for application to public health surveillance, as there is a growing number of people who search, post, and tweet about their illnesses before seeking medical care. Read More

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October 2016

Genetic association and gene expression studies suggest that genetic variants in the SYNE1 and TNF genes are related to menstrual migraine.

J Headache Pain 2014 Oct 14;15:62. Epub 2014 Oct 14.

Genomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology, Musk Ave, Kelvin Grove, Brisbane, QLD 4059, Australia.

Background: Menstrual migraine (MM) encompasses pure menstrual migraine (PMM) and menstrually-related migraine (MRM). This study was aimed at investigating genetic variants that are potentially related to MM, specifically undertaking genotyping and mRNA expression analysis of the ESR1, PGR, SYNE1 and TNF genes in MM cases and non-migraine controls.

Methods: A total of 37 variants distributed across 14 genes were genotyped in 437 DNA samples (282 cases and 155 controls). Read More

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October 2014

Cloudgene: a graphical execution platform for MapReduce programs on private and public clouds.

BMC Bioinformatics 2012 Aug 13;13:200. Epub 2012 Aug 13.

Division of Genetic Epidemiology; Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Innsbruck, Austria.

Background: The MapReduce framework enables a scalable processing and analyzing of large datasets by distributing the computational load on connected computer nodes, referred to as a cluster. In Bioinformatics, MapReduce has already been adopted to various case scenarios such as mapping next generation sequencing data to a reference genome, finding SNPs from short read data or matching strings in genotype files. Nevertheless, tasks like installing and maintaining MapReduce on a cluster system, importing data into its distributed file system or executing MapReduce programs require advanced knowledge in computer science and could thus prevent scientists from usage of currently available and useful software solutions. Read More

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