64,301 results match your criteria risk bias


The impact of prenatal stressful life events on adverse birth outcomes: A systematic review and meta-analysis.

J Affect Disord 2021 Mar 31;287:406-416. Epub 2021 Mar 31.

Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, No. 81 Meishan Road, Hefei 230032, Anhui, China; Centre for Evidence-Based Practice, Anhui Medical University, No. 81 Meishan Road, Hefei 230032, Anhui, China. Electronic address:

Background: Stressful life events as important stressors have gradually been recognized as the potential etiology that may lead to adverse birth outcomes such as preterm birth (PTB), low birth weight (LBW), and small for gestational age (SGA). However, researches on this topic have shown relatively inconsistent results. This systematic review and meta-analysis was performed to synthesize available data on the association between prenatal stressful life events and increased risks of PTB, LBW, and SGA. Read More

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Association between VPS13C rs2414739 polymorphism and Parkinson's disease risk: A meta-analysis.

Neurosci Lett 2021 Apr 7:135879. Epub 2021 Apr 7.

Department of Neurology, Affiliated Hospital of Qingdao University, Qingdao, China. Electronic address:

Objective: We aimed to estimate the role of vacuolar protein sorting 13C (VPS13C) gene single nucleotide polymorphism (SNP) rs2414739 variant in the risk of PD by meta-analysis.

Methods: Five eligible case-control studies including 2796 PD cases and 4138 health controls involved in this meta-analysis. The fixed or random effect model was selected based on the heterogeneity of the included studies which detected by I and Q tests. Read More

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Closure Device Use for Common Femoral Artery Antegrade Access is Higher Risk than Retrograde Access.

Ann Vasc Surg 2021 Apr 7. Epub 2021 Apr 7.

Department of Surgery, Division of Vascular and Endovascular Surgery, University of California, San Francisco, San Francisco, CA, USA.

Objective: Although the use of closure devices (CD) for femoral artery antegrade access (AA) is not in the instructions for use (IFU) for many devices, AA has been reported to be associated with a lower incidence of access site complications compared to manual compression alone. We hypothesized that CD use for AA would not be associated with a clinically significant increased odds of access site complications compared to CD use for retrograde access (RA).

Methods: This was a retrospective review of the Vascular Quality Initiative from 2010 to 2019 for infrainguinal peripheral vascular interventions with common femoral artery access closed with a CD. Read More

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A systematic review and meta-analysis of the effect of routine early angiography in patients with return of spontaneous circulation after Out-of-Hospital Cardiac Arrest.

Resuscitation 2021 Apr 7. Epub 2021 Apr 7.

Rescu, Emergency Department, St Michael's Hospital, Division of Emergency Medicine, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.

Background: Early coronary angiography (CAG) has been reported in individual studies and systematic reviews to significantly improve outcomes of patients with return of spontaneous circulation (ROSC) after cardiac arrest (CA).

Methods: We undertook a systematic review and meta-analysis to evaluate the impact of early CAG on key clinical outcomes in comatose patients after ROSC following out-of-hospital CA of presumed cardiac origin. We searched the PubMED, EMBASE, CINAHL, ERIC and Cochrane Central Register of Controlled Trials databases from 1990 until April 2020. Read More

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Treatment for bleeding oesophageal varices in people with decompensated liver cirrhosis: a network meta-analysis.

Cochrane Database Syst Rev 2021 Apr 10;4:CD013155. Epub 2021 Apr 10.

Division of Surgery and Interventional Science, University College London, London, UK.

Background: Approximately 40% to 95% of people with liver cirrhosis have oesophageal varices. About 15% to 20% of oesophageal varices bleed within about one to three years after diagnosis. Several different treatments are available, including, among others, endoscopic sclerotherapy, variceal band ligation, somatostatin analogues, vasopressin analogues, and balloon tamponade. Read More

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Carotid intima-media thickness in patients with hyperuricemia: a systematic review and meta-analysis.

Aging Clin Exp Res 2021 Apr 9. Epub 2021 Apr 9.

Department of Rheumatology and Immunology, Affiliated Hospital of Southwest Medical University, 1 Xianglin Road, Luzhou, 646000, Sichuan, China.

Objective: Despite the high incidence and mortality of cardiovascular events in hyperuricemia patients, the role of serum uric acid in cardiovascular diseases is still controversial. The aim of this meta-analysis was to explore the difference of carotid intima-media thickness in hyperuricemia and control groups.

