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Chemotherapy and Targeted Therapy for Patients With Human Epidermal Growth Factor Receptor 2-Negative Metastatic Breast Cancer That is Either Endocrine-Pretreated or Hormone Receptor-Negative: ASCO Guideline Update.

J Clin Oncol 2021 Jul 29:JCO2101374. Epub 2021 Jul 29.

UNC Lineberger Comprehensive Cancer Center, Chapel Hill, NC.

Purpose: This guideline updates recommendations of the ASCO guideline on chemotherapy and targeted therapy for patients with human epidermal growth factor receptor 2-negative metastatic breast cancer (MBC) that is either endocrine-pretreated or hormone receptor (HR)-negative.

Methods: An Expert Panel conducted a targeted systematic literature review guided by a signals approach to identify new, potentially practice-changing data that might translate into revised guideline recommendations.

Results: The Expert Panel reviewed abstracts from the literature review and retained 14 articles. Read More

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Hematopoietic Cell Transplantation Cures Adenosine Deaminase 2 Deficiency: Report on 30 Patients.

J Clin Immunol 2021 Jul 29. Epub 2021 Jul 29.

Pediatric Immunology, Hematology and Rheumatology Unit, Hôpital Necker-Enfants Malades, APHP, Paris, France.

Purpose: Deficiency of adenosine deaminase 2 (DADA2) is an inherited inborn error of immunity, characterized by autoinflammation (recurrent fever), vasculopathy (livedo racemosa, polyarteritis nodosa, lacunar ischemic strokes, and intracranial hemorrhages), immunodeficiency, lymphoproliferation, immune cytopenias, and bone marrow failure (BMF). Tumor necrosis factor (TNF-α) blockade is the treatment of choice for the vasculopathy, but often fails to reverse refractory cytopenia. We aimed to study the outcome of hematopoietic cell transplantation (HCT) in patients with DADA2. Read More

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Reducing SAR in 7T brain fMRI by circumventing fat suppression while removing the lipid signal through a parallel acquisition approach.

Sci Rep 2021 Jul 28;11(1):15371. Epub 2021 Jul 28.

Neurobiology Department, Weizmann Institute of Science, Rehovot, Israel.

Ultra-high-field functional magnetic resonance imaging (fMRI) offers a way to new insights while increasing the spatial and temporal resolution. However, a crucial concern in 7T human MRI is the increase in power deposition, supervised through the specific absorption rate (SAR). The SAR limitation can restrict the brain coverage or the minimal repetition time of fMRI experiments. Read More

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A comprehensive analysis of copy number variation in a Turkish dementia cohort.

Hum Genomics 2021 Jul 28;15(1):48. Epub 2021 Jul 28.

Department of Neurodegenerative Science, Van Andel Institute, Grand Rapids, Michigan, USA.

Background: Copy number variants (CNVs) include deletions or multiplications spanning genomic regions. These regions vary in size and may span genes known to play a role in human diseases. As examples, duplications and triplications of SNCA have been shown to cause forms of Parkinson's disease, while duplications of APP cause early onset Alzheimer's disease (AD). Read More

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Influence of intensified adherence counselling on viral load suppression of people receiving antiretroviral therapy at a health centre IV in southwestern Uganda: a qualitative study.

AIDS Res Ther 2021 Jul 28;18(1):45. Epub 2021 Jul 28.

Faculty of Medicine, Mbarara University of Science And Technology, P.O. Box 1410, Mbarara, Uganda.

Background: The prevalence of Human Immunodeficiency Virus (HIV) among adults and children in Uganda is 6.2% and 0.5% respectively. Read More

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Vapourized Hydrogen Peroxide Decontamination in a Hospital Setting Inactivates SARS-CoV-2 and HCoV-229E without Compromising Filtration Efficiency of Unexpired N95 Respirators.

Am J Infect Control 2021 Jul 25. Epub 2021 Jul 25.

