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Determinants of early antibody responses to COVID-19 mRNA vaccines in a cohort of exposed and naïve healthcare workers.

EBioMedicine 2022 Jan 11;75:103805. Epub 2022 Jan 11.

ISGlobal, Hospital Clínic, Universitat de Barcelona, Barcelona, Catalonia, Spain; CIBER de Enfermedades Infecciosas, Madrid, Spain. Electronic address:

Background: Two doses of mRNA vaccination have shown >94% efficacy at preventing COVID-19 mostly in naïve adults, but it is not clear if the second dose is needed to maximize effectiveness in those previously exposed to SARS-CoV-2 and what other factors affect responsiveness.

Methods: We measured IgA, IgG and IgM levels against SARS-CoV-2 spike (S) and nucleocapsid (N) antigens from the wild-type and S from the Alpha, Beta and Gamma variants of concern, after BNT162b2 (Pfizer/BioNTech) or mRNA-1273 (Moderna) vaccination in a cohort of health care workers (N=578). Neutralizing capacity and antibody avidity were evaluated. Read More

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January 2022

Alleviative mechanisms of silicon solubilizing Bacillus amyloliquefaciens mediated diminution of arsenic toxicity in rice.

J Hazard Mater 2022 Jan 3;428:128170. Epub 2022 Jan 3.

Division of Microbial Technology, CSIR-National Botanical Research Institute, RanaPratapMarg, Lucknow 226 001, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India. Electronic address:

Silicon (Si) has gained considerable attention for its utility in improved plant health under biotic and abiotic stresses through alteration of physiological and metabolic processes. Its interaction with arsenic (As) has been the compelling area of research amidst heavy metal toxicity. However, microbe mediated Si solubilization and their role for reduced As uptake is still an unexplored domain. Read More

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January 2022

Magnesium-regulated oxygen vacancies of cobalt-nickel layered double hydroxide nanosheets for ultrahigh performance asymmetric supercapacitors.

J Colloid Interface Sci 2021 Dec 29;612:772-781. Epub 2021 Dec 29.

School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang, Jiangsu 212013, PR China. Electronic address:

Rational design of layered double hydroxide (LDH) electrodes is of great significance for high-performance supercapacitors (SCs). Herein, ultrathin cobalt-nickel-magnesium layered double hydroxide (CoNiMg-LDH) nanosheets with plentiful oxygen vacancies are synthesized via sacrificial magnesium-based replacement reaction at room temperature. Self-doping and mild reduction of magnesium can significantly increase the concentration of oxygen vacancies in CoNiMg-LDH, which promotes the electrochemical charge transfer efficiency and enhances the adsorption ability of electrolytes. Read More

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December 2021

Investigating adjustment profiles in children exposed to intimate partner violence using a biopsychosocial resilience framework: A Canadian population-based study.

Child Abuse Negl 2022 Jan 13;125:105453. Epub 2022 Jan 13.

Department of Community Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada.

Background: The variability observed across different profiles of adjustment in children exposed to intimate partner violence (IPV) and the factors associated with resilience in this population are not yet well understood.

Objective: Within a biopsychosocial framework, this study aimed to identify and describe profiles of adjustment in a cohort of children who had previously experienced IPV exposure, as well as the specific risk and promotive factors that significantly predicted membership in the identified adjustment profiles. The moderating effect of children's biological sex was also tested. Read More

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January 2022

Malignant pleural mesothelioma: Germline variants in DNA repair genes may steer tailored treatment.

Eur J Cancer 2022 Jan 12;163:44-54. Epub 2022 Jan 12.

Department of Health Sciences, Università del Piemonte Orientale, Novara, Italy; Interdepartmental Center for Studies on Asbestos and Other Toxic Particulates "G. Scansetti", Università di Torino, Italy. Electronic address:

Introduction: Malignant pleural mesothelioma (MPM) is a tumour associated with asbestos exposure. Approximately, 10% of patients with MPM carry a germline pathogenic variant (PV), mostly in DNA repair genes, suggesting the occurrence of inherited predispositions.

