3,012,885 results match your criteria role


Genome-wide Association and Meta-analysis of Age-at-Onset in Parkinson Disease: Evidence From COURAGE-PD Consortium.

Neurology 2022 May 26. Epub 2022 May 26.

Sorbonne Université (SU) Unité Mixte de Recherche (UMR) 1127, INSERM U1127, CNRS UMR 7225, Institut du Cerveau et de la Moelle épinière, ICM, Paris, France.

Background And Objectives: Considerable heterogeneity exists in the literature concerning genetic determinants of the age of onset (AAO) of Parkinson's disease (PD), which could be attributed to lack of well-powered replication cohorts. The previous largest GWAS identified nd loci on chromosome (Chr) 4 with a significant influence on AAO of PD, these have not been independently replicated. The present study aims to conduct a meta-analysis of GWAS of PD AAO and validate previously observed findings in worldwide populations. Read More

View Article and Full-Text PDF

Comprehensive evolutionary analysis and nomenclature of plant G3BPs.

Life Sci Alliance 2022 Sep 26;5(9). Epub 2022 May 26.

Center for Desert Agriculture (CDA), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia

Stress induces extensive reprogramming of mRNA metabolism, which includes the transcription and translation of stress-related genes and the formation of stress granules. RasGAP SH3 domain-binding proteins (G3BPs, also called Rasputins) form a highly conserved family of proteins found throughout eukaryotic evolution, which coordinate signal transduction and posttranscriptional gene regulation and play a key role in the formation of stress granules. G3BPs play a role in osmotic, oxidative, and biotic stress in mammals, and recent results revealed that they play similar functions in higher plants. Read More

View Article and Full-Text PDF
September 2022

Volumetric Measurement of Relative CBV Using T1-Perfusion-Weighted MRI with High Temporal Resolution Compared with Traditional T2*-Perfusion-Weighted MRI in Postoperative Patients with High-Grade Gliomas.

AJNR Am J Neuroradiol 2022 May 26. Epub 2022 May 26.

From the Department of Radiology, Seoul St. Mary's Hospital, College of Medicine, the Catholic University of Korea, Seoul, Republic of Korea.

Background And Purpose: T1-PWI with high temporal resolution may provide a reliable relative CBV value as a valid alternative to T2*-PWI under increased susceptibility. The purpose of this study was to assess the technical and clinical performance of T1-relative CBV in patients with postoperative high-grade gliomas.

Materials And Methods: Forty-five MRIs of 34 patients with proved high-grade gliomas were included. Read More

View Article and Full-Text PDF

Frequent somatic gene conversion as a mechanism for loss of heterozygosity in tumor suppressor genes.

Genome Res 2022 May 26. Epub 2022 May 26.

SOKENDAI, The Graduate University for Advanced Studies

The major processes to carcinogenesis include inactivation of tumor suppressor genes (TSGs). While Knudson's two-hit model requires two independent inactivating mutations, perhaps more frequently, inactivation of a TSG can occur through loss of heterozygosity (LOH) of one inactivating mutation. Deletion and uniparental disomy (UPD) have been well documented as the mechanisms of LOH, but the role of gene conversion is poorly understood. Read More

View Article and Full-Text PDF

Evolution of transcription factor binding through sequence variations and turnover of binding sites.

Genome Res 2022 May 26. Epub 2022 May 26.

Weizmann Institute of Science;

Variations in noncoding regulatory sequences play a central role in evolution. Interpreting such variations, however, remains difficult even in the context of defined attributes such as transcription factor (TF) binding sites. Here, we systematically link variations in -regulatory sequences to TF binding by profiling the allele-specific binding of 27 TFs expressed in a yeast hybrid, in which two related genomes are present within the same nucleus. Read More

View Article and Full-Text PDF

The Complement System in the Modern Era of Kidney Transplantation: Mechanisms of Injury and Targeted Therapies.

