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The effects of different parenteral nutrition lipid formulations on clinical and laboratory endpoints in patients receiving home parenteral nutrition: A systematic review.

Clin Nutr 2021 Nov 14;41(1):80-90. Epub 2021 Nov 14.

Human Nutrition Research Centre, Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, UK.

Background: Home parenteral nutrition (HPN) is a life-sustaining therapy for individuals with intestinal failure in a community setting. It refers to the intravenous infusion of macronutrients, micronutrients, fluids and electrolytes. Routinely used HPN solutions contain different quantities of these components. Read More

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November 2021

Composition of intestinal flora affects the risk relationship between Alzheimer's disease/Parkinson's disease and cancer.

Biomed Pharmacother 2021 Dec 1;145:112343. Epub 2021 Dec 1.

Daxing Research Institute, University of Science and Technology Beijing, China; School of Chemistry and Biological Engineering, University of Science and Technology Beijing, China. Electronic address:

An increasing number of epidemiological studies have shown that there is a significant inverse relationship between the onset of Alzheimer's disease/Parkinson's disease (AD/PD) and cancer, but the mechanism is still unclear. Considering that intestinal flora can connect them, we tried to explain this phenomenon from the intestinal flora. This review briefly introduced the relationship among AD/PD, cancer, and intestinal flora, studied metabolites or components of the intestinal flora and the role of intestinal barriers and intestinal hormones in AD/PD and cancer. Read More

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December 2021

Multiple primary gastrointestinal tumors of gastric, pancreatic and rectal origin; a case report.

Int J Surg Case Rep 2021 Nov 18;89:106610. Epub 2021 Nov 18.

Department of Surgery, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Introduction: The occurrence of multiple primary synchronous or metachronous malignancies is a described phenomenon. Such cases may have genetic predisposition or could be related to environmental risk factors but may also be sporadic. We are reporting a unique combination of triple primary synchronous malignancies in the same patient. Read More

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November 2021

Glycoprotein 2 in health and disease: lifting the veil.

Genes Environ 2021 Dec 3;43(1):53. Epub 2021 Dec 3.

Department of Public Health, Aichi Medical University School of Medicine, 480-1195, Nagakute, Aichi, Japan.

In 2020, we discovered glycoprotein 2 (GP2) variants associated with pancreatic cancer susceptibility in a genome-wide association study involving the Japanese population. Individuals carrying a missense coding variant (rs78193826) in the GP2 gene resulting in a p.V432M substitution had an approximately 1. Read More

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December 2021

Whole-genome sequencing-based phylogeny, antibiotic resistance, and invasive phenotype of Escherichia coli strains colonizing the cervix of women in preterm labor.

BMC Microbiol 2021 Dec 3;21(1):330. Epub 2021 Dec 3.

University of Missouri Kansas City, 2411 Holmes Street, MO, 64108, Kansas City, USA.

Background: Escherichia coli is a major neonatal pathogen and the leading cause of early-onset sepsis in preterm newborns. Maternal E. coli strains are transmitted to the newborn causing invasive neonatal disease. Read More

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December 2021

Retroperitoneal GIST: An exceptional location of a rare tumour. A case report from Ouagadougou and review of the literature.

Int J Surg Case Rep 2021 Nov 19;89:106613. Epub 2021 Nov 19.

General and Digestive Surgery Department of Yalgado Ouedraogo University Hospital Center (CHU.YO), Ouagadougou, Burkina Faso.

Introduction: GIST can occur in all segments of the gastrointestinal tract with a predilection for the stomach. Retroperitoneal localization remains exceptional. We report a case to describe our diagnostic and therapeutic approach. Read More

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November 2021

Endoderm and mesoderm derivatives in embryonic stem cell differentiation and their use in developmental toxicity testing.

Reprod Toxicol 2021 Nov 30. Epub 2021 Nov 30.

Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands; Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, the Netherlands.

