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Impact of heat waves and cold spells on cause-specific mortality in the city of São Paulo, Brazil.

Int J Hyg Environ Health 2021 Oct 20;239:113861. Epub 2021 Oct 20.

Department of Geography, School of Philosophy, Literature and Human Sciences of the University of São Paulo, São Paulo, SP, Brazil; Institute of Advanced Studies, of the University of São Paulo, São Paulo, SP, Brazil. Electronic address:

The impact of heat waves and cold spells on mortality has become a major public health problem worldwide, especially among older adults living in low-to middle-income countries. This study aimed to investigate the effects of heat waves and cold spells under different definitions on cause-specific mortality among people aged ≥65 years in São Paulo from 2006 to 2015. A quasi-Poisson generalized linear model with a distributed lag model was used to investigate the association between cause-specific mortality and extreme air temperature events. Read More

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October 2021

Prevention of Bleeding After Percutaneous Biopsy with a Small Intestinal Submucosa Hemostatic Plug.

Acta Biomater 2021 Oct 20. Epub 2021 Oct 20.

Department of Biomedical Engineering, Universidad de los Andes; Research Department Fundación Cardioinfantil - Instituto de Cardiología. Electronic address:

Percutaneous biopsies (PBs) are the gold standard diagnostic procedures indicated for renal and hepatic disorders. Nevertheless, they can cause hemorrhages and are contraindicated for coagulopathic patients. In this study we designed, fabricated, and evaluated a small intestinal submucosa (SIS) plug to reduce, and potentially cease, bleeding to decrease death risk after percutaneous hepatic and renal biopsies in healthy and coagulopathic in vivo models. Read More

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October 2021

Predictive factors of surgical complications in the first year following kidney transplantation.

Ann Vasc Surg 2021 Oct 20. Epub 2021 Oct 20.

Department of Vascular Surgery, Lausanne University Hospital (CHUV) and University of Lausanne, Suisse. Electronic address:

Background: In the recent years, an increased use of marginal donors and grafts and a growing prevalence of peripheral arterial disease in the recipients have been observed. Meanwhile, the open surgical technique for kidney transplantation has not changed. The aim of this study is to analyze all surgical complications occurring in the first year after kidney transplant and to determine potential predictive risk factors. Read More

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October 2021

Outcomes of Endovascular Aneurysm Repair with Adjunctive Stenting.

Ann Vasc Surg 2021 Oct 20. Epub 2021 Oct 20.

Division of Vascular Surgery, University of Missouri, Columbia, MO. Electronic address:

Objective: Endovascular aneurysm repair is the standard of care for abdominal aortic aneurysm repair, however data regarding adjunctive stenting at the time of endovascular aneurysm repair (EVAR) are limited. The study aims to evaluate outcomes of patients undergoing EVAR with and without adjunctive stenting.

Methods: Patients undergoing EVAR with stenting (EVAR-S) and without stenting (EVAR) (2008 to 2017) were selected from Cerner HealthFacts® database using ICD-9 diagnosis and procedure codes. Read More

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October 2021

Social media's influence on adolescents' food choices: A mixed studies systematic literature review.

Appetite 2021 Oct 20:105765. Epub 2021 Oct 20.

Villanova University, M. Louise Fitzpatrick College of Nursing, 800 E. Lancaster Avenue, Villanova, PA, 19085, USA. Electronic address:

Over 90% of adolescents have at least one social media account, and their presence on social media continues to grow. Food and beverage brands capitalize on this trend by marketing their products on social media to adolescents. Depending on the nutrition value of the products being marketed, social media advertisements' influence may contribute to the risk of developing unfavorable health outcomes such as obesity, hypertension, and type 2 diabetes. Read More

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October 2021

Temporal-spatial variations, source apportionment, and ecological risk of trace elements in sediments of water-level-fluctuation zone in the Three Gorges Reservoir, China.

Environ Sci Pollut Res Int 2021 Oct 23. Epub 2021 Oct 23.

Environmental Change Research Centre, University College London, Gower Street, London, WC1E 6BT, UK.

