580,204 results match your criteria risk adverse

Systemic lupus erythematosus and autoimmune features in chronic hospitalized patients with schizophrenia.

Schizophr Res 2021 Sep 15;237:166-173. Epub 2021 Sep 15.

Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan; Department of Public Health, College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan; Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung, Taiwan. Electronic address:

Objectives: Recent studies highlighted the link of schizophrenia risk with genetic variations in complement, which share the same pathogenesis with systemic lupus erythematosus (SLE). However, the coexistence of SLE and schizophrenia were rarely reported. We aimed to explore the autoantibody profiles, complement levels and prevalence of SLE in chronic schizophrenia patients. Read More

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September 2021

Modified Valsalva maneuver for treatment of supraventricular tachycardias: A Meta-analysis.

Am J Emerg Med 2021 Aug 31;50:507-512. Epub 2021 Aug 31.

Department of Heart Center, The First Hospital of Lanzhou University, Medical College of Lanzhou University, Chengguan District, Lanzhou 730000, Gansu, China; Key Laboratory of Cardiovascular Diseases of Gansu Province, Medical College of Lanzhou University, Chengguan District, Lanzhou 730000, Gansu, China. Electronic address:

Backgroud: Valsalva maneuver (VM) is a simple and easy method for acute termination of supraventricular tachycardia (SVT), while a postural modification to the VM has been suggested to be superior to the standard VM (SVM). The objective of this meta-analysis is to explore the efficacy and safety of the modified VM (MVM) to terminate SVT compared with the SVM.

Methods: Extensive literature was conducted using the database such as PubMed, Embase, Web of Science, Cochrane library and included randomized controlled trials (RCTs) assessing the efficacy and safety of the MVM and SVM for SVT. Read More

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Maternal haemodynamic profile in pregnancy after assisted reproductive technology: A pilot study.

Pregnancy Hypertens 2021 Sep 11;26:62-64. Epub 2021 Sep 11.

Department of Neurosciences, Reproductive Science and Dentistry, University Federico II of Naples, Via Pansini, 5-80131 Naples, Italy.

Singleton pregnancies obtained by assisted reproductive technology (ART) are at increased risk of adverse pregnancy outcome. Aim of this pilot study was to compare maternal hemodynamic profile in ART and spontaneous singleton pregnancies. Patients were enrollered during a third trimester routine obstetric examination. Read More

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September 2021

A review of Liquid biopsy as a tool to assess Epigenetic, cfDNA and miRNA variability as Methotrexate response predictors in patients with Rheumatoid Arthritis.

Pharmacol Res 2021 Sep 15:105887. Epub 2021 Sep 15.

Health and Biomedical Innovation, UniSA: Clinical and Health Sciences, University of South Australia, Adelaide, SA, Australia.

Rheumatoid arthritis (RA) is a common autoimmune inflammatory disease affecting 0.5-1% of adults worldwide. Achieving long term remission or low disease activity is possible through early diagnosis, rapid initiation of disease modifying anti-rheumatic drugs (DMARDs) and implementation of a treat to target approach. Read More

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September 2021

Onasemnogene abeparvovec gene therapy for symptomatic infantile-onset spinal muscular atrophy type 1 (STR1VE-EU): an open-label, single-arm, multicentre, phase 3 trial.

Lancet Neurol 2021 Oct;20(10):832-841

Novartis Gene Therapies, Cambridge, UK.

Background: Spinal muscular atrophy is a rare, autosomal recessive, neuromuscular disease caused by biallelic loss of the survival motor neuron 1 (SMN1) gene, resulting in motor neuron dysfunction. In this STR1VE-EU study, we aimed to evaluate the safety and efficacy of onasemnogene abeparvovec gene replacement therapy in infants with spinal muscular atrophy type 1, using broader eligibility criteria than those used in STR1VE-US.

Methods: STR1VE-EU was a multicentre, single-arm, single-dose, open-label phase 3 trial done at nine sites (hospitals and universities) in Italy (n=4), the UK (n=2), Belgium (n=2), and France (n=1). Read More

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October 2021

Using Bayesian networks for environmental health risk assessment.

Environ Res 2021 Sep 15:112059. Epub 2021 Sep 15.

Institut Ecocitoyen pour la Connaissance des Pollutions, Centre de vie, La Fossette, Fos-sur-Mer, France.

