319,860 results match your criteria risk scientific


Prevalence and Factors Affecting Postoperative Delirium in a Neurosurgical Intensive Care Unit.

J Neurosci Nurs 2021 Jun 10. Epub 2021 Jun 10.

Questions or comments about this article may be directed to Gulsah Kose, Lecturer, PhD RN, at G.K. is Assistant Professor, Health Science Faculty, Department of Nursing, Mugla Sitki Kocman University, Muğla, Turkey. Keziban Şirin, RN, is Chief Nurse, Cerrahpasa Medical Faculty, Department of Neurosurgery, Istanbul University-Cerrahpasa, Istanbul, Turkey. Mehtap Balin Inel, is NSICU Nurse and Neurosurgical Nurse, Cerrahpasa Medical Faculty, Department of Neurosurgery, Istanbul University-Cerrahpasa, Istanbul, Turkey. Sevcan Mertoglu, is NSICU Nurse and Neurosurgical Nurse, Cerrahpasa Medical Faculty, Department of Neurosurgery, Istanbul University-Cerrahpasa, Istanbul, Turkey. Raziye Aksakal, is NSICU Nurse and Neurosurgical Nurse, Cerrahpasa Medical Faculty, Department of Neurosurgery, Istanbul University-Cerrahpasa, Istanbul, Turkey. Şule Kurucu, is NSICU Nurse and Neurosurgical Nurse, Cerrahpasa Medical Faculty, Department of Neurosurgery, Istanbul University-Cerrahpasa, Istanbul, Turkey.

Abstract: PURPOSE: The aim of this study was to identify the prevalence of, and factors affecting, postoperative delirium (POD) in patients in the neurosurgical intensive care unit. METHODS: A cross-sectional study of 127 Turkish neurosurgical intensive care unit patients admitted between May 2018 and May 2019 was conducted. Patients were assessed for the development of POD using the Intensive Care Delirium Screening Checklist. Read More

View Article and Full-Text PDF

Inches, Centimeters, and Yards: Overlooked Definition Choices Inhibit Interpretation of Morphine Equivalence.

Clin J Pain 2021 Jun 11. Epub 2021 Jun 11.

Injury Prevention Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA Department of Health Outcomes & Biomedical Informatics, University of Florida College of Medicine, Gainesville, Florida, USA Institute for Pharmaceutical Outcomes & Policy, University of Kentucky College of Pharmacy, Lexington, Kentucky, USA Department of Pharmacy Practice and Science, University of Kentucky College of Pharmacy, Lexington, Kentucky, USA Division of Pharmaceutical Outcomes and Policy, University of North Carolina School of Pharmacy, Chapel Hill, North Carolina, USA Cecil G. Sheps Center for Health Services Research, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA UNC Hospitals Pain Management Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA Department of Anesthesiology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.

Objective: Morphine-standardized doses are used in clinical practice and research to account for molecular potency. 90 milligrams of morphine equivalents (MME) per day are considered a "high dose" risk threshold in guidelines, laws, and by payers. Although ubiquitously cited, the "CDC definition" of daily MME lacks a clearly defined denominator. Read More

View Article and Full-Text PDF

Pathways linking census tract typologies with subjective neighborhood disorder and depressive symptoms in the Black Women's Experiences Living with Lupus (BeWELL) Study.

Health Place 2021 Jun 8;70:102587. Epub 2021 Jun 8.

Department of Global Community Health and Behavioral Sciences, Tulane University School of Public Health and Tropical Medicine, 1440 Canal St, New Orleans, LA, 70112, USA.

Depression is a common comorbidity among Black women with systemic lupus erythematosus (SLE), an understudied autoimmune disease characterized by major racial and gender inequities. Research is needed that examines how area-level factors influence risk of depression in this population. Latent profile analysis revealed four neighborhood typologies among metropolitan Atlanta, Georgia census tracts that participants (n=438) in the Black Women's Experiences Living with Lupus (BeWELL) Study were living in: Integrated/High-SES, Moderately Segregated/Mid-SES, Highly Segregated/Mid-SES, and Highly Segregated/Low-SES. Read More

View Article and Full-Text PDF

Vitamin B12 status is a risk factor for bone fractures among vegans.

Authors:
Roman Pawlak

Med Hypotheses 2021 Jun 5;153:110625. Epub 2021 Jun 5.

