6,144 results match your criteria risk autoimmunity


Psoriasis Susceptibility 1 Candidate 1 () Polymorphism is Associated with Autoimmune Thyroid Disease in a Chinese Han Population.

Immunol Invest 2021 Jul 30:1-10. Epub 2021 Jul 30.

Department of Endocrinology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, China.

Background: Autoimmune thyroid disease (AITD) is an inherited, complex gene- and immune-related disorder that mainly includes Graves' disease (GD) and Hashimoto's thyroiditis (HT). Psoriasis susceptibility 1 candidate 1 () is a susceptibility gene associated with many autoimmune diseases, but its role in an individual's predisposition to AITD is unknown.

Methods: This study included 1065 Chinese Han patients with AITD and 943 matched healthy individuals. Read More

View Article and Full-Text PDF

Long-term B cell depletion associates with regeneration of kidney function.

Immun Inflamm Dis 2021 Jul 29. Epub 2021 Jul 29.

Department of Internal Medicine, Division of Nephrology and Hypertension, Bonn, Germany.

Background: Chronic kidney disease (CKD) is a common condition that increases mortality and the risk of cardiovascular and other morbidities regardless of underlying renal condition. Chronic inflammation promotes renal fibrosis. Recently, renal B cell infiltrates were described in chronic kidney disease of various etiologies beyond autoimmunity. Read More

View Article and Full-Text PDF

Concomitant autoimmunity may be a predictor of more severe stages of endometriosis.

Sci Rep 2021 Jul 28;11(1):15372. Epub 2021 Jul 28.

Gynecology/Obstetrics Unit, IRCCS San Raffaele Scientific Institute, 20132, Milan, Italy.

Pathogenesis of endometriosis is still unclear and a role of both innate and adaptive immune system has been postulated. Some recent findings have revealed an increased risk to have concomitant autoimmune disease in women with endometriosis, but no study so far has investigated whether this association could affect endometriosis severity and stage. We retrospectively reviewed medical patients' notes of women with a confirmed diagnosis of endometriosis who referred to our endometriosis outpatient clinic between January 2015 and December 2019. Read More

View Article and Full-Text PDF

Colorectal Strictures in Patients With Inflammatory Bowel Disease Do Not Independently Predict Colorectal Neoplasia.

Inflamm Bowel Dis 2021 Jul 28. Epub 2021 Jul 28.

Section of Gastroenterology, Veterans Affairs San Diego Healthcare System, La Jolla, CA, USA.

Background: Colorectal strictures have been considered independent risk factors for neoplasia in patients with inflammatory bowel disease (IBD). We examined the association between colorectal stricture and subsequent risk of colorectal neoplasia (CRN) in patients with IBD colitis undergoing colonoscopic surveillance.

Methods: We conducted a retrospective cohort analysis of patients with IBD colitis enrolled in colonoscopic surveillance for CRN at an academic medical center between 2005 and 2017. Read More

View Article and Full-Text PDF

COVID-19 infection among autoimmune rheumatic disease patients: Data from an observational study and literature review.

J Autoimmun 2021 Jul 16;123:102687. Epub 2021 Jul 16.

Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece; Medical Sciences/Immunology, Academy of Athens, Athens, Greece.

The impact of SARS-CoV-2 infection in patients with autoimmune/auto-inflammatory rheumatic diseases (AARD) under immunomodulatory treatment has been a focus of interest during the COVID-19 pandemic. In this observational study, demographic data, disease related features and comorbidities, COVID-19 manifestations and outcome as well as antibody responses to SARS-CoV-2 were recorded among 77 consecutive patients with underlying AARD infected by SARS-CoV-2. Analysis of data was performed using univariate and multivariate models. Read More

View Article and Full-Text PDF

Acute Immune Thrombocytopenia (ITP) Following COVID-19 Vaccination in a Patient With Previously Stable ITP.