Aim: This article aimed to 1) search for new predisposing genes and assess the prevalence of PVs in DNA repair genes, by next-generation sequencing (NGS) analysis of germline DNA from 113 unselected patients with MPM and 2) evaluate whether these patients could be sensitive to tailored treatments. Read More

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January 2022

Efficient pollutant degradation under ultraviolet to near-infrared light irradiation and dark condition using CuSe nanosheets: Mechanistic insight into degradation.

J Colloid Interface Sci 2022 Jan 7;613:103-116. Epub 2022 Jan 7.

College of Life and Environmental Science, Minzu University of China, Beijing 100081, PR China; School of Science, Minzu University of China, Beijing 100081, PR China. Electronic address:

The hydrothermally prepared two-dimensional copper selenide nanosheets (2D CuSe NSs) have been employed for the first time to degrade rhodamine B (RhB) in the presence of hydrogen peroxide (HO) under ultraviolet to near-infrared (NIR) light irradiation and dark condition. The experimental measurements demonstrate that 99.7% RhB is degraded under NIR light irradiation for 120 min. Read More

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January 2022

Remodeling of extracellular matrix in the urinary bladder of paraplegic rats results in increased compliance and delayed fiber recruitment 16 weeks after spinal cord injury.

Acta Biomater 2022 Jan 12. Epub 2022 Jan 12.

Michigan State University, Department of Mechanical Engineering, 428 S. Shaw Lane, Rm 2555, East Lansing, MI 48824. Electronic address:

The ability of the urinary bladder to maintain low intravesical pressures while storing urine is key in ensuring proper organ function and highlights the key role that tissue mechanics plays in the lower urinary tract. Loss of supraspinal neuronal connections to the bladder after spinal cord injury can lead to remodeling of the structure of the bladder wall, which may alter its mechanical characteristics. In this study, we investigate if the morphology and mechanical properties of the bladder extracellular matrix are altered in rats 16 weeks after spinal cord injury as compared to animals who underwent sham surgery. Read More

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January 2022

The role of 5-HTR in the memory impairment of mice induced by long-term isoflurane anesthesia.

Neurobiol Learn Mem 2022 Jan 12:107584. Epub 2022 Jan 12.

Department of Anesthesiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu Province, China. Electronic address:

General anesthesia is widely utilized in the clinic for surgical and diagnostic procedures. However, growing evidence suggests that anesthetic exposure may affect cognitive function negatively. Unfortunately, little is known about the underlying mechanisms and efficient prevention and therapeutic strategies for the anesthesia-induced cognitive dysfunction. Read More

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January 2022

Identification of ribosomal protein L24 (RPL24) from the oriental river prawn, Macrobrachium nipponense, and its roles in ovarian development.

Comp Biochem Physiol A Mol Integr Physiol 2022 Jan 12:111154. Epub 2022 Jan 12.

Engineering Lab of Henan Province for Aquatic Animal Disease Control, Engineering Technology Research Center of Henan Province for Aquatic Animal Cultivation, College of Fisheries, Henan Normal University, Xinxiang 453007, PR China.

Ribosomal proteins exhibit various extraribosomal functions in addition to their roles in protein synthesis. In this study, complementary DNA (cDNA) of ribosomal protein L24 in Macrobrachium nipponense (MnRPL24) was isolated, and its role in ovarian development was investigated using quantitative real-time PCR (qPCR), immunohistochemistry (IHC), RNA interference (RNAi) and histological observations. The complete cDNA of MnRPL24 is 564 base pairs (bps) and contains a 486 bp open reading frame (ORF) encoding 162 amino acids (aas). Read More

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January 2022

Mechanisms of energy dissipation and relationship with tissue composition in human meniscus.

Osteoarthritis Cartilage 2022 Jan 12. Epub 2022 Jan 12.

Department of Mechanical and Aerospace Engineering, University of Miami, Coral Gables, FL; Department of Orthopaedic Surgery, University of Miami, Miami, FL; Max Biedermann Institute for Biomechanics at Mount Sinai Medical Center, Miami Beach, FL. Electronic address:

Objective: The human meniscus is essential in maintaining proper knee joint function. The meniscus absorbs shock, distributes loads, and stabilizes the knee joint to prevent the onset of osteoarthritis. The extent of its shock-absorbing role can be estimated by measuring the energy dissipated by the meniscus during cyclic mechanical loading. Read More

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January 2022

Degradation of toxic agrochemicals and pharmaceutical pollutants: Effective and alternative approaches toward photocatalysis.