Department of Nutrition Science, East Carolina University, Greenville, NC 27858, United States. Electronic address:

Several studies consistently showed vegans having a higher risk of bone fractures compared to individuals from other diet groups. While researchers have focused on several factors as possible explanation of these findings, both dietary (e.g. Read More

View Article and Full-Text PDF

Serum Inhibin-A and PAPP-A2 in the prediction of pre-eclampsia during the first and second trimesters in high-risk women.

Pregnancy Hypertens 2021 Jun 2;25:116-122. Epub 2021 Jun 2.

Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland; Department of Obstetrics and Gynecology, Tampere University Hospital and Tampere University, Faculty of Medicine and Health Technology, Tampere, Finland.

Objectives: Maternal serum inhibin-A, pregnancy associated plasma protein-A (PAPP-A) and PAPP-A2 together with placental growth factor (PlGF), maternal risk factors and uterine artery pulsatility index (UtA PI) were analysed to study their ability to predict pre-eclampsia (PE).

Study Design: Serial serum samples for the nested case-control study were collected prospectively at 12-14, 18-20 and 26-28 weeks of gestation from 11 women who later developed early-onset PE (EO PE, diagnosis < 34 + 0 weeks of gestation), 34 women who developed late-onset PE (LO PE, diagnosis ≥ 34 + 0 weeks) and 89 controls.

Main Outcome Measures: Gestational age -adjusted multiples of the median (MoM) values were calculated for biomarker concentrations. Read More

View Article and Full-Text PDF

Association of short-term fine particulate matter exposure with pulmonary function in populations at intermediate to high-risk of cardiovascular disease: A panel study in three Chinese cities.

Ecotoxicol Environ Saf 2021 Jun 8;220:112397. Epub 2021 Jun 8.

Department of Epidemiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China; Key Laboratory of Cardiovascular Epidemiology, Chinese Academy of Medical Sciences, Beijing 100037, China. Electronic address:

Background: Decline in pulmonary function contributes to increasing cardiovascular disease (CVD) risk. Although adverse effects of short-term exposure to fine particulate matter (PM) on pulmonary function have been recognized in healthy people or patients with respiratory disease, these results were not well illustrated among people with elevated CVD risk.

Materials And Methods: A panel study was conducted in three Chinese cities with three repeated visits among populations at intermediate to high-risk of CVD, defined as treated hypertension patients or those with blood pressure ≥ 130/80 mmHg, who met any of the three conditions including abdominal obesity, dyslipidemia, and diabetes mellitus. Read More

View Article and Full-Text PDF

Association of BPA exposure during pregnancy with risk of preterm birth and changes in gestational age: A meta-analysis and systematic review.

Ecotoxicol Environ Saf 2021 Jun 8;220:112400. Epub 2021 Jun 8.

Chinese Academy of Medical Science Research Unit (2019RU014), NHC Key Laboratory of Food Safety Risk Assessment, China National Center for Food Safety Risk Assessment, Beijing 100022, China.

The associations of bisphenol A exposure during pregnancy with risk of preterm birth (PTB) and changes in gestational age have remained controversial. To conduct the meta-analysis, the relevant studies were searched through PubMed, OVID, and Web of Science from inception through June ‎17, ‎2020. Data were independently extracted and analyzed using odds ratio (OR) or regression coefficient (β) and their 95% confidence intervals (CIs). Read More

View Article and Full-Text PDF

In vitro and in vivo study on angiogenesis of porcine induced pluripotent stem cell-derived endothelial cells.

Differentiation 2021 Jun 4;120:10-18. Epub 2021 Jun 4.

College of Life Science, Northeast Agricultural University, Harbin, 150030, PR China. Electronic address:

Pluripotent stem cells (PSCs) are a promising source of endothelial cells (ECs) for the treatment of cardiovascular diseases. Since clinical application of embryo stem cells (ESCs) involves issues of medical ethics and risk of immune rejection, induced pluripotent stem cells (iPSCs) will facilitate cell transplantation therapy for the cardiovascular diseases. Swine is identified as an ideal large-animal model for human, because of its similar organ size and physiological characteristics. Read More

View Article and Full-Text PDF

TiCT MXene sensor for rapid Hg analysis in high salinity environment.

J Hazard Mater 2021 Jun 2;418:126301. Epub 2021 Jun 2.