Semin Nephrol 2022 Jan;42(1):14-28

Division of Nephrology, Department of Medicine, Boston University School of Medicine, Boston, MA. Electronic address:

Kidney transplantation remains the treatment of choice for patients with end-stage kidney disease. Significant progress has been made over the course of many years to improve both patient and graft outcomes after transplant. Modern immunosuppressive therapy has reduced the rate of acute rejection and resulted in excellent short- and long-term graft survival. Read More

View Article and Full-Text PDF
January 2022

Relational support from teachers and peers matters: Links with different profiles of relational support and academic engagement.

J Sch Psychol 2022 Jun 20;92:209-226. Epub 2022 Apr 20.

Chungbuk National University, Republic of Korea.

The present study examined whether there were discrete groups of early adolescents who experienced different levels of relational support from teachers and peers and how distinct profiles of relational support were associated with different dimensions of academic engagement in the classroom. Data on nine different indicators of teacher and peer relational support were collected from 714 fifth- (n = 394) and sixth-grade (n = 320) students from South Korea, along with their concurrent and subsequent academic engagement. Latent profile analyses revealed that there were four distinct relational support profiles: (1) Low Support, (2) Moderate Support, (3) Peer-Oriented, and (4) High Support. Read More

View Article and Full-Text PDF

Temporal stability of relational aggression profiles in adolescents.

J Sch Psychol 2022 Jun 25;92:19-32. Epub 2022 Feb 25.

Department of Psychology, University of Cyprus, Cyprus.

The current study explored the temporal stability in relational aggressor's profiles over a 6-month period. Data were gathered at two time points from a sample of 2207 Greek junior high school students (52.8% females) aged between 13 and 16 (M = 14. Read More

View Article and Full-Text PDF

The academic benefits of maintaining friendships across the transition to high school.

J Sch Psychol 2022 Jun 13;92:136-147. Epub 2022 Apr 13.

University of California, Los Angeles, 502 Portola Plaza, Los Angeles, CA 90095, United States of America.

Extending past research on the social and academic disruption associated with the transition from middle to high school, this study examined the role of friendship stability. Specifically, the goal was to investigate how friendships maintained from middle school and perceived (academic and emotional) support from friends at ninth grade contributed to school-related affect (e.g. Read More

View Article and Full-Text PDF

The role of assisted hatching in in vitro fertilization: a guideline.

Authors:

Fertil Steril 2022 Jun;117(6):1177-1182

There is moderate evidence that assisted hatching does not significantly improve live birth rates in fresh assisted reproductive technology cycles and insufficient evidence for the benefit of assisted hatching in patients with poor prognosis or undergoing frozen embryo transfer cycles. This document replaces the document of the same name published in 2014. Read More

View Article and Full-Text PDF

Disruption of Circadian Rhythms by Shift Work Exacerbates Reperfusion Injury in Myocardial Infarction.

J Am Coll Cardiol 2022 May;79(21):2097-2115

State Key Laboratory for Oncogenes and Related Genes, Division of Cardiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Cancer Institute, Shanghai, China. Electronic address:

Background: Shift work is associated with increased risk of acute myocardial infarction (AMI) and worsened prognosis. However, the mechanisms linking shift work and worsened prognosis in AMI remain unclear.

Objectives: This study sought to investigate the impact of shift work on reperfusion injury, a major determinant of clinical outcomes in AMI. Read More

View Article and Full-Text PDF

Role of COVID-19 pandemic in the academic life and well-being of private sector university students: an exploratory qualitative study.

BMJ Open 2022 May 26;12(5):e055678. Epub 2022 May 26.

Department of Medicine, Aga Khan University, Karachi, Pakistan.

Objective: The advent of the COVID-19 pandemic has caused a drastic impact on students' life, causing physical and emotional sufferings. Considering the relevance of unprecedented conditions, we explored perceptions and attitudes of students towards their academic life and well-being amid the COVID-19 pandemic.

Setting: We conducted an exploratory qualitative study using a purposive sampling approach conducted at a single-centre private nursing institution in Karachi, Pakistan. Read More

View Article and Full-Text PDF

Mediator or moderator? The role of obesity in the association between age at menarche and blood pressure in middle-aged and elderly Chinese: a population-based cross-sectional study.

BMJ Open 2022 May 26;12(5):e051486. Epub 2022 May 26.

