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The Gender-Sensitive Social Risk Factors for Internet Addiction in College Undergraduate Students.

Psychiatry Investig 2021 Jul 22;18(7):636-644. Epub 2021 Jul 22.

Mental Health Center and Psychiatric Laboratory, Huaxi Brain Research Center, West China Hospital of Sichuan University, Chengdu, China.

Objective: The current study aims to explore precipitating and social risk factors for internet addiction (IA) in university undergraduate students, and to provide evidence for interventions and the early prevention of IA in different genders.

Methods: Four thousand eight hundred and fifty-eight college sophomores completed an online survey on their internet use-related behaviours and social risk factors.

Results: We found that more male (8. Read More

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Cognitive Impairment in Grandparents: A Systematic Review.

Psychiatry Investig 2021 Jul 22;18(7):593-602. Epub 2021 Jul 22.

Department of Clinical Neurosciences and Mental Health, Faculty of Medicine of Porto University, Porto, Portugal.

Objective: To evaluate the relationship between grandparenting and the cognitive impairment in older persons.

Methods: The protocol was submitted to the International Prospective Register of Systematic Reviews (PROSPERO), registration number: CRD42018105849. Authors conducted a systematic review, following "Preferred Reporting Items for Systematic Reviews and Meta-Analyses" (PRISMA) recommendations. Read More

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Key toolkits of non-pharmacological management in COPD: during and beyond COVID-19.

Front Biosci (Landmark Ed) 2021 Jul;26(7):246-252

Institute for Liver and Digestive Health, Division of Medicine, University College London, NW3 2PF London, UK.

Individuals with COPD are at higher risk of severe disease and mortality if they contract COVID-19. Shielding and social distancing have negatively impacted the delivery of routine care for COPD patients, which should be maintained to avoid further deterioration. We aimed to review the literature about the key toolkits of non-pharmacological treatments of COPD patients before and during the COVID-19 pandemic. Read More

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Nodal tumor volume as a prognostic factor for head and neck squamous cell carcinoma: a systematic review.

Front Biosci (Landmark Ed) 2021 Jul;26(7):235-245

1st Department of Otolaryngology - Head & Neck Surgery, Medical School, National & Kapodistrian University of Athens (NKUA), Hippokrateio Hospital, 11527 Athens, Greece.

: Several studies suggest that there is an association between the metastatic nodal tumor volume and the clinical outcome in patients with solid cancers. However, despite the prognostic potential of nodal volume, a standardized method for estimating the nodal volumetric parameters is lacking. Herein, we conducted a systematic review of the published scientific literature towards investigating the prognostic value of nodal volume in the carcinomas of head and neck, taking into consideration the primary tumor site and the human papillomavirus (HPV) status. Read More

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Phase II study of azacitidine with pembrolizumab in patients with intermediate-1 or higher-risk myelodysplastic syndrome.

Br J Haematol 2021 Aug 2. Epub 2021 Aug 2.

Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Programmed cell death protein 1 (PD-1) and PD-ligand 1 (PD-L1) expression is upregulated in cluster of differentiation 34 (CD34) bone marrow cells from patients with myelodysplastic syndromes (MDS). Hypomethylating agent (HMA) treatment results in further increased expression of these immune checkpoints. We hypothesised that combining an anti-PD-1 antibody with HMAs may have efficacy in patients with MDS. Read More

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Disease outcomes and biomarkers of progression in smouldering Waldenström macroglobulinaemia.

Br J Haematol 2021 Aug 2. Epub 2021 Aug 2.

Division of Hematology, Mayo Clinic, Rochester, MN, USA.

Patients with asymptomatic/smouldering Waldenström macroglobulinaemia (SWM) have a variable risk of progression to active WM. Our study evaluated 143 patients with SWM consecutively seen between January 1996 and December 2013. With a median [95% confidence interval (CI)] follow-up of 9·5 [8·1-11·5] years, the cumulative rate of progression was 11% at 1 year, 38% at 3 years and 55% at 5 years. Read More

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Recurrent bacterial infections, but not fungal infections, characterise patients with ELANE-related neutropenia: a French Severe Chronic Neutropenia Registry study.

Br J Haematol 2021 Aug 2. Epub 2021 Aug 2.