The Three Gorges Reservoir (TGR) plays a crucial role in providing electricity for mega-cities across China. However, since the impoundment was completed in 2006, attention to environmental concerns has also been intensive. In order to determine the distribution, sources, and pollution status of trace elements in the water fluctuation zone of the TGR following ten years of repeated "submergence" and "exposure", we systematically collected 16 paired surface sediment samples (n = 32) covering the entire main body of the TGR in March 2018 (following 6 months of submergence) and September 2018 (after 6 months of exposure), and quantitatively analyzed 13 elements (e. Read More

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October 2021

Functional abnormality in the sensorimotor system attributed to NRXN1 variants in boys with attention deficit hyperactivity disorder.

Brain Imaging Behav 2021 Oct 23. Epub 2021 Oct 23.

Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Huayuan Bei Road 51, Haidian District, Beijing, 100191, China.

Impaired sensorimotor circuits have been suggested in Attention-deficit/hyperactivity disorder (ADHD). NRXN1, highly expressed in cortex and cerebellum, was one of the candidate risk genes for ADHD, while its effects on sensorimotor circuits are unclear. In this content, we aimed to investigate the differential brain effects as functions of the cumulative genetic effects of NRXN1 variants in ADHD and healthy controls (HCs), identifying a potential pathway mapping from NRXN1, sensorimotor circuits, to ADHD. Read More

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October 2021

Descriptive and risk factor analysis of infantile cataracts: National Birth Defects Prevention Study, 2000-2011.

Am J Med Genet A 2021 Oct 23. Epub 2021 Oct 23.

Department of Epidemiology and Biostatistics, School of Public Health, University at Albany, Rensselaer, New York, USA.

Using National Birth Defects Prevention Study (NBDPS) data, we sought to estimate birth prevalence, describe clinical characteristics, and examine risk factors for infantile cataracts. We calculated birth prevalence using the numbers of NBDPS-eligible cataract cases and live births in the study area. We described case infants by the presence of associated ipsilateral eye defects (IEDs) and non-eye-related major birth defects. Read More

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October 2021

Nurturing Care for Early Childhood Development: Global Perspective and Guidance.

Indian Pediatr 2021 Nov;58 Suppl 1:S11-S15

Reproductive, Maternal, Newborn, Child and Adolescent Health and Healthy Ageing, World Health Organization, Regional Office for South-East Asia, New Delhi, India.

To develop to their full potential, all children need to receive nurturing care. This means that, starting in pregnancy, they are raised in a stable environment that is sensitive to their health and nutritional needs, with protection from threats, opportunities for early learning, and interactions that are responsive, emotionally supportive, and developmentally stimulating. Nurturing care ensures the foundations are laid early in life for an individual to survive and thrive. Read More

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November 2021

Unplanned admission to pediatric intensive care after general anesthesia: A seven-year retrospective cohort study in a tertiary children's hospital.

Paediatr Anaesth 2021 Oct 22. Epub 2021 Oct 22.

Department of Critical Care and Anesthesia, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo, 157-8535, Japan.

Background: Thorough preoperative risk assessment and planning is key to improving patient safety in the perioperative period. Analysis of unplanned ICU admissions after general anesthesia has been validated as a measure of patient safety and its use as a quality initiative is recommended in many countries.

Aims: The aims of this study were to determine the reasons for unplanned ICU admission, required interventions, and outcomes after general anesthesia in our hospital, as well as predictability and preventability of the events that led to admission with a view to improving anesthetic management. Read More

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October 2021

Activation of the adipocyte CREB/CRTC pathway in obesity.

Commun Biol 2021 Oct 22;4(1):1214. Epub 2021 Oct 22.

Peptide Biology Laboratories, The Salk Institute for Biological Studies, La Jolla, CA, 92037, USA.

Obesity is a major risk factor for the development of type II diabetes. Increases in adipose tissue mass trigger insulin resistance via the release of pro-inflammatory cytokines from adipocytes and macrophages. CREB and the CRTC coactivators have been found to promote insulin resistance in obesity, although the mechanism is unclear. Read More

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October 2021

Influence of gender and education on cocaine users in an outpatient cohort in Spain.

Sci Rep 2021 Oct 22;11(1):20928. Epub 2021 Oct 22.

Laboratorio de Medicina Regenerativa (LMR), Unidad de Gestión Clínica de Salud Mental, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Regional Universitario de Málaga, Avda. Carlos Haya 82, sótano, 29010, Málaga, Spain.