Environ Pollut 2022 Jan 12:118844. Epub 2022 Jan 12.

Department of Biotechnology, Rajalakshmi Engineering College, Chennai, 602105, India.

Emerging concern regarding the remediation of environmental pollution has expanded tremendously in recent years. Pharmaceutical industries and agricultural sectors release an enormous amount of residues containing toxic pollutants at trace levels which poses a serious impact on the environment and human health. To cope with the effect of hazardous and toxic contaminants, numerous methodologies have been developed for the treatment of effluents released from the agrochemical and pharmaceutical industries. Read More

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January 2022

Purification and characterization of a novel thermostable anticoagulant protein from medicinal leech Whitmania pigra Whitman.

J Ethnopharmacol 2022 Jan 12:114990. Epub 2022 Jan 12.

Department of Chinese Materia Medica and Pharmacy, School of Pharmacy, Jiangsu University, Zhenjiang, Jiangsu, 212013, PR China. Electronic address:

Ethnopharmacological Relevance: The prevalence of cardiovascular disease (CVD) is increasing worldwide. Despite significant improvements in novel targeted treatment agents, natural products purified from medicinal animals with minimal side effects have attracted much attention. Several native proteins explored from suck-blood leeches, such as non-thermostable hirudin and its variants, revealed potent anticoagulant activity. Read More

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January 2022

Cajanus cajan ameliorated CCl-induced oxidative stress in Wistar rats via the combined mechanisms of anti-inflammation and mitochondrial-membrane transition pore inhibition.

J Ethnopharmacol 2022 Jan 12:114920. Epub 2022 Jan 12.

Laboratories for Biomembrane Research and Biotechnology, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria.

Ethnopharmacological Relevance: Liver diseases is a public health issue in sub-saharan Africa and has been reported major cause of many hospital admissions. Oxidative stress, mitochondrial dysfunction and inflammation play important role in several diseases including liver injury. Cajanus cajan is an indigenous medicinal plant useful in the traditional treatment of jaundice, inflammation and liver injury. Read More

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January 2022

Efficient photocatalytic degradation of industrial contaminants by Piper longum mediated ZnO nanoparticles.

Environ Res 2022 Jan 12:112686. Epub 2022 Jan 12.

Department of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia.

Piper longum extract as a reducing agent in green synthesis method is used to synthesize ZnO nanoparticles (Zn-NPs). The impact of the reductant on the structural, optical and surface morphological properties of ZnO-NPs can be analyzed. Piper longum extract has delicately tuned the band gap of ZnO-NPs. Read More

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January 2022

The fast redox cycle of Cu(II)-Cu(I)-Cu(II) in the reduction of Cr(VI) by the Cu(II)-thiosulfate system.

Chemosphere 2022 Jan 12:133584. Epub 2022 Jan 12.

Tianjin Key Laboratory of Chemical Process Safety and Equipment Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300350, PR China. Electronic address:

Thiosulfate (SO) is an important ligand to complex metal cations, however, the reactivity of metal-thiosulfate complexes has barely been mentioned. In this study, the reactivity of the Cu(II)-SO system in the reduction of Cr(VI) was investigated. Kinetic results show that the reduction rates of Cr(VI) decrease when the pH increases from 3. Read More

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January 2022

Trauma and stressor-related disorders among health care workers during COVID-19 pandemic and the role of the gender: A prospective longitudinal survey.

J Affect Disord 2022 Jan 12. Epub 2022 Jan 12.

Mental Health Unit, Virgen del Rocio University Hospital, Seville, Spain; Translational Psychiatry Group, Seville Biomedical Research Institute (IBiS), Seville, Spain; Spanish Network for Research in Mental Health (CIBERSAM), Madrid, Spain; Department of Psychiatry, University of Seville, Seville, Spain.

