1,412,503 results match your criteria risk factors


Identification of distinct clinical subphenotypes in critically ill patients with COVID-19.

Chest 2021 May 5. Epub 2021 May 5.

Center for Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; Pulmonary, Allergy and Critical Care Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

Background: Subphenotypes have been identified in patients with sepsis and acute respiratory distress syndrome (ARDS), and are associated with different outcomes and response to therapies.

Research Question: Can unique subphenotypes be identified among critically ill patients with coronavirus disease 2019 (COVID-19)?

Study Design: & Methods: Using data from a multicenter cohort study that enrolled critically ill patients with COVID-19 from 67 hospitals across the United States, we randomly divided centers into Discovery and Replication cohorts. We utilized latent class analysis independently in each cohort to identify subphenotypes based on clinical and laboratory variables. Read More

View Article and Full-Text PDF

Regional Variation in Treatment for Highest-Risk Patients with Non-Small Cell Lung Cancer Patients.

Ann Thorac Surg 2021 May 5. Epub 2021 May 5.

Division of Thoracic Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA. Electronic address:

Background: Non-small cell lung cancer (NSCLC) patients with multiple high-risk socioeconomic factors experience treatment and survival disparities. We aim to assess whether disparities in treatment and survival vary by region for patients with three or more high-risk socioeconomic factors.

Methods: The National Cancer Database was queried for patients with clinical stage I-IIA NSCLC diagnosed between 2010-2015. Read More

View Article and Full-Text PDF

3-month, 6-month, 9-month, and 12-month respiratory outcomes in patients following COVID-19-related hospitalisation: a prospective study.

Lancet Respir Med 2021 May 5. Epub 2021 May 5.

Biological Sciences, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, UK; Institute for Life Sciences, University of Southampton, Southampton, UK; NIHR Southampton Biomedical Research Centre, University Hospital Southampton, Southampton, UK. Electronic address:

Background: The consequences of COVID-19 in those who recover from acute infection requiring hospitalisation have yet to be clearly defined. We aimed to describe the temporal trends in respiratory outcomes over 12 months in patients hospitalised for severe COVID-19 and to investigate the associated risk factors.

Methods: In this prospective, longitudinal, cohort study, patients admitted to hospital for severe COVID-19 who did not require mechanical ventilation were prospectively followed up at 3 months, 6 months, 9 months, and 12 months after discharge from Renmin Hospital of Wuhan University, Wuhan, China. Read More

View Article and Full-Text PDF

Outcomes of rotational atherectomy for severely calcified coronary lesions: A single center 5-year experience.

Catheter Cardiovasc Interv 2021 May 8. Epub 2021 May 8.

Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, China.

Objectives: The aim of this study was to investigate the influences of accumulated experience on rotational atherectomy (RA) operation regarding to in-hospital outcomes in the drug-eluting stent (DES) era.

Methods: Between 2015 and 2019, 540 de novo lesions with calcified coronary lesions treated by RA and DES implantation at our center were retrospectively assessed. In-hospital major adverse cardiac events (MACE) were defined as all cause death, cardiac death, target vessel revascularization, and stroke. Read More

View Article and Full-Text PDF

Correlates of memory and executive function in mid-aged and older adults in the CLSA: A minority stress approach.

J Gerontol B Psychol Sci Soc Sci 2021 May 8. Epub 2021 May 8.

School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada.

Objectives: Maintaining cognitive function is an important component of healthy aging. There is increasing recognition that extraneous factors expedite the typical cognitive aging process. Risk factors for cognitive decline cluster around inequalities and disproportionally affect minority and vulnerable groups. Read More

View Article and Full-Text PDF

Plasma HDL cholesterol and risk of dementia - observational and genetic studies.

Cardiovasc Res 2021 May 8. Epub 2021 May 8.

Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, 2100 Copenhagen, Denmark.

Aims: The association of plasma high-density lipoprotein (HDL) cholesterol with risk of dementia is unclear. We therefore tested the hypothesis that high levels of plasma HDL cholesterol are associated with increased risk of dementia and whether a potential association is of a causal nature.

