26 results match your criteria rop infancy

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Ophthalmologic outcome of premature infants with or without retinopathy of prematurity at 5-6 years of age.

J Family Med Prim Care 2020 Sep 30;9(9):4582-4586. Epub 2020 Sep 30.

Nurse in Yahyanejad Hospital, Babol University of Medical Sciences, Babol, Iran.

Purpose: Vision is the main source of sensory information to the brain in most species of living and human beings and is one of the most important senses for the normal physical and mental development of children. Retinopathy of Prematurity (ROP) is one of the leading causes of blindness and visual impairment worldwide. Refractive errors such as myopia, astigmatism, and anisometropia are common in premature infants with or without ROP. Read More

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September 2020

Late-Onset Retinal Findings and Complications in Untreated Retinopathy of Prematurity.

Ophthalmol Retina 2020 06 24;4(6):602-612. Epub 2019 Dec 24.

Retina and Vitreous of Texas, Houston, Texas. Electronic address:

Purpose: To investigate late retinal findings and complications of eyes with a history of retinopathy of prematurity (ROP) that did not meet treatment criteria and did not receive treatment during infancy.

Design: Retrospective, nonconsecutive, noncomparative, multicenter case series.

Participants: Three hundred sixty-three eyes of 186 patients. Read More

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Ocular Hypertension in Adults with a History of Prematurity.

Ophthalmol Retina 2018 06 1;2(6):629-635. Epub 2017 Dec 1.

Associated Retinal Consultants P.C., Royal Oak, Michigan; Oakland University William Beaumont School of Medicine, Department of Ophthalmology, Royal Oak, Michigan. Electronic address:

Purpose: To determine the ocular hypertension (OHT) incidence in patients with a history of prematurity and the effect of intervention for acute retinopathy of prematurity (ROP) in infancy on OHT incidence.

Design: Retrospective case series at a single tertiary referral vitreoretinal practice.

Participants: A total of 407 eyes of 213 patients were included, with ROP stage 0 to 5. Read More

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Type of Re-Hospitalization and Association with Neonatal Morbidities in Infants of Very Low Birth Weight.

Neonatology 2019 25;115(4):292-300. Epub 2019 Feb 25.

Women and Children's Health Research Unit, Gertner Institute for Epidemiology and Health Policy Research, Tel Hashomer, Israel.

Background: Preterm infants are at high risk for long-term morbidities and an increased rate of re-hospitalization.

Objective: The aim of this study was to evaluate the type of re-hospitalization of very low birth weight (VLBW) infants, from infancy through adolescence, and to assess the association of neonatal morbidities with specific types of re-hospitalization.

Study Design: The study cohort comprised 6,385 VLBW infants who were registered with the Maccabi Healthcare Services (MHS) from their birth hospitalization. Read More

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December 2019

Rapid neuroadaptation to surgically-induced aniseikonia in a 17-year-old patient with high preoperative anisometropia: A case report.

Am J Ophthalmol Case Rep 2018 Mar 10;9:75-76. Epub 2018 Jan 10.

Loma Linda University Eye Institute, Department of Ophthalmology, Loma Linda University, Loma Linda CA, USA.

Purpose: To report a case of rapid neuroadaptation to surgically-induced aniseikonia in a 17-year-old with preoperative anisometropia of 9.5 D.

Observations: A 17-year-old female with a history of retinopathy of prematurity (ROP) and progressive high myopia with resulting anisometropia secondary to conventional laser photocoagulation in her right eye was found to have diplopia after undergoing cataract surgery in that eye. Read More

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Children with blindness - major causes, developmental outcomes and implications for habilitation and educational support: a two-decade, Swedish population-based study.

Acta Ophthalmol 2018 May 23;96(3):295-300. Epub 2017 Nov 23.

Gillberg Neuropsychiatry Centre, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden.

Purpose: The aim was to describe the population of children with congenital or early infancy blindness in Sweden, with regard to causes of blindness and prevalence of neurodevelopmental impairments.

Methods: Medical, psychological and pedagogical records of Swedish children with congenital or early infancy blindness (total blindness or light perception at the most) born in 1988-2008 were analysed regarding year of birth, gender, cause of blindness, gestational age, associated neurological disorders/syndromes, associated neurodevelopmental impairments, cognitive level and type of school placement.

Results: A total of 150 individuals, 80 girls and 70 boys, were identified, corresponding to a prevalence of 7/100 000. Read More

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Bilateral large subconjunctival haemorrhages unmasking immune thrombocytopenic purpura during retinopathy of prematurity screening.