College of Environmental Science and Engineering, Biomedical Multidisciplinary Innovation Research Institute, Shanghai East Hospital, State Key Laboratory of Pollution Control and Resource Reuse, Tongji University, 1239 Siping Road, Shanghai 200092, China; Shanghai Institute of Pollution Control and Ecological Security, Shanghai 200092, China. Electronic address:

Mercury is one of the leading chemicals of concern and receives much attention in environmental safety. It is of great necessity to develop advanced Hg analysis method for rapid detection and monitoring. Field-effect transistor (FET) sensor, an emerging electronic sensor, has received great attention in environmental analysis since it has unique advantages in achieving rapid analysis of chemicals. Read More

View Article and Full-Text PDF

The seroprevalence of SARS-CoV-2 antibodies among health care workers before the Era of vaccination: A systematic review and meta-analysis.

Clin Microbiol Infect 2021 Jun 8. Epub 2021 Jun 8.

Koç University İş Bank Research Center for Infectious Diseases (KUISCID), Istanbul, Turkey; Koç University, School of Medicine, Department of Infectious Diseases and Clinical Microbiology, Istanbul, Turkey. Electronic address:

Background: The prevalence of SARS-CoV-2 infection among HCWs provide information to for the spread of COVID-19 within health care facilities, and to detect the risk groups.

Objective: We aimed to describe the rate of SARS-CoV-2 seroprevalence and its determinants among health care workers.

Data Sources: We used Web of Science, Scopus, MEDLINE, EBSCOhost and Cochrane Library. Read More

View Article and Full-Text PDF

T2 heterogeneity as an in vivo marker of microstructural integrity in medial temporal lobe subfields in ageing and mild cognitive impairment.

Neuroimage 2021 Jun 8:118214. Epub 2021 Jun 8.

Bristol Medical School, University of Bristol, Bristol, UK; Clinical Neurosciences, North Bristol NHS Trust, Bristol, UK.

A better understanding of early brain changes that precede loss of independence in diseases like Alzheimer's disease (AD) is critical for development of disease-modifying therapies. Quantitative MRI, such as T2 relaxometry, can identify microstructural changes relevant to early stages of pathology. Recent evidence suggests heterogeneity of T2 may be a more informative MRI measure of early pathology than absolute T2. Read More

View Article and Full-Text PDF

The role of radiation therapy in the management of cutaneous malignancies. Part II: When is radiation therapy indicated?

J Am Acad Dermatol 2021 Jun 8. Epub 2021 Jun 8.

Departments of Dermatology and Head and Neck Surgery, The University of Texas MD Anderson Cancer, Houston, Texas, USA.

Radiation therapy may be performed for a variety of cutaneous malignancies depending on patient health status, tumor clinical and histologic features, patient preference, and resource availability. Dermatologists should be able to recognize the clinical scenarios in which radiation therapy is appropriate as this may reduce morbidity, decrease risk of disease recurrence, and improve quality of life. The second article in this 2-part continuing medical education series focuses on the most common indications for radiation therapy in the treatment of basal cell carcinoma, cutaneous squamous cell carcinoma, dermatofibrosarcoma protuberans, Merkel cell carcinoma, Kaposi sarcoma, angiosarcoma, cutaneous lymphoma, melanoma, undifferentiated pleomorphic sarcoma, and sebaceous carcinoma. Read More

View Article and Full-Text PDF

A pilot study on automatic 3D quantification of Barrett's esophagus for risk stratification and therapy monitoring.

Gastroenterology 2021 Jun 8. Epub 2021 Jun 8.

Translational Gastroenterology Unit, Nuffield Department of Medicine, Experimental Medicine Div., John Radcliffe Hospital, University of Oxford, Oxford, UK;; Oxford NIHR Biomedical Research Centre, Oxford, UK;. Electronic address:

Background Aims: Barrett's epithelium measurement using widely accepted Prague C&M classification is highly operator dependent. We propose a novel methodology for measuring this risk score automatically. The method also enables quantification of the area of Barrett's epithelium (BEA) and islands which was not possible before. Read More

View Article and Full-Text PDF

Primary OA early joint degeneration induced by ER-stress is mitigated by resveratrol.

Am J Pathol 2021 Jun 8. Epub 2021 Jun 8.

