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Mortality rate during professionally guided scuba diving experiences for uncertified divers, 1992-2019.

Diving Hyperb Med 2021 Jun;51(2):147-151

Professional Association of Diving Instructors (PADI Worldwide Corp), Rancho Santa Margarita, CA, USA.

Introduction: The aim of this study was to re-examine the mortality rate among participants in the Professional Association of Diving Instructors' (PADI)'s Discover Scuba Diving (DSD) programme.

Methods: Fatalities reported to PADI as having occurred during DSD scuba dives were counted for each year between 1992 and 2019. DSD participant registrations were also counted for each year. Read More

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The association of phasic irritability (aggressive outbursts) and tonic irritability (irritable mood) to depression occurrences, symptoms, and subtypes.

J Affect Disord 2021 Jun 11;293:9-18. Epub 2021 Jun 11.

Vanderbilt University, Nashville, Tennessee.

Background: Research among adults has rarely differentiated between tonic irritability (i.e., irritable mood) and phasic irritability (i. Read More

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Koelreuteria paniculata invasiveness, yielding capacity and harvest date influence on biodiesel feedstock properties.

J Environ Manage 2021 Jun 19;295:113102. Epub 2021 Jun 19.

University of Novi Sad, Faculty of Agriculture, Trg Dositeja Obradovića 8, 21000, Novi Sad, Serbia. Electronic address:

Due to Koelreuteria paniculata Laxm., high abundance in Novi Sad (Serbia) and previously confirmed biodiesel feedstock suitability, this study aimed to assess generative potential and yield, assess K. paniculata invasive risk, and investigate the influence of harvesting periods on the oil content and quality. Read More

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A Nation-wide Review of Elective Surgery and COVID-Surge Capacity.

J Surg Res 2021 Jun 19;267:211-216. Epub 2021 Jun 19.

Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland; Surgery Service, Veterans Affairs Medical Centre, Baltimore, Maryland. Electronic address:

Background: The COVID-19 pandemic has resulted in over 225,000 excess deaths in the United States. A moratorium on elective surgery was placed early in the pandemic to reduce risk to patients and staff and preserve critical care resources. This report evaluates the impact of the elective surgical moratorium on case volumes and intensive care unit (ICU) bed utilization. Read More

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Management of vascular complications following facial hyaluronic acid injection: high-dose hyaluronidase protocol: a technical note.

J Stomatol Oral Maxillofac Surg 2021 Jun 19. Epub 2021 Jun 19.

Department of ENT and Maxillofacial surgery, Head and Neck Institute, University Hospital of Nice, France.. Electronic address:

Aesthetic medicine has experienced major developments in recent years, which is illustrated by the increasing number of hyaluronic acid injected in the area of facial rejuvenation. Although considered low risk, it can rarely result in arterial embolization with potentially major aesthetic and functional consequences. These vascular complications range from livedo to skin necrosis to permanent blindness. Read More

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Circulation of multidrug-resistant Shigella sonnei and Shigella flexneri among men who have sex with men in Barcelona, Spain, 2015-2019.

Int J Antimicrob Agents 2021 Jun 19:106378. Epub 2021 Jun 19.

Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain; Department of Genetics and Microbiology, Universitat Autònoma de Barcelona, Plaça Cívica, 08193 Bellaterra, Barcelona, Spain; Department of Clinical Microbiology, Vall d'Hebron Hospital Universitari, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain. Electronic address:

Background: In high-income countries shigellosis is mainly found in travellers to high-risk regions or among men who have sex with men (MSM). Here we investigated the genomic characteristics and the features of antimicrobial resistance of MSM-associated Shigella flexneri and Shigella sonnei circulating in Barcelona (Spain), elucidating their connectivity with contemporaneous Shigella from other countries.

Methods: Antimicrobial susceptibility, WGS, genomic characterization and phylogenetic analysis was performed in MSM-associated Shigella recovered from 2015 to 2019. Read More

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Non-invasive imaging for the diagnosis of acute rejection in transplantation: The next frontier.

Transpl Immunol 2021 Jun 19:101431. Epub 2021 Jun 19.

Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA, USA. Electronic address:

Acute rejection is a leading cause of organ transplant failure and the most common indication for re-transplantation. Clinically, suspicion of acute rejection is often dependent upon serum laboratory values which may only manifest after organ injury. The gold standard for diagnosis requires an invasive biopsy which can carry serious clinical risks including bleeding and graft loss as well as the risk of sampling error. Read More

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Prevalence and characteristics of myocardial injury during COVID-19 pandemic: A new role for high-sensitive troponin.

Int J Cardiol 2021 Jun 19. Epub 2021 Jun 19.

Department of Cardiovascular Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; Department of Cardiovascular and Pulmonary Sciences, Università Cattolica Sacro Cuore, Rome, Italy.

Background: Coronavirus disease 2019 (COVID-19) is a pandemic disease that is causing a public health emergency. Characteristics and clinical significance of myocardial injury remain unclear.

Methods: This retrospective single-center study analyzed analyzed 189 patients who received a COVID-19 diagnosis out of all 758 subjects with a high sensitive troponin I (Hs-TnI) measurement within the first 24 h of admission at the Policlinico A. Read More

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Growth Rates of Infants Randomized to CPAP or Intubation After Extremely Preterm Birth.

J Pediatr 2021 Jun 19. Epub 2021 Jun 19.

National Institute of Child Health and Human Development, Bethesda, MD and Department of Global and Community Health, George Mason University, Fairfax, VA.

Objective: To evaluate the effects of early treatment with CPAP on nutritional intake and in-hospital growth rates of extremely preterm (EPT) infants.

Study Design: EPT infants (24-0/7 to 27-6/7 weeks of gestation) enrolled in the Surfactant Positive Airway Pressure and Pulse Oximetry Trial (SUPPORT) were included. EPT infants who died before 36 weeks' postmenstrual age (PMA) were excluded. Read More

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Long-term Neurodevelopmental Outcomes of Children with Congenital Heart Defects.

J Pediatr 2021 Jun 19. Epub 2021 Jun 19.

Université de Paris, CRESS, INSERM, INRA, F-75004 Paris, France.

Objective: To assess whether children with symptomatic CHD at birth (cyanosis and/or heart failure) are at greater risk of adverse neurodevelopmental outcomes at 8 years of age.

Study Design: From a prospective population-based cohort study of newborns with CHD (EPICARD), we included 473 children with available neurodevelopmental assessments at 8 years of age. We grouped the CHD based on symptoms at birth and need for early neonatal intervention. Read More

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Prevalence of metabolic syndrome and its correlation with sexual dysfunction in adult psychiatric patients treated with psychotropics in a tertiary care hospital.

Int J Clin Pract 2021 Jun 22:e14559. Epub 2021 Jun 22.

Department of Pharmacy Practice, Vinayaka Mission's College of Pharmacy, Vinayaka Mission's Research Foundation (Deemed to be University), Salem, 636008, Tamil Nadu, India.

Background: In the past two decades, there has been a profound increase in the incidence of metabolic disorders among the general population, and psychotropics are also said to play a major role in the development of metabolic syndrome.

Aim: Determining the prevalence of Metabolic Syndrome (MetS) and sexual dysfunction (SD) and their correlation in psychiatric patients treated with psychotropics in a tertiary care hospital in Salem region, Tamilnadu, India.

Materials And Methods: A cross-sectional study was conducted in the psychiatric department of Vinayaka Mission's Medical College and Hospitals, Salem on patients (n=108) treated with psychotropics. Read More

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Review of cadmium exposure and smoking-independent effects on atherosclerotic cardiovascular disease in the general population.

J Intern Med 2021 Jun 22. Epub 2021 Jun 22.

Occupational and Environmental Medicine, Department of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg and Sahlgrenska University Hospital, Gothenburg, Sweden.

Exposure to cadmium (Cd) via food and smoking is associated with increased risk of atherosclerotic cardiovascular disease (ASCVD). Blood and urine levels of Cd are established biomarkers of exposure. Our aim was to review: 1) the smoking-independent associations between Cd exposure and ASCVD, including the possible presence of a non-linear dose-response relationship with Cd exposure; and 2) the causal effects of Cd exposure on different stages of atherosclerosis. Read More

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Transactional relations between maternal anxiety and toddler anxiety risk through toddler-solicited comforting behavior.

Depress Anxiety 2021 Jun 22. Epub 2021 Jun 22.

Department of Psychology, Miami University, Oxford, Ohio, USA.