Gender significantly influences sociodemographic, medical, psychiatric and addiction variables in cocaine outpatients. Educational level may be a protective factor showing less severe addictive disorders, longer abstinence periods, and better cognitive performance. The aim was to estimate gender-based differences and the influence of educational level on the clinical variables associated with cocaine use disorder (CUD). Read More

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October 2021

Differential Antimicrobial Efficacy of Multi-Purpose Solutions against Acanthamoeba Trophozoites.

Optom Vis Sci 2021 Oct 22. Epub 2021 Oct 22.

R&D Microbiology, Alcon Research, LLC, Fort Worth, Texas (all authors).

Significance: This investigation examines the effectiveness of several common contact lens solutions in the disinfection of Acanthamoeba, which causes a serious eye infection most often resulting from dysfunctional or improper use of contact lens products.

Purpose: Acanthamoeba keratitis (AK) is an eye infection caused by a free-living amoeba, which can lead to extensive corneal damage and frequently blindness. AK is linked with contact lens use combined with noncompliance with contact lens care cleaning regimens. Read More

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October 2021

Testing models at the neural level reveals how the brain computes subjective value.

Proc Natl Acad Sci U S A 2021 Oct;118(43)

Zurich Center for Neuroeconomics, Department of Economics, University of Zurich 8006 Zurich, Switzerland;

Decisions are based on the subjective values of choice options. However, subjective value is a theoretical construct and not directly observable. Strikingly, distinct theoretical models competing to explain how subjective values are assigned to choice options often make very similar behavioral predictions, which poses a major difficulty for establishing a mechanistic, biologically plausible explanation of decision-making based on behavior alone. Read More

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October 2021

Prognostic value of coronary computed tomography angiographic derived fractional flow reserve: a systematic review and meta-analysis.

Heart 2021 Oct 22. Epub 2021 Oct 22.

Cardiology, Glostrup University Hospital, Glostrup, Denmark.

Objectives: To obtain more powerful assessment of the prognostic value of fractional flow reserve testing we performed a systematic literature review and collaborative meta-analysis of studies that assessed clinical outcomes of CT-derived calculation of FFR (FFR) (HeartFlow) analysis in patients with stable coronary artery disease (CAD).

Methods: We searched PubMed and Web of Science electronic databases for published studies that evaluated clinical outcomes following fractional flow reserve testing between 1 January 2010 and 31 December 2020. The primary endpoint was defined as 'all-cause mortality (ACM) or myocardial infarction (MI)' at 12-month follow-up. Read More

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October 2021

COVID-19-Induced New-Onset Diabetes: Trends and Technologies.

Diabetes 2021 Oct 22. Epub 2021 Oct 22.

Department of Genetics, Stanford University, Stanford, CA

The coronavirus disease 2019 (COVID-19) global pandemic continues to spread worldwide with approximately 216 million confirmed cases and 4.49 million deaths to date. Intensive efforts are ongoing to combat this disease by suppressing viral transmission, understanding its pathogenesis, developing vaccination strategies, and identifying effective therapeutic targets. Read More

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October 2021

Associations Between Relative Grip Strength and the Risk of 15 Cancer Sites.

Am J Prev Med 2021 Oct 19. Epub 2021 Oct 19.

Institute of Cardiovascular & Medical Sciences, University of Glasgow, Glasgow, United Kingdom; Research Centre in Exercise Physiology, Mayor University, Santiago, Chile; Human Performance Research Lab, Physical Activity and Health Research Unit (GEEAFyS), University Católica del Maule, Talca, Chile. Electronic address:

Introduction: Grip strength is the most commonly used muscle strength proxy in clinical research. However, evidence regarding the associations of grip strength with cancer has been mainly restricted to overall cancer risk. Therefore, this study aims to evaluate the associations between grip strength relative to BMI and 15 cancer sites as well as with all-cause cancer mortality. Read More

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October 2021

Parkinsonism and cerebrovascular disease.

J Neurol Sci 2021 Oct 6:120011. Epub 2021 Oct 6.

Brain and Mind Centre and Faculty of Health and Medical Sciences, School of Medical Sciences, University of Sydney, Sydney, NSW, Australia.

The relationship between cerebrovascular disease and parkinsonism is commonly seen in everyday clinical practice but remains ill-defined and under-recognised with little guidance for the practising neurologist. We attempt to define this association and to illustrate key clinical, radiological and pathological features of the syndrome of Vascular Parkinsonism (VaP). VaP is a major cause of morbidity in the elderly associated with falls, hip fractures and cognitive impairment. Read More

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October 2021

Risk Stratification and Management of Extracranial Carotid Artery Disease.

