83 results match your criteria rounds thyroid


Salvage carbon dioxide transoral laser microsurgery for laryngeal cancer after (chemo)radiotherapy: a European Laryngological Society consensus statement.

Eur Arch Otorhinolaryngol 2021 Jul 5. Epub 2021 Jul 5.

Department of Otorhinolaryngology-Head and Neck Surgery, Head, Neck and Thyroid Cancer Unit, Guy's and St Thomas Hospital NHS Foundation Trust, London, UK.

Purpose: To provide expert opinion and consensus on salvage carbon dioxide transoral laser microsurgery (CO TOLMS) for recurrent laryngeal squamous cell carcinoma (LSCC) after (chemo)radiotherapy [(C)RT].

Methods: Expert members of the European Laryngological Society (ELS) Cancer and Dysplasia Committee were selected to create a dedicated panel on salvage CO TOLMS for LSCC. A series of statements regarding the critical aspects of decision-making were drafted, circulated, and modified or excluded in accordance with the Delphi process. Read More

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Health management and care following the Fukushima nuclear power plant accident: overview of Fukushima Health Management Survey.

Authors:
Kenji Kamiya

Ann ICRP 2021 Jul 5:1466453211015402. Epub 2021 Jul 5.

Fukushima Medical University Radiation Medical Science Centre for the Fukushima Health Management Survey, 1 Hikarigaoka, Fukushima City 960-1295, Japan.

Following the accident at Fukushima Daiichi nuclear power plant, Fukushima Prefecture is conducting the Fukushima Health Management Survey, which has been contracted out to Fukushima Medical University. The purpose of this survey is to investigate the exposure doses and health conditions of the residents of Fukushima Prefecture in order to prevent, diagnose, and treat diseases at an early stage, and to maintain and improve the health of residents in the future.This survey consists of a basic survey to estimate external exposure doses and detailed surveys to investigate health conditions. Read More

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Lessons learned from conducting disease monitoring in low-dose exposure conditions as a counter-measure after a nuclear disaster.

J Radiat Res 2021 May;62(Supplement_1):i64-i70

Department of Radiation Health Management, Fukushima Medical University, Fukushima, 960-1295, Japan.

The complex disaster of the Great East Japan Earthquake and the Fukushima nuclear accident caused concern about their various health impacts. Many types of intervention are desired as a countermeasure, depending on the phase of the disaster cycle. The importance of developing and applying codes of conduct has recently been emphasized for post-disaster investigations. Read More

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A Novel Thyroid Ultrasound Proficiency Metric Designed Through a Multidisciplinary Delphi Approach.

Am Surg 2021 Apr 28:31348211011151. Epub 2021 Apr 28.

Section of Endocrine Surgery, Division of General Surgery, Department of Surgery, 2358University of Virginia, Charlottesville, VA, USA.

Background: Thyroid ultrasounds extend surgeons' outpatient capabilities and are essential for operative planning. However, most residents are not formally trained in thyroid ultrasound. The purpose of this study was to create a novel thyroid ultrasound proficiency metric through a collaborative Delphi approach. Read More

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Management of endocrine surgical disorders during COVID-19 pandemic: expert opinion for non-surgical options.

Updates Surg 2021 Apr 11. Epub 2021 Apr 11.

Department of Endocrinology and Metabolism, School of Medicine, Koc University, Istanbul, Turkey.

Purpose: The COVID-19 pandemic brought unprecedented conditions for overall health care systems by restricting resources for non-COVID-19 patients. As the burden of the disease escalates, routine elective surgeries are being cancelled. The aim of this paper was to provide a guideline for management of endocrine surgical disorders during a pandemic. Read More

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Evidence-Based Use of Levothyroxine/Liothyronine Combinations in Treating Hypothyroidism: A Consensus Document.

Eur Thyroid J 2021 Mar 16;10(1):10-38. Epub 2021 Feb 16.

Thyroid Research Group, School of Medicine, Cardiff University, Cardiff, United Kingdom.

Background: Fourteen clinical trials have not shown a consistent benefit of combination therapy with levothyroxine (LT4) and liothyronine (LT3). Despite the publication of these trials, combination therapy is widely used and patients reporting benefit continue to generate patient and physician interest in this area. Recent scientific developments may provide insight into this inconsistency and guide future studies. Read More

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Selection and characterization of an ssDNA aptamer against thyroglobulin.