Methods And Results: In two prospective population-based studies, the Copenhagen General Population Study and the Copenhagen City Heart Study (N = 111,984 individuals), we first tested whether high plasma HDL cholesterol is associated with increased risk of any dementia and its subtypes. Read More

View Article and Full-Text PDF

Elevated serum tyrosine concentration is associated with a poor prognosis among patients with liver cirrhosis.

Hepatol Res 2021 May 8. Epub 2021 May 8.

Department of Gastroenterology and Hepatology, Juntendo University Shizuoka Hospital, Shizuoka, Japan.

Aim: Chronic liver insufficiency is often associated with changes in amino acid metabolism. We evaluated whether change in serum amino acid concentrations had prognostic value among patients with liver cirrhosis.

Methods: This retrospective study evaluated 158 patients who had been hospitalized with cirrhosis. Read More

View Article and Full-Text PDF

Association with clinic risk factors of Percheron artery infarction and magnetic resonance imaging involvement patterns.

Acta Neurol Belg 2021 May 8. Epub 2021 May 8.

Department of Radiology, Medical Faculty, Ataturk University, Erzurum, Turkey.

Radiological imaging is important in the diagnosis of the artery of Percheron (AOP) infarction. This study aimed to discuss the magnetic resonance imaging (MRI) findings of this abnormal variant of arterial supply. Patients who presented to our hospital with stroke symptoms between 2010 and 2019 and underwent brain MRI were evaluated retrospectively. Read More

View Article and Full-Text PDF

Management of oxidative stress and inflammation in cardiovascular diseases: mechanisms and challenges.

Environ Sci Pollut Res Int 2021 May 8. Epub 2021 May 8.

Biochemistry Division, Chemistry Department, Faculty of Science, Tanta University, Tanta, Egypt.

Cardiovascular diseases (CVDs) have diverse physiopathological mechanisms with interconnected oxidative stress and inflammation as one of the common etiologies which result in the onset and development of atherosclerotic plaques. In this review, we illustrate this strong crosstalk between oxidative stress, inflammation, and CVD. Also, mitochondrial functions underlying this crosstalk, and various approaches for the prevention of redox/inflammatory biological impacts will be illustrated. Read More

View Article and Full-Text PDF

Impact of Housing Instability and Social Risk Factors on Food Insecurity Among Vulnerable Residents in San Diego County.

J Community Health 2021 May 8. Epub 2021 May 8.

San Diego State University, 5500 Campanile Dr, San Diego, CA, 92182, USA.

To analyze the impact of housing instability and social risk facts on food insecurity using resource center client information. We utilized 2-1-1 San Diego's client database to analyze the association of food insecurity and housing instability among residents from August 2017 to March 2020. 3468 clients had food or housing needs assessed by a risk rating scale. Read More

View Article and Full-Text PDF

Weight Loss Results and Compliance with Follow-up after Bariatric Surgery.

Obes Surg 2021 May 8. Epub 2021 May 8.

Department of Bariatric Surgery, Spaarne Gasthuis, Haarlem, the Netherlands.

Purpose: The importance of follow-up (FU) for midterm weight loss (WL) after bariatric surgery is controversial. Compliance to this FU remains challenging. Several risk factors for loss to FU (LtFU) have been mentioned. Read More

View Article and Full-Text PDF

Genotype-phenotype correlations of heterozygous HTRA1-related cerebral small vessel disease: case report and systematic review.

Neurogenetics 2021 May 8. Epub 2021 May 8.

Department of Nephrology, Henan Provincial Key Laboratory of Kidney Disease and Immunology, Zhengzhou University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, 450003, Henan, China.

Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL) is caused by biallelic HTRA1 pathogenic variants. Recent studies have shown that heterozygous HTRA1 mutations are associated with autosomal dominant cerebral small vessel disease (CSVD). However, large studies evaluating heterozygous HTRA1 carriers are lacking and the genotype-phenotype correlation is unknown. Read More

View Article and Full-Text PDF

Colistin resistance increases 28-day mortality in bloodstream infections due to carbapenem-resistant Klebsiella pneumoniae.