Department of Emergency and Critical Care Nursing, School of Nursing, Wannan Medical College, Wuhu, Anhui, China.

Objective: We investigated the moderation/mediation between the age of menarche and obesity parameters in predicting blood pressure (BP) in middle-aged and elderly Chinese.

Design: Our study is a population-based cross-sectional study.

Setting: Participants in this study came from the China Health and Retirement Longitudinal Study (CHARLS). Read More

View Article and Full-Text PDF

Randomised controlled monocentric trial to compare the impact of using professional actors or peers for communication training in a competency-based inverted biochemistry classroom in preclinical medical education.

BMJ Open 2022 May 26;12(5):e050823. Epub 2022 May 26.

Institute of Biochemistry and Molecular Biolog, Ulm University, Ulm, Germany

Objective: In medical education, biochemistry topics are usually knowledge based, and students often are unaware of their clinical relevance. To improve students' awareness of the relevance, we integrated communication skills training into biochemistry education. No studies before have examined the difference between peer and standardised patient (SP) role plays where students explain the biochemical background of a disease in patient-centred language. Read More

View Article and Full-Text PDF

Impact of inland waters on highly pathogenic avian influenza outbreaks in neighboring poultry farms in South Korea.

J Vet Sci 2022 May;23(3):e36

Department of Veterinary Internal Medicine, College of Veterinary Medicine and BK21 FOUR Program, Chonnam National University, Gwangju 61186, Korea.

Background: Since 2003, the H5 highly pathogenic avian influenza (HPAI) subtype has caused massive economic losses in the poultry industry in South Korea. The role of inland water bodies in avian influenza (AI) outbreaks has not been investigated. Identifying water bodies that facilitate risk pathways leading to the incursion of the HPAI virus (HPAIV) into poultry farms is essential for implementing specific precautionary measures to prevent viral transmission. Read More

View Article and Full-Text PDF

Unique role for lncRNA HOTAIR in defining depot-specific gene expression patterns in human adipose-derived stem cells.

Genes Dev 2022 May 26. Epub 2022 May 26.

Division of Diabetes Endocrinology and Metabolism, Johns Hopkins University School of Medicine; Institute for Fundamental Biomedical Research, Johns Hopkins All Children's Hospital, St. Petersburg, Florida 33701, USA.

Accumulation of fat above the waist is an important risk factor in developing obesity-related comorbidities independently of BMI or total fat mass. Deciphering the gene regulatory programs of the adipose tissue precursor cells within upper body or abdominal (ABD) and lower body or gluteofemoral (GF) depots is important to understand their differential capacity for lipid accumulation, maturation, and disease risk. Previous studies identified the HOX transcript antisense intergenic RNA (HOTAIR) as a GF-specific lncRNA; however, its role in adipose tissue biology is still unclear. Read More

View Article and Full-Text PDF

Mechanism of effective combination radio-immunotherapy against 9464D-GD2, an immunologically cold murine neuroblastoma.

J Immunother Cancer 2022 May;10(5)

Department of Human Oncology, University of Wisconsin-Madison, Madison, Wisconsin, USA

Background: Most pediatric cancers are considered immunologically cold with relatively few responding to immune checkpoint inhibition. We recently described an effective combination radio-immunotherapy treatment regimen ( ombination daptive- nnate immunotherapy egimen (CAIR)) targeting adaptive and innate immunity in 9464D-GD2, an immunologically cold model of neuroblastoma. Here, we characterize the mechanism of CAIR and the role of major histocompatibility complex class I (MHC-I) in the treatment response. Read More

View Article and Full-Text PDF

Spatial transcriptomics of macrophage infiltration in non-small cell lung cancer reveals determinants of sensitivity and resistance to anti-PD1/PD-L1 antibodies.

