1,185 results match your criteria rop stage


Pitfalls of Advanced Retinopathy of Prematurity Presentation: A Content Analysis of Medical Records.

Risk Manag Healthc Policy 2021 16;14:3873-3882. Epub 2021 Sep 16.

Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Purpose: To identify the pitfalls in retinopathy of prematurity (ROP) screening leading to advanced disease at Ministry of Health (MOH) hospitals in Saudi Arabia.

Methods: A qualitative deductive content analysis was used to study the phenomena of defects in ROP screening. A retrospective review of medical records of newborns presenting to two tertiary eye care centers with advanced ROP (stage 4 and 5) from January 2012 to June 2019 was completed. Read More

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September 2021

Ten-Year Trend of Retinopathy of Prematurity Among Extremely Preterm Infants in One Neonatal Intensive Care Unit in China.

Front Pediatr 2021 3;9:717090. Epub 2021 Sep 3.

Department of Neonatology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.

Extremely preterm (EP) infants are at the highest risk of retinopathy of prematurity (ROP). With more EP infants survived in China, recent data of ROP is lacking. The aim of the study is to report the trend of incidence of ROP among EP infants in a large neonatal intensive care unit in China over the past 10-year period, in relation with the overall survival rate and the change of oxygen saturation targets. Read More

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September 2021

Clinical Features of Spontaneous Regression of Retinopathy of Prematurity in China: A 5-Year Retrospective Case Series.

Front Med (Lausanne) 2021 31;8:731421. Epub 2021 Aug 31.

Department of Ophthalmology, Eye Institute of Chinese PLA, Xijing Hospital, Fourth Military Medical University, Xi'an, China.

The aim of this study is to explore the clinical features of spontaneous regression of retinopathy of prematurity (ROP) in China, including fundus appearance, time course, and affecting factors. Data of pediatric patients in whom ROP spontaneously regressed without treatment were collected, including general demographics, medical history, zones and stages of ROP, and changes of fundus appearance. The fundus manifestations of spontaneous regression in ROP were systematically summarized. Read More

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Plasma levels of amino acids and derivatives in retinopathy of prematurity.

Int J Med Sci 2021 27;18(15):3581-3587. Epub 2021 Aug 27.

Department of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Retinopathy of prematurity (ROP) is a retinal disease that causes blindness in premature infants. This study aimed to reveal the changes in amino acids and derivatives in the plasma of ROP patients compared with premature infants without ROP. Metabolomics targeting amino acids and their derivatives was conducted to assess their plasma levels in ROP patients (=58) and premature infants without ROP (=25), and KEGG pathway analysis was used to identify the involved pathways. Read More

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Optimization of retinopathy of prematurity screening in a tertiary neonatal unit in Northern Greece based on 16-year data.

J Perinatol 2021 Sep 1. Epub 2021 Sep 1.

2nd Department of Ophthalmology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, "Papageorgiou" General Hospital of Thessaloniki, Thessaloniki, Greece.

Objective: The optimal modification of retinopathy of prematurity (ROP) screening policy in our unit, by tightening the applicable screening criteria, without missing treatment-requiring ROP (TR-ROP).

Study Design: Retrospective analysis of screened infants with gestational age (GA) < 32 weeks and/or birth weight (BW) < 1501 g as well as cases beyond these thresholds but with comorbidities (April 2004 to April 2020).

Result: Of 1560 included infants, 18. Read More

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September 2021

Incidence of retinopathy of prematurity treatment in extremely preterm infants in China.

Paediatr Perinat Epidemiol 2021 Sep 1. Epub 2021 Sep 1.

Children's Hospital of Fudan University, National Children's Medical Centre, Shanghai, China.

Background: Retinopathy of prematurity (ROP) continues to be a major cause of visual impairment and blindness in premature infants and children.

Objectives: To investigate the incidence of severe ROP receiving treatment in extremely preterm (EP) infants in China over time. The risk factors for ROP treatment were also assessed. Read More

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September 2021

Immediate Sequential Bilateral Vitrectomy Surgery for Retinopathy of Prematurity: A Single Surgeon Experience

Turk J Ophthalmol 2021 08;51(4):225-230

Gazi University Faculty of Medicine, Department of Anesthesiology and Reanimation, Ankara, Turkey

Objectives: We report the safety and efficacy of simultaneous bilateral vitrectomy for stage 4 and stage 5 retinopathy of prematurity (ROP).