Introduction: Health-care Workers (HCW) are facing a critical situation caused by Coronavirus Disease 2019 (COVID-19) which could impact on their mental health status. In addition, HCW women have been identified as a group at high-risk of developing psychological distress, although no previous longitudinal studies have explored this issue in a sample of HCW.

Aims: The main aim of the study was to observe the temporal pattern of the stress reactions among HCW as well as to explore its potential predictors of poor outcome. Read More

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January 2022

Proteomic profiling reveals antitumor effects of RT2 peptide on a human colon carcinoma xenograft mouse model.

Eur J Pharmacol 2022 Jan 12:174753. Epub 2022 Jan 12.

Protein and Proteomics Research Center for Commercial and Industrial Purposes (ProCCI), Faculty of Science, Khon Kaen University, Khon Kaen, 40002, Thailand; Department of Integrated Science, Faculty of Science, Khon Kaen University, Khon Kaen, 40002, Thailand. Electronic address:

A comparative study of human colon HCT-116 xenograft in nude mice treated with and without peptide RT2 at high doses is performed along with a label-free proteomic analysis of the tissue in order to understand the potential mechanisms by which RT2 acts in vivo against colorectal tumors. RT2 displays no significant systematic toxicity, but reduces tumor growth after either intraperitoneal or intratumoral injection demonstrating it is a safe and efficacious antitumor agent in vivo. Of the 3196 proteins identified by label-free proteomics, 61 proteins appear only in response to RT2 and are involved in cellular processes largely localized in the cells and cell parts. Read More

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January 2022

Puerarin attenuates cisplatin-induced apoptosis of hair cells through the mitochondrial apoptotic pathway.

Biochim Biophys Acta Mol Cell Res 2022 Jan 12:119208. Epub 2022 Jan 12.

Department of Radiology, Shaanxi Provincial People's Hospital, No.256, You Yi Xi Street, Xi'an 710068, PR China. Electronic address:

Puerarin, one of the main components of Pueraria lobata, has been reported to possess a wide range of pharmacological activities, including anti-inflammatory, antioxidative and anti-apoptotic effects. However, the role of puerarin in ototoxic drug-induced hair cell injury has not been well characterized. This study explored whether puerarin protects against cisplatin-induced hair cell damage and its potential mechanisms. Read More

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January 2022

Role of systems biology and multi-omics analyses in delineating spatial interconnectivity and temporal dynamicity of ER stress mediated cellular responses.

Biochim Biophys Acta Mol Cell Res 2022 Jan 12:119210. Epub 2022 Jan 12.

Structural Biology and Bioinformatics Division, CSIR-Indian Institute of Chemical Biology, IICB TRUE Campus, CN-6, Sector 5, Salt Lake, Kolkata Pin 700091, WB, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India. Electronic address:

The endoplasmic reticulum (ER) is a membranous organelle involved in calcium storage, lipid biosynthesis, protein folding and processing. Many patho-physiological conditions and pharmacological agents are known to perturb normal ER function and can lead to ER stress, which severely compromise protein folding mechanism and hence poses high risk of proteotoxicity. Upon sensing ER stress, the different stress signaling pathways interconnect with each other and work together to preserve cellular homeostasis. Read More

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January 2022

Mitigation of portal fibrosis and cholestatic liver disease in ANKS6-deficient livers by macrophage depletion.

FASEB J 2022 Feb;36(2):e22157

Division of Nephrology, Department of Pediatrics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Congenital hepatic fibrosis (CHF) is a developmental liver disease that is caused by mutations in genes that encode ciliary proteins and is characterized by bile duct dysplasia and portal fibrosis. Recent work has demonstrated that mutations in ANKS6 can cause CHF due to its role in bile duct development. Here, we report a novel ANKS6 mutation, which was identified in an infant presenting with neonatal jaundice due to underlying biliary abnormalities and liver fibrosis. Read More

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February 2022

Toward Greater Integration: Fellows Perspectives on Cognitive Science.

Authors:
Andrea Bender

Top Cogn Sci 2022 Jan 15. Epub 2022 Jan 15.

Department of Psychosocial Science & SFF Centre for Early Sapiens Behaviour (SapienCE), Faculty of Psychology, University of Bergen.