Registre des Neutropénies Chroniques, Centre de Référence des Neutropénies Chroniques, Hôpital Trousseau, Assistance Publique-Hôpitaux de Paris (APHP), Paris, France.

Among 143 patients with elastase, neutrophil-expressed (ELANE)-related neutropenia enrolled in the French Severe Chronic Neutropenia Registry, 94 were classified as having severe chronic neutropenia (SCN) and 49 with cyclic neutropenia (CyN). Their infectious episodes were classified as severe, mild or oral, and analysed according to their natural occurrence without granulocyte-colony stimulating factor (G-CSF), on G-CSF, after myelodysplasia/acute leukaemia or after haematopoietic stem-cell transplantation. During the disease's natural history period (without G-CSF; 1913 person-years), 302, 957 and 754 severe, mild and oral infectious events, respectively, occurred. Read More

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Elementary Laboratory Assays as Biomarkers of Ageing: Support for Treatment of COVID-19?

Gerontology 2021 Aug 2:1-14. Epub 2021 Aug 2.

Kantonsspital Graubünden, Chur, Switzerland.

Youth, working age and the elderly: On a timeline, chronological age (CA) and biological age (BA) may dissociate; nosological entities manifest themselves at different BAs. In determining which disease corresponds to a given age decade, statistical registries of causes of death are unreliable and this does not change with SARS CoV-2 infection. Beyond adolescence, ageing metrics involve estimations of changes in fitness, including prediction models to estimate the number of remaining years left to live. Read More

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Mechanisms of Caloric Restriction-Mediated Stress-Resistance in Acute Kidney Injury.

Nephron 2021 Aug 2:1-5. Epub 2021 Aug 2.

Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.

Caloric restriction (CR)-mediated organ protection has been shown to be extremely efficient in rodent models of acute kidney injury (AKI). Limited understanding of the underlying mechanisms paired with a risk of malnourishment and feasibility problems has hindered the translation of this immense potential to the patient setting. In this mini-review, the current mechanistic concepts of CR-mediated stress-resistance as potential key targets for renal protection in AKI will be highlighted. Read More

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The Association between TREM2 Gene and Late-Onset Alzheimer's Disease in Chinese Han Population.

Gerontology 2021 Aug 2:1-7. Epub 2021 Aug 2.

Institute of Literature in Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, China.

Objective: The objective of this study was to evaluate the impact of single nucleotide polymorphisms (SNPs) in triggering receptor expressed on the myeloid cells 2 protein (TREM2) gene and their interaction with environmental factors and haplotypes on late-onset Alzheimer's disease (LOAD).

Methods: DNA was extracted from the whole blood of the participants and genotyped using PCR and followed by restriction fragment length polymorphism. The Hardy-Weinberg equilibrium test was used in the control group. Read More

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Neuroendocrine and Adrenal Tumors, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology.

J Natl Compr Canc Netw 2021 Jul 28;19(7):839-868. Epub 2021 Jul 28.

7Vanderbilt-Ingram Cancer Center.

The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Neuroendocrine and Adrenal Gland Tumors focus on the diagnosis, treatment, and management of patients with neuroendocrine tumors (NETs), adrenal tumors, pheochromocytomas, paragangliomas, and multiple endocrine neoplasia. NETs are generally subclassified by site of origin, stage, and histologic characteristics. Appropriate diagnosis and treatment of NETs often involves collaboration between specialists in multiple disciplines, using specific biochemical, radiologic, and surgical methods. Read More

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The Future of Parallel Tumor and Germline Genetic Testing: Is There a Role for All Patients With Cancer?

J Natl Compr Canc Netw 2021 Jul 28;19(7):871-878. Epub 2021 Jul 28.

1Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

Under the traditional paradigm of genetic testing in cancer, the role of germline testing was to assess for the inherited risk of cancer, whereas the role of tumor testing was to determine therapeutic selection. Parallel tumor-normal genetic testing uses simultaneous genetic testing of the tumor and normal tissue to identify mutations and allows their classification as either germline or somatic. The increasing adoption of parallel testing has revealed a greater number of germline findings in patients who otherwise would not have met clinical criteria for testing. Read More

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Chemotherapy-Induced Peripheral Neurotoxicity in Cancer Survivors: Predictors of Long-Term Patient Outcomes.

