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A Cross-Sectional Observational Study on the Coexistence of Erectile Dysfunction and Premature Ejaculation.

Sex Med 2021 Sep 24;9(6):100438. Epub 2021 Sep 24.

Division of Urology, Department of Surgery, Kaohsiung Veterans General Hospital, Kaohsiung; School of Medicine, National Yang-Ming University, Taipei; and College of Health and Nursing, Meiho University, Pingtung, Taiwan. Electronic address:

Introduction: The interplay between erectile dysfunction (ED) and premature ejaculation (PE) needs more studies to clarify.

Aim: To evaluate the risk factors and temporal relationship for the coexistence of ED and PE.

Methods: The data were derived from clinical history. Read More

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September 2021

What is the threshold of mature oocytes to obtain at least one healthy transferable cleavage-stage embryo after preimplantation genetic testing for fragile X syndrome?

Hum Reprod 2021 Sep 26. Epub 2021 Sep 26.

Assistance Publique Hopitaux de Paris, Hopital Béclère, Service de Médecine de la Reproduction et Préservation de la Fertilité, Université Paris-Saclay, Clamart, France.

Study Question: What are the chances of obtaining a healthy transferable cleavage-stage embryo according to the number of mature oocytes in fragile X mental retardation 1 (FMR1)-mutated or premutated females undergoing preimplantation genetic testing (PGT)?

Summary Answer: In our population, a cycle with seven or more mature oocytes has an 83% chance of obtaining one or more healthy embryos.

What Is Known Already: PGT may be an option to achieve a pregnancy with a healthy baby for FMR1 mutation carriers. In addition, FMR1 premutation is associated with a higher risk of diminished ovarian reserve and premature ovarian failure. Read More

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September 2021

Increased Risk of Stillbirth among Women whose Partner Has Tuberculosis.

Biomed Res Int 2021 14;2021:1837881. Epub 2021 Sep 14.

Human Genetics Resource Center, National Research Institute for Family Planning, Beijing 100081, China.

Background: The relationship between tuberculosis (TB) and adverse pregnancy outcomes remains unclear. The aim of our study was to investigate whether TB is a risk factor for adverse pregnancy outcomes including premature birth, low birth weight, and stillbirth.

Method: We conducted a population-based retrospective cohort study in mainland China. Read More

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September 2021

Ovarian Tissue Reservation and Risk of Reimplantation in a Young Girl with Acute Lymphocytic Leukemia after 6-Month Chemotherapy: A Case Report.

South Asian J Cancer 2021 Apr 25;10(2):112-114. Epub 2021 Jul 25.

Molecular Medicine Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.

In the fertility preservation programs, ovarian cryopreservation is usually offered when the risk of premature ovarian failure is high (>30-50%) while the risk of ovarian metastasis is low. According to the guidelines, it must be done before the patient receives chemotherapy. A 22-year-old girl with acute lymphocytic leukemia was a candidate for ovarian cryopreservation after 6 months of chemotherapy. Read More

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Sudden cardiac death in patients with myocardial infarction: 1.5 primary prevention.

Rev Cardiovasc Med 2021 Sep;22(3):807-816

Department of Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, 200092 Shanghai, China.

Sudden cardiac death (SCD) is one of the most common causes of death in the world. Coronary heart disease (CHD) is the root cause of most patients with SCD, and myocardial infarction (MI) is the main cause of SCD among all types of CHD. Early identification of high-risk patients after an MI, and the application of related prevention strategies and disease-specific treatments will be the key to reduce SCD. Read More

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September 2021

The Impact of Prematurity on Morbidity and Mortality in Newborns with Dextro-transposition of the Great Arteries.

Pediatr Cardiol 2021 Sep 24. Epub 2021 Sep 24.

Department of Congenital Heart Disease/Pediatric Cardiology, German Heart Center Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.

Prematurity is a risk factor for adverse outcomes after arterial switch operation in newborns with D-TGA (D-TGA). In this study, we sought to investigate the impact of prematurity on postnatal and perioperative clinical management, morbidity, and mortality during hospitalization in neonates with simple and complex D-TGA who received arterial switch operation (ASO). Monocentric retrospective analysis of 100 newborns with D-TGA. Read More

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September 2021

The Burden of Opioid-Related Mortality in Texas, 1999 to 2019.

Ann Epidemiol 2021 Sep 21. Epub 2021 Sep 21.

Department of Demography, The University of Texas at San Antonio, San Antonio, TX 78249, Phone: (210) 458-3165. Electronic address:

Purpose: To examine and quantify the burden of opioid-related mortality utilizing a serial cross-sectional design of individuals 15 to 64 years of age whose death was related to opioid use from January 1, 1999, to January 31, 2019.