Open Forum Infect Dis 2021 Jul 24;8(7):ofab343. Epub 2021 Jun 24.

Department of Internal Medicine, Lincoln Medical Center, Bronx, New York, USA.

Immune thrombocytopenia (ITP) is an autoimmune condition associated with multiple risk factors including viral infections (hepatitis B virus/hepatitis C virus/cytomegalovirus, HIV, and recently severe acute respiratory syndrome coronavirus 2) and vaccines. Though immune mechanisms have been proposed to explain the pathogenesis of acute ITP, autoimmunity with the coronavirus disease 2019 (COVID-19) vaccine is still unclear and needs further research. We report a case of acute ITP after administration of the Pfizer-BioNTech mRNA COVID-19 vaccine in a patient with previously stable ITP. Read More

View Article and Full-Text PDF

Case Report: Hodgkin Lymphoma and Refractory Systemic Lupus Erythematosus Unveil Activated Phosphoinositide 3-Kinase-δ Syndrome 2 in an Adult Patient.

Front Pediatr 2021 8;9:702546. Epub 2021 Jul 8.

Pediatric Unit, Istituti di Ricovero e Cura a Carattere Scientifico Azienda Ospedaliero-Universitaria di Bologna, University of Bologna, Bologna, Italy.

Activated phosphoinositide 3-kinase-δ syndrome 2 (APDS2) is a rare primary immune regulatory disorder caused by heterozygous gain of function mutation in the gene encoding PI3Kδ regulatory p85α subunit and resulting in PI3Kδ hyperactivation. Clinical features range from recurrent infections to manifestations of immune dysregulation like autoimmunity, inflammation, systemic lymphoproliferation, and increased risk of cancer. We describe a new dominant mutation causing APDS2 presenting with lymphoma and systemic refractory autoimmunity. Read More

View Article and Full-Text PDF

Antibody-Mediated Autoimmune Diseases of the CNS: Challenges and Approaches to Diagnosis and Management.

Front Neurol 2021 7;12:673339. Epub 2021 Jul 7.

Department of Neurology, Mayo Clinic, Rochester, MN, United States.

Antibody-mediated disorders of the central nervous system (CNS) are increasingly recognized as neurologic disorders that can be severe and even life-threatening but with the potential for reversibility with appropriate treatment. The expanding spectrum of newly identified autoantibodies targeting glial or neuronal (neural) antigens and associated clinical syndromes (ranging from autoimmune encephalitis to CNS demyelination) has increased diagnostic precision, and allowed critical reinterpretation of non-specific neurological syndromes historically associated with systemic disorders (e.g. Read More

View Article and Full-Text PDF

Placental pathologic features in thyroid autoimmunity.

Placenta 2021 Jul 15;112:66-72. Epub 2021 Jul 15.

Department of Obstetrics and Gynecology, IRCCS Foundation Policlinico San Matteo, Piazzale Golgi n.19, 27100 Pavia, Italy; University of Pavia, Corso Strada Nuova n.65, 27100, Pavia, Italy.

Introduction: Data on placental pathologic features associated with thyreoperoxidase antibodies (TPO Ab) and/or hypothyroidism are limited. The objective of the study was to analyze placental pathologic features of women with TPO Ab positivity.

Methods: Prospective case-control observational study of pregnancy outcome among women screened for TPO Ab positivity and/or isolated hypothyroidism (TSH>4mU/L) during the first trimester of pregnancy. Read More

View Article and Full-Text PDF

Immune checkpoint inhibitor cardiotoxicity: Breaking barriers in the cardiovascular immune landscape.

J Mol Cell Cardiol 2021 Jul 22;160:121-127. Epub 2021 Jul 22.