J Natl Compr Canc Netw 2021 Jul 28;19(7):821-828. Epub 2021 Jul 28.

5Brain and Mind Centre, Faculty of Medicine and Health, University of Sydney, Camperdown, Australia.

Background: Chemotherapy-induced peripheral neurotoxicity (CIPN) is a major adverse effect of cancer treatment. However, its impact remains poorly understood. This study aimed to investigate the impact associated with CIPN on the lives of cancer survivors. Read More

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Patients characteristics related to screening mammography cancellation and rescheduling rates during the COVID-19 pandemic.

Clin Imaging 2021 Jul 29;80:205-210. Epub 2021 Jul 29.

Center for Evidence-Based Imaging, Brigham and Women's Hospital, Harvard Medical School, 1620 Tremont Street, Boston, MA 02120, United States of America. Electronic address:

Purpose: To identify patient characteristics associated with screening mammography cancellations and rescheduling during the COVID-19 pandemic.

Methods: Scheduled screening mammograms during three time periods were retrospectively reviewed: state-mandated shutdown (3/17/2020-6/16/2020) during which screening mammography was cancelled, a period of 2 months immediately after screening mammography resumed (6/17/2020-8/16/2020), and a representative period prior to COVID-19 (6/17/2019-8/16/2019). Relative risk of cancellation before COVID-19 and after reopening was compared for age, race/ethnicity, insurance, history of chronic disease, and exam location, controlling for other collected variables. Read More

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Proton beam therapy in rectal cancer: A systematic review and meta-analysis.

Surg Oncol 2021 Jul 27;38:101638. Epub 2021 Jul 27.

Department of Colorectal Surgery, Countess of Chester NHS Foundation Trust, UK; Institute of Systems, Molecular and Integrative Biology, University of Liverpool, 200 London Road, Liverpool, L3 9TA, UK. Electronic address:

Introduction: Locally advanced rectal cancer is often treated with neoadjuvant chemoradiotherapy and surgery. Radiotherapy carries significant risk of toxicity to organs at risk (OAR). Proton beam therapy (PBT) has demonstrated to be effective in other cancers, delivering equivalent dosimetric radiation but with the benefit of improved sparing of OAR. Read More

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Estimation of hazardous concentration of toluene in the terrestrial ecosystem through the species sensitivity distribution approach.

Environ Pollut 2021 Jul 27;289:117836. Epub 2021 Jul 27.

Department of Environmental Health Science, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, 05029, Republic of Korea. Electronic address:

Toluene is a highly flammable and commonly used industrial chemical with severe health consequences on humans upon exposure and ingestion. In this study, multispecies bioassays were conducted using a species sensitivity distribution approach to determine acute and chronic hazardous concentrations of toluene in soil. Acute and chronic toluene toxicity tests were conducted with seven soil species from four taxonomic groups. Read More

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Spatio-temporal modeling of PM risk mapping using three machine learning algorithms.

Environ Pollut 2021 Jul 28;289:117859. Epub 2021 Jul 28.

Department of Geography, Faculty of Literature and Humanities, Razi University, Kermanshah, Iran. Electronic address:

Urban air pollution is one of the most critical issues that affect the environment, community health, economy, and management of urban areas. From a public health perspective, PM is one of the primary air pollutants, especially in Tehran's metropolis. Owing to the different patterns of PM in different seasons, Spatio-temporal modeling and identification of high-risk areas to reduce its effects seems necessary. Read More

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An adverse outcome pathway based in vitro characterization of novel flame retardants-induced hepatic steatosis.

Environ Pollut 2021 Jul 28;289:117855. Epub 2021 Jul 28.

Faculty of Science, RECETOX, Masaryk University, Kamenice 5, CZ62500, Brno, Czech Republic. Electronic address:

A wide range of novel replacement flame retardants (nFRs) is consistently detected in increasing concentrations in the environment and human matrices. Evidence suggests that nFRs exposure may be associated with disruption of the endocrine system, which has been linked with the etiology of various metabolic disorders, including nonalcoholic fatty liver disease (NAFLD). NAFLD is a multifactorial disease characterized by the uncontrolled accumulation of fats (lipids) in the hepatocytes and involves multiple-hit pathogenesis, including exposure to occupational and environmental chemicals such as organophosphate flame retardants (OPFRs). Read More

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CT-defined emphysema in COPD patients and risk for change in desaturation status in 6-min walk test.