The study investigated the potential relationships between air pollution, socio-economy, and proven pathologies (e.g., respiratory, cardiovascular) within an industrial area in Southern France (Etang de Berre), gathering steel industries, oil refineries, shipping, road traffic and experiencing a Mediterranean climate. Read More

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September 2021

Neurological impairment and disability in children in rural Kenya.

Dev Med Child Neurol 2021 Sep 18. Epub 2021 Sep 18.

Department of Clinical Research (Neurosciences), Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya.

Aim: To investigate geographical change over time in the burden of neurological impairments in school-aged children in a demographic surveillance area.

Method: We investigated changes in neurological impairment prevalence in five domains (epilepsy and cognitive, hearing, vision, and motor impairments) using similar two-phase surveys conducted in 2001 (n=10 218) and 2015 (n=11 223) and determined changes in location-level prevalence, geographical clustering, and significant risk factors for children aged 6 to 9 years (mean7y 6mo, SD1y) of whom 50.4% were males. Read More

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September 2021

The efficacy and safety of novel classes of glucose-lowering drugs for cardiovascular outcomes: a network meta-analysis of randomised clinical trials.

Diabetologia 2021 Sep 18. Epub 2021 Sep 18.

Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.

Aims/hypothesis: Several cardiovascular outcome trials on sodium-glucose cotransporter 2 inhibitors (SGLT2i) have been released recently, including trials enrolling patients with congestive heart failure (CHF) and chronic kidney disease (CKD). Comparisons of the efficacy and safety of SGLT2i, glucagon-like peptide-1 receptor agonists (GLP-1RA) and dipeptidyl peptidase-4 inhibitors (DPP-4i) thus require an update. Assessments in patient subgroups, i. Read More

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September 2021

The peril and promise of sensitivity in eating disorders.

Int J Eat Disord 2021 Sep 18. Epub 2021 Sep 18.

Department of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis, Minnesota, USA.

Differential susceptibility, a reconceptualization of the diathesis-stress model of psychopathology, describes gene-environment interactions that reflect individual differences in responsiveness to environmental influences, both detrimental and beneficial. This model has been described metaphorically by the classification of orchids, which thrive under optimal care but wither under adverse conditions, and dandelions, which weather broad environmental circumstances but are less responsive to careful cultivation. Etiological research in the field of eating disorders has largely focused on the identification of specific behavioral phenotypes, temperamental traits, genotypes and neurobiological processes that confer risk. Read More

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September 2021

Immune signatures of bone marrow cells can independently predict prognosis in patients with myelodysplastic syndrome.

Br J Haematol 2021 Sep 18. Epub 2021 Sep 18.

Division of Haematology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.

Increasing evidence supports the role of the immune microenvironment and associated signalling in the pathogenesis of myelodysplastic syndromes (MDS). Nevertheless, the clinical relevancy of immune signals in patients with MDS remains elusive. To address this, we used single-sample gene-set enrichment analysis to score immune signatures of bone marrow (BM) samples from 176 patients with primary MDS. Read More

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September 2021

Prevalence of peripheral intravenous catheters and policy adherence: A point prevalence in a tertiary care university hospital.

J Clin Nurs 2021 Sep 17. Epub 2021 Sep 17.

Department of Nursing, Canterbury District Health Board, Christchurch, New Zealand.

Aims And Objectives: To determine prevalence and policy adherence for peripheral intravenous catheters (PIVC) in adult inpatients at a tertiary care university hospital (with about 83,000 inpatient admissions annually).

Background: Up to 80% of hospitalised patients receive intravenous therapy, most commonly via PIVCs. However, these devices are not risk-free. Read More

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September 2021

Efficacy and safety of closed-loop insulin delivery versus sensor-augmented pump in the treatment of adults with type 1 diabetes: a systematic review and meta-analysis of randomized-controlled trials.

J Endocrinol Invest 2021 Sep 17. Epub 2021 Sep 17.

Department of Thoracic Surgery, The Second Affiliated Hospital of Nanchang University, 1 Minde Road, Nanchang, 330006, China.

Background: Controversy remains regarding whether closed-loop (CL) insulin delivery or insulin sensor-augmented pump (SAP) delivery is more efficient for clinical treatment. Therefore, we aimed to compare the efficacy and safety of CL insulin delivery systems versus insulin SAP delivery for adults with type 1 diabetes (T1D).

