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Identification of cell surface targets for CAR-T cell therapies and antibody-drug conjugates in breast cancer.

ESMO Open 2021 Apr 7;6(3):100102. Epub 2021 Apr 7.

Department of Hematology, Hospital Clinic, August Pi I Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain. Electronic address:

Background: Two promising therapeutic strategies in oncology are chimeric antigen receptor-T cell (CAR-T) therapies and antibody-drug conjugates (ADCs). To be effective and safe, these immunotherapies require surface antigens to be sufficiently expressed in tumors and less or not expressed in normal tissues. To identify new targets for ADCs and CAR-T specifically targeting breast cancer (BC) molecular and pathology-based subtypes, we propose a novel in silico strategy based on multiple publicly available datasets and provide a comprehensive explanation of the workflow for a further implementation. Read More

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Adoptees facing adolescence: What accounts for their psychological well-being?

J Adolesc 2021 Apr 7;89:10-17. Epub 2021 Apr 7.

Universidad de Seville, Spain.

Introduction: In accordance with the "resilience paradigm", this study was aimed at exploring the role of the parent-child relationship in supporting internationally adopted adolescents' ability to develop a strong adoptive identity and a feeling of satisfaction with their own life.

Methods: Participants were 105 Italian adopted adolescents (13-17 years) asked to complete a self-report questionnaire.

Results: Results showed that adolescents generally feel fairly comfortable discussing adoption-related issues (especially with their mothers), have a medium-high level of adoptive identity, and appear to be quite satisfied with their life. Read More

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Design, synthesis and biological evaluation of anilide (dicarboxylic acid) shikonin esters as antitumor agents through targeting PI3K/Akt/mTOR signaling pathway.

Bioorg Chem 2021 Mar 29;111:104872. Epub 2021 Mar 29.

State Key Laboratory of Pharmaceutical Biotechnology, Institute of Plant Molecular Biology, School of Life Sciences, Nanjing University, Nanjing 210023, China; Co-Innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing 210037, China. Electronic address:

Triple-negative breast cancer (TNBC) has an unfavorable prognosis attribute to its low differentiation, rapid proliferation and high distant metastasis rate. PI3K/Akt/mTOR as an intracellular signaling pathway plays a key role in the cell proliferation, migration, invasion, metabolism and regeneration. In this work, we designed and synthesized a series of anilide (dicarboxylic acid) shikonin esters targeting PI3K/Akt/mTOR signaling pathway, and assessed their antitumor effects. Read More

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Addressing Challenges in Health Technology Assessment Institutionalization for Furtherance of Universal Health Coverage Through South-South Knowledge Exchange: Lessons From Bhutan, Kenya, Thailand, and Zambia.

Value Health Reg Issues 2021 Apr 7;24:187-192. Epub 2021 Apr 7.

Health Intervention and Technology Assessment Program, Nonthaburi, Thailand. Electronic address:

Health Technology Assessment (HTA), a tool for priority setting, has emerged as a means of ensuring the sustainability of a Universal Health Coverage (UHC) system. However, setting up an effective HTA system poses multiple challenges and knowledge exchange can play a crucial role in helping countries achieve their UHC targets. This article reports the results of the discussion during a preconference session at the 2019 HTAsiaLink Conference, an annual gathering of HTA agencies in Asia, which supports knowledge transfer and exchange among HTA practitioners. Read More

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The in vitro effects of hepatoblastoma cells on the growth and differentiation of blasts in transient abnormal myelopoiesis associated with Down syndrome.

Leuk Res 2021 Mar 31;105:106570. Epub 2021 Mar 31.

Department of Pediatrics, National Defense Medical College, Tokorozawa, Saitama-ken, Japan.

Transient abnormal myelopoiesis (TAM) in neonates with Down syndrome, which spontaneously resolves within several weeks or months after birth, may represent a special form of leukemia developing in the fetal liver (FL). To explore the role of hepatoblasts, one of the major constituents of the FL hematopoietic microenvironment, in the pathogenesis of TAM, we investigated the influence of a human hepatoblastoma cell line, HUH-6, on the in vitro growth and differentiation of TAM blasts. In a coculture system with membrane filters, which hinders cell-to-cell contact between TAM blasts and HUH-6 cells, the growth and megakaryocytic differentiation of TAM blast progenitors were increased in the presence of HUH-6 cells. Read More

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Brain activity of the emotional circuit in Parkinson's disease patients with freezing of gait.

Neuroimage Clin 2021 Mar 29;30:102649. Epub 2021 Mar 29.

Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy; Neurology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy; Neurorehablitation Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy; Neurophysiology Service, IRCCS San Raffaele Scientific Institute, Milan, Italy; Vita-Salute San Raffaele University, Milan, Italy. Electronic address:

Objective: Emotional processes might influence freezing of gait (FoG) in Parkinson's disease (PD) patients. We assessed brain functional MRI (fMRI) activity during a "FoG-observation-task" in PD-FoG patients relative to healthy controls.

Methods: Twenty-four PD-FoG patients and 18 age- and sex-matched healthy controls performed clinical and neuropsychological evaluations, and fMRI experiments including: i) "FoG-observation-task" consisting of watching a patient experiencing FoG during a walking task (usually evoking FoG); ii) "gait-observation-task" consisting of watching a healthy subject performing similar walking tasks without experiencing FoG. Read More

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Impact of COVID-19 on social media as perceived by the oncology community: results from a survey in collaboration with the European Society for Medical Oncology (ESMO) and the OncoAlert Network.

ESMO Open 2021 Apr 7;6(2):100104. Epub 2021 Apr 7.

Oncology Department, Centre Hospitalier Universitaire Vaudois (CHUV) and Lausanne University, Lausanne, Switzerland.

Background: The COVID-19 pandemic has impacted all aspects of modern-day oncology, including how stakeholders communicate through social media. We surveyed oncology stakeholders in order to assess their attitudes pertaining to social media and how it has been affected during the pandemic.

Materials And Methods: A 40-item survey was distributed to stakeholders from 8 July to 22 July 2020 and was promoted through the European Society for Medical Oncology (ESMO) and the OncoAlert Network. Read More

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The role of FeNO in stable COPD patients with eosinophilic airway inflammation.

Respir Med 2021 Mar 28;181:106377. Epub 2021 Mar 28.

Division of Respiratory Diseases, Department of Medicine, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium.

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Ga-labeled PET tracers for targeting tumor hypoxia: Role of bifunctional chelators on pharmacokinetics.

Nucl Med Biol 2021 Mar 26;96-97:61-67. Epub 2021 Mar 26.

Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Mumbai 400085, India. Electronic address:

Introduction: By virtue of their oxygen dependant accumulation in hypoxic cells, radiolabeled nitroimidazole analogues have been widely used for detecting tumor hypoxia. Present study evaluates two 2-nitroimidazole (2-NIM) based Ga-labeled radiotracers, [Ga]Ga-DOTAGA-2-NIM and [Ga]Ga-NODAGA-2-NIM, for hypoxia targeting applications.

Methods: Bifunctional chelating agents suitable for radiolabeling with Ga, viz. Read More

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Internalizing and externalizing problems across childhood and psychotic-like experiences in young-adulthood: The role of developmental period.

Schizophr Res 2021 Apr 7;231:108-114. Epub 2021 Apr 7.

Department of Psychology and Human Development, University College London, London WC1H 0AA, United Kingdom.

Background: Psychopathology in childhood and adolescence, commonly indexed by co-occurring internalizing and externalizing problem behaviors, has been found to predict psychotic-like experiences (PLEs) in adults. However, studies to date have rarely examined internalizing and externalizing problem behaviors simultaneously or identified in which developmental period do these problem behaviors predict PLEs in adults. This study tests to what extent internalizing and externalizing problem behaviors in childhood (4-9 years) or adolescence (11-16 years) predict PLEs in young-adulthood (18 years). Read More

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The role of depression in the prediction of a "late" remission in first-episode psychosis: An analysis of the OPTiMiSE study.

Schizophr Res 2021 Apr 7;231:100-107. Epub 2021 Apr 7.

Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, School of Medicine, Universidad Complutense, Madrid, Spain.

Objective: The identification of predictors of psychosis remission could guide early clinical decision-making for treatment of first-episode schizophrenia (FES).

Methods: We analyzed two non-independent subsamples of patients with FES ages 18-40 years from the OPTiMiSE study dataset to investigate the demographic and clinical factors that might help to differentiate "late" remitters (i.e. Read More

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Thiourea-assisted one-step fabrication of a novel nitrogen and sulfur co-doped biochar from nanocellulose as metal-free catalyst for efficient activation of peroxymonosulfate.

J Hazard Mater 2021 Apr 1;416:125796. Epub 2021 Apr 1.