Department of Medicine, Stanford University, Stanford, California 94305, USA; Stanford Cardiovascular Institute, Stanford University, Stanford, California 94305, USA; Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California 94305, USA. Electronic address:

Immune checkpoint inhibitors (ICI) have changed the landscape of cancer therapy, but their use carries a high risk of cardiac immune related adverse events (iRAEs). With the expanding utilization of ICI therapy, there is a growing need to understand the underlying mechanisms behind their anti-tumor activity as well as their immune-mediated toxicities. In this review, we will focus on clinical characteristics and immune pathways of ICI cardiotoxicity, with an emphasis on single-cell technologies used to gain insights in this field. Read More

View Article and Full-Text PDF

The Multifactorial Progression from the Islet Autoimmunity to Type 1 Diabetes in Children.

Int J Mol Sci 2021 Jul 13;22(14). Epub 2021 Jul 13.

Clinical Research Centre, Medical University of Białystok, Marii Skłodowskiej-Curie 24a, 15-276 Białystok, Poland.

Type 1 Diabetes (T1D) results from autoimmune destruction of insulin producing pancreatic ß-cells. This disease, with a peak incidence in childhood, causes the lifelong need for insulin injections and necessitates careful monitoring of blood glucose levels. However, despite the current insulin therapies, it still shortens life expectancy due to complications affecting multiple organs. Read More

View Article and Full-Text PDF

Characteristics of children diagnosed with type 1 diabetes before vs after 6 years of age in the TEDDY cohort study.

Diabetologia 2021 Jul 22. Epub 2021 Jul 22.

National Institute of Diabetes & Digestive & Kidney Diseases, Bethesda, MD, USA.

Aims/hypothesis: Prognostic factors and characteristics of children diagnosed with type 1 diabetes before 6 years of age were compared with those diagnosed at 6-13 years of age in the TEDDY study.

Methods: Genetically high-risk children (n = 8502) were followed from birth for a median of 9.9 years; 328 (3. Read More

View Article and Full-Text PDF

Ten years follow up of first degree relatives of type 1 diabetes patients: presence of autoimmune biomarkers and the progression to diabetes in a retrospective cohort.

Arch Endocrinol Metab 2021 Jul 16. Epub 2021 Jul 16.

Departamento de Nutrologia, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brasil.

Objective: The aim of the study was to assess the autoimmunity in first degrees relatives (FDR) of patients with type 1 diabetes (T1DM) and the progression to T1DM after 10 years of follow up in the Brazilian population.

Methods: Non-diabetic FDR of T1DM patients were interviewed and blood was drawn for autoantibodies measurement (GADA, IA-2A, IAA, ZnT8A). Serum samples were analyzed by standard radioligand binding assays performed at the Federal University of Rio de Janeiro (GADA, IAA and IA2A), and at the Skäne University Hospital, Sweden (ZnT8A). Read More

View Article and Full-Text PDF

Complete blood counts with red blood cell determinants associate with reduced beta-cell function in seroconverted Swedish TEDDY children.

Endocrinol Diabetes Metab 2021 Jul 3;4(3):e00251. Epub 2021 May 3.

Department of Clinical Sciences Clinical Research Centre Lund University Skåne University Hospital Malmö Sweden.

Objectives: To investigate whether changes in complete blood count (CBC) in islet autoantibody positive children with increased genetic risk for type 1 diabetes are associated with oral glucose tolerance tests (OGTT) and HbA1c over time.

Methods: The Environmental Determinants of Diabetes in the Young (TEDDY) study follows children with increased risk for type 1 diabetes in the United States, Germany, Sweden and Finland. In the current study, 89 Swedish TEDDY children (median age 8. Read More

View Article and Full-Text PDF

The role of the immune system in Alzheimer's disease.

Ageing Res Rev 2021 Jul 14;70:101409. Epub 2021 Jul 14.