J Immunother Cancer 2022 May;10(5)

Department of Medecine, Institut Bergonié, Bordeaux, France

Background: Tumor-associated macrophages (TAMs) having immunosuppressive properties are one of the most abundant immune cells in the tumor microenvironment (TME). Preclinical studies have highlighted the potential role of TAMs in resistance to immune checkpoint blockers (ICBs). Here, we investigated the predictive value of TAM infiltration in patients with non-small cell lung cancer (NSCLC) treated with ICBs and characterized their transcriptomic profiles. Read More

View Article and Full-Text PDF

Bufalin stimulates antitumor immune response by driving tumor-infiltrating macrophage toward M1 phenotype in hepatocellular carcinoma.

J Immunother Cancer 2022 May;10(5)

Institute of Infectious Disease, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People's Republic of China

Background: Immunotherapy for hepatocellular carcinoma (HCC) exhibits limited clinical efficacy due to immunosuppressive tumor microenvironment (TME). Tumor-infiltrating macrophages (TIMs) account for the major component in the TME, and the dominance of M2 phenotype over M1 phenotype in the TIMs plays the pivotal role in sustaining the immunosuppressive character. We thus investigate the effect of bufalin on promoting TIMs polarization toward M1 phenotype to improve HCC immunotherapy. Read More

View Article and Full-Text PDF

Excess ventilation and exertional dyspnoea in heart failure and pulmonary hypertension.

Eur Respir J 2022 May 26. Epub 2022 May 26.

Professor Emeritus, John Rankin Laboratory of Pulmonary Medicine, Dept of Population Health Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA.

Increased ventilation relative to metabolic secondary to alveolar hyperventilation and/or increased physiological dead space (excess ventilation) is a key cause of exertional dyspnoea. Excess ventilation has assumed a prominent role in the functional assessment of patients with heart failure (HF) with reduced (r) or preserved (p) ejection fraction, pulmonary arterial hypertension (PAH), and chronic thromboembolic PH (CTEPH). We herein provide the key pieces of information to the caring physician to a) gain unique insights into the seeds of patients' shortness of breath, and b) develop a rationale for therapeutically lessening excess ventilation to mitigate this distressing symptom. Read More

View Article and Full-Text PDF

Microvascular reactivity as a predictor of major adverse events in patients with on-pump cardiac surgery.

Korean J Anesthesiol 2022 May 27. Epub 2022 May 27.

Department of Anesthesia and Pain Medicine, Medical Research Institute, Pusan National University Hospital, Busan, Republic of Korea.

Background: Microcirculatory disturbance occurs most seriously during cardiopulmonary bypass (CPB) in cardiac surgery. If microvascular reactivity compensates for microcirculatory disturbance during CPB, tissue hypoxemia may be minimized. The primary aim of this study was to assess whether microvascular reactivity during CPB can predict major adverse events (MAE) after cardiac surgery. Read More

View Article and Full-Text PDF

Identification and analysis of six phosphorylation sites within the Xenopus laevis H1.0 C-terminal domain indicate distinct effects on nucleosome structure.

Mol Cell Proteomics 2022 May 23:100250. Epub 2022 May 23.

Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY 14642.

As a key structural component of the chromatin of higher eukaryotes, linker histones (H1s) are involved in stabilizing the folding of extended nucleosome arrays into higher-order chromatin structures and function as a gene-specific regulators of transcription in vivo. The H1 C-terminal domain (CTD) is essential for high affinity binding of linker histones to chromatin and stabilization of higher-order chromatin structure. Importantly, the H1 CTD is an intrinsically disordered domain that undergoes a drastic condensation upon binding to nucleosomes. Read More

View Article and Full-Text PDF

Molecular cloning, characterization, and tissue distribution of c-Myc from blood clam Tegillarca granosa and its role in cadmium-induced stress response.

Gene 2022 May 23:146611. Epub 2022 May 23.

Zhejiang Mariculture Research Institute, Zhejiang Key Lab of Exploitation and Preservation of Coastal Bio-Resource, Wenzhou Key Laboratory of Marine Biological Genetics and Breeding, Wenzhou 325005, China. Electronic address:

Cadmium (Cd) pollution threatens the cultivation of the blood clam Tegillarca granosa (T. granosa) in coastal regions of the East China Sea. The molecular mechanisms regulating Cd stress response and detoxification in blood clams are largely unclear. Read More

View Article and Full-Text PDF

Vorinostat combined with Busulfan, Fludarabine, and Clofarabine Conditioning Regimen for Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Acute Leukemia: Long-term Study Outcomes.