Dalla Lana School of Public Health, University of Toronto, 223 College Street, Toronto, ON, Canada, M5T 1R4; Department of Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Cir, Toronto, ON, Canada, M5S 1A8. Electronic address:

Background: The COVID-19 pandemic highlighted the need for evidence-based approaches to decontamination and reuse of N95 filtering facepiece respirators (FFRs). We sought to determine whether vapourized hydrogen peroxide (VHP) reduced SARS-CoV-2 bioburden on FFRs without compromising filtration efficiency. We also investigated coronavirus HCoV-229E as a surrogate for decontamination validation testing. Read More

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Total pancreatectomy sequelae and quality of life: results of islet autotransplantation as a possible mitigation strategy.

Updates Surg 2021 Jul 28. Epub 2021 Jul 28.

Chirurgia del Pancreas, Pancreas Translational and Clinical Center, IRCCS Ospedale San Raffaele, Milano, Italy.

Total pancreatectomy (TP) is a procedure weighed down not only by postoperative morbidity and mortality but also by long-term effects as a consequence of endocrine and exocrine pancreatic insufficiency. While the latter is now managed quite effectively with pancreatic enzyme replacement therapy, the former remains a challenge. The diabetes resulting after TP, with the complete loss of endogenous insulin and contraregulatory hormones, is characterized by important glycemic variations and is, therefore, frequently referred to as "brittle diabetes". Read More

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Long-Term Follow-Up of Cardioneuroablation to Treat Second-Degree Block After Slow Pathway Ablation.

JACC Case Rep 2020 Sep 15;2(11):1781-1788. Epub 2020 Sep 15.

Department of Cardiology and Interventional Cardiology, Santa Rita Cassia Hospital, Vitoria, Brazil.

We present the long-term follow-up of a 31-year-old woman who underwent cardioneuroablation (for atrioventricular (AV) block. Slow pathway ablation was performed in September 2017 with normal follow-up until April 2018, when the patient started noticing symptoms of palpitations at rest, and the electrocardiogram showed a Mobitz I AV block. A cardiac stress test and 24-h Holter monitoring demonstrated first- and second-degree block and normal AV conduction during times of higher heart rate. Read More

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September 2020

Unravelling the relation between processed crude oils and the composition of spent caustic effluents as well as the respective economic impact.

J Hazard Mater 2021 Jul 13;421:126629. Epub 2021 Jul 13.

IBET - Instituto de Biologia Experimental e Tecnológica, Apartado 12, 2780-157 Oeiras, Portugal. Electronic address:

Spent caustic discharges are responsible for increasing oil and grease (O&G) matter in refineries wastewater, leading to increasing treatment costs due to low water quality and environmental constraints associated with high O&G concentration discharges. As a way to settle and optimize treatment technologies for such complex effluents, more insight regarding the effluents impact and deeper characterization is necessary. The present study intends to assess the possibility of a relationship between the processed crude oils with the polar O&G concentration in naphthenic spent caustic as well as in the final wastewater; Sines refinery was considered as case-study. Read More

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Discovery of serum biomarkers for diagnosis of tuberculosis by NMR metabolomics including cross-validation with a second cohort.

Biomed J 2021 Jul 24. Epub 2021 Jul 24.

Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, 2780-157 Oeiras, Portugal. Electronic address:

Background: Tuberculosis (Tb) is a disease with worldwide presence and a major cause of death in several developing countries. Current diagnostic methodologies often lack specificity and sensitivity, whereas a long time is needed to obtain a conclusive result.

Material And Methods: In an effort to develop better diagnostic methods, this study aimed at the discovery of a biomarker signature for Tb diagnosis using a Nuclear Magnetic Resonance based metabolomics approach. Read More

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The role of Extracellular Vesicles during CNS development.

Prog Neurobiol 2021 Jul 24:102124. Epub 2021 Jul 24.