Department of Neurology & National Research Center for Aging and Medicine, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. Electronic address:

Alzheimer's disease (AD) is the most common neurodegenerative disorder where the accumulation of amyloid plaques and the formation of tau tangles are the prominent pathological hallmarks. Increasing preclinical and clinical studies have revealed that different components of the immune system may act as important contributors to AD etiology and pathogenesis. The recognition of misfolded Aβ and tau by immune cells can trigger a series of complex immune responses in AD, and then lead to neuroinflammation and neurodegeneration. Read More

View Article and Full-Text PDF

Pathogenesis Of Microscopic Colitis: A Systematic Review.

J Crohns Colitis 2021 Jul 17. Epub 2021 Jul 17.

Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas  (CIBEREHD)  Spain.

Background: While the exact aetiology of microscopic colitis (MC) remains unknown, a dysregulated immune response to luminal factors or medications is the most accepted pathogenesis hypothesis.

Objective: Systematic review of the pathogenesis of MC.

Methods: We applied the Joanna Briggs Institute methodologies and the PRISMA statement for the reporting of systematic reviews (PROSPERO Trial Identifier: CRD42020145008). Read More

View Article and Full-Text PDF

Single nucleotide polymorphism rs5029937 in TNFAIP3 gene is correlated with risk of rheumatoid arthritis.

Med J Islam Repub Iran 2021 31;35:42. Epub 2021 Mar 31.

Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Rheumatoid arthritis (RA) is a progressive and common autoimmune disease with multifactorial etiology. Several pieces of research show that genetic factors play a major role in the incidence of RA. Several genome-wide association studies (GWAS) have identified the tumor necrosis factor alpha inducible protein 3 (TNFAIP3) genes as one of the candidate loci. Read More

View Article and Full-Text PDF

Peripheral autoreactive CD8 T-cell frequencies are too variable to be a reliable predictor of disease progression of human type 1 diabetes.

Clin Transl Immunology 2021 11;10(7):e1309. Epub 2021 Jul 11.

Novo Nordisk Research Center Seattle, Inc. Seattle WA USA.

Objectives: The detection of a peripheral immune cell signature that specifically reflects autoimmunity in type 1 diabetes would enable the prediction and staging of disease on an individual basis. However, defining such a signature is technically challenging. Reliable interpretation of immune cell-related biomarkers depends on their inherent variability and, to understand this variability, longitudinal analyses are required. Read More

View Article and Full-Text PDF

Monogenic autoimmunity and infectious diseases: the double-edged sword of immune dysregulation.

Curr Opin Immunol 2021 Jul 12;72:230-238. Epub 2021 Jul 12.

Department of Pediatrics, Division of Rheumatology/Immunology, Washington University in St. Louis, St. Louis, MO, 63110, United States. Electronic address:

The study of monogenic autoimmune diseases has provided key insights into molecular mechanisms involved in development of autoimmunity and immune tolerance. It has also become clear that such inborn errors of immunity (IEIs) frequently present clinically not only with autoimmune diseases, but also frequently have increased susceptibility to infection. The genes associated with monogenic autoimmunity influence diverse functional pathways, and the resulting immune dysregulation also impacts the complex and coordinated immune response to pathogens, for example type I interferon and cytokine signaling, the complement pathway and proper differentiation of the immune response. Read More

View Article and Full-Text PDF

Identification of a Novel Immune-Related CpG Methylation Signature to Predict Prognosis in Stage II/III Colorectal Cancer.

Front Genet 2021 28;12:684349. Epub 2021 Jun 28.

Department of Radiology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.

With the increasing incidence of colorectal cancer (CRC) and continued difficulty in treating it using immunotherapy, there is an urgent need to identify an effective immune-related biomarker associated with the survival and prognosis of patients with this disease. DNA methylation plays an essential role in maintaining cellular function, and changes in methylation patterns may contribute to the development of autoimmunity, aging, and cancer. In this study, we aimed to identify a novel immune-related methylated signature to aid in predicting the prognosis of patients with CRC. Read More

View Article and Full-Text PDF

Cohort profile: SCREEN-RA: design, methods and perspectives of a Swiss cohort study of first-degree relatives of patients with rheumatoid arthritis.