Transplant Cell Ther 2022 May 23. Epub 2022 May 23.

Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA. Electronic address:

Background: Conditioning regimens play a major role in determining disease outcomes following allogeneic hematopoietic stem cell transplantation (allo-HSCT). The use of intravenous (IV) busulfan (Bu) as part of the conditioning chemotherapy has been shown to be effective in controlling disease relapse. However, disease relapse remains a major cause of death following allo-HSCT. Read More

View Article and Full-Text PDF

In-situ and ex-situ co-pyrolysis studies of waste biomass with spent motor oil: Elucidating the role of physical inhibition and mixing ratio to enhance fuel quality.

Bioresour Technol 2022 May 23:127364. Epub 2022 May 23.

Department of Chemical Engineering, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal 721302, India; Department of Chemical Engineering, School of Engineering, Howard College, University of Kwazulu-Natal, Durban 4041, South Africa. Electronic address:

Simultaneous renewable energy generation is an imperative part of sustainable hazardous waste management. Therefore, the present work explicates the co-pyrolysis of rice stubble (RS) waste biomass and spent motor oil (SMO) to upgrade the obtained bio-oil. Moreover, two different modes, namely, in-situ and ex-situ, were implemented to analyze the effect of physical inhibition. Read More

View Article and Full-Text PDF

The long noncoding RNA LTCONS5539 up-regulates the TRAF6-mediated immune responses in miiuy croaker (Miichthys miiuy).

Fish Shellfish Immunol 2022 May 23. Epub 2022 May 23.

Laboratory of Fish Molecular Immunology, College of Fisheries and Life Science, Shanghai Ocean University, Shanghai, China; Laboratory of Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China; Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources (Shanghai Ocean University), Ministry of Education, China; National Pathogen Collection Center for Aquatic Animals, Shanghai Ocean University, China. Electronic address:

With the further study of long noncoding RNAs (lncRNAs), an increasing number of biological studies have demonstrated that lncRNAs are involved in various physiological processes, including cell proliferation, apoptosis, invasion, development and disease states. However, unlike mammals, little is known about the role of lncRNAs in the innate immunity of teleost fish. Here, we identify a lncRNA, named LTCONS5539, as critical role in the antiviral and antibacterial response of miiuy croaker and the results showed that lncRNA LTCONS5539 plays a critical regulatory role on TRAF6. Read More

View Article and Full-Text PDF

Membrane orthologs of TLR5 of tongue sole Cynoglossus semilaevis: Expression patterns, signaling pathway and antibacterial property.

Fish Shellfish Immunol 2022 May 23. Epub 2022 May 23.

School of Ocean, Yantai University, Yantai, China.

Mammalian toll-like receptor 5 (TLR5) is crucial for recognizing bacterial flagellin and initiating the inflammatory signaling cascades via myeloid differentiation factor 88 (MyD88) signaling pathway, which plays vital role in innate immune against pathogenic bacteria. Herein, we reported the signaling pathway and antibacterial property of tongue sole (Cynoglossus semilaevis) membrane forms of TLR5 (i.e. Read More

View Article and Full-Text PDF

Sexual Dimorphism in Renal Heme Oxygenase-1 and Arachidonic Acid Metabolizing Enzymes in Spontaneously Hypertensive Rats versus Normotensive Wistar Kyoto Rats.

Prostaglandins Other Lipid Mediat 2022 May 23:106650. Epub 2022 May 23.

Department of Oral Biology & Diagnostic Sciences, Augusta University, Augusta, GA. 30912; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Mansoura University, Egypt. Electronic address:

Numerous studies have demonstrated a sexual dimorphism in blood pressure (BP) control in spontaneously hypertensive rats (SHR), however the mechanisms remain to be further elucidated. Based on the established role of arachidonic acid metabolites and heme oxygenase (HO) in BP control, we hypothesize that higher BP in male SHR is associated with differential expression in renal HO and arachidonic acid metabolizing enzymes vs. female SHR. Read More

View Article and Full-Text PDF