BMJ Case Rep 2017 Oct 4;2017. Epub 2017 Oct 4.

All India Institute of Medical Sciences, Dr Rajendra Prasad Centre for Ophthalmic Sciences, New Delhi, Delhi, India.

Although thrombocytopenia is known to be associated with pathogenesis of retinopathy of prematurity (ROP), immune thrombocytopenic purpura (ITP) is rare in infancy and not reported to occur with ROP. A preterm infant with aggressive posterior ROP developed bilateral massive subconjunctival haemorrhage after scleral indentation during screening. On evaluation, the infant was found to have severe ITP. Read More

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October 2017

Retinal, visual, and refractive development in retinopathy of prematurity.

Eye Brain 2016 20;8:103-111. Epub 2016 May 20.

Department of Ophthalmology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.

The pivotal role of the neurosensory retina in retinopathy of prematurity (ROP) disease processes has been amply demonstrated in rat models. We have hypothesized that analogous cellular processes are operative in human ROP and have evaluated these presumptions in a series on non-invasive investigations of the photoreceptor and post-receptor peripheral and central retina in infants and children. Key results are slowed kinetics of phototransduction and deficits in photoreceptor sensitivity that persist years after ROP has completely resolved based on clinical criteria. Read More

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Allocentric Spatial Performance Higher in Early-Blind and Sighted Adults Than in Retinopathy-of-Prematurity Adults.

Perception 2016 Mar 1;45(3):281-99. Epub 2015 Oct 1.

Department of Psychology, University of Toronto at Scarborough, ON, Canada.

The question as to whether people totally blind since infancy process allocentric or external spatial information like the sighted has caused considerable debate within the literature. Due to the extreme rarity of the population, researchers have often included individuals with retinopathy of prematurity (RoP--over oxygenation at birth) within the sample. However, RoP is inextricably confounded with prematurity per se. Read More

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Efficacy and safety of phenylephrine 2.5% with cyclopentolate 0.5% for retinopathy of prematurity screening in 1246 eye examinations.

Eur J Ophthalmol 2015 May-Jun;25(3):249-53. Epub 2014 Nov 14.

Royal Berkshire Hospital, Reading and King Edward VII Hospital, Windsor - UK.

Purpose: Retinopathy of prematurity (ROP) is a leading cause of visual loss in infancy that is largely preventable with careful screening. We report the safety and efficacy of the use of phenylephrine 2.5% and cyclopentolate 0. Read More

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Spinocerebellar ataxia type 13 mutation that is associated with disease onset in infancy disrupts axonal pathfinding during neuronal development.

Dis Model Mech 2012 Nov 26;5(6):921-9. Epub 2012 Jun 26.

Department of Physiology, University of California at Los Angeles, Los Angeles, CA 90095-1751, USA.

Spinocerebellar ataxia type 13 (SCA13) is an autosomal dominant disease caused by mutations in the Kv3.3 voltage-gated potassium (K(+)) channel. SCA13 exists in two forms: infant onset is characterized by severe cerebellar atrophy, persistent motor deficits and intellectual disability, whereas adult onset is characterized by progressive ataxia and progressive cerebellar degeneration. Read More

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November 2012

Refractive outcome of premature infants with or without retinopathy of prematurity at 2 years of age: a prospective controlled cohort study.

Kaohsiung J Med Sci 2012 Apr 12;28(4):204-11. Epub 2012 Feb 12.

Institute of Biophotonics, National Yang Ming University, Department of Ophthalmology, Taipei City Hospital, Taipei, Taiwan.

This study evaluated the extent to which refractive morbidity is correlated to preterm birth or retinopathy of prematurity (ROP) itself, or both, and examined the risk factors associated with refractive errors in a cohort of preterm infants with and without ROP compared with full-term infants. This longitudinal, prospective, controlled cohort study enrolled 109 infants, including 74 preterm and 35 full-term infants. Infants were divided into the following groups: no ROP, regressed ROP, laser-treated threshold ROP, and full-term. Read More

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[Diode laser photocoagulation of retinopathy of prematurity].

Arch Soc Esp Oftalmol 2011 Nov 1;86(11):368-73. Epub 2011 Oct 1.

Servicio de Oftalmología, Hospital Virgen del Rocío, Sevilla, España.

Objective: To describe diode laser photocoagulation results in retinopathy of prematurity (ROP) in our hospital.