Introduction: Transactional developmental and anxiety theories suggest that mothers and toddlers may influence each other's anxiety development across early childhood. Further, toddlers' successful solicitations of comfort during uncertain, yet manageable, situations, may be a behavioral mechanism by which mothers and toddlers impact each other over time. To test these ideas, the current study employed a longitudinal design to investigate bidirectional relations between maternal anxiety and toddler anxiety risk (observed inhibited temperament and mother-perceived anxiety, analyzed separately), through the mediating role of toddler-solicited maternal comforting behavior, across toddlerhood. Read More

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Demonstration of proof-of-concept of StrokeShield system for complete closure and occlusion of the left atrial appendage for non-valvular atrial fibrillation therapy.

PLoS One 2021 22;16(6):e0253299. Epub 2021 Jun 22.

Cor Habere Corporation, Louisville, Kentucky, United States of America.

In the US, the most significant morbidity and mortality associated with non-valvular atrial fibrillation (NVAF) is embolic stroke, with 90% of thrombus originating from the left atrial appendage (LAA). Anticoagulation is the preferred treatment for the prevention of stroke in NVAF patients, but clinical studies have demonstrated high levels of non-compliance and increased risk of bleeding or ineligibility for anticoagulation therapy, especially in the elderly population where the incidence of NVAF is highest. Alternatively, stroke may be preventing using clinically approved surgical and catheter-based devices to exclude or occlude the LAA, but these devices continue to be plagued by peri-device leaks and thrombus formation because of residual volume. Read More

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Public Awareness and Utilization of 937-telephone health services Before and During the COVID-19 Pandemic: A longitudinal study.

J Med Internet Res 2021 Jun 2. Epub 2021 Jun 2.

Risk Management Unit, Directorate of Quality and Safety, King Fahah Hospital of The University, Imam Abdulrahman bin Faisal University, Dammam, SA.

Background: Telehealth plays a key role in supporting healthcare systems and influencing methods of healthcare delivery. Government laws and medical operating protocols have been largely modified to provide remote care in order to reduce social contact and ensure a safer patient environment. In the Kingdom of Saudi Arabia (KSA), the Ministry of Health (MOH) introduced several forms of telemedicine as alternatives to face-to face consultations in clinical settings. Read More

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The Risk Factors of Psychological Responses for Chinese University Students on COVID-19 Outbreak: A Cross-Sectional Online Survey Study.

J Med Internet Res 2021 Jun 20. Epub 2021 Jun 20.

Department of Neurosurgery, The Fourth Hospital of China Medical University, No. 4 Chongshandong, Huanggu, Shenyang 110084, China., Shenyang, CN.

Background: The novel coronavirus pneumonia (COVID-19) is a highly contagious and highly pathogenic disease caused by a novel coronavirus(SARS-CoV-2)and has become a pandemic. As a vulnerable population, university students are at high-risk during the epidemic because they have high mobility and often overlook the severity of the disease due to incomplete information about the epidemic. The epidemic has brought not only the risk of death from infection but also unbearable psychological pressure. Read More

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Combination of aneuploidy and high S-phase fraction indicates increased risk of relapse in stage I endometrioid endometrial carcinoma.

Acta Oncol 2021 Jun 22:1-7. Epub 2021 Jun 22.

Department of Medical Biosciences, Pathology, Umeå University, Umeå, Sweden.

Introduction: Endometrioid endometrial carcinoma is a cancer type with generally excellent prognosis when diagnosed at an early stage, but there is a subset of patients with relapsing disease in spite of early diagnosis and surgical treatment. There is a need to find prognostic markers to identify these patients with increased risk of relapse. Depth of myometrial invasion, histological grade, and presence of lymphovascular invasion are known risk factors. Read More

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Gonadal Function Recovery in Patients With Advanced Hodgkin Lymphoma Treated With a PET-Adapted Regimen: Prospective Analysis of a Randomized Phase III Trial (AHL2011).

J Clin Oncol 2021 Jun 22:JCO2100068. Epub 2021 Jun 22.

Department of Haematology, University Hospital F Mitterrand and Inserm UMR1231, Dijon, France.

Purpose: The prospective, randomized AHL2011 trial demonstrated that the use of the doxorubicin, bleomycin, vinblastine, and dacarbazine regimen (ABVD) after two cycles of bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone (BEACOPP) in early responders on the basis of a positron emission tomography (PET)-driven strategy was safe and minimized toxicity compared with standard 6 BEACOPP cycles. This substudy investigated the benefit of this strategy in gonadal function and fertility in patients under 45 years old.