Key Laboratory of Yangtze River Water Environment, Ministry of Education, Tongji University, Shanghai 200092, PR China. Electronic address:

The N, S co-doped biochar (N, S-BC) with multistage pore structure was successfully synthesized from nanocellulose and thiourea by one-step pyrolysis, which could effectively activate peroxymonosulfate (PMS) to degrade sulfamethoxazole (SMX) in water. Moreover, the removal efficiency of SMX by this oxidation system was 2.3-3. Read More

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Subclinical upper motor neuron involvement at the diagnosis may predict disease progression in a cohort of lower motor neuron syndromes from Southern Italy.

J Neurol Sci 2021 Mar 16;425:117392. Epub 2021 Mar 16.

Neurology Unit, Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari "Aldo Moro", Piazza Giulio Cesare 11, 70100 Bari, Italy.

Background: Only few epidemiological studies on survival of Lower Motor Neuron (LMN) phenotype (LMNP) are available and with controversial results.

Aims: To prospectively evaluate a cohort of LMNP patients and assess the possible contribute on survival or disease's progression according to the presence of subclinical Upper Motor Neuron (UMN) impairment at the diagnosis.

Methods: Forty LMNP among 176 consecutive incident ALS cases observed in our tertiary center from the ALS-Apulia Register were enrolled in the study. Read More

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Entry of influenza A virus into host cells - recent progress and remaining challenges.

Curr Opin Virol 2021 Apr 7;48:23-29. Epub 2021 Apr 7.

Institute of Medical Virology, University of Zurich, 8057 Zurich, Switzerland. Electronic address:

Influenza A viruses (IAV) are a major burden for human health and thus the topic of intense research efforts. The entry of IAV into host cells is of particular interest as early infection steps are the ideal target for intervention strategies. Here, we review recent key findings in the field of IAV entry. Read More

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Effects of low-carbohydrate diet and ketogenic diet on glucose and lipid metabolism in type 2 diabetic mice.

Nutrition 2021 Mar 4;89:111230. Epub 2021 Mar 4.

State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, China. Electronic address:

Objective: With the prevalence of diabetes worldwide, it is urgent to find a suitable treatment. Recently, the ketogenic diet has shown beneficial effects in reducing blood glucose, but some concerns have been raised about its probable side effects, such as hyperlipidemia and hepatic steatosis. Because a low-carbohydrate diet replaces part of the fat with carbohydrates on the basis of the ketogenic diet, we would like to know whether it does better in treating type 2 diabetes. Read More

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Thrombin generation is associated with ischemic stroke at a young age.

Thromb Res 2021 Mar 29;202:139-144. Epub 2021 Mar 29.

Erasmus MC, University Medical Center Rotterdam, Department of Hematology, the Netherlands. Electronic address:

Introduction: Understanding the underlying mechanisms in ischemic stroke (IS) in young adults remains challenging. Thrombin activates processes that contribute to the development and progression of arterial diseases. We investigated the association between thrombin generation (TG) and a first IS or transient ischemic attack (TIA) in young adults. Read More

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The responses of Salmonella enterica serovar Typhimurium to vanillin in apple juice through global transcriptomics.

Int J Food Microbiol 2021 Mar 31;347:109189. Epub 2021 Mar 31.

School of Food Science and Engineering, South China University of Technology, Guangzhou City, Guangdong Province 510640, China. Electronic address:

Salmonella enterica serovar Typhimurium can survive some extreme environment in food processing, and vanillin generally recognized as safe is bactericidal to pathogens. Thus, we need to explore the responses of S. Typhimurium to vanillin in order to apply this antimicrobial agent in food processing. Read More

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Sustained IKKβ phosphorylation and NF-κB activation by superoxide-induced peroxynitrite-mediated nitrotyrosine modification of B56γ3 and PP2A inactivation.

Redox Biol 2020 Dec 18;41:101834. Epub 2020 Dec 18.

National University Cancer Institute, National University Health System, Singapore; Department of Physiology, Yong Loo Lin School of Medicine, NUS, Singapore; Integrative Science and Engineering Programme, NUS Graduate School, NUS, Singapore; Faculté de Medicine, University of Paris, Paris, France. Electronic address:

Apart from its physiological role in inflammation and immunity, the nuclear factor-kappa B (NF-κB) protein complex has been implicated in tumorigenesis and its progression. Here, we provide evidence that a pro-oxidant milieu is an upstream effector of oncogenic NF-κB signaling. Through pharmacological or genetic inhibition of SOD1, we show that elevated intracellular superoxide (O) mediates sustained IKK phosphorylation, and induces downstream degradation of IκBα, leading to the nuclear localization and transcriptional activation of NF-κB. Read More

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December 2020

The role of the BUN/albumin ratio in predicting mortality in COVID-19 patients in the emergency department.