Methods: We performed this meta-analysis by searching the PubMed, Cochrane Library, Embase and Web of Science databases up to July 2020. Read More

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Association between intake of sweetened beverages with all-cause and cause-specific mortality: a systematic review and meta-analysis.

J Public Health (Oxf) 2021 Apr 9. Epub 2021 Apr 9.

General Intensive Care Unit, The First Affiliated Hospital of Zhengzhou University; Henan Key Laboratory of Critical Care Medicine, Zhengzhou Key Laboratory of Sepsis; Henan Engineering Research Center for Critical Care Medicine, Zhengzhou 450052, China.

Background: Conclusions remain controversial between the consumption of sugar and artificially sweetened beverages (SSBs and ASBs) and mortality.

Methods: We systematically searched the PubMed, Embase, Cochrane Library and Web of Science databases from their inception date to 1st January 2020, prospective cohort studies researching the mortality risk and SSBs or ASBs consumption were included. Random effects meta-analyses and dose-response analyses were performed to measure the association. Read More

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The analgesic efficacy of liposomal bupivacaine compared with bupivacaine hydrochloride for the prevention of postoperative pain: a systematic review and meta-analysis with trial sequential analysis.

Reg Anesth Pain Med 2021 Apr 9. Epub 2021 Apr 9.

Anesthesiology and Intensive Care Medicine, University Hospital of Giessen and Marburg Campus Marburg, Marburg, Hessen, Germany

Background/importance: Liposomal bupivacaine (LB) is a prolonged release formulation of conventional bupivacaine designed for prolonging local or peripheral regional single injection anesthesia. To this day, the benefit of the new substance on relevant end points is discussed controversial.

Objective: The objective was to determine whether there is a difference in postoperative pain scores and morphine consumption between patients treated with LB and bupivacaine hydrochloride in a systematic review and meta-analysis. Read More

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Effects of general anaesthesia during pregnancy on neurocognitive development of the fetus: a systematic review and meta-analysis.

Br J Anaesth 2021 Apr 6. Epub 2021 Apr 6.

Department of Anaesthesiology, UZ Leuven, Leuven, Belgium; Department of Cardiovascular Sciences, Group Biomedical Sciences, KU Leuven, Leuven, Belgium. Electronic address:

Background: The US Food and Drug Administration warned that exposure of pregnant women to general anaesthetics may impair fetal brain development. This review systematically evaluates the evidence underlying this warning.

Methods: PubMed, EMBASE, and Web of Science were searched from inception until April 3, 2020. Read More

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Quantification of the misidentification of Plasmodium knowlesi as Plasmodium malariae by microscopy: an analysis of 1569 P. knowlesi cases.

Malar J 2021 Apr 9;20(1):179. Epub 2021 Apr 9.

Medical Technology, School of Allied Health Sciences, Walailak University, Tha Sala, Nakhon Si Thammarat, Thailand.

Background: Plasmodium knowlesi is recognized as the fifth Plasmodium species causing malaria in humans. It is morphologically similar to the human malaria parasite Plasmodium malariae, so molecular detection should be used to clearly discriminate between these Plasmodium species. This study aimed to quantify the rate at which P. Read More

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Examining the impact of weight bias on the association between exercise identity and maladaptive exercise behaviors.

Eat Behav 2021 Mar 29;41:101503. Epub 2021 Mar 29.

Department of Psychology, University of South Florida, Tampa, USA.

Objective: Though exercise behaviors are typically viewed as health-promoting, certain forms of exercise (i.e., excessive exercise, unhealthy muscle-building behaviors) are considered maladaptive and are associated with negative physical and psychological outcomes. Read More

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Effect of intrapartum oxygen on the rate of cesarean delivery: a meta-analysis: Condensation: Intrapartum oxygen administration does not change rate of cesarean delivery or other maternal or fetal outcomes.

Am J Obstet Gynecol MFM 2021 Apr 6:100374. Epub 2021 Apr 6.

Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Thomas Jefferson University Hospital, Philadelphia, PA, USA. Electronic address:

Background: Maternal supplemental oxygen is often used intrapartum, with other fetal resuscitative maneuvers, for non-reassuring fetal heart rate monitoring (NRFHRM).