Methods: Ovarian function was assessed by serum measurement of follicle-stimulating hormone (FSH), estradiol, and anti-müllerian hormone in women, and semen analysis, FSH, and testosterone levels were used to evaluate testicular function in men at baseline, end of treatment, and during 5 years of follow-up. Read More

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Neoadjuvant or Adjuvant Chemotherapy for Breast Cancer in Sub-Saharan Africa: A Retrospective Analysis of Recurrence and Survival in Women Treated for Breast Cancer at the Korle Bu Teaching Hospital in Ghana.

JCO Glob Oncol 2021 Jun;7:965-975

H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL.

Purpose: It is established that addition of systemic therapy to locoregional treatment for breast cancer improves survival. However, reliable data are lacking about the outcomes of such treatment in women with breast cancer in low middle-income countries. We compared the outcomes of treatment in patients who had received neoadjuvant chemotherapy (NACT) or adjuvant chemotherapy and examined the factors associated with breast cancer recurrence and survival at the National Radiotherapy Oncology and Nuclear Medicine Centre, Korle Bu Teaching Hospital, Ghana. Read More

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[Optical coherence tomography angiography in the diagnosis of retinal microvascular changes in chronic kidney disease (clinical observations)].

Vestn Oftalmol 2021 ;137(3):97-104

Novosibirsk State Medical University, Novosibirsk, Russia.

One distinctive pathological sign of chronic kidney disease (CKD) is microcirculatory disorders, which mark it as a microvascular disease. Similarity in the blood supply of the retina and kidneys, in the anatomy of their vascularization lead to identical complications in these organs. The retinal-choroidal microvascular system is easily accessible for clinical and morphological assessment and can be examined by the reproducible and non-invasive method - optical coherence tomography (OCT) and OCT angiography (OCTA). Read More

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January 2021

Predictors of poor outcomes among patients of acute methanol intoxication with particular reference to Sequential Organ Failure Assessment (SOFA) score.

Environ Sci Pollut Res Int 2021 Jun 22. Epub 2021 Jun 22.

Emergency Medicine Department, King Fahad Medical City (KFMC), Riyadh, Saudi Arabia.

Methanol intoxication is a global problem with serious morbidities and mortalities. Apart from the lifelong disabilities experienced by methanol intoxication survivors, mortality rates of up to 44% of exposed patients have been reported. The aim of the current study was to outline the early findings that could be utilized as effective in-hospital outcome predictors among cases of methanol exposure. Read More

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Health Disparities Across Lung Cancer Continuum Among Asian Americans: A Systematic Review.

J Immigr Minor Health 2021 Jun 22. Epub 2021 Jun 22.

Department of Health Systems Management, Rush University, Chicago, IL, USA.

The purpose of this systematic review is to synthesize lung cancer associated health disparities across the cancer continuum among Asian Americans. A systematic review design with the narrative method was used for conducting this study. Electronic literature databases, including PubMed, Google Scholar, and CINAHL, were searched. Read More

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Mammographic features of benign breast lesions and risk of subsequent breast cancer in women attending breast cancer screening.

Eur Radiol 2021 Jun 22. Epub 2021 Jun 22.

Department of Epidemiology and Evaluation, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.

Objectives: To evaluate the mammographic features in women with benign breast disease (BBD) and the risk of subsequent breast cancer according to their mammographic findings.

Methods: We analyzed data from a Spanish cohort of women screened from 1995 to 2015 and followed up until December 2017 (median follow-up, 5.9 years). Read More

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Clinical review of sick sinus syndrome and atrial fibrillation.

Herz 2021 Jun 22. Epub 2021 Jun 22.

Department of Ultrasound, the Second Affiliated Hospital of Dalian Medical University, 116027, Dalian, China.

Sick sinus syndrome (SSS) is a set of diseases with abnormal cardiac pacing, which manifests as diverse cardiac arrhythmias, especially bradycardia. The clinical presentation is inconspicuous in the early stage, but with the progression of this disease, patients may present with symptoms and signs of end-organ hypoperfusion. As a common result in the natural history of the disease, SSS coexisting with atrial fibrillation (AF) forms the basis of bradycardia-tachycardia syndrome. Read More

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Incidence of Early Police Contact Among Children With Emerging Mental Health Problems in Australia.