Talanta 2021 Feb 28;223(Pt 1):121690. Epub 2020 Sep 28.

Key Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology, China. Electronic address:

Thyroglobulin (Tg) is a significant biomarker for the diagnose and postoperative monitoring of differentiated thyroid cancer, and its recognition is urgent due to the rising prevalence. In this study, an ssDNA aptamer against Tg was obtained by capillary electrophoresis-systematic evolution of ligands via exponential enrichment (CE-SELEX). Under the optimized conditions, the sub-library was enriched well through two selection rounds. Read More

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February 2021

Evidence-Based Use of Levothyroxine/Liothyronine Combinations in Treating Hypothyroidism: A Consensus Document.

Thyroid 2021 02;31(2):156-182

Thyroid Research Group, School of Medicine, Cardiff University, Cardiff, United Kingdom.

Fourteen clinical trials have not shown a consistent benefit of combination therapy with levothyroxine (LT4) and liothyronine (LT3). Despite the publication of these trials, combination therapy is widely used and patients reporting benefit continue to generate patient and physician interest in this area. Recent scientific developments may provide insight into this inconsistency and guide future studies. Read More

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February 2021

Longitudinal Study of Thyroid Hormones between Conventional and Organic Farmers in Thailand.

Toxics 2020 Oct 5;8(4). Epub 2020 Oct 5.

Department of Public Health, University of Massachusetts Lowell, One University Ave, Lowell, MA 01854-2867, USA.

Many pesticides are endocrine-disrupting chemicals that can interfere with hormone levels. This study aimed to assess the longitudinal impact of exposure to pesticides on thyroid hormone levels, including Thyroid Stimulating Hormone (TSH), Free Triiodothyronine (FT3), Free Thyroxine (FT4), Triiodothyronine (T3), and Thyroxine (T4). Both conventional (i. Read More

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October 2020

Barriers Against Prevention Programs for Iodine Deficiency Disorders in Europe: A Delphi Study.

Thyroid 2021 04 21;31(4):649-657. Epub 2020 Oct 21.

Department of Public Health, Health Services Research and Health Technology Assessment, Institute of Public Health, Medical Decision Making and Health Technology Assessment, UMIT-University for Health Sciences, Medical Informatics and Technology, Hall in Tirol, Austria.

Although substantial progress has been made in recent decades in eliminating iodine deficiency, iodine deficiency disorders (IDDs) are still prevalent in European countries. Challenges include ineffective public health programs and discontinuation of IDD prevention. However, the barriers against the implementation and continuation of prevention and monitoring of IDD remain unclear. Read More

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Metamorphic acceleration following the exposure to lithium and selenium on American bullfrog tadpoles (Lithobates catesbeianus).

Ecotoxicol Environ Saf 2021 Jan 6;207:111101. Epub 2020 Sep 6.

Laboratory of Conservation Physiology (LaFisC), Federal University of São Carlos, Brazil. Electronic address:

To regulate the presence of contaminants in Brazilian water, the Brazilian Environmental Council (CONAMA) promulgates regulations regarding the concentrations of given compounds that are supposed to be safe for aquatic life. Considering these regulations, this study tested the effects of considered safe levels of lithium (2.5 mgL) and selenium (0. Read More

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January 2021

Recommendations for head and neck surgical oncology practice in a setting of acute severe resource constraint during the COVID-19 pandemic: an international consensus.

Lancet Oncol 2020 07 11;21(7):e350-e359. Epub 2020 Jun 11.

Department of Otolaryngology and Head and Neck Surgery, Hôpital Européen Georges-Pompidou, Assistance Publique-Hôpitaux de Paris, Université Paris Descartes, Paris, France.

The speed and scale of the global COVID-19 pandemic has resulted in unprecedented pressures on health services worldwide, requiring new methods of service delivery during the health crisis. In the setting of severe resource constraint and high risk of infection to patients and clinicians, there is an urgent need to identify consensus statements on head and neck surgical oncology practice. We completed a modified Delphi consensus process of three rounds with 40 international experts in head and neck cancer surgical, radiation, and medical oncology, representing 35 international professional societies and national clinical trial groups. Read More

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Development of an index of complexity for outpatient endocrinology and nutrition clinics.

Endocrinol Diabetes Nutr (Engl Ed) 2020 Oct 2;67(8):500-508. Epub 2020 Jun 2.