Materials And Methods: Babies who had immediate sequential bilateral vitrectomy surgery for stage 4 or stage 5 ROP were included in this retrospective study. Clinical history, demographic characteristics of the patients, surgical procedure details, perioperative and postoperative ophthalmic and systemic complications, and postoperative anatomical success rates were evaluated. Read More

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Non-metal with metal behavior: metal-free coordination-insertion ring-opening polymerization.

Chem Sci 2021 Aug 15;12(32):10732-10741. Epub 2021 Jun 15.

State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University 30 Puzhu Road South Nanjing 211816 China

The "coordination-insertion" ring-opening polymerization (ROP) mechanism has so far been the monopoly of metal catalysts. In this work, we present a metal-free "coordination-insertion" ROP of trimethylene carbonate (TMC) and -caprolactone (ε-CL), as well as their sequential block copolymerization, with -trimethylsilyl-bis (trifluoromethanesulfonyl)imide (TMSNTf) as the non-metallic initiator/catalyst. TMSNTf was proposed to work through an unprecedented metal-free "coordination-insertion" mechanism, which involves the coordination of monomer to the Si atom of TMSNTf, the nucleophilic attack of the -NTf group on the coordinated monomer, and the cleavage of the acyl-oxygen bond of the monomer. Read More

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The possible effect of pentoxifylline on development and severity of retinopathy of prematurity.

Cutan Ocul Toxicol 2021 Sep 14:1-6. Epub 2021 Sep 14.

Department of Neonatology, Kanuni Sultan Suleyman Training and Research Hospital, İstanbul, Turkey.

Background And Aim: Retinopathy of prematurity (ROP) is the major ocular problem of preterm infants that occurs with abnormal proliferation of immature retinal vessels. Although pentoxifylline (PTX) was reported to inhibit vasculogenesis and neovascularization in experimental studies, there is no clinical data about the effects of PTX treatment on the development and severity of ROP. This clinical study aimed to investigate the possible effects of PTX on the development of ROP. Read More

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September 2021

Erythropoietin is not a risk factor for severe retinopathy of prematurity among high risk preterm infants.

Early Hum Dev 2021 Aug 8;161:105440. Epub 2021 Aug 8.

Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, California, United States of America.

Background: Retinopathy of prematurity (ROP) is a developmental retinal vaso-proliferative disease and a leading cause of blindness in children. Early gestational age, low birth weight and unregulated oxygen exposure are the main risk factors for the development of ROP. There are conflicting reports of a possible association between recombinant Erythropoietin (rhEPO) use and an increased risk for the development of ROP. Read More

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Outcomes of very preterm infants with neonatal hyperglycaemia: a systematic review and meta-analysis.

Arch Dis Child Fetal Neonatal Ed 2021 Jul 30. Epub 2021 Jul 30.

Neonatology, King Edward Memorial Hospital for Women, Subiaco, Western Australia, Australia.

Objective: To explore the association between hyperglycaemia and adverse outcomes in very preterm infants.

Design: Systematic review and meta-analysis. Data were pooled separately for adjusted and unadjusted odds ratios (ORs) using random-effects model. Read More

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Study protocol for a multicentre, open-label, single-arm phase I/II trial to evaluate the safety and efficacy of ripasudil 0.4% eye drops for retinopathy of prematurity.

BMJ Open 2021 07 27;11(7):e047003. Epub 2021 Jul 27.

Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Introduction: Retinopathy of prematurity (ROP) is a vascular proliferative disorder that occurs in preterm infants. Existing treatments are only indicated in severe ROP cases due to the high invasiveness and the potential risk of irreversible side effects. We previously elucidated that ripasudil, a selective inhibitor of the Rho-associated protein kinase, has the ability to inhibit abnormal retinal neovascularisation in animal models. Read More

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Atypical Late-Onset Exudative Retinal Detachment in a Treatment-Naïve Infant With Retinopathy of Prematurity.

