797 results match your criteria risk dgf


The Relationship Between Pre-Transplant Serum Phosphorus Before Kidney Transplantation with Early Graft Dysfunction.

Iran J Kidney Dis 2021 Mar;1(2):148-154

1Kidney Transplantation Complications Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Introduction: Pre-transplant serum phosphorus level is shown to be associated with some transplant outcomes in patients with chronic kidney disease. However, its association with Delayed graft function (DGF) has an aura of ambiguity. DGF means either the patient needs dialysis during the first week after transplantation or the creatinine level is ≥ 3. Read More

View Article and Full-Text PDF

Effect of delayed graft function on longer-term outcomes after kidney transplantation from donation after circulatory death donors in the UK: a national cohort study.

Am J Transplant 2021 Mar 23. Epub 2021 Mar 23.

Department of Nephrology and Transplantation, NHS Foundation Trust, Guy's and St Thomas, London, UK.

Kidneys from donation after circulatory death (DCD) donors are utilized variably worldwide, in part due to high rates of delayed graft function (DGF) and putative associations with adverse longer-term outcomes. We aimed to determine whether the presence of DGF, and its duration, were associated with poor longer-term outcomes after kidney transplantation from DCD donors. Using the UK transplant registry, we identified 4714 kidney-only transplants from controlled DCD donors to adult recipients between 2006-2016; 2832 recipients (60·1%) had immediate graft function and 1882 (39. Read More

View Article and Full-Text PDF

Delayed graft function and rejection are risk factors for cytomegalovirus breakthrough infection in kidney transplant recipients.

Pharmacol Res 2021 Mar 17;167:105565. Epub 2021 Mar 17.

Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Postbus 9600, 2300 RC Leiden, The Netherlands.

Breakthrough cytomegalovirus (CMV) disease during valganciclovir prophylaxis is rare but may cause significant morbidity and even mortality. In order to identify patients at increased risk the incidence of CMV disease was studied in a large population of renal transplant recipients who underwent a kidney transplantation in the Radboud University Medical Center between 2004 and 2015 (n = 1300). CMV disease occurred in 31/1300 patients. Read More

View Article and Full-Text PDF

Exploring the causes of the high incidence of delayed graft function after kidney transplantation in Brazil: A multicenter study.

Transpl Int 2021 Mar 19. Epub 2021 Mar 19.

Hospital do Rim, Fundação Oswaldo Ramos, São Paulo, SP, Brazil.

This retrospective multicenter (n=18) cohort study evaluated the incidence, risk factors, and the impact of delayed graft function (DGF) on 1-year kidney transplant (KT) outcomes. Of 3,992 deceased donor KT performed in 2014-2015, the incidence of DGF was 54%, ranging from 29.9% to 87. Read More

View Article and Full-Text PDF

Kidney transplantation from donation after circulatory death using abdominal normothermic oxygenated circulation: are the outcomes equivalent?

Int Urol Nephrol 2021 Mar 15. Epub 2021 Mar 15.

Urology Department, Centro Hospitalar Universitário São João, Alameda Prof. HernaniMonteiro, 4200-319, Porto, Portugal.

Purpose: To increase the pool of kidneys available for transplantation, a renewed interest in donation after circulatory death (DCD) has emerged. This study aims to determine the outcomes of kidney transplantation from DCD after abdominal normothermic oxygenated circulation (ANOR) support.

Methods: From January 2016 to December 2018, 58 kidneys were implanted from uncontrolled DCD after ANOR support. Read More

View Article and Full-Text PDF

A prediction model of delayed graft function in deceased donor for renal transplant: a multi-center study from China.

Ren Fail 2021 Dec;43(1):520-529

Tianjin First Central Hospital, Tianjin, China.

Background: Kidneys obtained from deceased donors increase the incidence of delayed graft function (DGF) after renal transplantation. Here we investigated the influence of the risk factors of donors with DGF, and developed a donor risk scoring system for DGF prediction.

Methods: This retrospective study was conducted in 1807 deceased kidney donors and 3599 recipients who received donor kidneys transplants in 29 centers in China. Read More

View Article and Full-Text PDF
December 2021

The predictive value of urinary kidney injury molecular-1 for long-term graft function in kidney transplant patients: a prospective study.