Respir Med 2021 Jul 23;187:106542. Epub 2021 Jul 23.

Centre for International Health, Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.

Background: Emphysema and exercise induced desaturation (EID) are both related to poorer COPD prognosis. More knowledge of associations between emphysema and desaturation is needed for more efficient disease management.

Research Question: Is emphysema a risk factor for both new and repeated desaturation, and is emphysema of more or less importance than other known risk factors?

Methods: 283 COPD patients completed a 6-min walk test (6MWT) at baseline and one year later in the Bergen COPD cohort study 2006-2011. Read More

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Prevalence and associated factors of post-traumatic stress disorder in Lebanon: A literature review.

Authors:
Magalie El Hajj

Asian J Psychiatr 2021 Jul 29;63:102800. Epub 2021 Jul 29.

Partner 4 Health, Oslo, Norway. Electronic address:

Lebanon has been under continuous conflict for more than four decades, putting millions of Lebanese at a high risk for post-traumatic stress disorder (PTSD) and creating a complex collective trauma. This paper aimed to review all studies from Lebanon reporting on PTSD in order to describe the prevalence of PTSD and its associated risk factors among Lebanese adults. A search of the MEDLINE/PubMed database was conducted in February/March 2021 to identify research articles on PTSD in Lebanese adults. Read More

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Posttraumatic stress symptom clusters differentially predict late positive potential to cocaine imagery cues in trauma-exposed adults with cocaine use disorder.

Drug Alcohol Depend 2021 Jul 28;227:108929. Epub 2021 Jul 28.

Department of Psychology, University of Houston, Houston, TX, United States.

Background: While studies have investigated the effects of posttraumatic stress disorder (PTSD) symptoms on substance use, information on these associations in the context of drug cue reactivity is lacking, which can provide meaningful information about risk for relapse. The current study assessed the associations between PTSD symptom clusters and reactivity to cues in trauma-exposed adults with cocaine use disorder.

Methods: We recorded electroencephalogram on 52 trauma-exposed participants (M = 51. Read More

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The effect of next day responsibilities and an adaptive purchase task on cannabis demand.

Drug Alcohol Depend 2021 Jul 28;227:108919. Epub 2021 Jul 28.

Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA; Center for Pain Research and Behavioral Health, University of Florida, Gainesville, FL, USA. Electronic address:

Background: The marijuana purchase task (MPT) is a commonly used behavioral economic measure of relative cannabis value (i.e. demand) that presents specific methodological concerns due to non-standardized measurement, variability in modality of use, and evolving legalization policies. Read More

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The partitioning behavior of PAHs between settled dust and its extracted water phase: Coefficients and effects of the fluorescent organic matter.

Ecotoxicol Environ Saf 2021 Jul 30;223:112573. Epub 2021 Jul 30.

School of Geography and Environment, Key Laboratory of Poyang Lake Wetland and Watershed Research, Ministry of Education, Jiangxi Normal University, 99 Ziyang Road, Nanchang 330022, China.

The occurrence and distribution of polycyclic aromatic hydrocarbons (PAHs) in a city of Central China were determined in the settled dust and its extracted water phase from different land use types and bus stops in Nanchang City. The physicochemical properties of its water extracted dissolved organic matter (WEOM) were characterized to investigate the effect of fluorescence organic matter on the dust-water partitioning coefficients (K) using three-dimensional excitation-emission matrix fluorescence spectroscopy combined parallel factor analysis. Results showed that the range of ∑PAHs in settled dust and the extracted water phase was 0. Read More

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Distribution and antimicrobial resistance of Vibrio parahaemolyticus isolated from fish and shrimp aquaculture farms along the Korean coast.

Mar Pollut Bull 2021 Jul 30;171:112785. Epub 2021 Jul 30.

West Sea Fisheries Research Institute, National Institute of Fisheries Science, Incheon 22383, Republic of Korea.