Ophthalmic Surg Lasers Imaging Retina 2021 Jul 1;52(7):403-406. Epub 2021 Jul 1.

A male infant born at 23 weeks gestation with a birthweight of 660 grams presented with retinopathy of prematurity (ROP) that began progressing at 44 weeks. He subsequently developed Zone III, Stage 3, pre-plus disease in both eyes (OU), as well as scattered exudates in the macula, dragged vessels temporally, and an exudative retinal detachment temporally in the left eye after a period of regressing and stable ROP. After bilateral laser photocoagulation, there was regression of the neovascularization, resolution of the exudative detachment, and eventual stabilization of disease OU by 12 months postmenstrual age. Read More

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Retinopathy of prematurity screening and retinal hemorrhages - Our experience among Indian babies.

Indian J Ophthalmol 2021 08;69(8):2147-2150

Minto Regional Institute of Ophthalmology, Bangalore Medical College and Research Institute, Bangalore, Karnataka, India.

Purpose: To evaluate the clinical characteristics of intraocular hemorrhages among babies screened for retinopathy of prematurity (ROP) and thereby their additional risk to the progression of ROP.

Methods: A descriptive study was conducted at a tertiary referral hospital, which included 108 eyes of 60 neonates who were discovered to have retinal hemorrhages on retinal screening of 540 babies at risk for ROP. Maternal, obstetric, and neonatal risk factors were assessed in neonates with retinal hemorrhages. Read More

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Five-year demographic profile of retinopathy of prematurity at a tertiary care institute in North India.

Indian J Ophthalmol 2021 08;69(8):2127-2131

Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Purpose: The purpose of this study is to study the demographic profile and pattern of retinopathy of prematurity (ROP) at a tertiary care institute in India.

Methods: An ambispective study from January 2013 to December 2017. Infants with birth weights (BWs) <1750 g and gestational ages <34 weeks were screened for ROP. Read More

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Retinopathy of Prematurity: Advances in the Screening and Treatment of Retinopathy of Prematurity Using a Single Center Approach.

Am J Ophthalmol 2021 Jul 20. Epub 2021 Jul 20.

Murray Oncology and Retina, 6705 Red Road, Suite 412, South Miami, FL, 33143.

Purpose: To focus on the longitudinal evaluation of high-risk infants for the development of retinopathy of prematurity (ROP) at a single tertiary neonatal intensive care unit (NICU) and to evaluate evolving demographics of ROP and the transition of treatment-warranted disease.

Methods: Consecutive retrospective review was performed of all infants screened for ROP between 1990 and 2019 at the Jackson Memorial Hospital neonatal intensive care unit. All inborn infants meeting a birth criteria of <32 weeks gestational age (GA) or a birthweight (BW) of 1500 grams were included. Read More

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Risk Factors for Retinopathy of Prematurity in the Netherlands: A Comparison of Two Cohorts.

Neonatology 2021 22;118(4):462-469. Epub 2021 Jul 22.

Wilhelmina Children's Hospital, Utrecht, The Netherlands.

Introduction: Retinopathy of prematurity (ROP) remains an important cause for preventable blindness. Aside from gestational age (GA) and birth weight, risk factor assessment can be important for determination of infants at risk of (severe) ROP.

Methods: Prospective, multivariable risk-analysis study (NEDROP-2) was conducted, including all infants born in 2017 in the Netherlands considered eligible for ROP screening by pediatricians. Read More

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September 2021

Fundus fluorescein angiography in retinopathy of prematurity.

Eye (Lond) 2021 Jul 21. Epub 2021 Jul 21.

Department of Neonatology, Government Medical College and Hospital, Chandigarh, India.

Background/objectives: Retinopathy of prematurity (ROP) is a potentially blinding disease of immature retinal vasculature. ROP regresses in majority of the cases and very few go on to develop ROP needing treatment. Fundus fluorescein angiography (FFA) is the gold standard technique to study retinal vasculature. Read More

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Evolving outcomes of surgery for retinal detachment in retinopathy of prematurity: the need for a national service in the United Kingdom : An audit of surgery for acute tractional retinal detachment complicating ROP in the UK.

Eye (Lond) 2021 Jul 21. Epub 2021 Jul 21.