Ann Transl Med 2021 Feb;9(3):244

Department of Nephrology, Molecular Cell Laboratory for Kidney Disease, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Background: Monitoring allograft function during the early stages is crucial, and therefore requires biomarkers more sensitive than serum creatinine (Scr). Kidney injury molecular-1 (KIM-1) is a potent biomarker; however, disparities exist in the literature concerning its predictive value in allograft function. Therefore, this study aimed to evaluate its predictive value for the long-term prognosis of kidney transplantation patients. Read More

View Article and Full-Text PDF
February 2021

Risk Prediction for Delayed Allograft Function: Analysis of The Deterioration of Kidney Allograft Function (Dekaf) Study Data.

Transplantation 2021 Feb 23. Epub 2021 Feb 23.

University of Minnesota, Department of Surgery, Transplantation Division, Minneapolis, MN; University of Minnesota, School of Public Health, Biostatistics Division, Minneapolis, MN; University of Alabama, Department of Medicine, Birmingham, AL; Hennepin Healthcare, Division of Nephrology, Minneapolis, MN; University of Manitoba, Department of Internal Medicine, Winnipeg, Manitoba. University of Iowa, Department of Internal Medicine, Iowa City, IA; Mayo Clinic, Division of Nephrology & Hypertension, Department of Internal Medicine, Rochester, MN; Mayo Clinic, Division of Anatomic Pathology, Department of Laboratory Medicine and Pathology, Rochester, MN; University of California, UCLA Immunogenetics Center, Los Angeles, CA Univeristy of Nebraska Medical Center and Nebraska-Western Iowa Veterans Affairs Medical Center, Omaha, NE.

Background: Delayed graft function (DGF) of a kidney transplant results in increased cost and complexity of management. For clinical care or a DGF trial, it would be ideal to accurately predict individual DGF risk and provide preemptive treatment. A calculator developed by Irish et al has been useful for predicting population, but not individual risk. Read More

View Article and Full-Text PDF
February 2021

Clinical Outcomes of Older Kidney Transplant Recipients.

Am J Med Sci 2021 Feb 25. Epub 2021 Feb 25.

Division of Transplant Surgery, Department of Surgery, Medical University of South Carolina, Charleston, SC.

Background: Older kidney transplant recipients (OKTR) are vulnerable to infections and AKI, often prompting hospitalization. This study elucidates etiology of hospitalizations, AKI, and outcomes in OKTR.

Methods: Retrospective study of 500 patients age ≥ 60, who underwent kidney transplantation from 2005-2015. Read More

View Article and Full-Text PDF
February 2021

Phase 3 trial Design of the Hepatocyte Growth Factor Mimetic ANG-3777 in Renal Transplant Recipients With Delayed Graft Function.

Kidney Int Rep 2021 Feb 13;6(2):296-303. Epub 2020 Nov 13.

Angion Biomedica, Uniondale, NY.

Introduction: One-third of kidney transplantation patients experience acute kidney injury (AKI) resulting in delayed graft function (DGF), associated with increased risk of graft failure and mortality. Preclinical and phase 2 data indicate that treatment with ANG-3777 (formerly BB3), a hepatocyte growth factor (HGF) mimetic, may improve long-term kidney function and reduce health care resource use and cost, but these data require validation in a phase 3 randomized controlled trial.

Methods: The Graft Improvement Following Transplant (GIFT) trial is a multicenter, double-blind randomized controlled trial, designed to determine the efficacy and safety of ANG-3777 in renal transplantation patients showing signs of DGF. Read More

View Article and Full-Text PDF
February 2021

Rate, Factors, and Outcome of Delayed Graft Function After Kidney Transplantation of Deceased Donors.

Transplant Proc 2021 Feb 18. Epub 2021 Feb 18.

Department of Internal Medicine III/Collaborative Kidney Transplant Center, University Hospital Jena - Friedrich Schiller University, Jena, Germany. Electronic address:

Background: Delayed graft function (DGF) is a frequent complication after kidney transplantation affecting long-term outcome.

Patients And Methods: A total of 525 consecutive recipients (age 54.2 ± 13. Read More

View Article and Full-Text PDF
February 2021

Protection From the Second Warm Ischemic Injury in Kidney Transplantation Using an Ex Vivo Porcine Model and Thermally Insulating Jackets.

Transplant Proc 2021 Mar 11;53(2):750-754. Epub 2021 Feb 11.

Sydney Medical School, University of Sydney, Sydney, Australia; Department of Surgery, Westmead Hospital, Westmead, Australia.