Methods: Data was obtained from the CDC WONDER Multiple Cause of Death Online Database, which captures mortality and population estimates across the United States stratified by geography, age, sex, race, and ethnicity. The burden of opioid-related deaths in Texas was evaluated as the proportion of all deaths attributable to this underlying cause of death over the study period and years of potential life lost (YPLL). Read More

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September 2021

A 584 bp deletion in CTRB2 inhibits chymotrypsin B2 activity and secretion and confers risk of pancreatic cancer.

Am J Hum Genet 2021 Sep 18. Epub 2021 Sep 18.

Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA. Electronic address:

Genome-wide association studies (GWASs) have discovered 20 risk loci in the human genome where germline variants associate with risk of pancreatic ductal adenocarcinoma (PDAC) in populations of European ancestry. Here, we fine-mapped one such locus on chr16q23.1 (rs72802365, p = 2. Read More

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September 2021

The pattern of orthopedic fractures and visceral injury in road traffic crash victims, Addis Ababa, Ethiopia.

PLoS One 2021 24;16(9):e0253690. Epub 2021 Sep 24.

School of Public Health, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

Background: Road Traffic crash injury is one of the main public health problems resulting in premature death and disability particularly in low-income countries. However, there is limited evidence on the crash fractures in Ethiopia.

Objective: The study was conducted to assess the magnitude of road traffic crash fractures and visceral injuries. Read More

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September 2021

Recurrent preterm birth risk assessment for two delivery subtypes: A multivariable analysis.

J Am Med Inform Assoc 2021 Sep 24. Epub 2021 Sep 24.

Institute for Computational Medicine, Whiting School of Engineering, Johns Hopkins University, Baltimore, Maryland, USA.

Objective: The study sought to develop and apply a framework that uses a clinical phenotyping tool to assess risk for recurrent preterm birth.

Materials And Methods: We extended an existing clinical phenotyping tool and applied a 4-step framework for our retrospective cohort study. The study was based on data collected in the Genomic and Proteomic Network for Preterm Birth Research Longitudinal Cohort Study (GPN-PBR LS). Read More

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September 2021

Prevalence of obstructive sleep apnea in diabetic patients.

Ann Afr Med 2021 Jul-Sep;20(3):206-211

Department of Respiratory Medicine, KGMU, Lucknow, Uttar Pradesh, India.

Context: Obstructive sleep apnea (OSA)-related hypoxemia stimulates release of acute-phase proteins and reactive oxygen species that exacerbate insulin resistance and lipolysis and cause an augmented prothrombotic and proinflammatory state which can leads to premature death.

Aims: This study aims to study the prevalence of OSA in diabetic patients.

Setting And Design: It was a cross-sectional study, done over a period of 1 year in a tertiary care hospital. Read More

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September 2021

Evaluation of physical and cardiorespiratory fitness in 7-year-old prematurely born children - preliminary study.

Ann Agric Environ Med 2021 Sep 9;28(3):502-508. Epub 2020 Sep 9.

Department of Sports Medicine, Faculty of Health Science, Medical University, Lublin, Poland.

Introduction: Premature birth is connected with the risk of incidence of numerous health complications, the consequences of which are observed in the long-term. Decreased physical and cardiorespiratory fitness can also be associated with preterm birth.

Objective: The aim of the study is evaluation of the development level of physical and cardiorespiratory fitness in 7-year-old prematurely born children. Read More

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September 2021

Changes in Life Expectancy of Respiratory Diseases from Attaining Daily PM Standard in China: A Nationwide Observational Study.

Innovation (N Y) 2020 Nov 4;1(3):100064. Epub 2020 Nov 4.

Department of Epidemiology, School of Public Health, Sun Yat-sen University, No. 74 Zhongshan Road 2, Yuexiu District, Guangzhou 510080, China.

Although exposure to air pollution increases the risk of premature mortality and years of life lost (YLL), the effects of daily air quality improvement to the life expectancy of respiratory diseases remained unclear. We applied a generalized additive model (GAM) to assess the associations between daily PM exposure and YLL from respiratory diseases in 96 Chinese cities during 2013-2016. We further estimated the avoidable YLL, potential gains in life expectancy, and the attributable fraction by assuming daily PM concentration decrease to the air quality standards of China and World Health Organization. Read More

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November 2020

Enteral feeding advancement and growth until 5 years in extremely preterm infants.

BMC Pediatr 2021 Sep 23;21(1):420. Epub 2021 Sep 23.

Department of Neonatology, University Children's Hospital, Eberhard Karls University, Tuebingen, Calwerstr. 7, 72076, Tuebingen, Germany.

Background: In-utero weight gain can be achieved in very preterm infants through rapid advancement of enteral feeds without increasing risk of necrotizing enterocolitis. There are concerns, however, that such rapid weight gain may lead to an increased childhood adiposity risk, although long-term data are sparse.