Oxford Eye Hospital, John Radcliffe Hospital, Oxford, UK.

Objectives: To audit the structural and functional outcomes of surgery for acute tractional retinal detachment due to retinopathy or prematurity between 2004 and 2014 in Oxford UK.

Methods: Consecutive operations were identified from a surgical log. Clinical data including demography, perioperative data, and retinal outcomes were extracted into a spreadsheet and compared against two international data sets referenced in the method section. Read More

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Effects of Early Treatment of Retinopathy of Prematurity at a Tertiary Care Hospital in Saudi Arabia: A Retrospective Study.

J Pediatr Ophthalmol Strabismus 2021 Jul-Aug;58(4):240-245. Epub 2021 Jul 1.

Purpose: To estimate the prevalence of retinopathy of prematurity (ROP) among high-risk neonates and to illuminate the benefits of early treatment in type 2 ROP (zone II, stage 3 without plus) and ROP milder than type 1 with pre-plus disease (zone III, stage 3).

Methods: This retrospective cross-sectional study was conducted among 307 high-risk neonates (614 eyes) with a gestational age of 32 weeks or younger at birth and a birth weight of 1,500 g or less, from 2011 to 2016. Treatment was initiated for neonates with low-risk type 2 ROP and ROP milder than type 1 with pre-plus disease, whenever retinopathy was evident for 3 clock hours with or without vitreous hemorrhage. Read More

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An experimental investigation into the borehole drilling and strata characteristics.

PLoS One 2021 20;16(7):e0253663. Epub 2021 Jul 20.

Key Laboratory of Deep Coal Resource Mining, Ministry of Education of China, School of Mines, China University of Mining and Technology, Xuzhou, China.

Measurement while drilling is an important part of the intelligent development of coal mines. The main purpose of this paper is to comprehensively analyze the response characteristics of borehole drilling parameters and find a better method to predict rock mechanical properties based on drilling parameters. Firstly, six concrete blocks and multiple specimens were prepared with different material ratios. Read More

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Early Postnatal Oxygen Exposure Predicts Choroidal Thinning in Neonates.

Invest Ophthalmol Vis Sci 2021 07;62(9):23

Department of Pediatrics, Division of Neonatology and Developmental Biology, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, United States.

Purpose: To evaluate whether choroidal thickness (CT) using arm-mounted optical coherence tomography (OCT) in infants screened for retinopathy of prematurity (ROP) correlates with oxygen exposure in neonates.

Methods: OCT images were obtained in infants screened for ROP in a single level IV neonatal intensive care unit. CT was measured at three different locations: the subfoveal center and 1. Read More

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International Classification of Retinopathy of Prematurity, Third Edition.

Ophthalmology 2021 Oct 8;128(10):e51-e68. Epub 2021 Jul 8.

Department of Pediatric Retina, Narayana Nethralaya Eye Institute, Bangalore, Karnataka, India.

Purpose: The International Classification of Retinopathy of Prematurity is a consensus statement that creates a standard nomenclature for classification of retinopathy of prematurity (ROP). It was initially published in 1984, expanded in 1987, and revisited in 2005. This article presents a third revision, the International Classification of Retinopathy of Prematurity, Third Edition (ICROP3), which is now required because of challenges such as: (1) concerns about subjectivity in critical elements of disease classification; (2) innovations in ophthalmic imaging; (3) novel pharmacologic therapies (e. Read More

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October 2021

Assistive Framework for Automatic Detection of All the Zones in Retinopathy of Prematurity Using Deep Learning.

J Digit Imaging 2021 Aug 8;34(4):932-947. Epub 2021 Jul 8.

Symbiosis Centre for Applied Artificial Intelligence (SCAAI), Symbiosis International (Deemed) University, Pune, India.

Retinopathy of prematurity (ROP) is a potentially blinding disorder seen in low birth weight preterm infants. In India, the burden of ROP is high, with nearly 200,000 premature infants at risk. Early detection through screening and treatment can prevent this blindness. Read More

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An Observational Study of Different Treatment Practices for Aggressive Posterior Retinopathy of Prematurity.

J Pediatr Ophthalmol Strabismus 2021 Jun 1:1-7. Epub 2021 Jun 1.

