26,777 results match your criteria role predicting


Predicting mean ribosome load for 5'UTR of any length using deep learning.

PLoS Comput Biol 2021 May 10;17(5):e1008982. Epub 2021 May 10.

Department of Informatics, Technical University of Munich, Garching, Germany.

The 5' untranslated region plays a key role in regulating mRNA translation and consequently protein abundance. Therefore, accurate modeling of 5'UTR regulatory sequences shall provide insights into translational control mechanisms and help interpret genetic variants. Recently, a model was trained on a massively parallel reporter assay to predict mean ribosome load (MRL)-a proxy for translation rate-directly from 5'UTR sequence with a high degree of accuracy. Read More

View Article and Full-Text PDF

Collectively coping with coronavirus: Local community identification predicts giving support and lockdown adherence during the COVID-19 pandemic.

Br J Soc Psychol 2021 May 10. Epub 2021 May 10.

Università Degli Studi della Campania Luigi Vanvitelli, Naples, Italy.

The role of shared identity in predicting both ingroup helping behaviour and adherence to protective norms during COVID-19 has been extensively theorized, but remains largely under-investigated. We build upon previous Social Identity research into community resilience by testing the role of pre-existing local community (or 'neighbourhood') identity as a predictor of these outcomes, via the mediator of perceived social support. Community residents in the UK completed a longitudinal online survey four months before lockdown (T1; N = 253), one month before lockdown (T2; N = 217), and two months into lockdown (T3; N = 149). Read More

View Article and Full-Text PDF

A Bayesian approach to comparing common models of life-course epidemiology.

Int J Epidemiol 2021 May 10. Epub 2021 May 10.

Jacobs Center for Productive Youth Development, University of Zurich, Zurich, Switzerland.

Background: Life-course epidemiology studies people's health over long periods, treating repeated measures of their experiences (usually risk factors) as predictors or causes of subsequent morbidity and mortality. Three hypotheses or models often guide the analyst in assessing these sequential risks: the accumulation model (all measurement occasions are equally important for predicting the outcome), the critical period model (only one occasion is important) and the sensitive periods model (a catch-all model for any other pattern of temporal dependence).

Methods: We propose a Bayesian omnibus test of these three composite models, as well as post hoc decompositions that identify their best respective sub-models. Read More

View Article and Full-Text PDF

COVID-19 pneumonia: current evidence of chest imaging features, evolution and prognosis.

Chin J Acad Radiol 2021 May 4:1-12. Epub 2021 May 4.

Bracco Diagnostics Inc., Global Medical and Regulatory Affairs, Monroe Twp, NJ USA.

COVID-19 pneumonia represents a global threatening disease, especially in severe cases. Chest imaging, with X-ray and high-resolution computed tomography (HRCT), plays an important role in the initial evaluation and follow-up of patients with COVID-19 pneumonia. Chest imaging can also help in assessing disease severity and in predicting patient's outcome, either as an independent factor or in combination with clinical and laboratory features. Read More

View Article and Full-Text PDF

The effectiveness of plasma miR-33a-5p as a predictive biomarker for the efficacy of colorectal cancer chemotherapy.

Oncol Lett 2021 Jun 22;21(6):489. Epub 2021 Apr 22.

Department of Gastrointestinal Surgery, Graduate School, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8519, Japan.

Several chemotherapeutic options are available for patients with metastatic colorectal cancer (mCRC), making it important to individualize treatment regimens. Individualization requires the clinical application of biomarkers for regimen selection, which is presently insufficient. miRNAs serve an important role in the control of biological processes in several types of cancer, acting as plasma biomarkers. Read More

View Article and Full-Text PDF

Spatial Thinking in Term and Preterm-Born Preschoolers: Relations to Parent-Child Speech and Gesture.

Front Psychol 2021 23;12:651678. Epub 2021 Apr 23.

Department of Psychological and Brain Sciences, University of Iowa, Iowa, IA, United States.

Spatial skills predict important life outcomes, such as mathematical achievement or entrance into Science, Technology, Engineering, and Mathematics (STEM) disciplines. Children significantly vary in their spatial performance even before they enter formal schooling. One correlate of children's spatial performance is the spatial language they produce and hear from others, such as their parents. Read More

View Article and Full-Text PDF

A Transfer Learning-Based Approach for Lysine Propionylation Prediction.

Front Physiol 2021 21;12:658633. Epub 2021 Apr 21.