Objective: To determine if maternal intrapartum administration of oxygen altered the rate of cesarean delivery (CD) when compared to room air.

Study Design: This was a systematic review and meta-analysis of randomized controlled trials (RCTs). Read More

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Impact of high-intensity interval training on cardiorespiratory fitness, body composition, physical fitness, and metabolic parameters in older adults: A meta-analysis of randomized controlled trials.

Exp Gerontol 2021 Apr 6:111345. Epub 2021 Apr 6.

School of Sport Sciences, Nanjing Normal University, Nanjing, China. Electronic address:

High-intensity interval training (HIIT) can effectively increase peak oxygen consumption, body composition, physical fitness, and health-related characteristics of adults; however, its impact in the older population remains highly debated. This review and meta-analysis aimed to evaluate the effects of high-intensity interval training on cardiorespiratory fitness, body composition, physical fitness, and health-related outcomes in older adults. Four electronic databases (PubMed, Scopus, Medline, and Web of Science) were searched (until July 2020) for randomized trials comparing the effect of HIIT on physical fitness, metabolic parameters, and cardiorespiratory fitness in older adults. Read More

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Frontal sinuses as tools for human identification: a systematic review of imaging methods.

Dentomaxillofac Radiol 2021 Apr 9:20200599. Epub 2021 Apr 9.

Department of Stomatology, Public Health and Forensic Odontology, School of Dentistry of Ribeirão Preto, USP-University of São Paulo, Ribeirão Preto, Brazil.

The frontal sinuses are potential evidences for human identification because of the inherent distinctiveness of their morphology. Over the last decades, several techniques emerged to enable the visualization and analysis of the frontal sinuses via bi- and three-dimensional imaging. This systematic review aimed to compile different methodological approaches found in the scientific literature to contribute to human identification. Read More

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Association of Brain-Derived Neurotrophic Factor rs6265 G>A polymorphism and Post-traumatic Stress Disorder susceptibility: A systematic review and meta-analysis.

Brain Behav 2021 Apr 9:e02118. Epub 2021 Apr 9.

Department of Neurology, Hubei Key Laboratory of Embryonic Stem Cell Research, Taihe Hospital, Hubei University of Medicine, Shiyan, China.

Background: Previous studies have shown that the brain-derived neurotrophic factor (BDNF) rs6265 G > A polymorphism is closely related post-traumatic stress disorder (PTSD) risk. However, the results were not consistent. We therefore conducted a meta-analysis to explore the underlying relationships between BDNF rs6265 G > A polymorphism and PTSD risk. Read More

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Systematic Review of Machine Learning Models for Personalised Dosing of Heparin.

Br J Clin Pharmacol 2021 Apr 9. Epub 2021 Apr 9.

Department of Pharmacy, Princess Alexandra Hospital, Brisbane, Queensland, Australia.

Aim: To identify and critically appraise studies of prediction models, developed using machine learning (ML) methods, for determining the optimal dosing of unfractionated heparin (UFH).

Methods: Embase, PubMed, CINAHL, Web of Science, International Pharmaceutical Abstracts and IEEE Xplore databases were searched from inception to 31 January 2020 to identify relevant studies using key search terms synonymous with artificial intelligence or ML, 'prediction', 'dose', 'activated partial thromboplastin time (aPTT)' and 'UFH.' Studies had to have used ML methods for developing models that predicted optimal dose of UFH or target therapeutic aPTT levels in the hospital setting. Read More

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Safety incidents associated with extended working hours. A systematic review and meta-analysis.

Scand J Work Environ Health 2021 Apr 9. Epub 2021 Apr 9.

National Institute of Occupational Health, PB 5330 Majorstuen, 0304 Oslo, Norway.

Objective: We performed a systematic review to assess potential consequences of extended working hours on accidents, near-accidents, safety incidents and injuries (incidents) by considering the overall certainty of evidence.

Methods: We searched five databases systematically (Medline, Embase, PsycINFO, Web of Science, and Proquest Health and safety Science Abstract) and identified 10072 studies published until December 2020. Twenty-two studies met the inclusion criteria. Read More

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Which Bone-Modifying Agent is Associated with Better Outcomes in Patients with Skeletal Metastases from Lung Cancer? A Systematic Review and Network Meta-analysis.

Clin Orthop Relat Res 2021 Apr 7. Epub 2021 Apr 7.