Department of Biochemistry, Maastricht University, Cardiovascular Research Institute Maastricht, Maastricht, the Netherlands; GKC-Rett Expertise Centre, Maastricht University Medical Centre, Maastricht, the Netherlands. Electronic address:

With a diverse set of neuronal and glial cell populations, Central Nervous System (CNS) has one of the most complex structures in the body. Intercellular communication is therefore highly important to coordinate cell-to-cell interactions. Besides electrical and chemical messengers, CNS cells also benefit from another communication route, what is known as extracellular vesicles, to harmonize their interactions. Read More

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CAPABLE program improves disability in multiple randomized trials.

J Am Geriatr Soc 2021 Jul 27. Epub 2021 Jul 27.

Johns Hopkins School of Nursing, Baltimore, Maryland, USA.

Background: Programs to reduce disability are crucial to the quality of life for older adults with disabilities. Reducing disability is also important to avert unnecessary and costly hospitalizations, relocation, or nursing home placements. Few programs reduce disability and few have been replicated and scaled beyond initial research settings. Read More

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Advance Directives for Adolescents and Young Adults Living With Neuromuscular Disease: An Integrative Review of the Literature.

J Hosp Palliat Nurs 2021 Jul 26. Epub 2021 Jul 26.

Vanessa Battista, DNP, MBA, MS, RN, CPNP-PC, CHPPN, is pediatric nurse practitioner, The Children's Hospital of Philadelphia, PA. Deborah J. Baker, DNP, ACNP, NEA-BC, is senior vice president for Nursing, Vice President for Nursing & Patient Care Services, and Chief Nursing Officer, Johns Hopkins Health System - The Johns Hopkins Hospital, Baltimore, MD; and associate dean for Health Systems Partnership and Innovation, Johns Hopkins University School of Nursing, Baltimore, MD. Tara Trimarchi, DNP, RN, CRNP, is senior director of Care Management, The Children's Hospital of Philadelphia, PA. Bushra Sabri, PhD, MSW, is assistant professor, Johns Hopkins University School of Nursing. Rita F. D'Aoust, PhD, is associate professor and associate dean for Teaching and Learning, Johns Hopkins School of Nursing. Rebecca Wright, PhD, BSc (Hons), RN, is an assistant professor, Johns Hopkins School of Nursing, Baltimore, MD.

The use of advance directives is an important component in helping individuals living with chronic and/or life-threatening illnesses establish goals of care and make decisions regarding care at the end of life. Advance care planning may help achieve enhanced health outcomes, yet it is not routinely offered to adolescents/young adults living with neuromuscular disease. An integrative review of the literature was conducted to examine the evidence related to the use of advance directives with adolescents/young adults living with neuromuscular disease and to identify reasons why they are not being used and how this can be improved. Read More

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Comment to "Percutaneous Intradermal Purse-String Closure for Correction of Male Tuberous Nipple-Areola Complex Deformity".

Aesthetic Plast Surg 2021 Jul 22. Epub 2021 Jul 22.

Department of Medical Biotechnology and Translational Medicine BIOMETRA - Plastic Surgery Unit, Reconstructive and Aesthetic Plastic Surgery School, Humanitas Clinical and Research Center, University of Milan, Rozzano, Milan, Italy.

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Paid Family Leave and Mental Health in the U.S.: A Quasi-Experimental Study of State Policies.

Am J Prev Med 2021 Aug 28;61(2):182-191. Epub 2021 Jun 28.

UCSF Philip R. Lee Institute for Health Policy Studies, University of California San Francisco, San Francisco, California; Department of Family and Community Medicine, University of California San Francisco, San Francisco, California. Electronic address:

Introduction: Several U.S. states have implemented paid family leave policies for new parents. Read More

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Genetic hypervariability of a Northeastern Atlantic venomous rockfish.

PeerJ 2021 12;9:e11730. Epub 2021 Jul 12.

MARE-Marine and Environmental Sciences Centre, ISPA Instituto Universitário de Ciências Psicológicas, Sociais e da Vida, Lisbon, Portugal.