School of Computer Science and Technology, Hunan Institute of Technology, Hengyang, China.

Lysine propionylation is a newly discovered posttranslational modification (PTM) and plays a key role in the cellular process. Although proteomics techniques was capable of detecting propionylation, large-scale detection was still challenging. To bridge this gap, we presented a transfer learning-based method for computationally predicting propionylation sites. Read More

View Article and Full-Text PDF

Reduced Function Variants and Genotype/Phenotype Translations of CYP2D6 Intermediate Metabolizers: Implications for Personalized Drug Dosing in Psychiatry.

Front Pharmacol 2021 22;12:650750. Epub 2021 Apr 22.

Section of Pharmacogenetics, Department of Physiology and Pharmacology, Biomedicum 5B, Karolinska Institutet, Stockholm, Sweden.

Genetic differences in cytochrome P450 (CYP)-mediated metabolism have been known for several decades. The clinically most important polymorphic CYP enzyme is CYP2D6, which plays a key role in the metabolism of many antidepressants and antipsychotics, along with a range of non-psychiatric medications. Dose individualization based on genotype to improve the effect and safety of drug treatment has been an ambition for a long time. Read More

View Article and Full-Text PDF

Expression of CK 19 as a biomarker in early detection of oral squamous cell carcinoma.

J Oral Maxillofac Pathol 2020 Sep-Dec;24(3):523-529. Epub 2021 Jan 9.

Department of Biostatistics, Amrita School of Medicine, AIMS, Amrita Vishwa Vidyapeetham, Kochi, Kerala, India.

Background: Increased mortality in oral squamous cell carcinoma (OSCC) had been attributed to delay in diagnosis. Lack of a specific marker to assess the malignant potential of premalignant lesions is thought to be one of the reasons for late detection. Expression of Cytokeratin 19, which is widely used as an odontogenic epithelial marker had been reported in OSCC. Read More

View Article and Full-Text PDF
January 2021

Platelet Function Monitoring Performed after Carotid Stenting during Endovascular Stroke Treatment Predicts Outcome.

J Stroke Cerebrovasc Dis 2021 May 4;30(7):105800. Epub 2021 May 4.

Stroke Unit, Neurology Unit, Department of Neuroscience, Ospedale Civile, Azienda Ospedaliera Universitaria di Modena, Via Giardini 1355, Modena, Emilia Romagna 41126, Italy. Electronic address:

Objectives: Many studies showed that platelet reactivity testing can predict ischemic events after carotid stenting or ischemic stroke. The aim of our study was to assess the role of early platelet function monitoring in predicting 90-days functional outcome, stent thrombosis and hemorrhagic transformation in patients with ischemic stroke treated with endovascular procedures requiring emergent extracranial stenting.

Materials And Methods: We performed a retrospective study on consecutive patients with acute anterior circulation stroke admitted to our hospital between January 2015 and March 2020, in whom platelet reactivity testing was performed within 10 days from stenting. Read More

View Article and Full-Text PDF

Predicting anti-PD-1 responders in malignant melanoma from the frequency of S100A9+ monocytes in the blood.

J Immunother Cancer 2021 May;9(5)

Department of Medicine, Centre for Molecular Medicine, Karolinska Institutet, Stockholm, Stockholm, Sweden

Background: While programmed cell death receptor 1 (PD-1) blockade treatment has revolutionized treatment of patients with melanoma, clinical outcomes are highly variable, and only a fraction of patients show durable responses. Therefore, there is a clear need for predictive biomarkers to select patients who will benefit from the treatment.

Method: To identify potential predictive markers for response to PD-1 checkpoint blockade immunotherapy, we conducted single-cell RNA sequencing analyses of peripheral blood mononuclear cells (PBMC) (n=8), as well as an in-depth immune monitoring study (n=20) by flow cytometry in patients with advanced melanoma undergoing treatment with nivolumab at Karolinska University Hospital. Read More

View Article and Full-Text PDF

The Role of the Lateral Habenula in Inhibitory Learning from Reward Omission Experiences.

eNeuro 2021 May 7. Epub 2021 May 7.

Universidad Iberoamericana

The lateral habenula (LHb) is a phylogenetically primitive brain structure that plays a key role in learning to inhibit distinct responses to specific stimuli. This structure is activated by primary aversive stimuli, cues predicting an imminent aversive event, unexpected reward omissions, and cues associated with the omission of an expected reward. The most widely described effect of LHb activation is acutely suppressing midbrain dopaminergic signaling. Read More

View Article and Full-Text PDF

Transcranial Doppler: A Useful Tool to Predict Brain Death Still Not Confirmed by Clinical Assessment.