BMJ Open 2021 Jul 14;11(7):e048409. Epub 2021 Jul 14.

Division of Rheumatology, Geneva University Hospitals (HUG), Geneve, Switzerland.

Purpose: Rheumatoid arthritis (RA) is an insidious autoimmune disease, with an immunological onset years before diagnosis. Early interventions in preclinical stages could prevent or minimise the progression towards irreversible joint damage. The SCREEN-RA cohort (Evaluation of a SCREENing strategy for Rheumatoid Arthritis) aims to characterise the preclinical stages of the disease, to identify environmental risk factors, and to discover or validate novel biomarkers predictive for RA development. Read More

View Article and Full-Text PDF

Sarcoidosis and autoimmunity.

Curr Opin Pulm Med 2021 Jul 12. Epub 2021 Jul 12.

Division of Academic Internal Medicine Division of Rheumatology Division of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, University of Illinois at Chicago Division of Medical Division of Research Services, Jesse Brown VA Medical Center, Chicago, Illinois, USA.

Purpose Of Review: Sarcoidosis is a poorly understood multisystem granulomatous disease that frequently involves the lungs but can affect any organ system. In this review, we summarize recent developments in the understanding of the immune dysregulation seen in sarcoidosis and propose a new expanded definition of human autoimmunity in sarcoidosis, and the implications it would have on treating sarcoidosis with targeted immunotherapy regimens in the future.

Recent Findings: Sarcoidosis has been linked to infectious organisms like Mycobacterium and Cutibacterium, and certain manifestations of sarcoidosis have been linked to specific HLA alleles, but the overall pathogenesis remains uncertain. Read More

View Article and Full-Text PDF

Microbiome signatures of progression toward celiac disease onset in at-risk children in a longitudinal prospective cohort study.

Proc Natl Acad Sci U S A 2021 Jul;118(29)

Division of Pediatric Gastroenterology and Nutrition, MassGeneral Hospital for Children, Harvard Medical School, Boston, MA 02114;

Other than exposure to gluten and genetic compatibility, the gut microbiome has been suggested to be involved in celiac disease (CD) pathogenesis by mediating interactions between gluten/environmental factors and the host immune system. However, to establish disease progression markers, it is essential to assess alterations in the gut microbiota before disease onset. Here, a prospective metagenomic analysis of the gut microbiota of infants at risk of CD was done to track shifts in the microbiota before CD development. Read More

View Article and Full-Text PDF

Interplay Between Class II HLA Genotypes and the Microbiome and Immune Phenotypes in Individuals With PTEN Hamartoma Tumor Syndrome.

JCO Precis Oncol 2021 9;5. Epub 2021 Feb 9.

Genomic Medicine Institute, Cleveland Clinic, Cleveland, OH.

We evaluate potential contributors to the development of autoimmunity and other phenotypes consistent with immune dysregulation in individuals with germline mutations in the tumor suppressor gene in this observational report.

Materials And Methods: Illumina sequencing of bacterial and fungal microbes was carried out on patient-donated fecal samples in a cohort of 67 patients with pathogenic germline mutations, including 41 individuals with autoimmunity and/or phenotypes consistent with immune dysregulation (cases) and 26 individuals without (controls). From these data, we measured differences in alpha and beta diversity between cases and controls and identified differentially abundant bacterial and fungal taxa using and packages in R. Read More

View Article and Full-Text PDF
February 2021

The Air We Breathe: Air Pollution as a Prevalent Proinflammatory Stimulus Contributing to Neurodegeneration.

Front Cell Neurosci 2021 24;15:647643. Epub 2021 Jun 24.

Department of Brain Biochemistry, Maj Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland.