Methods: Embase, Ovid MEDLINE, PubMed, ScienceDirect, Scopus, the Cochrane Library, and other databases were searched for related articles, and we analyzed the average blood glucose (BG), time in range (TIR), and adverse effects (AEs) as primary endpoints to evaluate efficacy and safety. Read More

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September 2021

[State of the art: fertility and pregnancy in rheumatic diseases].

Z Rheumatol 2021 Sep 17. Epub 2021 Sep 17.

Poliklinik für Rheumatologie und Hiller Forschungszentrum, Universitätsklinikum Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Deutschland.

Inflammatory rheumatic diseases often affect women of childbearing age, for whom pregnancy is still associated with increased risks. At the same time, we are gaining more and more insights into risk factors and preventive strategies, enabling almost all women to have successful pregnancies with few adverse outcomes. The cornerstones are planning of the pregnancy under effective disease control and the modification of individual risk factors. Read More

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September 2021

Continuing Medical Education Questions: February 2021.

Am J Gastroenterol 2021 Feb;116(2):242

Center for Digestive & Liver Health, Savannah, Georgia.

Article Title: The Role of Noninvasive Tests in Clinical Gastroenterology Practices to Identify Patients With Non-Alcoholic Steatohepatitis at High Risk for Adverse Outcomes: Expert Panel Recommendations. Read More

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February 2021

Overuse of Oral Corticosteroids, Underuse of Inhaled Corticosteroids, and Implications for Biologic Therapy in Asthma.

Respiration 2021 Sep 14:1-6. Epub 2021 Sep 14.

Department of Respiratory Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

Background: Asthma patients using high cumulative doses of oral corticosteroids (OCSs) are at risk of serious adverse events and are increasingly being treated with steroid-sparing asthma biologics. However, it is unknown whether prescribing these expensive biologics is always justified.

Objectives: This study aimed to (1) assess the prevalence of asthma patients using high cumulative doses of OCSs, (2) explore the role of suboptimal inhaler therapy, and (3) estimate the proportion of patients to whom asthma biologics might be prescribed unnecessarily. Read More

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September 2021

Multiple myeloma and malignant lesions: a potential risk factor for local anesthetic systemic toxicity.

Reg Anesth Pain Med 2021 Sep 17. Epub 2021 Sep 17.

Department of Anesthesiology and Perioperative Medicine, Mayo Clinic Arizona, Scottsdale, Arizona, USA.

Background: Multiple myeloma is a cancer of plasma cells that often leads to complications including osteolytic bone lesions, nephropathy and neuropathy. Multiple myeloma is only one etiology of many cancer pain conditions that may necessitate interventional pain treatment when refractory to multimodal medications. Notably, local anesthetic systemic toxicity is a rare but life-threatening complication of local anesthetic administered for these interventions. Read More

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September 2021

The United Kingdom Research study into Ethnicity And COVID-19 outcomes in Healthcare workers (UK-REACH): protocol for a prospective longitudinal cohort study of healthcare and ancillary workers in UK healthcare settings.

BMJ Open 2021 Sep 17;11(9):e050647. Epub 2021 Sep 17.

Department of Respiratory Sciences, University of Leicester, Leicester, UK

Introduction: The COVID-19 pandemic has resulted in significant morbidity and mortality and devastated economies globally. Among groups at increased risk are healthcare workers (HCWs) and ethnic minority groups. Emerging evidence suggests that HCWs from ethnic minority groups are at increased risk of adverse COVID-19-related outcomes. Read More

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September 2021

Effectiveness and safety of ivermectin in the treatment of COVID-19: protocol for a systematic review and meta-analysis.

BMJ Open 2021 Sep 17;11(9):e050532. Epub 2021 Sep 17.

Graduate Program in Sciences Applied to Women's Health, Maternidade Escola Januário Cicco (MEJC/EBSERH), Federal University of Rio Grande do Norte Health Sciences Center, Natal, Brazil.

Introduction: Ivermectin is a drug with antiviral properties and has been proposed as an alternative treatment for patients with COVID-19, in some countries; however, there is limited evidence to support its clinical use. Accordingly, the aim of this review and meta-analysis is to obtain superior evidence on the effectiveness and safety of ivermectin in treatment of COVID-19.

Methods And Analysis: We will search in the medical databases and International Clinical Trials Registry Platform databases for randomised clinical trials and quasi-randomised trials published from December 2019. Read More

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September 2021

Therapeutic ultrasound for knee osteoarthritis: A systematic review and meta-analysis with grade quality assessment.