Department of Pediatrics(,) The University of Texas Health Science Center at Houston (UTHealth), TX. Electronic address:

Given the increasing number of people living with OA, due to population aging and rising rates of obesity, there is an urgent need to identify effective treatment and preventions. Two top risk factors for OA, age and obesity, are associated with ER stress. The I-ERS mouse, an ER stress driven model of primary OA, was developed to study the role of ER stress in primary OA susceptibility. Read More

View Article and Full-Text PDF

Systematic and bibliographic review of sustainability indicators for contaminated site remediation: Comparison between China and western nations.

Environ Res 2021 Jun 8:111490. Epub 2021 Jun 8.

Key Laboratory of Ecosystem Network Observation and Modeling, Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing, 100101, China.

Sustainable remediation, which promotes the use of more sustainable practices during environmental clean-up activities, is an area of intense international development. While numerous indicators related to sustainable remediation assessment have been utilized and published in related academic literature, they are difficult to unify and vary in emphasis between countries. Following literature retrieval from CNKI, Springer, ScienceDirect, and Wiley Online databases, we present a systematic and bibliometric analysis of relevant national and international literature to define the most frequently considered indicators of sustainability, which play important roles in selecting remediation technologies or site management methods from a sustainability perspective. Read More

View Article and Full-Text PDF

Hydrogeochemistry and health hazards of fluoride-enriched groundwater in the Tarim Basin, China.

Environ Res 2021 Jun 8:111476. Epub 2021 Jun 8.

College of Natural Resources and Environment, Northwest A&F University, Yangling, Shaanxi, 712100, China. Electronic address:

Fluoride (F) enrichment reduces the availability of groundwater resources in the arid region, and it is thus important to investigate the hydrogeochemistry and health hazards of fluoride-enriched groundwater. Seventy-two groundwater samples (20 unconfined samples from the piedmont plain, 22 unconfined samples and 30 shallow confined samples from the alluvial plain) were collected in the Tarim Basin of China to illustrate the geochemical processes driving the F enrichment and the incidence of dental fluorosis. The patterns of average ions contents in groundwater are Na > Ca > Mg > K and SO > Cl > HCO > NO > F. Read More

View Article and Full-Text PDF

Comparison of Cystatin C-based and creatinine-based glomerular filtration rate in the prediction of postoperative residual hypertension in aldosterone-producing adenoma patients after adrenalectomy.

Clin Chim Acta 2021 Jun 8. Epub 2021 Jun 8.

Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan. Electronic address:

Renal function is associated with postoperative residual hypertension in aldosterone-producing adenoma(APA) patients. Cystatin C-based glomerular filtration rate (GFR) can more accurately estimate renal function than creatinine-based methods. However, which renal function estimation method can more accurately predict postoperative hypertension in APA patients is still unknown. Read More

View Article and Full-Text PDF

The epidemiology of psychiatric disorders in Africa: a scoping review.

Lancet Psychiatry 2021 Jun 8. Epub 2021 Jun 8.

Division of Translational Epidemiology, Department of Psychiatry, New York State Psychiatric Institute, New York, NY, USA; Columbia University Vagelos College of Physicians and Surgeons; New York State Psychiatric Institute, New York, NY, USA. Electronic address:

This scoping review of population-based epidemiological studies was done to provide background information on the prevalences and distribution of psychiatric disorders in Africa for calls to broaden diversity in psychiatric genetic studies. We searched PubMed, EMBASE, and Web of Science to retrieve relevant literature in English, French, and Portuguese from Jan 1, 1984, to Aug 18, 2020. In 36 studies from 12 African countries, the lifetime prevalence ranged from 3·3% to 9·8% for mood disorders, from 5·7% to 15·8% for anxiety disorders, from 3·7% to 13·3% for substance use disorders, and from 1·0% to 4·4% for psychotic disorders. Read More

View Article and Full-Text PDF

Alcohol consumption and age-related macular degeneration: A systematic review and dose-response meta-analysis.

Curr Eye Res 2021 Jun 11. Epub 2021 Jun 11.

Department of Epidemiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.

Purpose: To perform a systematic review on the association between alcohol consumption and risk of age-related macular degeneration (AMD) using a meta-analytical approach.