Background: Understanding the interplay between climate and current and historical factors shaping genetic diversity is pivotal to infer changes in marine species range and communities' composition. A phylogeographical break between the Atlantic and the Mediterranean has been documented for several marine organisms, translating into limited dispersal between the two basins.

Methods: In this study, we screened the intraspecific diversity of 150 individuals of the Madeira rockfish () across its distributional range (seven sampling locations in the Atlantic and Mediterranean basins) using the mitochondrial control region and the nuclear S7 first intron. Read More

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Effects of Cognitive Remediation on Cognition, Metacognition, and Social Cognition in Patients With Schizophrenia.

Front Psychiatry 2021 9;12:649737. Epub 2021 Jul 9.

Department of Neuroscience "Rita Levi Montalcini", Azienda Ospedaliera Universitaria (AOU) Città della Salute e della Scienza, University of Turin, Turin, Italy.

We aimed to evaluate in a sample of outpatients with schizophrenia (SCZ) the effectiveness of a cognitive remediation (CR) program (through the use of the Cogpack software) [computer-assisted CR (CACR)] in addition to standard therapy on cognitive outcomes as compared with that in a control active group (CAG) and to highlight a possible effect on social cognition (SC), metacognition, symptomatology, and real-world functioning. Of the 66 subjects enrolled, 33 were allocated to CACR and 33 to the CAG. Twenty-three patients in the CACR group and 25 subjects in the CAG completed at least 80% of the 48 prescribed CACR sessions, performed twice a week, for a total of 24 weeks of treatment. Read More

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International Consensus Recommendations for the Treatment of Pediatric NMDAR Antibody Encephalitis.

Neurol Neuroimmunol Neuroinflamm 2021 Jul 22;8(5). Epub 2021 Jul 22.