Cognitive science is a multidisciplinary field. Whereas debates on whether this is beneficial continue to spring up, this multidisciplinarity comes with at least one obvious challenge, namely, safeguarding an increasing integration across its subfields. The new and open-ended topic preluded here attempts to address this challenge by pursuing a multilayered agenda: to introduce the Fellows of the Cognitive Science Society and earn them the recognition and profile they deserve; to furnish a platform for reflection on cognitive science from a bird's eye view; and to present role models for younger generations. Read More

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January 2022

Monocytes and pyrophosphate promote mesenchymal stem cell viability and early osteogenic differentiation.

J Mater Sci Mater Med 2022 Jan 15;33(1):11. Epub 2022 Jan 15.

Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Pyrophosphate-containing calcium phosphate implants promote osteoinduction and bone regeneration. The role of pyrophosphate for inflammatory cell-mesenchymal stem cell (MSC) cross-talk during osteogenesis is not known. In the present work, the effects of lipopolysaccharide (LPS) and pyrophosphate (PPi) on primary human monocytes and on osteogenic gene expression in human adipose-derived MSCs were evaluated in vitro, using conditioned media transfer as well as direct effect systems. Read More

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January 2022

[Association of leptin with anthropometric indexes, dyslipidemia and carbohydrate metabolism in Kazakh adults].

Vopr Pitan 2021 26;90(6):85-91. Epub 2021 Oct 26.

West Kazakhstan Marat Ospanov State Medical University, 030019, Aktobe, Republic of Kazakhstan.

Leptin plays an important role in eating behavior, the central action of this hormone is the regulation of appetite and energy expenditure. Anthroponutritiology as a new scientific direction uses the methods of medical anthropology and nutritional science. The study of the relationship between the regulation of energy metabolism, taking into account constitutional features, and anthropometric parameters provides relevance in this direction. Read More

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October 2021

AAPred-CNN: accurate predictor based on deep convolution neural network for identification of anti-angiogenic peptides.

Methods 2022 Jan 11. Epub 2022 Jan 11.

Department of Spine Surgery, Changzheng Hospital, Naval Medical University, Shanghai, China. Electronic address:

Recently, deep learning techniques have been developed for various bioactive peptide prediction tasks. However, there are only conventional machine learning-based methods for the prediction of anti-angiogenic peptides (AAP), which play an important role in cancer treatment. The main reason why no deep learning method has been involved in this field is that there are too few experimentally validated AAPs to support the training of deep models but researchers have believed that deep learning seriously depends on the amounts of labeled data. Read More

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January 2022

Historical biogeographical analysis of the Udoteaceae (Bryopsidales, Chlorophyta) elucidates origins of high species diversity in the Central Indo-Pacific, Western Indian Ocean and Greater Caribbean regions.

Mol Phylogenet Evol 2022 Jan 11:107412. Epub 2022 Jan 11.

UMR ENTROPIE (IRD, UR, UNC, CNRS, IFREMER), Institut de Recherche pour le Développement, B.P. A5 Nouméa Cedex, Nouvelle-Calédonie, 98848, France.

There is a growing interest in elucidating the biogeographical processes underlying biodiversity patterns of seaweeds, with recent studies largely focusing on red and brown macroalgae. This study focuses on the siphonous green algal family Udoteaceae, which is diverse and globally distributed in tropical to warm-temperate seas, and includes species that form important components of tropical reefs. We explored the historical processes that have shaped current biodiversity patterns in the family by analyzing a comprehensive dataset of 568 specimens sampled across its geographical range, and including 45 species, corresponding to 59% of the known diversity. Read More

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January 2022

Ecological divergence and synchronous Pleistocene diversification in the widespread South American butter frog complex.

Mol Phylogenet Evol 2022 Jan 11:107398. Epub 2022 Jan 11.

Laboratório de Anfíbios e Répteis (LAR), Departamento de Botânica e Zoologia da Universidade Federal do Rio Grande do Norte, Campus Universitário. Lagoa Nova, 59078-900, Natal, Rio Grande do Norte, Brazil.