Method: Systematic literature research was conducted according to the Preferred Reporting Items for Systematic Review and Meta-Analyses guidelines. Both categorical and dose-response meta-analysis was performed separately for early and late AMD. Read More

View Article and Full-Text PDF

Cognitive Performance Trajectories Before and After Sleep Treatment Initiation in Middle-Aged and Older Adults: Results from the Health and Retirement Study.

J Gerontol A Biol Sci Med Sci 2021 Jun 11. Epub 2021 Jun 11.

Division of Pulmonary Medicine, Critical Care, and Sleep Medicine, University of California San Diego, La Jolla, CA.

Background: Sleep disturbances are associated with risk of cognitive decline but it is not clear if treating disturbed sleep mitigates decline. We examined differences in cognitive trajectories before and after sleep treatment initiation.

Methods: Data came from the 2006-2014 Health and Retirement Study. Read More

View Article and Full-Text PDF

Relationship between diarrhoea risk and the combinations of drinking water sources in the Kathmandu Valley, Nepal.

Int Health 2021 Jun 11. Epub 2021 Jun 11.

Interdisciplinary Centre for River Basin Environment, University of Yamanashi, 4-3-11 Takeda, Kofu, Yamanashi 400-8511, Japan.

In Nepal, the number of diarrhoea hospitalizations in all ages is seriously high. According to the World Health Organization, diarrheal diseases can be substantially prevented through safe drinking water sources. In the Kathmandu Valley, because of the shortage of piped water, local residents use alternative water sources, such as groundwater, jars and tanker water. Read More

View Article and Full-Text PDF

Variables affecting the quality of anticoagulation in atrial fibrillation patients newly initiating vitamin K antagonists: insights from the national and multicentre SULTAN registry.

Europace 2021 Jun 11. Epub 2021 Jun 11.

Department of Cardiology, Hospital Clínico Universitario Virgen de la Arrixaca, University of Murcia, Instituto Murciano de Investigación Biosanitaria (IMIB-Arrixaca), CIBERCV, Ctra. Madrid-Cartagena s/n, 30120 El Palmar, Murcia, Spain.

Aims: Vitamin K antagonists (VKAs) are effective drugs reducing the risk for stroke in atrial fibrillation (AF), but the benefits derived from such therapy depend on the international normalized ratio (INR) maintenance in a narrow therapeutic range. Here, we aimed to determine independent variables driving poor anticoagulation control [defined as a time in therapeutic range (TTR) <65%] in a 'real world' national cohort of AF patients.

Methods And Results: The SULTAN registry is a multicentre, prospective study, involving patients with non-valvular AF from 72 cardiology units expert in AF in Spain. Read More

View Article and Full-Text PDF

Knowledge about mother to child transmission of HIV/AIDS, its prevention and associated factors among reproductive-age women in sub-Saharan Africa: Evidence from 33 countries recent Demographic and Health Surveys.

PLoS One 2021 11;16(6):e0253164. Epub 2021 Jun 11.

Department of Human Anatomy, College of Medicine and Health Science, School of Medicine, University of Gondar, Gondar, Ethiopia.

Background: In sub-Saharan Africa (SSA) 90 percent of babies acquired HIV/AIDS from infected mothers. Maternal knowledge about mother to child transmission (MTCT) of HIV/AIDS and its prevention is a cornerstone for elimination of MTCT of HIV/AIDS. Despite this, there is limited evidence about knowledge about MTCT of HIV/AIDS and its prevention and associated factors in SSA. Read More

View Article and Full-Text PDF

Aedes aegypti SNAP and a calcium transporter ATPase influence dengue virus dissemination.

PLoS Negl Trop Dis 2021 Jun 11;15(6):e0009442. Epub 2021 Jun 11.

Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America.

Dengue virus (DENV) is a flavivirus that causes marked human morbidity and mortality worldwide, and is transmitted to humans by Aedes aegypti mosquitoes. Habitat expansion of Aedes, mainly due to climate change and increasing overlap between urban and wild habitats, places nearly half of the world's population at risk for DENV infection. After a bloodmeal from a DENV-infected host, the virus enters the mosquito midgut. Read More

View Article and Full-Text PDF

A soft voting ensemble classifier for early prediction and diagnosis of occurrences of major adverse cardiovascular events for STEMI and NSTEMI during 2-year follow-up in patients with acute coronary syndrome.