Purpose: To evaluate risk factors and outcomes of preferred practice for infants with aggressive posterior retinopathy of prematurity (APROP) at a tertiary eye center in India.

Methods: This was an observational study of infants with APROP where patients were divided into three groups after 2 weeks of initial treatment depending on the treatment received: anti-VEGF only, laser only, and combination of anti-VEGF injection followed by laser within 2 weeks of anti-VEGF injection (combined group). All infants were evaluated for risk factors and followed up at 1, 2, 4, 8, and 12 weeks to determine treatment outcomes in terms of regression, vascular re-growth, progression, and recurrence of the disease. Read More

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Clinical Features and Outcomes of Infants with Retinopathy of Prematurity Who Fail Anti-VEGF Therapy.

Retina 2021 Jun 25. Epub 2021 Jun 25.

Emory Eye Center, 1365B Clifton Road, Atlanta, GA 30322.

Purpose: To describe characteristics and outcomes of patients with retinopathy of prematurity (ROP) who failed intravitreal anti-VEGF.

Methods: A retrospective case series of 211 eyes (112 patients) treated with anti-VEGF as initial therapy for ROP at a single academic institution between 2011-2019, and an additional 6 eyes (3 patients) referred to us for management of failed anti-VEGF.

Results: Among 211 eyes receiving initial treatment at our institution, 17 (11%) failed. Read More

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[Pathogenetically oriented approach to prevention of retinopathy of prematurity (experimental study)].

Vestn Oftalmol 2021 ;137(3):26-31

Helmholtz National Medical Research Center of Eye Diseases, Moscow, Russia.

Intraperitoneal injections of exogenous melatonin during the development of the retinal vascular system in experimental rats has been shown in a number of experimental studies on the model of EROP to prevent the appearance of histological signs of the development of experimental retinopathy of prematurity (EROP), stabilize the blood-retinal barrier and have a pronounced antioxidant effect, but pathogenetic basis for these phenomena hasn't been studied.

Purpose: To study the influence mechanism of melatonin and its analogues on the development of EROP at the preclinical stage of the pathological process to substantiate new approaches to prevention of ROP.

Material And Methods: The study included 42 Wistar rat pups (84 eyes) divided into 6 groups: control group, experimental group (rat pups with EROP), experimental groups who underwent injections of melatonin and its analogues K-148, AL-3, K-096. Read More

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Clinical Characteristics of Preterm Neonates with Aggressive Posterior Retinopathy of Prematurity.

Clin Ophthalmol 2021 1;15:2263-2277. Epub 2021 Jun 1.

Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt.

Purpose: We aimed to identify the risk factors that may predispose preterm neonates to develop aggressive posterior retinopathy of prematurity (APROP).

Methods: This retrospective case control study included 16 infants with APROP in zone 1 or posterior zone 2. Thirty-four gestational age and birth weight-matched controls with stage 2 or less ROP were included. Read More

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Incidence and Risk Factors Associated with Retinopathy of Prematurity in Peru.

Clin Ophthalmol 2021 24;15:2141-2148. Epub 2021 May 24.

Human Medicine School, Peruvian Union University (UPeU), Lima, Peru.

Purpose: The purpose of this research is to determine retinopathy of prematurity (ROP) prevalence and possible risk factors associated with ROP development in newborns admitted to a neonatal unit of a Peruvian National Reference Hospital.

Patients And Methods: This retrospective study included 216 preterm infants. The data were collected between January 2016 and December 2018. Read More

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Bilateral Retinoblastoma Presenting in an in vitro Fertilization Infant with Retinopathy of Prematurity.

Case Rep Ophthalmol 2021 Jan-Apr;12(1):306-310. Epub 2021 Apr 30.

Department of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.

Retinopathy of prematurity (ROP) and retinoblastoma (RB) are well-described entities in premature babies. Although their pathogeneses are different, with ROP representing a disorder of interrupted development and RB a genetic disease, a few co-occurring cases have been reported, raising the possibility that the 2 conditions. Here, we report the sixth such case of co-occurring ROP and RB in an 8-month-old infant conceived by in vitro fertilization (IVF) who developed bilateral retinoblastoma a few months after treatment for advanced-stage ROP. Read More

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