Transplant Proc 2021 May 4. Epub 2021 May 4.

Department of Neurology, Laboratory for Neurosonology and Cerebral Hemodynamics, Hospital das Clínicas, São Paulo University Medical School, São Paulo, Brazil.

Background: Diagnosing brain death (BD) with accuracy and urgency is of great importance because an early diagnosis may guide the clinical management, optimize hospital beds, and facilitate organ transplantation. The clinical diagnosis of nonreactive and irreversible coma can be confirmed with additional tests. Among the complimentary exams that may testify brain circulatory arrest, transcranial Doppler (TCD) can be an option. Read More

View Article and Full-Text PDF

The role of volumetric ADC histogram analysis in preoperatively evaluating the tumour subtype and grade of endometrial cancer.

Eur J Radiol 2021 Apr 30;140:109745. Epub 2021 Apr 30.

Department of Radiology, Jinshan Hospital, Fudan University, Longhang Road, Shanghai, 201508, People's Republic of China. Electronic address:

Purpose: To assess the value of volumetric ADC histogram metrics in evaluating the histological subtype and grade of endometrial cancer.

Method: Preoperative MRI datasets of 317 patients with endometrial cancer were used to obtain volumetric ADC histogram metrics (tumour volume; minADC, maxADC and meanADC; 10th, 25th, 50th, 75th and 90th percentiles of ADC; skewness; and kurtosis). The Mann-Whitney test or Student's t-test was used to compare the difference in ADC histogram metrics between endometrioid adenocarcinomas (EACs) and serous endometrial cancers (SECs) and between different tumour grades (G1, G2, G3). Read More

View Article and Full-Text PDF

OriC-ENS: A sequence-based ensemble classifier for predicting origin of replication in S. cerevisiae.

Comput Biol Chem 2021 Apr 26;92:107502. Epub 2021 Apr 26.

Department of Computer Science and Engineering, United International University, Plot-2, United City, Madani Avenue, Badda, Dhaka, 1212, Bangladesh. Electronic address:

DNA Replication plays the most crucial part in biological inheritance, ensuring an even flow of genetic information from parent to offspring. The beginning site of DNA Replication which is called the Origin of Replication (ORI), plays a significant role in understanding the molecular mechanisms and genomic analysis of DNA. Hence, it is paramount to accurately identify the origin of replication to gain a more accurate understanding of the biochemical and genomic properties of DNA. Read More

View Article and Full-Text PDF

Identification of autophagy-related genes signature predicts chemotherapeutic and immunotherapeutic efficiency in bladder cancer (BLCA).

J Cell Mol Med 2021 May 7. Epub 2021 May 7.

Department of Internal Medicine, Division of Nephrology, Leiden University Medical Center, Leiden, The Netherlands.

Autophagy maintains cellular homeostasis by degrading and recycling cytoplasmic components under stress conditions, which is identified to be involved in tumorigenesis and now has been recognized as novel target in cancer treatment. In present study, we gathered total autophagy-related genes and established an autophagy-related genes signature (ATGRS) through LASSO cox regression analysis in BLCA. Kaplan-Meier survival and multivariate cox regression analyses both showed the ATGRS was a robust independent prognostic factor with high accuracy. Read More

View Article and Full-Text PDF

Profiles of Maltreatment in the Child Welfare System: Predicting Mental Health Outcomes and Examining Age as a Moderator.

J Trauma Stress 2021 May 6. Epub 2021 May 6.

Department of Psychology, Loyola University Chicago, Chicago, Illinois, USA.

This longitudinal study explored the unique profiles of maltreatment among youth in the child welfare system and examined their relation to mental health outcomes over time. We additionally examined the moderating role of age. Participants included 316 youth in the foster care system (age range: 6-13 years). Read More

View Article and Full-Text PDF

Immunological resilience and biodiversity for prevention of allergic diseases and asthma.

Allergy 2021 May 6. Epub 2021 May 6.

Skin and Allergy Hospital, Helsinki University Hospital, University of Helsinki, Finland.

