973,003 results match your criteria risk disease

Risk Factors of Outcomes of COVID-19 Patients in Korea: Focus on Early Symptoms.

J Korean Med Sci 2021 May 10;36(18):e132. Epub 2021 May 10.

Department of Urology, Kyung Hee University School of Medicine, Seoul, Korea.

Background: Coronavirus disease 2019 (COVID-19) has spread around the globe, and it is important to determine the risk factors of death in the general population. Our study aimed to determine the risk factors of death and severe illness requiring supplemental oxygen therapy based on the demographic and clinical characteristics of COVID-19 patients in Korea.

Methods: In this study, we used data provided by the Korea Disease Control and Prevention Agency (KDCA) and analyzed a total of 5,068 patients with COVID-19, excluding 19 pregnant women and 544 individuals with missing data. Read More

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Sodium-glucose Co-transporter 2 Inhibitors: a New Path for Heart Failure Treatment.

Korean Circ J 2021 May;51(5):399-408

Division of Cardiology, Department of Internal Medicine, Severance Cardiovascular Hospital, Cardiovascular Research Institute, Yonsei University College of Medicine, Seoul, Korea.

Results from cardiovascular outcome trials (CVOT) with 5 different sodium-glucose co-transporter 2 inhibitors (SGLT2i; empagliflozin, canagliflozin, dapagliflozin, ertugliflozin, sotagliflozin), initially developed for their glucose-lowering effect by blocking tubular glucose reabsorption in kidney, have been shown to decrease the risk of heart failure hospitalization (HFH) across a range of patients with and without atherosclerotic cardiovascular disease in patients with type 2 diabetes mellitus (T2DM). Following these CVOT results, SGLT2i (dapagliflozin, empagliflozin, sotagliflozin) also were reported to reduce HFH and cardiovascular death in patients with heart failure with reduced ejection fraction (HFrEF), regardless of existence or absence of T2DM. Ongoing studies have been conducted to evaluate the clinical benefit of SGLT2i (empagliflozin, dapagliflozin) in patients with heart failure with preserved ejection fraction (HFpEF). Read More

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Implementation of National Health Policy for the Prevention and Control of Cardiovascular Disease in South Korea: Regional-Local Cardio-Cerebrovascular Center and Nationwide Registry.

Korean Circ J 2021 May;51(5):383-398

Department of Internal Medicine, Kangdong Sacred Heart Hospital, Hallym University Medical Center, Seoul, Korea.

Cardiovascular disease (CVD) remains the leading cause of morbidity, mortality, and health care costs in South Korea. The prevalence of preventable and treatable risk factors for CVD such as obesity, hypercholesterolemia, and smoking has continued to increase, despite improvements management of hypertension. Active leadership, participation, and support of professional organizations and medical institutions in national cardiovascular registries and regional treatment network have proven to be effective models to reduce the global burden of CVD in the Europe and North America. Read More

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Type D personality is associated with depressive symptoms and clinical activity in inflammatory bowel disease.

Aliment Pharmacol Ther 2021 May 11. Epub 2021 May 11.

Clinic for Visceral Surgery and Medicine, Inselspital Bern and Bern University, Bern, Switzerland.

Background: Inflammatory bowel disease (IBD) can be exacerbated by stress and depression. Type D personality, characterised by high negative affectivity and social inhibition, represents a vulnerability towards stressors and is associated with adverse outcomes in coronary heart disease.

Aims: To assess the prevalence of Type D personality in IBD patients and investigate potential associations with disease course. Read More

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The impact of genetic risk on liver fibrosis in non-alcoholic fatty liver disease as assessed by magnetic resonance elastography.

Aliment Pharmacol Ther 2021 May 11. Epub 2021 May 11.

Division of Gastroenterology, NAFLD Research Center, University of California at San Diego, La Jolla, CA, USA.

Background: Variants in multiple genetic loci modify the risk of non-alcoholic fatty liver disease (NAFLD) and cirrhosis but there are limited data on the quantitative impact of variant copies on liver fibrosis.

Aim: To investigate the effect of PNPLA3, TM6SF2, MBOAT7, GCKR and HSD17B13 genotype on liver fibrosis assessed by magnetic resonance elastography (MRE), a reproducible, accurate, continuous biomarker of liver fibrosis.