From the Paediatric Neurology and Neurophysiology Unit (M.N.), Department of Women's and Children's Health, University Hospital of Padova; Neuroimmunology Group (M.N.), Paediatric Research Institute "Città della Speranza," Padova, Italy; Department of Paediatrics (T.T.), Neurology Service, KK Women's and Children's Hospital, Singapore; School of Biomedical Engineering & Imaging Sciences (M.E.), King's College London; Children's Neurosciences (M.E.), Evelina London Children's Hospital at Guy's and St Thomas' NHS Foundation Trust, United Kingdom; Department of Pediatric Neurology (B.A.), Hacettepe University, Ankara, Turkey; Neuroimmunology Program (T.A.), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, Universitat de Barcelona; Pediatric Neuroimmunology Unit (T.A.), Neurology Department, Sant Joan de Déu (SJD) Children's Hospital, University of Barcelona, Spain; Alberta Children's Hospital Research Institute (S.M.B.), Department of Pediatrics, Cumming School of Medicine, University of Calgary; Division of Rheumatology (T.C.), Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada; Assistance Publique-Hôpitaux de Paris (K.D.), Pediatric Neurology Department, University Hospitals Paris Saclay, Bicêtre Hospital, France; French Reference Network of Rare Inflammatory Brain and Spinal Diseases (K.D.), Le Kremlin Bicêtre, France and European Reference Network-RITA; Departments of Neurology and Pediatrics (W.G.), Stanford University and Lucile Packard Children's Hospital, Palo Alto, CA; Division of Pediatric Neurology (G.G.), Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, GA; Department of Neurology (M.P.G.), Boston Children's Hospital, Harvard Medical School, Boston, MA; Department of Neuroinflammation (Y.H.), Queen Square MS Centre, UCL Institute of Neurology, University College London; Department of Paediatric Neurology (Y.H.), Great Ormond Street Hospital for Children, London, United Kingdom; Department of Pediatrics (Y.J.), Peking University First Hospital, Beijing, China; Department of Pediatrics (B.C.L.), Pediatric Clinical Neuroscience Center, Seoul National University Children's Hospital, Seoul National University College of Medicine, South Korea; Department of Pediatrics (E.M.), Section Rheumatology, Co-appointment in the Section of Neurology and Developmental Neuroscience, Texas Children's Hospital, Baylor College of Medicine, Houston; Division of Paediatric Neurology (A.N.), Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town; Faculty of Health Sciences (A.N.), University of Cape Town Neuroscience Institute, South Africa; Department of Neurology (R.N.), Erasmus Medical Center, Rotterdam, the Netherlands; Department of Pediatric Neurology (K.R.), Children's Hospital Datteln, University Witten/Herdecke, Germany; Department of Brain and Neural Science (H.S.), Tokyo Metropolitan Institute of Medical Science, Japan; Department of Pediatrics (Neurology Division) (S.S.), Lady Hardinge Medical College and Associated Kalawati Saran Children's Hospital, New Delhi, India; Department of Neurology (S.N.T.), National Pediatric Hospital Dr. J. Garrahan, Buenos Aires, Argentina; Department of Pediatrics (H.A.V.M.), Duke University, Durham, NC; Department of Neurology (E.W.), Children's National Medical Center, Washington, DC; Neuropaediatric Unit (R.W.), Karolinska University Hospital, Stockholm, Sweden; Department of Neurology (A.K.Y.), Icahn School of Medicine at Mount Sinai, New York; Oxford Autoimmune Neurology Group (S.R.I.), Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital; Department of Neurology (S.R.I.), Oxford University Hospitals NHS Foundation Trust, United Kingdom; Neuroimmunology Program (J.D.), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, University of Barcelona, Spain; Department of Neurology (J.D.), University of Pennsylvania, Philadelphia; Institució Catalana de Recerca i Estudis Avançats (ICREA) (J.D.), Barcelona, Spain; Children's Neurosciences (M.L.), Evelina London Children's Hospital at Guy's and St Thomas' NHS Foundation Trust; King's Health Partners Academic Health Science Centre (M.L.); Faculty of Life Sciences and Medicine (M.L.), King's College Hospital, United Kingdom; and Kids Neuroscience Centre (R.C.D.), The Children's Hospital at Westmead, Faculty of Medicine and Health, University of Sydney, NSW, Australia.

Objective: To create an international consensus treatment recommendation for pediatric NMDA receptor antibody encephalitis (NMDARE).

Methods: After selection of a panel of 27 experts with representation from all continents, a 2-step Delphi method was adopted to develop consensus on relevant treatment regimens and statements, along with key definitions in pediatric NMDARE (disease severity, failure to improve, and relapse). Finally, an online face-to-face meeting was held to reach consensus (defined as ≥75% agreement). Read More

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Personalized profiles of antioxidant signaling pathway in patients with tuberculosis.

J Microbiol Immunol Infect 2021 Jul 17. Epub 2021 Jul 17.

Unit of Neuromuscular and Neurodegenerative Diseases, Department of Neuroscience, Children's Hospital Bambino Gesù, IRCCS, Rome, Italy. Electronic address:

Background/purpose: The non-protein thiol glutathione is protective against infection by Mycobacterium tuberculosis (MTB) and, together with the transcription factor NRF2 (the nuclear factor erythroid 2-related factor 2), plays a crucial role in counteracting MTB-induced redox imbalance. Many genes implicated in the antioxidant response belong to the NRF2-signalling pathway, whose central role in the pathogenesis of tuberculosis (TB) has been recently proposed.

Methods: In this study, we measured GSH levels in blood of patients with active TB and analysed the individual NRF2-mediated redox profile, in order to provide additional tools for discriminating the pathologic TB state and addressing therapeutic interventions. Read More

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Pharmacological Treatment for Social Cognition: Current Evidence.

Int J Mol Sci 2021 Jul 12;22(14). Epub 2021 Jul 12.

Department of Neuroscience "Rita Levi Montalcini", University of Turin, 10100 Turin, Italy.