Braz J Phys Ther 2021 Sep 9. Epub 2021 Sep 9.

Center for Treatment Comparison and Integrative Analysis, Division of Rheumatology, Tufts Medical Center, Boston, MA, USA; Center for Complementary and Integrative Medicine, Division of Rheumatology, Tufts Medical Center, Boston, MA, USA. Electronic address:

Background: Therapeutic ultrasound (US) is a widely used intervention in physical therapy to manage pain and to aid in the healing of soft tissue.

Objective: This systematic review aimed to determine the effects of therapeutic US on knee osteoarthritis (KOA) symptoms.

Methods: PubMed, MEDLINE, EMBASE, Google Scholar, and the Cochrane databases were searched from inception to April 2019. Read More

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September 2021

Predicting mortality in intensive care unit patients infected with Klebsiella pneumoniae: A retrospective cohort study.

J Infect Chemother 2021 Sep 14. Epub 2021 Sep 14.

Department of Family Medicine & Population Health (FAMPOP), University of Antwerp, Antwerp, Belgium; Vaccine & Infectious Disease Institute (VAXINFECTIO), University of Antwerp, Antwerp, Belgium.

Introduction: Although several models to predict intensive care unit (ICU) mortality are available, their performance decreases in certain subpopulations because specific factors are not included. Moreover, these models often involve complex techniques and are not applicable in low-resource settings. We developed a prediction model and simplified risk score to predict 14-day mortality in ICU patients infected with Klebsiella pneumoniae. Read More

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September 2021

The impact of COVID-19 on diet quality, food security and nutrition in low and middle income countries: A systematic review of the evidence.

Clin Nutr 2021 Aug 27. Epub 2021 Aug 27.

Ghent University, Faculty of Bioscience Engineering, Department of Food Technology, Safety and Health, Belgium; University of Namur, Faculty of Medicine, Department of Medicine, Belgium.

Background & Aims: The current global pandemic of Coronavirus (COVID-19), and measures adopted to reduce its spread, threaten the nutritional status of populations in Low- and middle-income countries (LMICs). Documenting how the COVID-19 affects diets, nutrition and food security can help generating evidence-informed recommendations for mitigating interventions and policies.

Methods: We carried out a systematic literature review. Read More

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Low COVID-19 vaccine hesitancy in Brazil.

Vaccine 2021 Sep 7. Epub 2021 Sep 7.

National Institute of Women, Children and Adolescents' Health Fernandes Figueira, FIOCRUZ, Avenue Rui Barbosa, 716, Flamengo, Rio de Janeio, RJ 22250-020, Brazil.

Background: The COVID-19 pandemic has affected the entire world, and the vaccine has emerged as a source of hope for return to normal life. Still, various countries have reported high vaccine hesitancy rates. It is important to know the vaccine hesitancy profile in Brazil to help design adequate communication strategies. Read More

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September 2021

Can I Send This Syncope Patient Home From the Emergency Department?

J Emerg Med 2021 Sep 14. Epub 2021 Sep 14.

Department of Emergency Medicine, University of Maryland School of Medicine, Baltimore, Maryland.

Background: Syncope is a common presentation to the emergency department (ED). A significant minority of these patients have potentially life-threatening pathology. Reliably identifying that patients require hospital admission for further workup and intervention is imperative. Read More

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September 2021

Effects of Hydroxychloroquine on endOthelial function in eLDerly with sleep apnea (HOLD): study protocol for a randomized clinical trial.

Trials 2021 Sep 17;22(1):638. Epub 2021 Sep 17.

Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.

Background: Sleep apnea and coronary artery disease are prevalent and relevant diseases. The mechanism by which sleep apnea leads to coronary artery disease remains unclear. Intermittent hypoxia, caused by sleep apnea, leads to inflammation and consequent endothelial dysfunction. Read More

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September 2021

The role of postoperative radiotherapy in pN1 oral cavity cancer without extranodal extension.

World J Surg Oncol 2021 Sep 17;19(1):279. Epub 2021 Sep 17.

Department of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Kwei-Shan, Taoyuan, Taiwan.

Background: The administration of postoperative radiotherapy remains controversial in pN1 oral cavity cancer patients without extranodal extension. The aim is to determine whether postoperative radiotherapy reduces the neck recurrence rate and improves the survival outcomes of pN1 patients.