Air pollution is regarded as an important risk factor for many diseases that affect a large proportion of the human population. To date, accumulating reports have noted that particulate matter (PM) is closely associated with the course of cardiopulmonary disorders. As the incidence of Alzheimer's disease (AD), Parkinson's disease (PD), and autoimmune disorders have risen and as the world's population is aging, there is an increasing interest in environmental health hazards, mainly air pollution, which has been slightly overlooked as one of many plausible detrimental stimuli contributing to neurodegenerative disease onset and progression. Read More

View Article and Full-Text PDF

The dark side of insulin: A primary autoantigen and instrument of self-destruction in type 1 diabetes.

Mol Metab 2021 Jul 7:101288. Epub 2021 Jul 7.

Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, 3052, Australia; Department of Medical Biology, University of Melbourne, Melbourne, VIC, 3010, Australia. Electronic address:

Background: Since its discovery 100 years ago, insulin, as the 'cure' for type 1 diabetes, has rescued the lives of countless individuals. As the century unfolded and the autoimmune nature of type 1 diabetes was recognised, a darker side of insulin emerged. Autoimmunity to insulin was found to be an early marker of risk for type 1 diabetes in young children. Read More

View Article and Full-Text PDF

Traditional risk factors and combined genetic markers of recurrent ischemic stroke in adults.

J Thromb Haemost 2021 Jul 9. Epub 2021 Jul 9.

Laboratory of Neurogenetics, Disease and Cerebrovascular Disease (LR-12-SP-19), University of Sfax, Sfax, Tunisia.

Background: The involvement of traditional risk factors and combined genetic markers of recurrent arterial ischemic stroke (AIS) in adults remains unclear.

Aim: This study aims to determine significant clinical and genetic factors of AIS recurrent, and to investigate the combined effect of genotypes on the occurrence of a second cerebral ischemic attack.

Methods: We investigated a cohort study of AIS patients (18-50 years) followed in the neurology department within 5 years. Read More

View Article and Full-Text PDF

Temporal change in inflammatory biomarkers and risk of cardiovascular events: the Multi-ethnic Study of Atherosclerosis.

ESC Heart Fail 2021 Jul 9. Epub 2021 Jul 9.

Division of Cardiology, Department of Medicine, Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MD, 21287-0409, USA.

Aims: Little is known about the association of temporal changes in inflammatory biomarkers and the risk of death and cardiovascular diseases. We aimed to evaluate the association between temporal changes in C-reactive protein (CRP), fibrinogen, and interleukin-6 (IL-6) and risk of heart failure (HF), cardiovascular disease (CVD), and all-cause mortality in individuals without a history of prior CVD.

Methods And Results: Participants from the Multi-Ethnic Study of Atherosclerosis (MESA) cohort with repeated measures of inflammatory biomarkers and no CVD event prior to the second measure were included. Read More

View Article and Full-Text PDF

Antibodies against the pituitary and hypothalamus in boxers.

Handb Clin Neurol 2021 ;181:187-191

Department of Endocrinology, Yeditepe University, İstanbul, Turkey.

Traumatic brain injury (TBI), a growing public health problem worldwide, has recently been recognized as one of the leading causes of hypopituitarism. The main causes of TBI-induced pituitary dysfunction are car accidents, falls, violence, sports-related brain injury, and war accidents, including blast-related brain injuries. Car accidents and falls are the most common causes of TBI and pituitary dysfunction among the younger generation and elderly population, respectively. Read More

View Article and Full-Text PDF

Autoimmunity as an Etiological Factor of Cancer: The Transformative Potential of Chronic Type 2 Inflammation.

Front Cell Dev Biol 2021 21;9:664305. Epub 2021 Jun 21.

Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, United States.

Recent epidemiological studies have found an alarming trend of increased cancer incidence in adults younger than 50 years of age and projected a substantial rise in cancer incidence over the next 10 years in this age group. This trend was exemplified in the incidence of non-cardia gastric cancer and its disproportionate impact on non-Hispanic white females under the age of 50. The trend is concurrent with the increasing incidence of autoimmune diseases in industrialized countries, suggesting a causal link between the two. Read More

View Article and Full-Text PDF