Unidad de Endocrinología y Nutrición, Hospital Comarcal de Hellín, Hellín, Albacete, España.

Introduction: The tools for analyzing the case-mix in outpatient clinics are scarce few and unsatisfactory. The objective of this study conducted by Sociedad Castellano Manchega de Endocrinología, Nutrición y Diabetes (SCAMEND) was to develop a tool that allows for analyzing the case-mix in outpatient endocrinology and nutrition clinics, considering bearing in mind the complexity of the conditions seen.

Material And Methods: Using the Delphi method, the SCAMEND index of complexity in outpatient endocrinology and nutrition clinics (ISCCE-EyN) was developed by endocrinologists in two rounds, comparing the complexity of each condition being compared with that of a review visit of primary hypothyroidism. Read More

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October 2020

Metachronous Pancreatic and Thyroid Metastases from Primary Soft-Tissue Myoepithelioma in the Clavicular Region: A Case Report of a Long-Term Survivor.

Am J Case Rep 2020 Jan 27;21:e920702. Epub 2020 Jan 27.

Department of Gastrointestinal Surgery, Hokkaido Cancer Center, Sapporo, Hokkaido, Japan.

BACKGROUND Myoepithelioma is a rare neoplasm that differentiates toward myoepithelial cells. This condition mainly occurs in the salivary gland and rarely in the  soft tissue or internal organs. Long-term survival with repeated multiple rounds of resection for recurrence is rarely reported. Read More

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January 2020

Transoral robotic thyroidectomy versus conventional open thyroidectomy: comparative analysis of surgical outcomes using propensity score matching.

Surg Endosc 2021 01 10;35(1):124-129. Epub 2020 Jan 10.

Department of Otolaryngology - Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Background: Various approaches for thyroid surgery became possible with the use of robotic systems. Transoral robotic thyroidectomy (TORT) is one of the newest approaches and draws attention because of its cosmetic excellence. In this study, we compared the surgical outcomes of TORT and conventional open thyroidectomy (OT). Read More

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January 2021

Clinical aspects of autoimmune hypothalamitis, a variant of autoimmune hypophysitis: Experience from one center.

J Int Med Res 2020 Mar 29;48(3):300060519887832. Epub 2019 Nov 29.

Department of Endocrinology, The First Medical Center of the Chinese PLA General Hospital, Beijing, China.

Objective: Autoimmune hypothalamitis (AHT) is a rare inflammatory disorder that involves the hypothalamus. It remains unclear whether autoimmune hypophysitis (AH) and AHT represent different diseases or different aspects of the same disease. Thus, further investigation of AHT is required. Read More

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2019 European Thyroid Association Guidelines for the Treatment and Follow-Up of Advanced Radioiodine-Refractory Thyroid Cancer.

Eur Thyroid J 2019 Oct 28;8(5):227-245. Epub 2019 Aug 28.

Division of Endocrinology, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.

The vast majority of thyroid cancers of follicular origin (TC) have a very favourable outcome, but 5-10% of cases will develop metastatic disease. Around 60-70% of this subset, hence less than 5% of all patients with TC, will become radioiodine refractory (RAI-R), with a significant negative impact on prognosis and a mean life expectancy of 3-5 years. Since no European expert consensus or guidance for this challenging condition is currently available, a task force of TC experts was nominated by the European Thyroid Association (ETA) to prepare this document based on the principles of clinical evidence. Read More

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October 2019

Thyroid Incidentalomas in Association With Low-Dose Computed Tomography in the National Lung Screening Trial.

Am J Epidemiol 2020 01;189(1):27-33

Early Detection Research Branch, Division of Cancer Prevention, National Cancer Institute, Rockville, Maryland.

Advances in cancer screening methods have opened avenues for incidental findings and cancer overdiagnosis. We performed a secondary analysis of the National Lung Screening Trial (enrollment from 2002-2004), a randomized controlled trial comparing low-dose computed tomography (LDCT; n = 26,722) with chest radiography (CXR; n = 26,732) for lung cancer detection, to examine incidental findings related to thyroid cancer (ThCa). Three screening rounds were included, and median follow-up was 6. Read More

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January 2020

ENT Quality Improvement Program as a tool to improve the collection of morbidity and mortality data: a multisite audit carried out over 6 months.

BMJ Open Qual 2019 12;8(3):e000501. Epub 2019 Aug 12.

