Adv Cancer Res 2021 31;151:305-344. Epub 2021 Mar 31.
Department of Gastroenterology, Boston University Medical Center, Boston, MA, United States; Department of Internal Medicine, Baylor College of Medicine, Houston, TX, United States. Electronic address:
Colorectal cancer (CRC) is characterized by genetic-environmental interplay leading to diffuse changes in the entire colonic mucosa (field carcinogenesis or field of injury) and to a pro-neoplastic genetic/epigenetic/physiological milieu. The clinical consequences are increased risk of synchronous and metachronous neoplasia. Factors such as genetics, race, ethnicity, age, and socioeconomic status are thought to influence neoplasia development. Read More