Material And Method: Retrospective cross-sectional study based on clinical histories of the premature infants treated during the period from 2004 to 2008.

Results: In the treated group we found a predominance of pre-threshold retinopathy versus threshold retinopathy (84. Read More

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November 2011

Dynamics of human foveal development after premature birth.

Ophthalmology 2011 Dec 21;118(12):2315-25. Epub 2011 Sep 21.

Department of Ophthalmology, Duke University School of Medicine, Durham, North Carolina 27710, USA.

Purpose: To determine the dynamic morphologic development of the human fovea in vivo using portable spectral domain-optical coherence tomography (SD-OCT).

Design: Prospective, observational case series.

Participants: Thirty-one prematurely born neonates, 9 children, and 9 adults. Read More

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December 2011

Lack of association of genetic polymorphisms of angiotensin-converting enzyme gene I/D and glutathione-S-transferase enzyme T1 and M1 with retinopathy of prematures.

Genet Mol Res 2010 Oct 26;9(4):2131-9. Epub 2010 Oct 26.

Department of Ophthamology, Uludag University, Medical Faculty, Bursa, Turkey.

One of the most frequently observed causes of blindness in infancy is the pathogenesis known as retinopathy of prematurity (ROP). Angiotensin-converting enzyme (ACE) is a vital enzyme in the renin-angiotensin-aldosterone system; it is involved in the development of cardiovascular system diseases linked to I/D polymorphism of the ACE gene. Glutathione-S-transferase enzyme (GST) is one of the most important regulating components of the antioxidant system; there are indications that certain polymorphisms of GST genes (GSTT1, GSTM1), especially the null genotypes, increase the tendency for oxidative stress diseases. Read More

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October 2010

An analysis of neonatal risk factors associated with the development of ophthalmologic problems at infancy and early childhood: a study of premature infants born at or before 32 weeks of gestation.

J Pediatr Ophthalmol Strabismus 2010 Nov-Dec;47(6):331-7. Epub 2010 Feb 23.

Department of Pediatrics, Gulhane Military Medical Academy, Ankara, Turkey.

Background: To determine the frequency of ophthalmologic problems and the risk factors that affect the occurrence of these problems in premature newborns with a gestational age of 32 weeks or less.

Methods: Premature newborns observed at a neonatal intensive care unit between January 2002 and March 2006 were included. A control visit including an ophthalmologic examination was performed at 10 months of age or later. Read More

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December 2013

Cost-utility analysis of screening and laser treatment of retinopathy of prematurity.

J AAPOS 2009 Apr;13(2):186-90

Department of Ophthalmology, Loma Linda University, Loma Linda, California 92354, USA.

Purpose: Retinopathy of prematurity (ROP) is a major cause of lifelong blindness beginning in infancy. Utility analysis is used to describe the effect of illness and medical intervention on an individual's quality of life during the course of a lifetime. In this study, cost-utility analysis is used to evaluate the cost-effectiveness of both screening and laser photoablation for ROP. Read More

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Severe visual impairment in children with mild or moderate retinal residua following regressed threshold retinopathy of prematurity.

J AAPOS 2007 Apr;11(2):148-152

Dean A. McGee Eye Institute, Department of Ophthalmology, University of Oklahoma, Oklahoma City, Oklahoma, USA.

Purpose: To describe clinical features of patients from the Cryotherapy for Retinopathy of Prematurity (CRYO-ROP) trial who, after developing severe ROP in infancy, had minimal or moderate retinal residua in at least one eye but a visual acuity of worse than 20/200 in both eyes at the 10 year examination.

Methods: Data from the 10 year CRYO-ROP Trial follow-up exams were evaluated to identify all patients with retinal outcomes of no retinopathy of prematurity (ROP) residua, straightened temporal vessels, or macular heterotopia in at least one eye, but visual acuity less than 20/200 in both eyes. Presence of optic atrophy, nystagmus, and optic disk cupping and developmental survey results were examined. Read More

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Early ametropia and rod photoreceptor function in retinopathy of prematurity.

Optom Vis Sci 2005 Apr;82(4):307-17

Department of Ophthalmology, Children's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.

Purpose: Early ametropia, particularly myopia, is frequent in children with a history of preterm birth and retinopathy of prematurity (ROP). The retina is known to govern eye growth and refractive development. We tested the hypothesis that deficits in retinal function are significantly associated with early ametropia in ROP subjects. Read More

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Neonatal complications following preterm birth.