Am J Emerg Med 2021 Apr 5;48:33-37. Epub 2021 Apr 5.

Emergency Department, Necmettin Erbakan University, Meram School of Medicine, Konya, Turkey.

Introduction: Due to the high mortality and spread rates of coronavirus disease 2019 (COVID-19), there are currently serious challenges in emergency department management. As such, we investigated whether the blood urea nitrogen (BUN)/albumin ratio (BAR) predicts mortality in the COVID-19 patients in the emergency department.

Methods: A total of 602 COVID-19 patients who were brought to the emergency department within the period from March to September 2020 were included in the study. Read More

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Three-dimensional heterogeneity analysis of climate aid's carbon reduction effect.

J Environ Manage 2021 Apr 7;289:112524. Epub 2021 Apr 7.

School of Economics, Wuhan University of Technology, Wuhan, Hubei, 430070, PR China.

Exploring the effectiveness of climate aid is crucial to distribute funds scientifically and maximize its impact. A body of related literature has estimated the impact of international climate aid on carbon emissions. However, these studies did not adequately consider the multi-dimensional heterogeneity of climate aid's carbon reduction effect. Read More

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Boron-toxicity induced changes in cell wall components, boron forms, and antioxidant defense system in rice seedlings.

Ecotoxicol Environ Saf 2021 Apr 7;216:112192. Epub 2021 Apr 7.

State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, Root Biology Center, College of Natural Resources and Environment, South China Agricultural University, Guangzhou, 510642 Guangdong, PR China. Electronic address:

Boron (B) is an indispensable micronutrient that ensures the optimal growth and productivity of the plant. However, excessive use of B fertilizers results in B toxicity which is relatively difficult to correct as compared to B deficiency. Moreover, underlying mechanisms of B toxicity induced changes in cell wall components and the association of B forms in the appearance of toxicity symptoms in rice seedlings are lacking. Read More

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Role of eprinomectin as inhibitor of the ruminant ABCG2 transporter: Effects on plasma distribution of danofloxacin and meloxicam in sheep.

Res Vet Sci 2021 Apr 1;136:478-483. Epub 2021 Apr 1.

Departmento de Ciencias Biomédicas, Fisiología, Facultad de Veterinaria, Instituto de Desarrollo Ganadero y Sanidad Animal (INDEGSAL), Universidad de León, Campus de Vegazana, León, Spain. Electronic address:

Therapeutic outcome results of the coadministration of several drugs in veterinary medicine is affected by, among others, the relationship between drugs and ATP-binding cassette (ABC) transporters, such as ABCG2. ABCG2 is an efflux protein involved in the bioavailability and milk secretion of drugs. The aim of this work was to determine the role of eprinomectin, a macrocyclic lactone (ML) member of avermectin class, as inhibitor of ABCG2. Read More

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Study on the Hg removal characteristics and synergistic mechanism of iron-based modified biochar doped with multiple metals.

Bioresour Technol 2021 Apr 2;332:125086. Epub 2021 Apr 2.

College of Electrical and Power Engineering, Taiyuan University of Technology, Taiyuan 030024, PR China. Electronic address:

An iron-based composite adsorbent with biochar as the support was prepared by coprecipitation and the sol-gel method. Both single-iron-based modified biochar without doping with other metals and iron-based modified biochar doped with multiple metals (Ce, Cu, Co, Mn) were synthesised. The adsorption kinetics were analysed, and temperature-programmed desorption measurements were performed to reveal the inherent difference in mechanism between the oxidation and adsorption of Hg by the modified biochar and to elucidate the key mechanism of Hg removal. Read More

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Inclined and multi-directional surface impacts accelerate biodegradation and improve mechanical properties of pure iron.

J Mech Behav Biomed Mater 2021 Apr 2;119:104476. Epub 2021 Apr 2.

Department of Mechanical Engineering, Politecnico di Milano, Milan, Italy.

Impact based surface treatments with adequate kinetic energy have favorable effects on promoting cell-substrate interactions, reducing bacterial adhesion, and enhancing fatigue performance of metallic biomaterials. Here, we used both numerical and experimental approaches to evaluate the potential of these treatments for addressing the major issue associated with the application of pure iron in biomedical implants, i.e. Read More

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Photocatalytic degradation of ibuprofen on S-doped BiOBr.