ENT, Wigan, Wrightington and Leigh, Wigan, UK.

Objective: This project aims to assess the role of a standardised process of data collection to improve morbidity and mortality data across the region.

Design: Six hospitals within the North West (UK) were recruited and adopted the ENT Quality Improvement Program (QIP) into their daily practice. Monthly anonymous data were sent back to the reviewer for trend analysis. Read More

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Association between the detection rate of thyroid cancer and the external radiation dose-rate after the nuclear power plant accidents in Fukushima, Japan.

Medicine (Baltimore) 2019 Sep;98(37):e17165

Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Computational Biology, Ingolstädter Landstr. 1, D-85764 Neuherberg, Germany.

A thyroid cancer ultrasonography screening for all residents 18 years old or younger living in the Fukushima prefecture started in October 2011 to investigate the possible effect of the radiological contamination after the Fukushima Daiichi Nuclear Power Plant accidents as of March 12 to 15, 2011. Thyroid cancer in 184 cases was reported by February 2017. The question arises to which extent those cancer cases are a biological consequence of the radiation exposure or an artefactual result of the intense screening of a large population. Read More

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September 2019

Reducing inappropriate prescribing for older adults with advanced frailty: A review based on a survey of practice in four countries.

Maturitas 2019 Aug 20;126:1-10. Epub 2019 Apr 20.

Centre for Gerontology and Rehabilitation, University College Cork, St Finbarr's Hospital, Cork City, Ireland.

The management of medications in persons with frailty presents challenges. There is evidence of inappropriate prescribing and a lack of consensus among healthcare professionals on the judicious use of medications, particularly for patients with more severe frailty. This study reviews the evidence on the use of commonly prescribed pharmacological treatments in advanced frailty based on a questionnaire of prescribing practices and attitudes of healthcare professionals at different stages in their careers, in different countries. Read More

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Small cell lung cancer with panhypopituitarism due to ectopic adrenocorticotropic hormone syndrome: A case report.

World J Clin Cases 2019 May;7(10):1177-1183

Department of Endocrinology, Zhejiang University School of Medicine Sir Run Run Shaw Hospital, Hangzhou 310016, Zhejiang Province, China.

Background: Small cell lung cancer (SCLC) accounts for 15% of lung cancers, and it commonly expresses peptide and protein factors that are active as hormones. These secreting factors manifest as paraneoplastic disorders, such as ectopic adrenocorticotropic hormone (ACTH) syndrome (EAS). The clinical features are abnormalities in carbohydrate metabolism, hypokalemia, peripheral edema, proximal myopathy, hypertension, hyperpigmentation, and severe systemic infection. Read More

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Incidence of Thyroid Cancer Among Children and Young Adults in Fukushima, Japan, Screened With 2 Rounds of Ultrasonography Within 5 Years of the 2011 Fukushima Daiichi Nuclear Power Station Accident.

JAMA Otolaryngol Head Neck Surg 2019 01;145(1):4-11

Radiation Medical Science Center for the Fukushima Health Management Survey, Fukushima Medical University, Fukushima, Japan.

Importance: Ultrasonographic (US) screening for thyroid cancer was performed in the Fukushima Health Management Survey after the 2011 Fukushima Daiichi nuclear power station accident. Clinical characteristics of thyroid cancers screened by US among children and young adults during the first 5 years after the accident were analyzed.

Objectives: To evaluate the number of detected thyroid cancers by age group within 5 years of the Fukushima Daiichi nuclear power station accident and to compare the basic clinical characteristics and demographic patterns in first- and second-round examinations. Read More

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January 2019

2018 European Thyroid Association (ETA) Guidelines on the Diagnosis and Management of Central Hypothyroidism.

Eur Thyroid J 2018 Oct 19;7(5):225-237. Epub 2018 Jul 19.

Department of Pediatric Endocrinology, Emma Children's Hospital, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.

Objectives: Central hypothyroidism (CeH) is a rare form of hypothyroidism characterized by insufficient thyroid stimulation due to disturbed pituitary and/or hypothalamic functioning. Due to its origin and the whole clinical context, CeH represents a challenging condition in clinical practice as it is characterized by suboptimal accuracy of clinical and biochemical parameters for diagnosis and management. Since no expert consensus or guidance for this condition is currently available, a task force of experts received the commitment from the European Thyroid Association (ETA) to prepare this document based on the principles of clinical evidence. Read More

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October 2018

Bougie-assisted cricothyroidotomy: Delphi-derived essential steps for the novice learner.