Methods: This is a cross-sectional analysis derived from a well-characterised cohort at risk for NAFLD who underwent genotyping and MRE assessment. Read More

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Leveraging Artificial Intelligence to Improve Chronic Disease Care: Methods and Application to Pharmacotherapy Decision Support for Type-2 Diabetes Mellitus.

Methods Inf Med 2021 May 11. Epub 2021 May 11.

Department of Biomedical Informatics, University of Utah, Salt Lake City, Utah, United States.

Objectives:  Artificial intelligence (AI), including predictive analytics, has great potential to improve the care of common chronic conditions with high morbidity and mortality. However, there are still many challenges to achieving this vision. The goal of this project was to develop and apply methods for enhancing chronic disease care using AI. Read More

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[Acute facial paresis as a possible complication of vaccination against SARS-CoV-2].

Laryngorhinootologie 2021 May 11. Epub 2021 May 11.

Klinik und Poliklinik für Hals-Nasen-Ohrenheilkunde und Fazialis-Nerv-Zentrum, Universitätsklinikum Jena.

Although acute facial nerve palsy (Bell's palsy) is explicitly mentioned in the information sheets for vaccines as a possible complication of vaccination against SARS-CoV-2, from our point of view the benefits of the vaccination clearly outweigh the possible risks. At most, if at all, a slightly increased risk can be derived from the previous case reports. In general, the risk of acute facial palsy is described in association with many vaccinations. Read More

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Risk Factors and Clinical Characteristics of Metabolic Bone Disease of Prematurity.

Am J Perinatol 2021 May 11. Epub 2021 May 11.

Department of Pediatric Endocrinology, Karadeniz Technical University Faculty of Medicine, Trabzon, Turkey.

Objective:  The study aimed to analyze the risk factors and clinical features of metabolic bone disease of prematurity (MBDP) in premature infants compared with infants of similar gestational age and birthweight without MBDP.

Study Design:  This retrospective case-control study was performed by comparing 81 cases of MBDP with 63 controls to identify potential risk factors. Premature infants with a gestational age ≤33 weeks and birthweight <1,500 g were included. Read More

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The varied role, scope of practice, and education of cardiovascular nurses in ESC-affiliated countries: an ACNAP survey.

Eur J Cardiovasc Nurs 2021 May 11. Epub 2021 May 11.

School of Nursing and Midwifery, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK.

Aims: Cardiovascular disease burden is increasing globally, pressuring nursing staff to deliver high-quality care across a diverse range of treatment areas. As such, an evaluation of the educational preparation of nurses is needed. To determine the current role, scope of practice, education level, and needs of cardiovascular nurses working across the European Society of Cardiology (ESC)-affiliated countries. Read More

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Patient-reported outcomes after oesophagectomy in the multicentre LASER study.

Br J Surg 2021 May 11. Epub 2021 May 11.

Oesophago-gastric Centre, Churchill Hospital, University of Oxford, Oxford, UK.

Background: Data on the long-term symptom burden in patients surviving oesophageal cancer surgery are scarce. The aim of this study was to identify the most prevalent symptoms and their interactions with health-related quality of life.

Methods: This was a cross-sectional cohort study of patients who underwent oesophageal cancer surgery in 20 European centres between 2010 and 2016. Read More

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Obesity in Renal Transplantation.

Nephron 2021 May 11:1-10. Epub 2021 May 11.

Nephrology Department, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Spain.

Background: Data from the WHO show an increasing rate of overweight and obesity in general population in the last decades. This increase in obesity also affects population with end-stage renal disease (ESRD) and kidney transplant (KT) candidates.

Summary: In this review, we focused on how obesity impacts on KT stages: access to KT and outcomes of KT candidates; how to reduce weight and its consequences; short and long-term outcomes in obese recipients and the impact of weight variations; and the implications of obesity in living donor KT. Read More

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CHA2DS2-VASc Score as a Predictor of Cardiovascular and All-Cause Mortality in Chronic Kidney Disease Patients.

Am J Nephrol 2021 May 11:1-8. Epub 2021 May 11.

Department of Nephrology, Clinic for Internal Medicine, University Medical Centre Maribor, Maribor, Slovenia.