Increase of allergic conditions has occurred at the same pace with the Great Accleration, which stands for the rapid growth rate of human activities upon Earth from 1950s. Changes of environment and lifestyle along with escalating urbanization, are acknowledged as the main underlying causes. Secondary (tertiary) preventionfor better disease control hasadvanced considerably with innovations for oral immunotherapy and effective treatment of inflammation with corticosteroids, calcineurin inhibitors and biologic medications. Read More

View Article and Full-Text PDF

STAM Prolongs Clear Cell Renal Cell Carcinoma Patients' Survival Inhibiting Cell Growth and Invasion.

Front Oncol 2021 20;11:611081. Epub 2021 Apr 20.

Department of Urology and Guangdong Key Laboratory of Urology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China.

Signal transducing adaptor molecule 1 (STAM1) was considered to mediate cell growth and be involved in multiple signaling pathways; however, no research on the role of STAM1 in any tumors has been published yet. Our study aimed to investigate the prognostic value of STAM1 for clear cell renal cell carcinoma (ccRCC) and its role in modulating cancer cell function. Data from The Cancer Genome Atlas (TCGA) in December 2019 were used to examine the role of STAM1 in indicating ccRCC patients' survival. Read More

View Article and Full-Text PDF

Elevated Neutrophil to Lymphocyte Ratio Associated With Increased Risk of Recurrent Vascular Events in Older Minor Stroke or TIA Patients.

Front Aging Neurosci 2021 20;13:646961. Epub 2021 Apr 20.

Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.

Background: The risk of recurrent stroke following a minor stroke or transient ischemic attack (TIA) is high, when inflammation might play an important role. We aimed to evaluate the value of neutrophil to lymphocyte ratio (NLR) in predicting composite cardiovascular events in patients with minor stroke and TIA.

Methods: Consecutive patients with acute minor stroke or TIA admitted within 24 h of symptoms onset during a 5-year period in a prospective stroke registry were analyzed. Read More

View Article and Full-Text PDF

T-Natural Killers and Interferon Gamma/Interleukin 4 in Augmentation of Infection in Foot Ulcer in Type 2 Diabetes.

Diabetes Metab Syndr Obes 2021 29;14:1897-1908. Epub 2021 Apr 29.

Immunology, Zoology & Entomology Department, Faculty of Science for Girls, Al-Azhar University, Cairo, Egypt.

Background: The link between immune system and type 2 diabetes mellitus (T2DM) pathogenesis attracted attention to demonstrate the role of immune cells and their secreted cytokines in T2DM development and its subsequent foot complications.

Objective: To investigate the relation between T Natural killer cell (TNK) %, Interleukin 4 (IL4) and Interferon gamma (IFN-γ) and diabetic foot infection (DFI) development in patients with diabetic foot ulcer (DFU).

Patients And Methods: Ninety patients with diabetes were included in this work, divided as T2DM group (n=30), DFU group (n=30), and DFI group (n=30). Read More

View Article and Full-Text PDF

Exploration of the Associations of lncRNA Expression Patterns with Tumor Mutation Burden and Prognosis in Colon Cancer.

Onco Targets Ther 2021 29;14:2893-2909. Epub 2021 Apr 29.

Department of General Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, People's Republic of China.

Background: Tumor mutation burden (TMB) is emerging as a new biomarker to monitor the response of cancer patients to immunotherapy. Long non-coding RNAs (lncRNAs) are critical in regulating gene expression and play a significant role in cancer-associated immune responses. However, the association between lncRNA expression patterns and TMB levels and survival outcomes remains unknown in colon cancer. Read More

View Article and Full-Text PDF

The Role of Biological Effective Dose in Predicting Obliteration After Stereotactic Radiosurgery of Cerebral Arteriovenous Malformations.

Mayo Clin Proc 2021 May;96(5):1157-1164

Department of Neurological Surgery, Mayo Clinic, Rochester, MN; Department of Radiation Oncology, Mayo Clinic, Rochester, MN. Electronic address:

Objective: To determine whether biological effective dose (BED) was predictive of obliteration after stereotactic radiosurgery (SRS) for cerebral arteriovenous malformations (AVMs).

Patients And Methods: We studied patients undergoing single-session AVM SRS between January 1, 1990, and December 31, 2014, with at least 2 years of imaging follow-up. Excluded were patients with syndromic AVM, previous SRS or embolization, and patients treated with volume-staged SRS. Read More

View Article and Full-Text PDF

Baseline spirometry parameters as predictors of airway hyperreactivity in adults with suspected asthma.

BMC Pulm Med 2021 May 6;21(1):153. Epub 2021 May 6.