Cardiol Clin 2021 Nov;39(4):539-549

Richard A. and Susan F. Smith Center for Outcomes Research in Cardiology, Division of Cardiology, Department of Medicine, Beth Israel Deaconess Medical Center, 375 Longwood Avenue, 4th Floor, Boston, MA 02215, USA; Harvard Medical School, Boston, MA, USA; Division of Cardiology, Department of Medicine, Beth Israel Deaconess Medical Center, 185 Pilgrim Road, Palmer Building, 4th Floor, Boston, MA 02215, USA. Electronic address:

Stroke is the fifth leading cause of death in the United States and is a leading cause of disability. Extracranial internal carotid artery stenosis is a major cause of ischemic stroke, as it is estimated to cause 8% to 15% of ischemic strokes. It is critical to improve our strategies for stroke prevention and treatment in order to reduce the burden of this disease. Read More

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November 2021

Long-acting antimuscarinic therapy in patients with chronic obstructive pulmonary disease receiving beta-blockers.

Respir Res 2021 Oct 22;22(1):272. Epub 2021 Oct 22.

Formerly of AstraZeneca, Barcelona, Spain.

Background: Beta-blocker therapies for cardiovascular comorbidities are often withheld in patients with chronic obstructive pulmonary disease (COPD) due to potential adverse effects on airway obstruction. We carried out a post hoc analysis to determine the efficacy and safety of aclidinium in patients with moderate-to-very severe COPD and increased cardiovascular risk receiving beta-blockers at baseline versus non-users.

Methods: ASCENT-COPD was a Phase 4, multicenter, double-blind, randomized, placebo-controlled, parallel-group study. Read More

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October 2021

Protective Effects of Salicylic Acid and Calcium Chloride on Sage Plants ( L. and Vahl) under High-Temperature Stress.

Plants (Basel) 2021 Oct 5;10(10). Epub 2021 Oct 5.

Department of Horticulture and Landscape Architecture, National Taiwan University, Taipei 11106, Taiwan.

High-temperature stress is a major risk to fresh-market production, and heat intolerance is a major constraint in sage cultivation, particularly during the hot summer season. Previously, we investigated heat tolerance in five common-market cultivars of sage plants using leaf relative injury (RI) values and found that Vahl (SE) and L. (SO) were the most and least heat-tolerant species, respectively. Read More

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October 2021

How (Epi)Genetic Regulation of the LIM-Domain Protein FHL2 Impacts Multifactorial Disease.

Cells 2021 Oct 1;10(10). Epub 2021 Oct 1.

Department of Medical Biochemistry, Amsterdam University Medical Centers, Amsterdam Cardiovascular Sciences, and Amsterdam Gastroenterology, Endocrinology and Metabolism, 1105 AZ Amsterdam, The Netherlands.

Susceptibility to complex pathological conditions such as obesity, type 2 diabetes and cardiovascular disease is highly variable among individuals and arises from specific changes in gene expression in combination with external factors. The regulation of gene expression is determined by genetic variation (SNPs) and epigenetic marks that are influenced by environmental factors. Aging is a major risk factor for many multifactorial diseases and is increasingly associated with changes in DNA methylation, leading to differences in gene expression. Read More

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October 2021

A Human 3D Cardiomyocyte Risk Model to Study the Cardiotoxic Influence of X-rays and Other Noxae in Adults.

Cells 2021 Sep 30;10(10). Epub 2021 Sep 30.

Biophysics Department, GSI Helmholtzzentrum für Schwerionenforschung GmbH, 64291 Darmstadt, Germany.

The heart tissue is a potential target of various noxae contributing to the onset of cardiovascular diseases. However, underlying pathophysiological mechanisms are largely unknown. Human stem cell-derived models are promising, but a major concern is cell immaturity when estimating risks for adults. Read More

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September 2021

The HPSE Gene Insulator-A Novel Regulatory Element That Affects Heparanase Expression, Stem Cell Mobilization, and the Risk of Acute Graft versus Host Disease.

Cells 2021 Sep 23;10(10). Epub 2021 Sep 23.