Introduction: Chronic kidney disease (CKD) is a risk factor for cardiovascular and all-cause mortality. Recognition of high-risk patients is important and could lead to a different approach and better treatment. The CHA2DS2-VASc score was originally used to predict cerebral infarction in patients with atrial fibrillation (AF), but it is also a useful predictor of outcome in other cardiovascular conditions, independent of AF. Read More

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Cerebral Venous Thrombosis Associated with COVID-19 Infection: An Observational, Multicenter Study.

Cerebrovasc Dis Extra 2021 May 11;11(2):55-60. Epub 2021 May 11.

Rashid Hospital, Dubai, United Arab Emirates.

Background And Purpose: Coronavirus disease 2019 (CO-VID-19) has an increased propensity for systemic hypercoagulability and thromboembolism. An association with cerebrovascular diseases, especially cerebral venous thrombosis (CVT), has been reported among these patients. The objective of the present study was to identify risk factors for CVT as well as its presentation and outcome in COVID-19 patients. Read More

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Association Between Penile Color Doppler Ultrasonography and Cardiorespiratory Fitness in Patients With Vascular Erectile Dysfunction.

Sex Med 2021 May 8;9(3):100347. Epub 2021 May 8.

Sports and Exercise Medicine Division, Department of Medicine, University of Padova, Padova, Italy.

Introduction: Vascular erectile dysfunction (ED) is a burdensome condition, associated with increased cardiovascular risk. Peak systolic velocity (PSV) represents the maximum pulse velocity in the cavernous artery measured by a penile color doppler ultrasonography (PCDU) during a pharmacologically induced erection and is considered a reliable parameter for the diagnosis of vascular ED. However, the cut-off value of standard PSV (30 cm/s) provides high sensitivity only in the diagnosis of advanced arteriogenic disease. Read More

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Polymorphisms in TNFAIP3, but not in STAT4, BANK1, BLK, and TNFSF4, are associated with susceptibility to Takayasu arteritis.

Cell Immunol 2021 May 4;365:104375. Epub 2021 May 4.

Unidad de Investigación, Hospital Juárez de México, México City, Mexico. Electronic address:

Background: Takayasu arteritis (TAK) is considered a rare disease characterized by nonspecific inflammation of the large arteries, especially the aorta and its major branches. Because TAK is an autoimmune disease (AD), it could share susceptibility loci with other pathologies such as systemic lupus erythematosus (SLE), and rheumatoid arthritis (RA), among others. Widely explored polymorphisms in non-HLA genes, including TNFAIP3, STAT4, TNFSF4, BANK1, and BLK have been consistently associated with both SLE and RA, but they have not been evaluated in TAK. Read More

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Validating and implementing cardiac telemetry for continuous QTc monitoring: A novel approach to increase healthcare personnel safety during the COVID-19 pandemic.

J Electrocardiol 2021 Apr 27;67:1-6. Epub 2021 Apr 27.

Department of Cardiovascular Medicine, Heart, Vascular and Thoracic Institute, Cleveland Clinic Foundation, Cleveland, OH, USA. Electronic address:

Background: Minimizing direct patient contact among healthcare personnel is crucial for mitigating infectious risk during the coronavirus disease 2019 (COVID-19) pandemic. The use of remote cardiac telemetry as an alternative to 12‑lead electrocardiography (ECG) for continuous QTc monitoring may facilitate this strategy, but its application has not yet been validated or implemented.

Methods: In the validation component of this two-part prospective cohort study, a total of 65 hospitalized patients with simultaneous ECG and telemetry were identified. Read More

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Mis-reporting of energy intake among older Australian adults: Prevalence, characteristics, and associations with quality of life.

Nutrition 2021 Apr 6;90:111259. Epub 2021 Apr 6.

Monash University, School of Public Health & Preventive Medicine, Melbourne, Australia. Electronic address:

Objectives: Mis-reporting is common in dietary assessment, leading to misinterpretation of disease risk and could be important in older adults with increased chronic disease risk. This study investigated the prevalence and characteristics of mis-reporting among older adults and its association with health outcomes including quality of life (QoL).

Methods: The study was conducted in 335 community-dwelling older adults at increased risk for cardiovascular disease, participating in the SCReening Evaluation of the Evolution of New Heart Failure Study dietary substudy. Read More

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Rhabdomyolysis in Severe COVID-19: Male Sex, High BMI, and Prone Positioning Confer High Risk.