Design: This retrospective observational study included two well-characterized cohorts comprising 145 infants born at < 28 weeks or with < 1000 g birth weight. Read More

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September 2021

Survey: acceptability of opportunistic bilateral salpingectomy in Flanders.

Facts Views Vis Obgyn 2021 Sep;13(3):245-253

Background: The VVOG (Flemish Society of Obstetrics and Gynaecology) published a consensus statement promoting opportunistic bilateral salpingectomy (OBS).

Objectives: The aim of the study was to obtain insight into the current opinion and general practice of Flemish gynaecologists to counsel and perform OBS.

Materials And Methods: A questionnaire was distributed to Flemish gynaecologists three months following publication. Read More

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September 2021

Short- and Long-Term Complications of Bronchopulmonary Dysplasia.

Respir Care 2021 Oct;66(10):1618-1629

Department of Internal Medicine, Saint Louis University School of Medicine, St. Louis, Missouri.

Bronchopulmonary dysplasia (BPD) is a chronic lung disease most commonly seen in preterm infants of low birthweight who required postnatal respiratory support. Although overall incidence rates have not changed, recent advancements in medical care have resulted in lower mortality rates, and those affected are beginning to live longer. As a result, the long-term repercussions of BPD are becoming more apparent. Read More

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October 2021

Child maltreatment, early life socioeconomic disadvantage and all-cause mortality in mid-adulthood: findings from a prospective British birth cohort.

BMJ Open 2021 Sep 22;11(9):e050914. Epub 2021 Sep 22.

UCL Division of Surgery & Interventional Science, University College London, London, UK

Objectives: Early-life adversities (ELAs) such as child maltreatment (neglect and abuse) and socioeconomic disadvantage have been associated with adult mortality. However, evidence is sparse for specific types of ELA. We aimed to establish whether specific ELAs (ie, different types of child maltreatment and socioeconomic disadvantage) were associated independently with all-cause mortality in mid-adulthood and to examine potential intermediary pathways. Read More

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September 2021

Can Anakinra and corticosteroid treatment be an effective option in pregnant women with severe Covid-19?

Women Health 2021 Sep 22:1-8. Epub 2021 Sep 22.

Department of Internal Medicine, Division of Rheumatology, Ankara City Hospital, Yıldırım Beyazıt University, Ankara, Turkey.

Anakinra, which is an Interleukin-1 (IL-1) receptor antagonist with the advancing disease process, has started to be considered as an alternative treatment for Covid-19 patients with cytokine storms. We evaluated the effect of corticosteroids and IL-1 receptor blockage with anakinra on pregnant patients with Covid-19 at high risk for respiratory distress, ongoing fever, deterioration in their general condition and consequently maternal and fetal complications. Fourteen pregnant women who received anakinra (median dosage: 400 mg) and corticosteroid (methylprednisolone-median dosage: 80 mg) treatment were evaluated retrospectively. Read More

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September 2021

Stem cells immortalized by hTERT perform differently from those immortalized by SV40LT in proliferation, differentiation, and reconstruction of matrix microenvironment.

Acta Biomater 2021 Sep 19. Epub 2021 Sep 19.

Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, WV, USA; WVU Cancer Institute, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, WV, USA. Electronic address:

Although matrix microenvironment has the potential to improve expanded stem cell proliferation and differentiation capacity, decellularized extracellular matrix (dECM) deposited by senescent cells does not contribute to the rejuvenation of adult stem cells, which has become a barrier to personalized stem cell therapy. Genetic modification is an effective strategy to protect cells from senescence but it carries the increased risk of malignant transformation and genetic instability. In this study, lentivirus carrying either human telomerase reverse transcriptase (hTERT) or simian virus 40 large T antigen (SV40LT) was used to transduce human infrapatellar fat pad-derived stem cells (IPFSCs). Read More

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September 2021

[PsyYoung: A transcantonal project for facilitating access to care for young people at risk for psychotic disorders].

Rev Med Suisse 2021 Sep;17(751):1597-1601

Service de psychiatrie générale, Département de psychiatrie, CHUV et Université de Lausanne, 1011 Lausanne.

Approximately 2% of adolescents and young adults display symptoms indicating a high risk for psychotic disorders. Apart from a risk of 20-35% of developing a psychotic disorder, these individuals show high rates of persisting mental health problems and functional impairment, even in the absence of a psychotic transition. Treatment in specialized centers can improve outcomes in these patients, but the need to provide timely access to care needs to be balanced against the risks of premature psychiatrization, stigmatization and unnecessary medication treatment. Read More

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September 2021

Association of physical activity with arterial stiffness among Black adults.

Vasc Med 2021 Sep 22:1358863X211032725. Epub 2021 Sep 22.

Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.