Institute of Pulmonary Medicine, Chaim Sheba Medical Center, Derech Sheba st. 2, 52621, Ramat Gan, Israel.

Background: Methacholine challenge tests (MCTs) are used to diagnose airway hyperresponsiveness (AHR) in patients with suspected asthma where previous diagnostic testing has been inconclusive. The test is time consuming and usually requires referral to specialized centers. Simple methods to predict AHR could help determine which patients should be referred to MCTs, thus avoiding unnecessary testing. Read More

View Article and Full-Text PDF

Hepatitis B Core-Related Antigen: From Virology to Clinical Application.

Semin Liver Dis 2021 May 6. Epub 2021 May 6.

Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong.

Hepatitis B core-related antigen (HBcrAg) is a composite measure of the serum levels of hepatitis B e antigen, hepatitis B core antigen, and a 22-kDa precore protein. It has been shown to reflect the level and transcriptional activity of covalently closed circular DNA in the liver. Longitudinal cohort studies have improved our understanding of the role of this novel viral marker in the natural history of chronic hepatitis B. Read More

View Article and Full-Text PDF

Dose optimization based on pharmacokinetic/pharmacodynamic target of tigecycline.

J Glob Antimicrob Resist 2021 May 3. Epub 2021 May 3.

Department of Pharmacy, Shandong Provincial Hospital Affiliated to Shandong First Medical University; 324 Jingwu Road, Huaiyin District, Jinan, 250021, China; Department of Pharmacy, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China. Electronic address:

Tigecycline, a new glycylcycline antibiotic, has a promising efficacy against a broad spectrum of microbials. It is widely prescribed for various infections, with most prescriptions being considered for off-label use. However, only a few years after its approval by the US Food and Drug Administration, tigecycline is suspected of increasing all-cause mortality. Read More

View Article and Full-Text PDF

Adding value to tumor staging in head and neck cancer: The role of metabolic parameters as prognostic factors.

Head Neck 2021 May 6. Epub 2021 May 6.

Department of Otorhinolaryngology-Head and Neck Surgery, Puerta de Hierro University Hospital, Madrid, Spain.

Background: Validated biomarkers in head and neck squamous cell carcinoma (HNSCC) are scarce.

Methods: We retrospectively analyzed 62 patients with HNSCC treated with radiotherapy +/- concurrent chemotherapy. Pretreatment metabolic tumor volume (MTV) and total lesion glycolysis (TLG) were measured in a F-FDG positron emission tomography using a liver dependent standardized uptake value threshold. Read More

View Article and Full-Text PDF

Neurocognitive mechanisms explaining the role of math attitudes in predicting children's improvement in multiplication skill.

Cogn Affect Behav Neurosci 2021 May 6. Epub 2021 May 6.

Department of Psychology and Human Development, Vanderbilt University, Nashville, TN, USA.

Enhancing student's math achievement is a significant educational challenge. Numerous studies have shown that math attitudes can predict improvement in math performance, but no study has yet revealed the underlying neurocognitive mechanisms explaining this effect. To answer this question, 50 children underwent functional magnetic resonance imaging (fMRI) when they were 11 (time 1; T1) and 13 (time 2; T2) years old. Read More

View Article and Full-Text PDF

Harvesting social media sentiment analysis to enhance stock market prediction using deep learning.

PeerJ Comput Sci 2021 13;7:e476. Epub 2021 Apr 13.

Symbiosis Centre for Applied Artificial Intelligence, Symbiosis International University, Pune, Maharastra, India.

Information gathering has become an integral part of assessing people's behaviors and actions. The Internet is used as an online learning site for sharing and exchanging ideas. People can actively give their reviews and recommendations for variety of products and services using popular social sites and personal blogs. Read More

View Article and Full-Text PDF

Association of Common Genetic Risk Variants With Gestational Diabetes Mellitus and Their Role in GDM Prediction.

Front Endocrinol (Lausanne) 2021 19;12:628582. Epub 2021 Apr 19.

Almazov National Medical Research Centre, Saint Petersburg, Russia.

Objective: We aimed to explore the associations between common genetic risk variants with gestational diabetes mellitus (GDM) risk in Russian women and to assess their utility in the identification of GDM cases.

Methods: We conducted a case-control study including 1,142 pregnant women (688 GDM cases and 454 controls) enrolled at Almazov National Medical Research Centre. The International Association of Diabetes and Pregnancy Study Groups criteria were used to diagnose GDM. Read More

View Article and Full-Text PDF