CJEM 2019 03 28;21(2):283-290. Epub 2018 Jun 28.

*Division of Emergency Medicine,Department of Medicine.

Objective: A cricothyroidotomy is a life-saving procedure, performed as a final option to emergency airway algorithms, and is essential for all clinicians who perform emergency airway management. The bougie-assisted cricothyroidotomy (BAC) is a novel technique that may be performed faster and with fewer complications than other traditional approaches. There is no established standard set of steps to guide the instruction of BAC performance. Read More

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False-positive radioiodine accumulation in a huge pelvic mass after thyroidectomy for papillary carcinoma, a case report from Syria.

J Surg Case Rep 2018 Feb 28;2018(2):rjy028. Epub 2018 Feb 28.

Faculty of Medicine, Surgery Department, Damascus University, Liver Surgery and Transplant Team in Al-Assad University Hospital, Damascus, Syria.

Iodine has always been connected to thyroid gland, and the fact that thyroid tissue traps, organificates and stores iodine more than other tissues is well known, hence the use of radioiodine as a diagnostic and therapeutic tool for thyroid disorders. However, false-positive cases do occur. We present a case of a 34-year-old patient who underwent total thyroidectomy for papillary carcinoma. Read More

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February 2018

Temporal and spatial expression of insulin-like peptide (insl5a and insl5b) paralog genes during the embryogenesis of Danio rerio.

J Exp Zool B Mol Dev Evol 2018 01 10;330(1):33-40. Epub 2018 Jan 10.

Dipartimento di Medicina Sperimentale, Sez. Fisiologia Umana e Funzioni Biologiche Integrate, Università degli Studi della Campania "Luigi Vanvitelli, Napoli, Italy.

Relaxin (RLN) and insulin (INSL)-like peptides are member of the INSL/RLN superfamily, which are encoded by seven genes in humans and can activate the G-protein coupled receptor RXFP 1-4. These peptides evolved from a common ancestor, RLN3-like gene. Two rounds of whole genome duplication (WGD) in early vertebrate evolution, together with an additional WGD in the teleost lineage, caused an expansion of RLN genes set in the genome of Danio rerio. Read More

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January 2018

Lessons from Fukushima: Latest Findings of Thyroid Cancer After the Fukushima Nuclear Power Plant Accident.

Thyroid 2018 01 1;28(1):11-22. Epub 2017 Dec 1.

3 Department of Radiation Molecular Epidemiology, Atomic Bomb Disease Institute, Nagasaki University , Nagasaki, Japan .

The increase in risk for late-onset thyroid cancer due to radiation exposure is a potential health effect after a nuclear power plant accident mainly due to the release of radioiodine in fallout. The risk is particularly elevated in those exposed during infancy and adolescence. To estimate the possibility and extent of thyroid cancer occurrence after exposure, it is of utmost importance to collect and analyze epidemiological information providing the basis for evaluation of radiation risk, and to consider radiobiology and molecular genetics. Read More

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January 2018

Screening specific polypeptides of breast cancer stem cells from a phage display random peptide library.

Oncol Lett 2016 Dec 13;12(6):4727-4731. Epub 2016 Oct 13.

Cancer Center, Taian Hospital, Taishan Medical College, Taian, Shandong 271000, P.R. China.

The present study aimed to identify polypeptides that specifically bond to breast cancer stem cells from a phage display random 12 peptide library, in addition to the affinity and specificity of polypeptides. A phage display random 12 peptide library was screened using breast cancer stem cells as targets isolated from the MDA-MB-231 cell line using the serum-free culture technique with hs578bst and MDA-MB-231 cells as subtract-screening cells. Positive and specific binding clones were amplified and sent for sequencing. Read More

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December 2016

Hypothalamic-Pituitary Axis Dysfunction in Survivors of Childhood CNS Tumors: Importance of Systematic Follow-Up and Early Endocrine Consultation.

J Clin Oncol 2016 12 31;34(36):4315-4319. Epub 2016 Oct 31.

Wassim Chemaitilly, Gregory T. Armstrong, Amar Gajjar, and Melissa M. Hudson, St Jude Children's Research Hospital, Memphis, TN.

The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors' suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published in Journal of Clinical Oncology, to patients seen in their own clinical practice. Read More

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December 2016