Chaim Sheba Medical Center, Department of Hematology and Bone Marrow Transplantation, Tel-Hashomer, Ramat Gan 5266202, Israel.

The HPSE gene encodes heparanase (HPSE), a key player in cancer, inflammation, and autoimmunity. We have previously identified a strong HPSE gene enhancer involved in self-regulation of heparanase by negative feedback exerted in a functional rs4693608 single-nucleotide polymorphism (SNP) dependent manner. In the present study, we analyzed the HPSE gene insulator region, located in intron 9 and containing rs4426765, rs28649799, and rs4364254 SNPs. Read More

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September 2021

Natural Aporphine Alkaloids with Potential to Impact Metabolic Syndrome.

Molecules 2021 Oct 10;26(20). Epub 2021 Oct 10.

Nanjing Institute of Product Quality Inspection, Nanjing 210019, China.

The incidence and prevalence of metabolic syndrome has steadily increased worldwide. As a major risk factor for various diseases, metabolic syndrome has come into focus in recent years. Some natural aporphine alkaloids are very promising agents in the prevention and treatment of metabolic syndrome and its components because of their wide variety of biological activities. Read More

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October 2021

Changes in Dietary Patterns and Clinical Health Outcomes in Different Countries during the SARS-CoV-2 Pandemic.

Nutrients 2021 Oct 15;13(10). Epub 2021 Oct 15.

Integrated Center for Research, Development and Innovation in Advanced Materials, Nanotechnologies, and Distributed Systems for Fabrication and Control, Stefan cel Mare University of Suceava, 720229 Suceava, Romania.

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to an excess in community mortality across the globe. We review recent evidence on the clinical pathology of COVID-19, comorbidity factors, immune response to SARS-CoV-2 infection, and factors influencing infection outcomes. The latter specifically includes diet and lifestyle factors during pandemic restrictions. Read More

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October 2021

Vitamin D and Cardiovascular Disease: Current Evidence and Future Perspectives.

Nutrients 2021 Oct 14;13(10). Epub 2021 Oct 14.

Centro Cardiologico Monzino IRCCS, 20138 Milan, Italy.

Vitamin D deficiency is a prevalent condition, occurring in about 30-50% of the population, observed across all ethnicities and among all age groups. Besides the established role of vitamin D in calcium homeostasis, its deficiency is emerging as a new risk factor for cardiovascular disease (CVD). In particular, several epidemiological and clinical studies have reported a close association between low vitamin D levels and major CVDs, such as coronary artery disease, heart failure, and atrial fibrillation. Read More

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October 2021

Type 2 Diabetes-Related Health Economic Impact Associated with Increased Whole Grains Consumption among Adults in Finland.

Nutrients 2021 Oct 13;13(10). Epub 2021 Oct 13.

Department of Public Health and Welfare, Finnish Institute for Health and Welfare, 00271 Helsinki, Finland.

The prevalence of type 2 diabetes (T2D) is increasing rapidly worldwide. A healthy diet supporting the control of energy intake and body weight has major importance in the prevention of T2D. For example, a high intake of whole grain foods (WGF) has been shown to be inversely associated with risk for T2D. Read More

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October 2021

Reduction of Major Adverse Cardiovascular Events (MACE) after Bariatric Surgery in Patients with Obesity and Cardiovascular Diseases: A Systematic Review and Meta-Analysis.

Nutrients 2021 Oct 12;13(10). Epub 2021 Oct 12.

Department of Physiology and Pharmacology, State University of New York (SUNY) Downstate Health Sciences University, Brooklyn, NY 11203, USA.

Cardiovascular diseases (CVDs) are the leading cause of death worldwide and obesity is a major risk factor that increases the morbidity and mortality of CVDs. Lifestyle modifications (e.g. Read More

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October 2021

Vitamin D Intake in Slovenian Adolescents, Adults, and the Elderly Population.

Nutrients 2021 Oct 8;13(10). Epub 2021 Oct 8.

Nutrition Institute, Tržaška Cesta 40, SI-1000 Ljubljana, Slovenia.

Vitamin D is involved in calcium and phosphorus metabolism, and is vital for numerous bodily functions. In the absence of sufficient UV-B light-induced skin biosynthesis, dietary intake becomes the most important source of vitamin D. In the absence of biosynthesis, the recommended dietary vitamin D intake is 10-20 µg/day. Read More

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October 2021