BJOG 2003 Apr;110 Suppl 20:8-16

Division of Neonatology, University of Utah, Utah, Salt Lake City 84132, USA.

Improvements in neonatal intensive care during the last 20 years have increased the survival of the most immature newborns at 23 weeks from 0% to 65% at some centres, although rates vary widely among neonatal care centres. University of Utah, USA data show that each week in utero after week 23 raises survival by 6-9%, to 90% by 27-28 weeks and 95% by 33 weeks. Provision of care in specialised centres to provide high-risk obstetric and neonatal intensive care, prenatal treatment with corticosteroids, postnatal treatment with surfactant and nitric oxide, and improvements in respirators and equipment to care for extremely immature infants all contribute to these changes. Read More

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Multicenter trial of cryotherapy for retinopathy of prematurity. Snellen visual acuity and structural outcome at 5 1/2 years after randomization.


Arch Ophthalmol 1996 Apr;114(4):417-24

Casey Eye Institute, Oregon Health Sciences University, Portland, OR, USA.

Objective: To evaluate outcome at 5 1/2 years after randomization in eyes that underwent cryotherapy and in control eyes of patients in the Multicenter Trial of Cryotherapy for Retinopathy of Prematurity.

Design: During infancy, patients with bilateral threshold retinopathy of prematurity (ROP) were assigned to receive cryotherapy for one eye and no cryotherapy for the other eye. Those with threshold ROP in only one eye (asymmetric) were randomly assigned to cryotherapy or no cryotherapy for that eye. Read More

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The course of myopia in children with mild retinopathy of prematurity.

Vision Res 1995 May;35(9):1329-35

Department of Ophthalmology, Children's Hospital, Boston, MA 02115, USA.

The courses of spherical equivalent in patients (n = 62) who had mild, non-cicatricial retinopathy of prematurity (ROP), and in those without a history of ROP (n = 25) were modeled as a linear function of age; an exponential model was also considered. A few (n = 5) without ROP have abnormal courses characterized by hyperopia in early infancy; none have poor acuity. Although the majority of patients with ROP have courses indistinguishable from those of term born controls, 27 (43. Read More

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Cryotherapy for retinopathy of prematurity. International perspectives and some recommendations for treatment.

T Flage

Acta Ophthalmol Suppl 1993 (210):66-7

Department of Ophthalmology, National Hospital, University of Oslo, Norway.

Retinopathy of prematurity (ROP) is a leading cause of severe visual impairment and blindness in infancy. Transscleral cryotherapy has been shown to be effective in arresting the progression of ROP into the sight-threatening fibrovascular stages of the disease. It is currently recommended that all eyes reaching 'threshold' ROP should be treated. Read More

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Fundus hemorrhages in infancy.

B Kaur D Taylor

Surv Ophthalmol 1992 Jul-Aug;37(1):1-17

Hospitals for Sick Children, London, England.

The anatomical location and appearance of retinal hemorrhages in the infant provide important clues in the diagnosis of underlying disorders. While neonatal retinal hemorrhages related to birth trauma are common, benign, and self-limited, other retinal hemorrhages in infancy may signify intracranial aneurysms, accidental or non-accidental injury, and a variety of ocular (e.g. Read More

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September 1992

Visual field development in infants with stage 3 retinopathy of prematurity.

Invest Ophthalmol Vis Sci 1989 Mar;30(3):580-2

Department of Psychology, University of Pittsburgh, PA 15260.

Binocular visual field development was measured in 11 infants who had stage 3 ROP in early infancy and in 11 infants without ROP, matched for birthweight and gestational age. Kinetic perimetry was used to measure visual fields along the 45 degree, 135 degree, 225 degree and 315 degree half-meridia. Infants were tested at 4, 9, and 18 months from due date. Read More

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[Perinatal events and handicaps].

C Corchia

Pediatr Med Chir 1986 Jul-Aug;8(4):461-70

It is difficult to assess how large is the proportion of handicap in the pediatric age related to perinatal events; this is mainly due to the following reasons: lack of uniform criteria and accuracy in defining both "handicap" and the "perinatal period"; variable involvement of perinatal factors in the genesis of the different types of impairment; and multifactorial origin of most sensory, neural and developmental damages. For the same reasons it is no easy to assess if handicaps of perinatal origin are declining or increasing with time. Cerebral palsy (CP), retinopathy of prematurity (ROP), deafness and relational problems are probably the clinical conditions most strictly related to perinatal events, tough recently biological and familial prenatal factors have also been proposed as important antecedents of CP. Read More

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