A. Bozzo, D. Axelrod, K. Masrouha, D. Wilson, M. Ghert, Division of Orthopaedic Surgery, Department of Surgery, McMaster University, Hamilton, Ontario, Canada.

Background: Lung cancer is one of the most commonly diagnosed cancers and is the leading cause of cancer-related deaths. Metastatic bone disease occurs in 20% to 40% of patients with lung cancer, and these patients often present with pain or skeletal-related events (SREs) that are associated with decreased survival. Bone-modifying agents such as denosumab or bisphosphonates are routinely used; however, to our knowledge, there has been no quantitative synthesis of randomized controlled trial data to determine the most effective pharmacologic treatment of metastatic bone disease because of lung cancer. Read More

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Use of Facebow device in prosthodontics: A systematic review on randomized control trials.

J Indian Prosthodont Soc 2021 Jan-Mar;21(1):11-18

Department of Prosthodontics, Rajarajeswari Dental College and Hospital, Bengaluru, Karnataka, India.

Aim: Recording the maxillomandibular relationship is important in various prosthodontic treatments. Evidence of face-bow transfer resulting in improved outcome is conflicting. Hence the objective of this study is to determine the use of face-bow transfer in prosthodontics. Read More

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Is Seismicity Operating at a Critical Point?

Phys Rev Lett 2021 Mar;126(12):128501

Department of Management, Technology and Economics, ETH Zürich, Scheuchzerstrasse 7, 8092 Zürich, Switzerland.

Seismicity and faulting within the Earth's crust are characterized by many scaling laws that are usually interpreted as qualifying the existence of underlying physical mechanisms associated with some kind of criticality in the sense of phase transitions. Using an augmented epidemic-type aftershock sequence (ETAS) model that accounts for the spatial variability of the background rates μ(x,y), we present a direct quantitative test of criticality. We calibrate the model to the ANSS catalog of the entire globe, the region around California, and the Geonet catalog for the region around New Zealand using an extended expectation-maximization (EM) algorithm including the determination of μ(x,y). Read More

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Instruments to assess upper-limb function in children and adolescents with neuromuscular diseases: a systematic review.

Dev Med Child Neurol 2021 Apr 8. Epub 2021 Apr 8.

Department of Health Science, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.

Aim: To synthesize clinical and scientific evidence regarding the instruments available to assess upper-limb function in paediatric patients with neuromuscular disease (NMD).

Method: This systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses and COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) guidelines (Prospective Registry of Systematic Reviews no. CRD42020140343). Read More

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Effects of virtual reality in post-stroke aphasia: a systematic review and meta-analysis.

Neurol Sci 2021 Apr 9. Epub 2021 Apr 9.

Department of Neurology, Dongzhimen Hospital, Beijing University of Chinese Medicine, No.5 Haiyuncang, Dongcheng District, Beijing, 100700, China.

Objective: To investigate whether virtual reality (VR) interventions have beneficial effects on the functional communication and language function of patients with post-stroke aphasia (PSA).

Methods: We searched nine electronic literature databases and two clinical registry platforms to identify randomized controlled trials (RCTs) and quasi-RCTs performed up to September 2020. Screening, quality assessment, and data collection were performed by two authors independently, using standard protocols. Read More

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Web-based decision aids for cancer clinical decisions: a systematic review and meta-analysis.

Support Care Cancer 2021 Apr 8. Epub 2021 Apr 8.

The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, No.17 Lujiang Road, Hefei, People's Republic of China.

Objective: The aim of this study is to evaluate the effectiveness of web-based decision aids (WDAs) on cancer-related clinical care in terms of different decision categories and by different cancer types.

Methods: Literature retrieval utilized highly inclusive algorithms searching randomized controlled trials (RCTs) in MEDLINE, EMBASE, and Cochrane Library and manual searching of eligible studies from reference lists of relevant articles. Two researchers examined the articles selected separately and extracted the information about the studies (e. Read More

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A Meta-Analysis of a Cohort Study on the Association between Sleep Duration and Type 2 Diabetes Mellitus.

J Diabetes Res 2021 24;2021:8861038. Epub 2021 Mar 24.

Department of Nursing, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.

Objective: To study the association between sleep duration and the incidence of type 2 diabetes mellitus (T2DM) and to provide a theoretical basis for the prevention of T2DM through a meta-analysis.