The present study investigated the distribution and antimicrobial susceptibility patterns of Vibrio parahaemolyticus in water samples and aquatic animals (fish and shrimp) from major aquaculture farms along the Korean coast in 2018. V. parahaemolyticus is the most common pathogen causing seafood-borne illness. Read More

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Chemical analysis of materials used in pig housing with respect to the safety of products of animal origin.

Animal 2021 Jul 30;15(9):100319. Epub 2021 Jul 30.

Department Safety in the Food Chain, German Federal Institute for Risk Assessment, Max-Dohrn-Str. 8-10, 10589 Berlin, Germany. Electronic address:

Bedding, environmental enrichment materials and disinfectant powders in pig farming are meant to ensure a hygienic bedding environment or allow pigs to perform explorative behaviour. To our knowledge, no legal regulation exists, that established maximum contents for undesirable substances, such as toxic metals, dioxins or trace elements in these materials, although oral ingestion could be expected. In the present study, a total of 74 materials (disinfectant powders [n = 51], earth/peat [n = 12], biochar [n = 8], recycled manure solids [n = 3]) were analysed for their content of various toxic metals, trace elements, dioxins and polychlorinated biphenyls. Read More

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Association of N-terminal pro-brain natriuretic peptide level with adverse outcomes in patients with acute myocardial infarction: A meta-analysis.

Heart Lung 2021 Jul 30;50(6):863-869. Epub 2021 Jul 30.

Department of Cardiology, Tongde Hospital of Zhejiang Province, Hangzhou City, Zhejiang Province, 310012, PR China. Electronic address:

Background: Studies evaluating the association of blood level of N-terminal pro-brain natriuretic peptide (NT-proBNP) with adverse prognosis have yielded conflicting results in patients with acute myocardial infarction (AMI). This meta-analysis sought to evaluate the prognostic value of blood level of NT-proBNP in patients with AMI.

Methods: Two authors independently searched articles in PubMed and Embase databases up to June 13, 2021. Read More

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At-risk gambling in patients with severe psychiatric illness and in community subjects matched for age and sex.

Psychiatry Res 2021 Jul 26;304:114142. Epub 2021 Jul 26.

Institute of Clinical Physiology, National Council of Research (CNR), Rome, Italy.

In the recent literature the rates of gambling in psychiatric patients have been compared only indirectly with those found in community samples and no study has so far matched a clinical sample with community controls. We selected 875 outpatients attending two community mental health centers and 3.500 community subjects, matched for age and sex. Read More

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The neurocognitive and functional profile of schizophrenia in a genetically homogenous European sample.

Psychiatry Res 2021 Jul 26;304:114140. Epub 2021 Jul 26.

Center for Research in Neuropsychology and Cognitive Behavioral Intervention (CINEICC), University of Coimbra, Portugal.

Schizophrenia is a complex heritable brain disorder that entails significant social, neurocognitive, and functional deficits, and significant psychosocial challenges to affected and unaffected family members. In this cross-sectional study, we explore impairments in specific neurocognitive and social cognition processes in patients affected with schizophrenia, unaffected relatives, and in controls to provide a characterization of a genetically homogenous European sample from an endophenotypic and functional standpoint. A sample of 38 affected patients, 28 first-degree relatives, and 97 controls performed a series of computerized and skills-based assessments. Read More

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UniPortal thoracoscopic pneumonectomy does not compromise perioperative and long-term survival in patients with NSCLC: A retrospective, multicenter, and propensity score matching study.

Lung Cancer 2021 Jul 24;159:135-144. Epub 2021 Jul 24.

Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, People's Republic of China. Electronic address:

Objectives: To compare the perioperative and oncologic outcomes following pneumonectomy performed by uniportal video-assisted thoracoscopic surgery (U-VATS) and thoracotomy in patients with centrally located non-small cell lung cancer (NSCLC).

Materials And Methods: Patients with NSCLC who underwent pneumonectomy at the Shanghai Pulmonary Hospital (SPH) and Sun Yat-sen University Cancer Center (SYUCC) with the U-VATS approach or open approach between 2011 and 2016 were selected. Propensity score matching (1:3) was performed to balance the baseline covariates. Read More

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