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Inhibition of synapse assembly in mammalian muscle in vivo by RNA interference.

EMBO Rep 2004 Feb 16;5(2):183-8. Epub 2004 Jan 16.

Biozentrum, University of Basel, Basel, Switzerland.

The formation of the vertebrate neuromuscular junction (NMJ) requires the receptor tyrosine kinase MuSK and the adaptor molecule rapsyn. Here, we report that the phenotypes of mice deficient in these two molecules can be reproduced by RNA interference (RNAi) in rat muscle in vivo. Specifically, double-stranded RNA (dsRNA) targeting MuSK and rapsyn inhibited the formation of the NMJ in rat muscle fibres in vivo, while dsRNA targeting nonessential proteins did not have any effect. Read More

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February 2004
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