JAMA Netw Open 2021 Jun 1;4(6):e2112057. Epub 2021 Jun 1.

School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.

Importance: In adulthood and adolescence, mental health vulnerability is known to be associated with risk of criminal justice system contact as both a perpetrator and survivor of crime, but whether this association is apparent early in child development is unknown. Prevention of poor outcomes, including repeated contact with the criminal justice system, relies on the identification of vulnerability early in life and at the start of such contact.

Objective: To ascertain whether children with emotional or behavioral problems and general developmental vulnerabilities are at an increased risk of subsequent contact with police as a person of interest, a survivor of crime, or a witness. Read More

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Identification and Validation of Plasma Metabolomic Signatures in Precancerous Gastric Lesions That Progress to Cancer.

JAMA Netw Open 2021 Jun 1;4(6):e2114186. Epub 2021 Jun 1.

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Cancer Epidemiology, Peking University Cancer Hospital & Institute, Beijing, China.

Importance: Metabolic deregulation plays an important role in gastric cancer (GC) development. To date, no studies have comprehensively explored the metabolomic profiles along the cascade of gastric lesions toward GC.

Objective: To draw a metabolic landscape and define metabolomic signatures associated with the progression of gastric lesions and risk of early GC. Read More

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First-line pembrolizumab with or without platinum doublet chemotherapy in non-small-cell lung cancer patients with PD-L1 expression ≥50.

Future Oncol 2021 Jun 22. Epub 2021 Jun 22.

Department of Pneumology & Thoracic Oncology, CH Annecy-Genevois, 74370, Metz-Tessy, France.

Pembrolizumab plus chemotherapy is currently used in the first-line treatment of advanced non-small-cell lung cancer without mutations or rearrangements, regardless of PD-L1 expression status. A study comparing chemotherapy plus pembrolizumab versus pembrolizumab alone has never been performed in patients with PD-L1 ≥50%. The aim of this trial is to perform such a comparison as first-line treatment in patients not eligible for locally advanced treatment who have expression of PD-L1 on ≥50% of tumor cells. Read More

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[Surgical and conservative treatment of patients with non-traumatic intracerebral hematoma: pros and cons].

Zh Vopr Neirokhir Im N N Burdenko 2021 ;85(3):53-61

Belarusian State Medical University, Minsk, Belarus.

Background: The risk and benefits of early neurosurgical intervention in patients with non-traumatic intracerebral hematoma (NICH) are still unclear.

Objective: To evaluate an effectiveness of early surgery in patients with NICH compared to primary conservative therapy.

Material And Methods: There were 115 patients with indications for surgery. Read More

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January 2021

Adaption of Lung Fibroblasts to Fluoro-Edenite Fibers: Evaluation of Molecular and Physiological Dynamics.

Cell Physiol Biochem 2021 Jun;55(3):327-343

Department of Biomedical and Biotechnological Science - Section of Physiology, University of Catania, Catania, Italy,

Background/aims: The fluoro-edenite fibrous amphibole was identified as an environmental pollutant associate to risk of carcinogenicity. In Sicily (Italy), it represents a public health issue because fluoro-edenite fibers are present in the soil of Biancavilla, a town located on the south-west slopes of the volcano Etna. Since the relationship between exposure to fluoro-edenite and the onset of lung disorders have been documented, in vitro studies were performed to clarify the mechanisms of damage, but most aspects remain unknown. Read More

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Prevalence and risk factors of peripheral artery disease in a population with chronic kidney disease in Australia: A systematic review and meta-analysis.

Nephrology (Carlton) 2021 Jun 22. Epub 2021 Jun 22.

School of Public Health, Curtin University, Perth, WA, Australia.

There is a lack of clarity and guidance for screening peripheral artery disease (PAD) in persons with chronic kidney disease (CKD) and end stage kidney disease (ESKD) despite this group being at excess risk of cardiovascular disease (CVD). In this current study, we performed a systematic review and meta-analysis to examine the prevalence and risk factors for PAD in persons with CKD in Australian cohorts. We used the inverse variance heterogeneity meta-analysis with double arcsine transformation to summarize the prevalence of PAD (with 95% CIs). Read More

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