PLoS One 2021 11;16(6):e0249338. Epub 2021 Jun 11.

Department of Computer Science, Chungbuk National University, Cheongju, Chungbuk, South Korea.

Objective: Some researchers have studied about early prediction and diagnosis of major adverse cardiovascular events (MACE), but their accuracies were not high. Therefore, this paper proposes a soft voting ensemble classifier (SVE) using machine learning (ML) algorithms.

Methods: We used the Korea Acute Myocardial Infarction Registry dataset and selected 11,189 subjects among 13,104 with the 2-year follow-up. Read More

View Article and Full-Text PDF

Dance Exposure, Individual Characteristics, and Injury Risk over Five Seasons in a Professional Ballet Company.

Med Sci Sports Exerc 2021 Jun 10. Epub 2021 Jun 10.

Faculty of Sport, Allied Health and Performance Science, St Mary's University, Twickenham, United Kingdom Ballet Healthcare, The Royal Ballet, Royal Opera House, London, United Kingdom Institute of Sport Science, Dance Science, University of Bern, Bern, Switzerland Department for Health, University of Bath, Bath, United Kingdom Division of Surgery and Interventional Science, University College London, London, United Kingdom.

Purpose: To describe the relationships between dance exposure, dancer characteristics, and injury risk across five seasons in a professional ballet company.

Methods: Dance exposure time and clinician-reported time-loss and medical attention injury data were prospectively collected from 118 professional dancers of The Royal Ballet between 2015/16 and 2019/20. Cox proportional hazards and shared frailty models were fitted to overuse and traumatic injuries; individualized robust Z-scores for 7-day and 28-day accumulated exposure, and week-to-week change in exposure, age, sex, company rank, and injury history were included as time-varying covariates. Read More

View Article and Full-Text PDF

Hypotony-associated Complications after Deep Sclerectomy: Incidence, Risk Factors, and Long-Term Outcomes.

J Glaucoma 2021 Jun 10. Epub 2021 Jun 10.

Department of Ophthalmology, Gloucestershire Hospitals NHS Foundation Trust, Cheltenham, United Kingdom Department of Ophthalmology, University Vita-Salute, IRCCS San Raffaele Scientific Institute, Milan, Italy Department of Ophthalmology, Calderdale and Huddersfield NHS Trust, Huddersfield, UK.

Precis: Chronic hypotony is not uncommon following deep sclerectomy, but only a minor proportion of patients develop hypotony-associated complications. Numerical hypotony does not affect the visual outcomes. This study identifies factors associated with hypotony. Read More

View Article and Full-Text PDF

High-grade Papillary Early Gastric Carcinoma With High Risk for Lymph Node Metastasis and Poor Prognosis: A Clinicopathologic Study of 96 Cases Among 1136 Consecutive Radical Gastrectomies.

Am J Surg Pathol 2021 Jun 10. Epub 2021 Jun 10.

Departments of Pathology Oncology Gastroenterology of the Affiliated Changzhou Second People's Hospital of Nanjing Medical University, Changzhou Department of Pathology of the First Affiliated Hospital of Soochow University, Suzhou, China Department of Pathology and Laboratory Medicine of Veterans Affairs Boston Healthcare System, Harvard Medical School and Brigham and Women's Hospital, MA.

Papillary early gastric carcinoma (EGC) is believed to have a low risk of lymph node metastasis (LNM) and thus can be resected endoscopically. We observed anecdotally that some papillary EGC tumors showed conspicuous high-grade dysplastic features, but the significance of these observations is unknown. In this bicenter study we investigated papillary EGCs that were divided into high-grade (n=96) and low-grade (n=118) groups among 1136 consecutive EGC radical resection cases. Read More

View Article and Full-Text PDF

Evolving trends in risk profiles and outcomes in older adults undergoing kidney re-transplantation.

Transplantation 2021 Jun 2. Epub 2021 Jun 2.

1 Division of Nephrology, Department of Medicine, McGill University Health Centre, Montreal, Quebec 2 Research Institute of the McGill University Health Centre, Montreal, Quebec 3 Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 4 Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.

Background: In older adults (≥65) access to and outcomes following kidney transplantation (KT) have improved over the past three decades. It is unknown if there were parallel trends in re-KT. We characterized the trends, changing landscape, and outcomes of re-KT in older adults. Read More

View Article and Full-Text PDF