Phylogeographic studies primarily focus on the major role of landscape topography in driving lineage diversification. However, populational phylogeographic breaks may also occur as a result of either niche conservatism or divergence, in the absence of geographic barriers to gene flow. Furthermore, these two factors are not mutually exclusive and can act in concert, making it challenging to evaluate their relative importance on explaining genetic variation in nature. Read More

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January 2022

Calcium Selective Channel TRPV6: Structure, Function, and Implications in Health and Disease.

Gene 2022 Jan 11:146192. Epub 2022 Jan 11.

Division of Nephrology, Department of Medicine, Nephrology Research and Training Center, Department of Urology, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Electronic address:

Calcium-selective channel TRPV6 (Transient Receptor Potential channel family, Vanilloid subfamily member 6) belongs to the TRP family of cation channels and plays critical roles in transcellular calcium (Ca) transport, reuptake of Ca into cells, and maintaining a local low Ca environment for certain biological processes. Recent crystal and cryo-electron microscopy-based structures of TRPV6 have revealed mechanistic insights on how the protein achieves Ca selectivity, permeation, and inactivation by calmodulin. The TRPV6 protein is expressed in a range of epithelial tissues such as the intestine, kidney, placenta, epididymis, and exocrine glands such as the pancreas, prostate and salivary, sweat, and mammary glands. Read More

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January 2022

KEPI Plays a Negative Role in the Repression that Accompanies Translational Inhibition Guided by the uORF Element of Human chop Transcript during Stress Response.

Gene 2022 Jan 11:146160. Epub 2022 Jan 11.

Institute of Biomedical Sciences, Mackay Medical College, New Taipei City, Taiwan; Institute of Molecular and Cellular Biology, National Taiwan University, Taipei, Taiwan; Department of Life Science, Fu-Jen Catholic University, New Taipei City, Taiwan. Electronic address:

Translation of the downstream coding sequence of some mRNAs may be repressed by the upstream open reading frame (uORF) at their 5'-end. The mechanism underlying this uORF-mediated translational inhibition (uORF-MTI) is not fully understood in vivo. Recently, it was found that zebrafish Endouc or its human orthologue ENDOU (Endouc/ENDOU) plays a positive role in repressing the uORF-MTI of human chop (uORF-MTI) during stress by blocking its activity However, the repression of uORF-MTI assisted by an as-yet unidentified negative effector remains to be elucidated. Read More

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January 2022

Fuchs Endothelial Corneal Dystrophy associated risk variant, rs3768617 in LAMC1 shows allele specific binding of GFI1B.

Gene 2022 Jan 11:146179. Epub 2022 Jan 11.

School of Biological Sciences, National Institute of Science Education and Research (NISER) Bhubaneswar, Homi Bhabha National Institute (HBNI), P.O. Bhimpur-Padanpur, Jatni, Khurda, Odisha, 752050, India. Electronic address:

Aims: To investigate the genetic and functional association of an intronic variant of LAMC1, rs3768617 with Fuchs endothelial corneal dystrophy (FECD) in the Indian population.

Methods: Blood samples were collected from age and sex matched 356 controls and 120 FECD patients after a detailed assessment via specular microscopy. Genomic DNA was extracted and genotyping was done by fluorescence based capillary electrophoresis. Read More

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January 2022

Skin pharmacokinetics of diclofenac and co-delivered functional excipients.

Int J Pharm 2022 Jan 11:121469. Epub 2022 Jan 11.

University of Bath, Department of Pharmacy & Pharmacology, Claverton Down, Bath, BA2 7AY, UK. Electronic address:

An important question in the development of a dermatological drug product is whether a target concentration has been achieved in, for example, the viable epidermis following topical administration. When attempting to address this challenge, it is essential to consider the role of excipients in the formulation that may influence drug partitioning and diffusion in the different layers of the skin. The objective, therefore, was to correlate, in human subjects, the skin pharmacokinetics of diclofenac (specifically, its uptake into and clearance from the stratum corneum (SC)) from an approved drug product (Voltaren® medicated plaster) with the in vivo co-uptake of two key excipients, namely propylene glycol and butylene glycol. Read More

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January 2022