Chemosphere 2021 Mar 30;278:130376. Epub 2021 Mar 30.

Department of Chemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China. Electronic address:

Doping heterogeneous atoms into BiOX is recognized as an effective method to improve its photocatalytic activity. Here, S-doped BiOBr (S-BiOBr) was synthesized via a solvothermal method in the absence of water, which is supposed to substitute O as S in the lattice. This material is firstly used for the visible-light-driven degradation of ibuprofen, a model anti-inflammatory drug. Read More

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The graceful art, significant function and wide application behavior of ultrasound research and understanding in carbamazepine (CBZ) enhanced removal and degradation by Fe/PDS/US.

Chemosphere 2021 Apr 2;278:130368. Epub 2021 Apr 2.

School of Civil and Transportation Engineering, Guangdong University of Technology, Guangzhou, 510006, Guangdong, China.

Carbamazepine (CBZ) antibiotic organic contamination wastewater poses a huge threat to environmental safety. An advanced oxidation technology (Fe/PDS/US) of using ultrasound (US) enhanced zero-valent iron/potassium persulfate (Fe/PDS) can remove CBZ effectively. The optimal reaction conditions were determined by exploring the effect of single-factor experimental conditions such as ultrasonic power, ultrasonic frequency, CBZ concentration, solution pH, PDS dosage, and Fe dosage on the removal of CBZ. Read More

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Evaluating the mitochondrial activity and inflammatory state of dimethyl sulfoxide differentiated PLB-985 cells.

Mol Immunol 2021 Apr 7;135:1-11. Epub 2021 Apr 7.

Department of Chemistry and Biochemistry, Université de Moncton, Moncton, NB, Canada; New Brunswick Center for Precision Medicine, Moncton, NB, Canada. Electronic address:

Neutrophils play a key role in the innate immunity with their ability to generate and release inflammatory mediators that promote the inflammatory response and consequently restore the hemostasis. As active participants in several steps of the normal inflammatory response, neutrophils are also involved in chronic inflammatory diseases such as asthma, atherosclerosis, and arthritis. Given their dual role in the modulation of inflammation, regulating the inflammatory response of neutrophils has been suggested as an important therapeutic approach by numerous researchers. Read More

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The effects of antibiotics on the efficacy of immune checkpoint inhibitors in patients with non-small-cell lung cancer differ based on PD-L1 expression.

Eur J Cancer 2021 Apr 7;149:73-81. Epub 2021 Apr 7.

Department of Allergy and Respiratory Medicine, Okayama University Hospital, Japan.

Background: Immune checkpoint inhibitors (ICIs) are essential for treatment of various malignancies, including non-small-cell lung cancer (NSCLC). Recently, several studies have shown that the gut microbiome plays an important role in ICI treatment of solid cancers, and antibiotic (ATB) use had a negative impact on the outcomes of ICI treatment via dysbiosis in the gut. However, whether this is applicable to NSCLC remains unclear. Read More

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Identification of inference fallacies in solid waste generation estimations of developing countries. A case-study in Panama.

Waste Manag 2021 Apr 7;126:454-465. Epub 2021 Apr 7.

Institut de Ciència i Tecnologia Ambientals, Universitat Autònoma de Barcelona, Bellaterra, Spain; Institució Catalana de Recerca i Estudis Avançats, Barcelona, Spain.

The absence of sound sampling procedures and statistical analyses to estimate solid waste generation in many developing countries has resulted in incomplete historical records of waste quantity and composition. Data is often arbitrarily aggregated or disaggregated as a function of waste generators to obtain results at the desired spatial level of analysis. Inference fallacies arising from the generalization or individualization of results are almost never considered. Read More

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Pre and postnatal exposure to mercury and respiratory health in preschool children from the Spanish INMA Birth Cohort Study.

Sci Total Environ 2021 Mar 20;782:146654. Epub 2021 Mar 20.

Epidemiology and Environmental Health Joint Research Unit, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region, FISABIO-Public Health, FISABIO-Universitat Jaume I-Universitat de València, Av. Catalunya 21, 46020 Valencia, Spain; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Av. Monforte de Lemos, 3-5. Pabellón 11, 28029 Madrid, Spain.

Effects of mercury on maturing immune system have been reported, however the association with respiratory and allergy problems during infancy remains unclear. The aim of this study is to evaluate the association between pre and postnatal mercury exposure and respiratory and allergy problems among preschool children and to examine the role of potential modifying factors. Study subjects were children participant in Spanish Childhood and Environment Project (INMA, 2003-2008). Read More

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