Embryonic stem cell differentiation models have increasingly been applied in non-animal test systems for developmental toxicity. After the initial focus on cardiac differentiation, attention has also included an array of neuro-ectodermal differentiation routes. Alternative differentiation routes in the mesodermal and endodermal germ lines have received less attention. Read More

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November 2021

Fat soluble vitamin status in children on home parenteral nutrition in a tertiary paediatric intestinal rehabilitation unit.

Clin Nutr ESPEN 2021 Dec 20;46:240-245. Epub 2021 Oct 20.

Department of Gastroenterology and Nutrition, Nutritional Support and Intestinal Failure Team, Birmingham Women's and Children's Hospital, Steelhouse Lane, Birmingham, B4 6NH, UK.

Backgrounds & Aims: Children with intestinal failure on home parenteral nutrition are at risk of fat malabsorption and fat soluble vitamin deficiency. Fish oil containing mixed lipid emulsions (SMOFlipid®) with higher vitamin E content, have a theoretical risk of exceeding current recommendations for vitamin E dosing and, may influence other fat soluble vitamin status in these children. The aim of this study was to assess for fat soluble vitamin status in children on long-term home parental nutrition receiving a mixed lipid emulsion (SMOFlipid®) compared with those receiving traditional soy or soy/olive oil based (non- SMOFlipid®) lipid emulsions and whether this is influenced by the underlying cause of intestinal failure. Read More

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December 2021

A specific structure and high richness characterize intestinal microbiota of HIV-exposed seronegative individuals.

PLoS One 2021 2;16(12):e0260729. Epub 2021 Dec 2.

Facultad de Medicina, Grupo Inmunovirología, Universidad de Antioquia UdeA, Medellín, Colombia.

Intestinal microbiota facilitates food breakdown for energy metabolism and influences the immune response, maintaining mucosal homeostasis. Overall, HIV infection is associated with intestinal dysbiosis and immune activation, which has been related to seroconversion in HIV-exposed individuals. However, it is unclear whether microbiota dysbiosis is the cause or the effect of immune alterations and disease progression or if it could modulate the risk of acquiring the HIV infection. Read More

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December 2021

Association of small intestinal bacterial overgrowth with nonalcoholic fatty liver disease in children: A meta-analysis.

PLoS One 2021 2;16(12):e0260479. Epub 2021 Dec 2.

Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, Chengdu, China.

It has been suggested that small intestinal bacterial overgrowth (SIBO) could cause nonalcoholic fatty liver disease (NAFLD), but this association was not examined in children by meta-analysis. This meta-analysis aimed to determine the association between SIBO and NAFLD in children. The electronic databases PubMed, Embase, and Cochrane Library were searched for studies published before April 22, 2021. Read More

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December 2021

The Role of Microbiota in the Development of Cancer Tumour Cells and Lymphoma of B and T Cells.

Cureus 2021 Oct 25;13(10):e19047. Epub 2021 Oct 25.

Medical Oncology and Haematology, All India Institute of Medical Sciences, Rishikesh, IND.

Human body harbours enormous numbers of microbial organisms, including bacteria, viruses, and fungi which have a momentous role in well-being and illness in humans. Immune system shelters us from pathogenic bacteria, microorganisms found in human tissues have many benefits related to the functional movement of the host by regulating important procedures such as immunity, signalling, and breakdown. Lymphocytes assume a significant part in the reaction to bacterial colonization, primarily by prompting a safe reaction to obstruction or initiation. Read More

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October 2021

The Role of Fecal and as Early Diagnostic Markers of Colorectal Cancer.

Dis Markers 2021 22;2021:1171239. Epub 2021 Nov 22.

Medical College of Shantou University, Shantou, China.

Background: Accurate analysis of intestinal microbiota will facilitate establishment of an evaluating system for assessing colorectal cancer (CRC) risk and prognosis. This study evaluates the potential role of () and with a gene () in early CRC diagnosis.

Methods: We recruited 139 patients, including CRC ( = 60), colorectal adenomatous polyposis (CAP) ( = 37), and healthy individuals ( = 42) based on their colonoscopy examinations. Read More

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November 2021

Special Considerations of Anastomotic Leaks in Crohn's Disease.

Clin Colon Rectal Surg 2021 Nov 1;34(6):412-416. Epub 2021 Oct 1.