J Surg Res 2021 Apr 6;266:35-43. Epub 2021 Apr 6.

Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital, Boston, Massachusetts. Electronic address:

Background: Bedside experience and studies of critically ill patients with coronavirus disease 2019 (COVID-19) indicate COVID-19 to be a devastating multisystem disease. We aim to describe the incidence, associated variables, and outcomes of rhabdomyolysis in critically ill COVID-19 patients.

Materials And Methods: Data for all critically ill adult patients (≥18 years old) admitted to the ICU at a large academic medical center with confirmed COVID-19 between March 13, 2020 and April 18, 2020 were prospectively collected. Read More

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2020 List of human papillomavirus assays Suitable for primary cervical cancer screening.

Clin Microbiol Infect 2021 May 8. Epub 2021 May 8.

Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.

Background: Only clinically validated HPV assays can be accepted in cervical cancer screening.

Objectives: To update the list of high-risk HPV assays that fulfil the 2009 international validation criteria (Meijer-2009).

Data Sources: PubMed/Medline, Embase, Scopus, references from selected studies; published in January 2014-August 2020. Read More

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Effects of astaxanthin in animal models of obesity-associated diseases: a systematic review and meta-analysis.

Free Radic Biol Med 2021 May 8. Epub 2021 May 8.

Centre for Obesity Research and Education (CORE), School of Pharmacy and Life Sciences, Robert Gordon University, Aberdeen, UK. Electronic address:

Background And Aim: Obesity is a major risk factor for several diseases, including metabolic syndrome (MetS), non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2D). The use of natural products, such as astaxanthin (ASX), a potent antioxidant compound produced by the freshwater green microalga Haematococcus pluvialis, has gained particular interest to reduce oxidative stress and inflammation, and to improve redox status, often associated with obesity. A systematic review and meta-analysis was performed to comprehensively examine the effects of ASX in animal models of diet induced obesity-associated diseases in order to inform the design of future human clinical studies for ASX use as supplement or nutraceutical. Read More

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The role of sex and inflammation in cardiovascular outcomes and mortality in COVID-19.

Int J Cardiol 2021 May 8. Epub 2021 May 8.

Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA. Electronic address:

Objective: Higher mortality in COVID-19 in men compared to women is recognized, but sex differences in cardiovascular events are less well established. We aimed to determine the independent contribution of sex to stroke, myocardial infarction and death in the setting of COVID-19 infection.

Methods: We performed a retrospective cohort study of hospitalized COVID-19 patients in a racially/ethnically diverse population. Read More

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A Comparative Analysis of Mucormycosis in Immunosuppressed hosts Including Patients with Uncontrolled Diabetes in the Southwest United States.

Am J Med 2021 May 8. Epub 2021 May 8.

Division of Infectious Diseases, Banner University Medical Center, University of Arizona, Tucson, United States.

Background: Mucormycosis (Zygomycosis) is an invasive fungal infection that carries a high risk of morbidity and mortality. Uncontrolled diabetes mellitus and other immunocompromising conditions are risk factors for Mucormycosis development. We here describe the differences in characteristics and outcomes of Mucormycosis among solid organ transplant, hematological malignancy, and diabetes mellitus groups at our institution. Read More

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Incidence and risk factors for severe preeclampsia, HELLP syndrome and eclampsia at preterm and term gestation: a population-based study.

Am J Obstet Gynecol 2021 May 8. Epub 2021 May 8.

Department of Obstetrics and Gynaecology, University of British Columbia, and the Children's and Women's Hospital and Health Centre of British Columbia, Vancouver, BC, Canada; School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada.

Background: A majority of previous studies of severe preeclampsia, eclampsia and HELLP (hemolysis, elevated liver enzymes and low platelets) syndrome were hospital-based or included a relatively small number of women. Large population-based studies examining gestational age-specific incidence patterns and risk factors for these severe pregnancy complications are lacking.

Objectives: To assess gestational age-specific incidence rates and risk factors for severe preeclampsia, HELLP syndrome, and eclampsia. Read More

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Gene selection using hybrid dragonfly black hole algorithm: a case study on RNA-seq COVID-19 data.