Methods: This study consecutively enrolled 1056 patients with newly diagnosed oral squamous cell carcinoma who underwent tumor wide excision and neck dissection from September 2002 to November 2019. Read More

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September 2021

A Clinically Applicable Gene Expression based Score predicts Resistance to Induction Treatment in Acute Myeloid Leukemia.

Blood Adv 2021 Sep 17. Epub 2021 Sep 17.

Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Center for Environmental Health (HMGU), Germany.

Prediction of resistant disease at initial diagnosis of acute myeloid leukemia (AML) can be achieved with high accuracy by using cytogenetic data and 29 gene expression markers (PS29MRC). Our aim was to establish PS29MRC as a clinically usable assay by using the widely implemented NanoString platform and further validate the classifier in a more recently treated patient cohort. 351 patients with newly diagnosed AML intensively treated within the AMLCG registry were analyzed. Read More

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September 2021

Comparison of Triple-Rule-Out Prospectively ECG-triggered Systolic and Diastolic Acquisition Protocol in Patients With Acute Chest Pain.

J Thorac Imaging 2021 Sep 17. Epub 2021 Sep 17.

Department of Radiology, Santa Maria di Ca' Foncello Hospital, Treviso Department of Radiological, Oncological and Pathological Science, Sant'Andrea Hospital, "La Sapienza" University of Rome, Rome Department of Medicine-DIMED, Institute of Radiology, University of Padova, Padua, Italy.

Purpose: The purpose of this study was to compare image quality and coronary interpretability of triple-rule-out systolic and diastolic protocols in patients with acute chest pain.

Materials And Methods: From March 2016 to October 2017 the authors prospectively enrolled patients with undifferentiated acute chest pain, who were at low to intermediate cardiovascular risk. Those with heart rate >75 bpm underwent a systolic prospectively triggered acquisition (systolic triggering [ST]), and in those with ≤75 bpm, end-diastolic triggering (DT) was instead performed. Read More

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September 2021

Outdoor thermal stress changes in South Korea: Increasing inter-annual variability induced by different trends of heat and cold stresses.

Sci Total Environ 2021 Sep 4;805:150132. Epub 2021 Sep 4.

High Impact Weather Research Department, National Institute of Meteorological Sciences, South Korea. Electronic address:

Changes of thermal environment can lead to unfavorable impacts such as a decrease of thermal stratification, increase of energy consumption, and increase of thermal health risk. Investigating changes in outdoor thermal environments can provide meaningful information for addressing economic and social issues and related challenges. In this study, thermal environment changes in South Korea were investigated using a nonstationary two-component Gaussian mixture model (NSGMM) for air temperature and two thermal comfort indices. Read More

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September 2021

Plasma and genetic determinants of soluble TREM-1 and major adverse cardiovascular events in a prospective cohort of acute myocardial infarction patients. Results from the FAST-MI 2010 study.

Int J Cardiol 2021 Sep 14. Epub 2021 Sep 14.

Sorbonne Université, Université Pierre et Marie Curie site St Antoine, F-75012 Paris, France; FACT (French Alliance for CV clinical Trials), F-CRIN Network, Inserm U-1148, Paris, France; Hôpitaux de Paris, Clinical Pharmacology Department, Plateforme de Recherche Clinique de L'Est Parisien (URCEST-CRCEST-CRBHUEP-SU), Hôpital Saint Antoine, Paris, France.

Introduction: Triggering receptor expressing on myeloid cells (TREM)-1 is involved in the pathophysiology of ischemic heart disease. Plasma soluble TREM-1 levels (sTREM-1) has been associated with increased risk of major adverse cardiovascular events (MACE) in acute myocardial infarction (AMI) patients. However, the causative link between TREM-1 and MACE remains unknown and requires further investigation before developing potential therapeutic approaches. Read More

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September 2021

The Cardiac Effects of COVID-19 Review of articles.

Curr Probl Cardiol 2021 Sep 14:100981. Epub 2021 Sep 14.

Cardiovascular Research Center of Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Cardiovascular wellbeing has been dramatically affected by SARS-CoV-2, the reason for the COVID-19 pandemic. There is a greater risk of morbidity and death in individuals with preexisting heart diseases. Clinical syndromes of the acute coronary syndrome, acute myocardial injury, myocarditis, arrhythmias, heart failure, and venous thromboembolism can, directly and indirectly, affect the heart. Read More

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September 2021