Background: Kidney transplantation is the optimum treatment for kidney failure in carefully selected patients. Technical surgical complications and second warm ischemic time (SWIT) increase the risk of delayed graft function (DGF) and subsequent short- and long-term graft outcomes including the need for post-transplant dialysis and graft failure. Intraoperative organ thermal regulation could reduce SWIT, minimizing surgical complications due to time pressure, and limiting graft ischemia-reperfusion injury. Read More

View Article and Full-Text PDF

Outcomes of Delayed Graft Function in Kidney Transplant Recipients Stratified by Histologic Biopsy Findings.

Transplant Proc 2021 Feb 9. Epub 2021 Feb 9.

Division of Nephrology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI. Electronic address:

Delayed graft function (DGF) after kidney transplantation is associated with an increased risk of graft failure. We studied the histologic findings among adult kidney transplant recipients transplanted between January 2000 and June 2015 who had DGF and had a kidney biopsy within 14 days of transplant. Death censored graft failure (DCGF) and death at 1 and 3 years after transplant were examined. Read More

View Article and Full-Text PDF
February 2021

Risk factors and outcomes for delayed kidney graft function in simultaneous heart and kidney transplant recipients: A UNOS/OPTN database analysis.

Am J Transplant 2021 Feb 10. Epub 2021 Feb 10.

Division of Nephrology, Department of Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin.

There are no prior studies assessing the risk factors and outcomes for kidney delayed graft function (K-DGF) in simultaneous heart and kidney (SHK) transplant recipients. Using the OPTN/UNOS database, we sought to identify risk factors associated with the development of K-DGF in this unique population, as well as outcomes associated with K-DGF. A total of 1161 SHK transplanted between 1998 and 2018 were included in the analysis, of which 311 (27%) were in the K-DGF (+) group and 850 in the K-DGF (-) group. Read More

View Article and Full-Text PDF
February 2021

Evidence to support a drain-free strategy in kidney transplantation using a retrospective comparison of 500 consecutively transplanted cases at a single center.

BMC Surg 2021 Feb 5;21(1):74. Epub 2021 Feb 5.

Department of Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.

Introduction: Routine placement of surgical drains at the time of kidney transplant has been debated in terms of its prognostic value.

Objectives: To determine whether the placement of a surgical drain affects the incidence rate of developing wound complications and other clinical outcomes, particularly after controlling for other prognostic factors.

Methods: Retrospective analysis of 500 consecutive renal transplant cases who did not (Drain-free, DF) vs. Read More

View Article and Full-Text PDF
February 2021

Risk factors for delayed graft function and their impact on graft outcomes in live donor kidney transplantation.

Int Urol Nephrol 2021 Mar 4;53(3):439-446. Epub 2021 Jan 4.

Department of Urology and Renal Transplant, University of Toledo, 3000, Arlington Ave, MS1091, Toledo, OH, 43614, USA.

Background: Delayed graft function (DGF) is a manifestation of acute kidney injury uniquely framed within the transplant process and a predictor of poor long-term graft function1. It is less common in the setting of living donor (LD) kidney transplantation. However, the detrimental impact of DGF on graft survival is more pronounced in LD2. Read More

View Article and Full-Text PDF

Hypothermic machine perfusion utilization and outcomes for deceased-donor kidneys: A retrospective cohort study.

Int J Crit Illn Inj Sci 2020 Sep 16;10(Suppl 1):17-20. Epub 2020 Sep 16.

Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, Washington, USA.

Introduction: Hypothermic machine perfusion (HMP) has been established as an efficacious method for preserving kidney allografts from deceased donors in clinical trials, but little data are available on the effectiveness of HMP in real-world settings. We examined factors associated with HMP use and clinical outcomes in a real-world organ procurement organization setting.

Methods: We conducted a retrospective cohort study of the Lifecenter Northwest organ procurement database from 2010 to 2015, linked to the United Network of Organ Sharing outcomes database. Read More

View Article and Full-Text PDF
September 2020

Delayed graft function and acute rejection following HLA-incompatible living donor kidney transplantation.

Am J Transplant 2021 04 27;21(4):1612-1621. Epub 2021 Feb 27.

Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Incompatible living donor kidney transplant recipients (ILDKTr) have pre-existing donor-specific antibody (DSA) that, despite desensitization, may persist or reappear with resulting consequences, including delayed graft function (DGF) and acute rejection (AR). To quantify the risk of DGF and AR in ILDKT and downstream effects, we compared 1406 ILDKTr to 17 542 compatible LDKT recipients (CLDKTr) using a 25-center cohort with novel SRTR linkage. We characterized DSA strength as positive Luminex, negative flow crossmatch (PLNF); positive flow, negative cytotoxic crossmatch (PFNC); or positive cytotoxic crossmatch (PCC). Read More

View Article and Full-Text PDF

Decreased incidence of acute rejection without increased incidence of cytomegalovirus (CMV) infection in kidney transplant recipients receiving rabbit anti-thymocyte globulin without CMV prophylaxis - a cohort single-center study.

Transpl Int 2021 Feb 31;34(2):339-352. Epub 2020 Dec 31.

Department of Nephrology, Hospital do Rim, Universidade Federal de São Paulo, São Paulo, Brazil.

Induction therapy with rabbit anti-thymocyte globulin (rATG) in low-risk kidney transplant recipients (KTR) remains controversial, given the associated increased risk of cytomegalovirus (CMV) infection. This natural experiment compared 12-month clinical outcomes in low-risk KTR without CMV prophylaxis (January/3/13-September/16/15) receiving no induction or a single 3 mg/kg dose of rATG. We used logistic regression to characterize delayed graft function (DGF), negative binomial to characterize length of hospital stay (LOS), and Cox regression to characterize acute rejection (AR), CMV infection, graft loss, death, and hospital readmissions. Read More

View Article and Full-Text PDF
February 2021

Incidence and risk factors for high-level BK viruria: a single center study in China.

Virol J 2020 11 26;17(1):189. Epub 2020 Nov 26.

Department of Organ Transplant, Jiangxi Provincial People's Hospital Affiliated to Nanchang University, No. 152 Aiguo Rd, Nanchang, 330006, China.

Background: BK virus allograft nephropathy is a serious complication after kidney transplantation, and the effect of pre-emptive intervention for high-level BK viruria has been verified, but protocols after kidney transplantation for early identification of high-level viruria are lacking.

Methods: This was a single-center study. The clinical data of the kidney transplant recipients and their donors in our center from January 1, 2015 to December 31, 2018, were collected. Read More

View Article and Full-Text PDF
November 2020

Analysis of risk factors for early urinary tract infection after kidney transplantation.

Transl Androl Urol 2020 Oct;9(5):2211-2217

Department of Nursing, the First Affiliated Hospital of Soochow University, Suzhou, China.

Background: Urinary tract infection (UTI) is the most common kind of infection in the early stage after kidney transplantation. Although many studies have investigated the risk factors for UTI following kidney transplantation, few studies have focused on the risk factors for UTI in the early stage after transplantation.

Methods: The early-stage data of patients who underwent kidney transplantation between January 2018 and December 2019 in a first-class tertiary hospital in Suzhou, China, were retrospectively analyzed. Read More

View Article and Full-Text PDF
October 2020

Outcomes of Living-Donor Kidney Transplantation in Female Recipients with Possible Pregnancy-Related Pre-Sensitization According to Donor Relationship.

Ann Transplant 2020 Nov 6;25:e925229. Epub 2020 Nov 6.

Division of Kidney and Pancreas Transplantation, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

BACKGROUND Given that pregnancy is an immune-sensitizing event, female kidney transplant recipients who receive allografts from their offspring or husbands may have a higher risk of rejection and graft failure due to pre-sensitization acquired during pregnancy or childbirth. We investigated the association between donor relatedness (i.e. Read More

View Article and Full-Text PDF
November 2020

The Systemic Immune-Inflammation Index Predicts Clinical Outcomes in Kidney Transplant Recipients.

In Vivo 2020 Nov-Dec;34(6):3349-3360

Department of Surgery, Duke University Medical Center, Durham, NC, U.S.A.

Background: Outcomes after kidney transplantation (KTx) remain limited by delayed graft function (DGF) and acute rejection. Non-invasive biomarkers may help identify patients at increased risk for these events. We examined the association between the systemic immune-inflammation index (SII), a novel inflammatory biomarker, and outcomes after KTx and evaluated its ability to predict post-transplant prognosis. Read More

View Article and Full-Text PDF

Personalized prediction of delayed graft function for recipients of deceased donor kidney transplants with machine learning.

Sci Rep 2020 10 27;10(1):18409. Epub 2020 Oct 27.

Terasaki Research Institute, Los Angeles, CA, USA.