Anal Biochem 2021 May 8:114242. Epub 2021 May 8.

Department of Computer Engineering, Istanbul Gelisim University, Istanbul, Turkey. Electronic address:

This paper introduces a new hybrid approach (DBH) for solving gene selection problem that incorporates the strengths of two existing metaheuristics: binary dragonfly algorithm (BDF) and binary black hole algorithm (BBHA). This hybridization aims to identify a limited and stable set of discriminative genes without sacrificing classification accuracy, whereas most current methods have encountered challenges in extracting disease-related information from a vast amount of redundant genes. The proposed approach first applies the minimum redundancy maximum relevancy (MRMR) filter method to reduce the dimensionality of feature space and then utilizes the suggested hybrid DBH algorithm to determine a smaller set of significant genes. Read More

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Radiation without endocrine therapy in older women with stage I estrogen-receptor (ER) positive breast cancer is not associated with a higher risk of second breast cancer events.

Int J Radiat Oncol Biol Phys 2021 May 8. Epub 2021 May 8.

Department of Population Health, NYU School of Medicine, New York, NY. Electronic address:

Purpose: The omission of radiation therapy (RT) in elderly women with stage 1 estrogen-receptor positive (ER+) breast cancer receiving endocrine therapy (ET) is an acceptable strategy based on randomized trial data. Less is known about the omission of ET +/- RT.

Patient And Methods: We analyzed SEER-Medicare data for 13,321 women ≥ 66 years with stage I ER+ breast cancer from 2007-2012 who underwent breast conserving surgery. Read More

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Hematological Biomarkers, Mortality, Transfusion and Acute Heart Disease.

Am J Med Sci 2021 May 8. Epub 2021 May 8.

Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Background: Patients hospitalized with acute heart disease [acute myocardial infarction (MI); heart disease exacerbation] may require red blood cell (RBC) transfusion. These patients are at increased risk for morbidity and mortality. Hematological biomarkers may help to identify increased mortality risk. Read More

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Cell and Tissue Therapy for the Treatment of Chronic Liver Disease.

Annu Rev Biomed Eng 2021 May 11. Epub 2021 May 11.

Division of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA; email:

Liver disease is an important clinical problem, impacting 600 million people worldwide. It is the 11th-leading cause of death in the world. Despite constant improvement in treatment and diagnostics, the aging population and accumulated risk factors led to increased morbidity due to nonalcoholic fatty liver disease and steatohepatitis. Read More

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Vestibular Function in Older Adults With Cognitive Impairment: A Systematic Review.

Ear Hear 2021 Apr 22. Epub 2021 Apr 22.

1Department of Translational Neurosciences, University of Antwerp, Antwerp, Belgium 2Department of Otorhinolaryngology-Head and neck surgery, Antwerp University Hospital, Edegem, Belgium 3Department of Education, Health & Social Work, University College Ghent, Ghent, Belgium 4Department of Neurology, UZ Brussel and Center for Neurosciences (C4N), VUB, Brussels, Belgium 5Department of Biomedical Sciences and Institute Born-Bunge, University of Antwerp, Antwerp, Belgium 6Department of Neurology, Antwerp University Hospital, Edegem, Belgium.

Importance: Given the rising prevalence of patients with dementia and those at risk for it, early identification is prioritized. As vestibular dysfunction is associated with Alzheimer's disease (AD) and may contribute to its onset, vestibular assessment may yield an opportunity in early dementia screening.

Objective: This systematic review structures and compares the different raw outcome measures used to assess vestibular function while comparing older adults with preserved cognition to individuals with cognitive impairment, either suffering from mild cognitive impairment (MCI) or AD. Read More

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One year into the COVID-19 pandemic - temporomandibular disorders and bruxism: What we have learned and what we can do to improve our manner of treatment.

Dent Med Probl 2021 May 11. Epub 2021 May 11.

Department of Oral Rehabilitation, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Israel.

The coronavirus disease 2019 (COVID-19) pandemic has drastically changed the routine way of life and challenged the ways in which health and dental services are provided. During the 1st lockdown, practiced in most of the countries, routine dental procedures were suspended. Even after the lockdown was eased, visiting crowded dental clinics was still considered health-threatening, especially among populations at high risk of developing a severe reaction to COVID-19. Read More

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