Cognitive impairment is currently considered a core feature of schizophrenia (SZ) and is gaining attention as a fundamental therapeutic target. Standard treatment for SZ involves the use of antipsychotics that are successfully used to control positive symptoms and disorganized behaviour. However, it is still unclear whether they are effective on social cognition (SC) impairment. Read More

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Unraveling the long-term effect of influenza vaccines.

Authors:
Maria Rescigno

Cell 2021 Jul;184(15):3845-3847

IRCCS Humanitas Research Hospital, Via Manzoni 56, 20089 Rozzano, Milan, Italy; Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, 20090 Pieve Emanuele, Milan, Italy. Electronic address:

The past decade has witnessed the emergence of highly sophisticated vaccines; still their mechanism of action is not fully understood. Wimmers et al. use advanced techniques to evaluate the immune landscape induced by flu vaccines and show that their effect on the immune system can last even 6 months from administration. Read More

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Psychological functioning in survivors of COVID-19: Evidence from recognition of fearful facial expressions.

PLoS One 2021 22;16(7):e0254438. Epub 2021 Jul 22.

Istituto Auxologico Italiano, IRCCS, U.O. di Neurologia e Neuroriabilitazione, Ospedale S. Giuseppe, Piancavallo, Italy.

Evidence about the psychological functioning in individuals who survived the COVID-19 infectious is still rare in the literature. In this paper, we investigated fearful facial expressions recognition, as a behavioural means to assess psychological functioning. From May 15th, 2020 to January 30th, 2021, we enrolled sixty Italian individuals admitted in multiple Italian COVID-19 post-intensive care units. Read More

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Outcomes of patients with unexpected diagnosis of infection at total hip or total knee arthroplasty revisions.

Int Orthop 2021 Jul 22. Epub 2021 Jul 22.

IRCCS Humanitas Research Hospital, Via Manzoni 56, Rozzano, 20089, Milan, Italy.

Purpose: The pre-operative differential diagnosis between periprosthetic joint infections (PJIs) and aseptic failure is challenging particularly in low virulence and biofilm-related infections. This study aimed to assess the incidence and survival of patients with unexpected PJIs in a presumed aseptic revision of total hip (THA) and knee (TKA) arthroplasties.

Methods: A retrospective analysis of a prospective cohort of patients was performed with 295 patients undergoing THA (n = 241) or TKA (n = 54) revision for presumed aseptic causes. Read More

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Sustaining COVID-19 pandemic lockdown era air pollution impact through utilization of more renewable energy resources.

Heliyon 2021 Jul 30;7(7):e07455. Epub 2021 Jun 30.

Chemical Engineering Department, Alex Ekwueme Federal University, Ndufu Alike, Abakaliki, Nigeria.

The lock down engendered by COVID-19 pandemic has impacted positively on the environment through reduction of the emissions of green house gases, CO, CO and other pollutants into the atmosphere below the pre-COVID-19 levels. There are fears that the gains made in the environment during COVID-19 may be frittered away as nations around the world make serious efforts to boost the COVID-19 recessed economy through massive investments in the sectors of the economy that are not environmentally friendly. This paper emphasizes on the essence of maintaining the COVID-19 pandemic era environmental impact levels in post COVID-19 era without retarding the efforts towards economic recovery. Read More

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Meta-Analysis of Microdissected Breast Tumors Reveals Genes Regulated in the Stroma but Hidden in Bulk Analysis.

Cancers (Basel) 2021 Jul 5;13(13). Epub 2021 Jul 5.

Molecular Biotechnology Center, Department of Molecular Biotechnology and Health Sciences, University of Turin, Via Nizza 52, 10126 Turin, Italy.