Arterial stiffness is a precursor for the development of hypertension and premature cardiovascular disease (CVD). Physical activity has been associated with lower arterial stiffness among largely White populations, but the types of activity required and whether these findings apply to Black adults remain unknown. We examined whether physical activity levels were associated with arterial stiffness among Black adults in two independent cohorts. Read More

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September 2021

Hemoglobin concentration, hematocrit and red blood cell count predict major adverse cardiovascular events in patients with familial hypercholesterolemia.

Atherosclerosis 2021 Sep 15;335:41-46. Epub 2021 Sep 15.

Genetic Dyslipidemias Clinic of the Montreal Clinical Research Institute, Québec, Canada; Department of Medicine, Divisions of Experimental Medicine and Medical Biochemistry, McGill University, Québec, Canada. Electronic address:

Background And Aims: Familial hypercholesterolemia (FH) is a genetic disease associated with an important risk of premature and recurrent atherosclerotic cardiovascular disease (ASCVD). Red blood cell (RBC) parameters such as cell count and hematocrit (HCT) have previously been associated with ASCVD risk in the general population. However, little is known concerning their effect in FH. Read More

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September 2021

The relationship between step count and all-cause mortality and cardiovascular events: A dose-response meta-analysis.

J Sport Health Sci 2021 Sep 18. Epub 2021 Sep 18.

Key Laboratory of Environmental Medicine Engineering of Ministry of Education, Department of Epidemiology and Biostatistics, School of Public Health, Southeast University, Nanjing 210009, China. Electronic address:

Background: A goal of 10,000 steps per day is widely advocated, but there is little evidence to support that goal. Our purpose was to examine the dose-response relationships between step count and mortality and cardiovascular disease risk.

Methods: Cochrane Central Register of Controlled Trials, EMBASE, OVID, PubMed, Scopus, and Web of Science databases were systematically searched for studies published before July 09, 2021, that evaluated the association between daily steps and at least 1 outcome. Read More

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September 2021

Outcomes of pregnancies with trisomy 16 mosaicism detected by NIPT: a series of case reports.

Mol Cytogenet 2021 Sep 20;14(1):44. Epub 2021 Sep 20.

Prenatal Diagnosis Centre, Maternal and Children Metabolic-Genetic Key Laboratory, Guangdong Women and Children Hospital, 521-523 Xingnan Road, Guangzhou, 511442, Guangdong, China.

Background: Trisomy 16 (T16) is thought to be the most frequent chromosome abnormality at conception, which is often associated with a high risk of abnormal outcomes.

Methods: A retrospective analysis of 14 cases with high risk of T16 by noninvasive prenatal testing (NIPT) was conducted. All cases in the analysis involved prenatal diagnosis, karyotyping and chromosomal microarray analysis. Read More

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September 2021

Trisomy 21 and Assisted Reproductive Technologies: A review.

JBRA Assist Reprod 2021 Sep 20. Epub 2021 Sep 20.

EmbryoFertility Reproductive Biomedicine, Lima, Peru.

Trisomy 21 is the most common genetic disorder seen among infants, and it causes spontaneous abortions, abnormal neural development and other pathologies associated with newborn development. In newborns with this trisomy, 90-95% have full trisomy, 1.4-1. Read More

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September 2021

Loneliness and the Social Brain: How Perceived Social Isolation Impairs Human Interactions.

Adv Sci (Weinh) 2021 Sep 20:e2102076. Epub 2021 Sep 20.

Division of Medical Psychology, Department of Psychiatry and Psychotherapy, University Hospital Bonn, 53105, Bonn, Germany.

Loneliness is a painful condition associated with increased risk for premature mortality. The formation of new, positive social relationships can alleviate feelings of loneliness, but requires rapid trustworthiness decisions during initial encounters and it is still unclear how loneliness hinders interpersonal trust. Here, a multimodal approach including behavioral, psychophysiological, hormonal, and neuroimaging measurements is used to probe a trust-based mechanism underlying impaired social interactions in loneliness. Read More

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September 2021

Impact of early life exposures on COPD in adulthood: A systematic review and meta-analysis.

Respirology 2021 Sep 19. Epub 2021 Sep 19.

Department of Preventive Medicine, Shantou University Medical College, Shantou, China.

Early life represents a critical period for the development and growth of the lungs. Adverse exposures in this stage may drive the development of chronic obstructive pulmonary disease (COPD). Thus, we quantitatively evaluated the impact of different early life exposures on COPD in adulthood. Read More

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September 2021

Perceptions on preeclampsia and eclampsia among senior, older women, in rural Southwestern Uganda.

J Glob Health Rep 2021 3;5. Epub 2021 Mar 3.

Department of Community Health, Mbarara University of Science and Technology, Mbarara, Uganda.

Background: Eclampsia is among the leading causes of maternal mortality. It is a serious hypertensive complication of pregnancy and increases the risk of cardiovascular disease in later life. Pregnancy-related hypertension complications predispose to chronic hypertension and premature heart attacks. Read More

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