Division of Colorectal Surgery, Department of Surgery, Penn State Health Milton S. Hershey Medical Center, Hershey, Pennsylvania.

Rates of anastomotic leak following intestinal resections in the setting of inflammatory bowel disease are significantly influenced by clinical characteristics. While the literature can be contradictory due to significant heterogeneity in the published data, several common themes appear to consistently arise. With respect to Crohn's disease, low serum albumin, preoperative abscess, reoperative abdominal surgery, and steroid use are associated with an increased risk of postoperative intra-abdominal septic complications. Read More

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November 2021

Minimal invasive surgery for multiple adhesive small bowel obstruction: Results of a comparative multicenter study.

Cir Cir 2021 ;89(6):710-717

Emergency and Trauma Surgery Unit, Maggiore Hospital Regional Emergency Surgery and Trauma Center-Bologna Local Health District, Bologna, Italy.

Aim Of The Study: Laparoscopic adhesiolysis in small bowel obstruction (SBO) is getting increasingly normal. In patients with multiple adhesive SBOs (MASBO), laparoscopic approaches might increase the risk of bowel injury due to the distended and potentially compromised small bowel. It remains a challenge to the surgeons, entails an interdisciplinary team, trying to achieve the least complications as possible. Read More

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January 2021

Effects of Dicyclohexyl Phthalate Exposure on PXR Activation and Lipid Homeostasis in Mice.

Environ Health Perspect 2021 Dec 1;129(12):127001. Epub 2021 Dec 1.

Division of Biomedical Sciences, School of Medicine, University of California, Riverside, Riverside, California.

Background: Exposure to plastic-associated endocrine disrupting chemicals (EDCs) has been associated with an increased risk of cardiovascular disease (CVD) in humans. However, the underlying mechanisms for this association are unclear. Many EDCs have been shown to function as ligands of the nuclear receptor pregnane X receptor (PXR), which functions as xenobiotic sensor but also has pro-atherogenic effects . Read More

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December 2021

Bringing to Light the Risk of Colorectal Cancer in Inflammatory Bowel Disease: Mucosal Glycosylation as a Key Player.

Inflamm Bowel Dis 2021 Nov 29. Epub 2021 Nov 29.

i3S-Institute for Research and Innovation in Health, University of Porto, Porto, Portugal.

Colitis-associated cancer is a major complication of inflammatory bowel disease remaining an important clinical challenge in terms of diagnosis, screening, and prognosis. Inflammation is a driving factor both in inflammatory bowel disease and cancer, but the mechanism underlying the transition from colon inflammation to cancer remains to be defined. Dysregulation of mucosal glycosylation has been described as a key regulatory mechanism associated both with colon inflammation and colorectal cancer development. Read More

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November 2021

Four decades in the making: Collagen III and mechanisms of vascular Ehlers Danlos Syndrome.

Matrix Biol Plus 2021 Dec 9;12:100090. Epub 2021 Nov 9.

Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary & Life Sciences, University of Glasgow, G12 8QQ, UK.

Vascular Ehlers Danlos (vEDS) syndrome is a severe multi-systemic connective tissue disorder characterized by risk of dissection and rupture of the arteries, gastro-intestinal tract and gravid uterus. vEDS is caused by mutations in , that encodes the alpha 1 chain of type III collagen, which is a major extracellular matrix component of the vasculature and hollow organs. The first causal mutations were identified in the 1980s but progress in our understanding of the pathomolecular mechanisms has been limited. Read More

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December 2021

Release of sediment metals bound by glomalin related soil protein in waterfowls inhabiting mangrove patches.

Environ Pollut 2021 Nov 27;293:118577. Epub 2021 Nov 27.

Key Laboratory of the Ministry of Education for Coastal and Wetland Ecosystems, Xiamen University, Xiamen, 361102, China. Electronic address:

Glomalin-related soil protein (GRSP) has received extensive attention due to its ability to immobilize metals in the environment. However, whether it can enter the food chain through digestion is still unclear. Mangroves occupy the transition zone between the sea and land, have important ecological functions. Read More

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November 2021