Transcriptome data provide a valuable resource for the study of cancer molecular mechanisms, but technical biases, sample heterogeneity, and small sample sizes result in poorly reproducible lists of regulated genes. Additionally, the presence of multiple cellular components contributing to cancer development complicates the interpretation of bulk transcriptomic profiles. To address these issues, we collected 48 microarray datasets derived from laser capture microdissected stroma or epithelium in breast tumors and performed a meta-analysis identifying robust lists of differentially expressed genes. Read More

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Development of a Deep-Learning Pipeline to Recognize and Characterize Macrophages in Colo-Rectal Liver Metastasis.

Cancers (Basel) 2021 Jul 1;13(13). Epub 2021 Jul 1.

Department of Pathology, IRCCS Humanitas Research Hospital, Via Manzoni 56, 20089 Rozzano, Italy.

Quantitative analysis of Tumor Microenvironment (TME) provides prognostic and predictive information in several human cancers but, with few exceptions, it is not performed in daily clinical practice since it is extremely time-consuming. We recently showed that the morphology of Tumor Associated Macrophages (TAMs) correlates with outcome in patients with Colo-Rectal Liver Metastases (CLM). However, as for other TME components, recognizing and characterizing hundreds of TAMs in a single histopathological slide is unfeasible. Read More

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First insight into plastics ingestion by fish in the Gulf of California, Mexico.

Mar Pollut Bull 2021 Jul 16;171:112705. Epub 2021 Jul 16.

Laboratorio de Ecologia e Gerenciamento de EcossistemasCosteiros e Estuarinos, Departamento de Oceanografia, Universidade Federal de Pernambuco, CEP 50740-550 Recife, Brazil.

Plastic particle occurrence in the digestive tracts of fishes from a tropical estuarine system in the Gulf of California was investigated. A total of 1095 fish were analysed, representing 15 species. In total 1384 particles of plastic debris were recovered from the gastrointestinal tracts of 552 specimens belonging to 13 species, and all consisted of threads, the majority of which were small microplastics (0. Read More

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Italian adaptation of the Beaumont Behavioral Inventory (BBI): psychometric properties and clinical usability.

Amyotroph Lateral Scler Frontotemporal Degener 2021 Jul 19:1-6. Epub 2021 Jul 19.

"Rita Levi Montalcini" Department of Neuroscience, University of Turin, ALS Centre, Turin, Italy.

Up to 50% of patients affected by amyotrophic lateral sclerosis (ALS) show behavioral changes within the of frontotemporal degeneration (FTD). Behavioral dysfunctions in ALS patients negatively impact on management, prognosis and survival. It is, thus, crucial to develop ALS-specific psychometric tools for early detecting alterations in behavior. Read More

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Tumour-infiltrating lymphocytes in non-invasive breast cancer: A systematic review and meta-analysis.

Breast 2021 Jul 9;59:183-192. Epub 2021 Jul 9.

Institut Jules Bordet, Université Libre de Bruxelles (U.L.B.), Brussels, Belgium.

Background: The role of tumour infiltrating lymphocytes (TILs) as a biomarker in non-invasive breast cancer is unclear. This meta-analysis assessed the prognostic impact of TIL levels in patients with non-invasive breast cancer.

Methods: Systematic literature search was performed to identify studies assessing local recurrence in patients with non-invasive breast cancer according to TIL levels (high vs. Read More

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Longitudinal assessment of kidney function in migrant farm workers.

Environ Res 2021 Jul 14;202:111686. Epub 2021 Jul 14.

Mel and Enid Zuckerman College of Public Health, University of Arizona, 1295 N. Martin Ave, PO 245210, Tucson, AZ, 85724, USA.

Chronic kidney disease of unknown etiology (CKDu) is an epidemic that affects young agricultural workers in several warm regions of the world. However, there is a lack of monitoring of kidney issues in regions with extremely warm environments such as the Northwest of Mexico, a semi-arid region with a growing agricultural industry, where migrant and seasonal farm workers (MSFWs) travel to work in the fields. The objective of this study was to longitudinally assess kidney functioning of MSFWs in relation to pesticide exposure, heat stress and dehydration in a large-scale farm in Mexico. Read More

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