Methods: PubMed, Web of Science, Scopus, Embase, Cochrane Library, ProQuest, CNKI, Wanfang, VIP, and SINOMED were searched from their inception until May 2020. All cohort studies on the relationship between sleep duration and T2DM in adults were included. Read More

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Ten Years of Research on Automatic Voice and Speech Analysis of People With Alzheimer's Disease and Mild Cognitive Impairment: A Systematic Review Article.

Front Psychol 2021 23;12:620251. Epub 2021 Mar 23.

Faculty of Psychology, University of Salamanca, Salamanca, Spain.

The field of voice and speech analysis has become increasingly popular over the last 10 years, and articles on its use in detecting neurodegenerative diseases have proliferated. Many studies have identified characteristic speech features that can be used to draw an accurate distinction between healthy aging among older people and those with mild cognitive impairment and Alzheimer's disease. Speech analysis has been singled out as a cost-effective and reliable method for detecting the presence of both conditions. Read More

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Predictive models for cardiovascular and kidney outcomes in patients with type 2 diabetes: systematic review and meta-analyses.

Heart 2021 Apr 8. Epub 2021 Apr 8.

Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada

Objective: To inform a clinical practice guideline (BMJ Rapid Recommendations) considering sodium glucose cotransporter-2 inhibitors and glucagon-like peptide-1 receptor agonists for treatment of adults with type 2 diabetes, we summarised the available evidence regarding the performance of validated risk models on cardiovascular and kidney outcomes in these patients.

Methods: We systematically searched bibliographic databases in January 2020 to identify observational studies evaluating risk models for all-cause and cardiovascular mortality, heart failure (HF) hospitalisations, end-stage kidney disease (ESKD), myocardial infarction (MI) and ischaemic stroke in ambulatory adults with type 2 diabetes. Using a random effects model, we pooled discrimination measures for each model and outcome, separately, and descriptively summarised calibration plots, when available. Read More

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Safety of treatment with chloroquine and hydroxychloroquine: A ten-year systematic review and meta-analysis.

Eur J Intern Med 2021 Apr 5. Epub 2021 Apr 5.

Escola Bahiana de Medicina e Saúde Pública, Salvador, Bahia, Brazil.

Objective: To estimate the incidence rate ratio (IRR) of adverse events (AE) in chloroquine or hydroxychloroquine users.

Methods: We systematically reviewed randomized controlled trials (RCTs), using MEDLINE (2010-2020) and EMBASE (2010-2020) databases, reporting AE in chloroquine or hydroxychloroquine users during treatment for lupus, rheumatoid arthritis, malaria and COVID-19. The protocol for this systematic review is registered at the PROSPERO database (CRD42020197938). Read More

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Chemical hazard in glacial melt? The glacial system as a secondary source of POPs (in the Northern Hemisphere). A systematic review.

Sci Total Environ 2021 Jan 29:145244. Epub 2021 Jan 29.

Department of Analytical Chemistry, Chemical Faculty, Gdańsk University of Technology, G. Narutowicza 11/12, 80-233 Gdańsk, Poland.

Toxicity of compounds belonging to persistent organic pollutants (POPs) is widely known, and their re-emission from glaciers has been conclusively demonstrated. However, the harmful effects associated with such secondary emissions have yet to be thoroughly understood, especially in the spatial and temporal context, as the existing literature has a clear sampling bias with the best recognition of sites in the European Alps. In this review, we elaborated on the hazards associated with the rapid melting of glaciers releasing organochlorine pesticides (OCPs), polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs) and polycyclic aromatic hydrocarbons (PAHs). Read More

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January 2021

The effects of vitamin E supplementation on malondialdehyde as a biomarker of oxidative stress in haemodialysis patients: a systematic review and meta-analysis.

BMC Nephrol 2021 Apr 9;22(1):126. Epub 2021 Apr 9.

Centre for Public Health, Queen's University Belfast, Belfast, UK.

Background: Haemodialysis (HD) patients tend to have higher levels of oxidative stress (OS), associated with increased morbidity and premature mortality, compared to the general population. Levels of malondialdehyde (MDA), a biomarker of OS, are reduced by the antioxidant properties of vitamin E (VE) but outcomes from randomised control trials of VE supplementation on MDA in HD patients have been inconsistent.

Methods: We undertook a systematic review and meta-analysis of adult HD patients from VE supplementation studies with measures of MDA. Read More

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