Machine learning (ML) has shown its potential to improve patient care over the last decade. In organ transplantation, delayed graft function (DGF) remains a major concern in deceased donor kidney transplantation (DDKT). To this end, we harnessed ML to build personalized prognostic models to predict DGF. Read More

View Article and Full-Text PDF
October 2020

Procurement Biopsies Can Predict Unfavorable Outcomes in Kidneys With Low MAPI Score Values.

Transplant Proc 2021 Mar 16;53(2):602-606. Epub 2020 Oct 16.

Division of Transplantation, General Hospital of Fortaleza, Fortaleza (CE), Brazil.

Background: There are few reports about the usefulness of Maryland Aggregate Pathology Index (MAPI) score in procurement biopsies. This study aimed to evaluate the association between histopathological analysis according to MAPI and unfavorable outcomes in the first year after kidney transplantation (KT).

Methods: This retrospective study included deceased-donor KT patients whose grafts were biopsied before transplantation and had low MAPI scores (<8) in frozen sections (FSs). Read More

View Article and Full-Text PDF

African American polycystic kidney patients receive higher risk kidneys, but do not face increased risk for graft failure or post-transplant mortality.

Am J Surg 2020 Sep 28. Epub 2020 Sep 28.

Department of Surgery, Albany Medical College, Albany, NY, USA.

African Americans (AA) are disproportionately affected by end-stage renal disease (ESRD) and have worse outcomes following renal transplantation. Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic condition leading to ESRD necessitating transplant. We explored this population with respect to race by conducting a retrospective analysis of the UNOS database between 2005 and 2019. Read More

View Article and Full-Text PDF
September 2020

Kidney transplantation in children with CAKUT and non-CAKUT causes of chronic kidney disease: Do they have the same outcomes?

Pediatr Transplant 2020 12 4;24(8):e13763. Epub 2020 Oct 4.

Nephrology Unit, Hospital de Pediatría JP Garrahan, Buenos Aires, Argentina.

Almost half the children who undergo kidney transplantation (KTx) have congenital abnormalities of the kidney and urinary tract (CAKUT). We compared patient, graft survival, and kidney function at last follow-up between CAKUT and non-CAKUT patients after KTx. We divided the analysis into two eras: 1988-2000 and 2001-2019. Read More

View Article and Full-Text PDF
December 2020

Acute rejection in pediatric renal transplantation: Retrospective study of epidemiology, risk factors, and impact on renal function.

Pediatr Transplant 2021 Mar 30;25(2):e13856. Epub 2020 Sep 30.

Pediatric Nephrology Division, Pediatric Department, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.

AR is a major relevant and challenging topic in pediatric kidney transplantation. Our objective was to evaluate cumulative incidence of AR in pediatric kidney transplant patient, risk factors for this outcome, and impact on allograft function and survival. A retrospective cohort including pediatric patients that underwent kidney transplantation between 2011 and 2015 was designed. Read More

View Article and Full-Text PDF

Combined donor-recipient genotypes of leptin receptor and adiponectin gene polymorphisms affect the incidence of complications after renal transplantation.

Mol Genet Metab Rep 2020 Dec 12;25:100648. Epub 2020 Sep 12.

Department of Medical and Surgical Therapeutics, Division of Pharmacology, Medical School, University of Extremadura, Badajoz, Spain.

Background: We aimed to examine whether combined donor/recipient variants in the leptin receptor () and adiponectin () genes may affect outcomes in renal transplantation.

Methods: A total of 233 donors and their corresponding 307 recipients were genotyped for rs1805094, rs1137100 and rs1137101, and rs1501299 and rs224176. Combined donor/recipient genetic scores were created to investigate associations with delayed graft function (DGF), graft loss and estimated glomerular filtration rate (eGFR). Read More

View Article and Full-Text PDF
December 2020

Pre-transplant HLA Antibodies and Delayed Graft Function in the Current Era of Kidney Transplantation.

Front Immunol 2020 26;11:1886. Epub 2020 Aug 26.

Institute of Immunology, Heidelberg University Hospital, Heidelberg, Germany.

Delayed graft function (DGF) occurs in a significant proportion of deceased donor kidney transplant recipients and was associated with graft injury and inferior clinical outcome. The aim of the present multi-center study was to identify the immunological and non-immunological predictors of DGF and to determine its influence on outcome in the presence and absence of human leukocyte antigen (HLA) antibodies. 1,724 patients who received a deceased donor kidney transplant during 2008-2017 and on whom a pre-transplant serum sample was available were studied. Read More

View Article and Full-Text PDF