Eur J Clin Microbiol Infect Dis 2021 May 8. Epub 2021 May 8.

Istanbul Universitesi-Cerrahpasa, Cerrahpasa Faculty of Medicine, Cerrahpasa Tip Fakultesi, İstanbul, Turkey.

Mortality due to K. pneumoniae bacteremia is on rise, particularly in regions with high rates of carbapenem and colistin resistance. We aimed to define risk factors for colistin resistance and its impact on mortality. Read More

View Article and Full-Text PDF

Inter-eye relationship of intraocular pressure change after unilateral trabeculectomy, filtering canaloplasty, or PreserFlo™ microshunt implantation.

Graefes Arch Clin Exp Ophthalmol 2021 May 8. Epub 2021 May 8.

Department of Ophthalmology, University Medical Center of the Johannes Gutenberg University Mainz, Langenbeckstraße 1, 55131, Mainz, Germany.

Purpose: This study assesses short-term intraocular pressure (IOP) change in the fellow eye of glaucoma patients after mitomycin C-augmented trabeculectomy, filtering canaloplasty, or PreserFlo™ microshunt implantation in the treated eye.

Materials And Methods: Retrospective chart review of 235 glaucoma patients (235 eyes) was performed. Patients underwent initial trabeculectomy (187 patients), filtering canaloplasty (25 patients), or PreserFlo™ microshunt implantation (23 patients) in one eye, while the fellow eye was naïve to any previous glaucoma surgery. Read More

View Article and Full-Text PDF

Quality of life and lung function after pleurectomy/decortication for malignant pleural mesothelioma.

Interact Cardiovasc Thorac Surg 2021 May 8. Epub 2021 May 8.

Department of Thoracic Surgery, Hyogo College of Medicine, Hyogo, Japan.

Objectives: Impact of pleurectomy/decortication (P/D) on quality of life (QOL) is not widely reported. We investigated QOL and lung function after P/D.

Methods: A single-centre, retrospective cohort study was performed among patients who underwent P/D for malignant mesothelioma between June 2014 and June 2018 at Hyogo College of Medicine. Read More

View Article and Full-Text PDF

Influence of childhood asthma on dental caries: A longitudinal study.

Clin Exp Dent Res 2021 May 8. Epub 2021 May 8.

Department of Dental Diseases and Endodontology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.

Objectives: The study investigated the influence of childhood asthma on dental caries development and caries risk factors among children with asthma in Slovenia.

Material And Methods: The study population consisted of 2-17 years old children (n = 138), who had used anti-asthmatic medicines for at least 1 year. Controls were their non-asthmatic siblings (n = 140). Read More

View Article and Full-Text PDF

Epinephrine administration in venoarterial extracorporeal membrane oxygenation patients is associated with mortality: a retrospective cohort study.

ESC Heart Fail 2021 May 8. Epub 2021 May 8.

Department of Anesthesia and Critical Care, Pontchaillou, University Hospital of Rennes, Rennes, France.

Aims: Knowledge about the impact of epinephrine on the outcome in venoarterial (VA) extracorporeal membrane oxygenation (ECMO) patients is limited, and existing data are conflicting.

Methods And Results: We conducted a retrospective cohort study in a 1500 bed tertiary university hospital. Five hundred and eighty-nine VA-ECMO patients were analysed. Read More

View Article and Full-Text PDF

Early initiation of antiretroviral therapy following in utero HIV infection is associated with low viral reservoirs but other factors determine subsequent plasma viral rebound.

J Infect Dis 2021 May 8. Epub 2021 May 8.

HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.

Background: Early HIV diagnosis allows combination antiretroviral therapy (cART) initiation in the first days of life following in utero (IU) infection. The impact of early cART initiation on infant viral reservoir size in the setting of high-frequency cART non-adherence is unknown.

Methods: Peripheral blood total HIV DNA from 164 early treated (day 0-21 of life) IU HIV-infected South African infants was measured using droplet digital PCR at birth and following suppressive cART. Read More

View Article and Full-Text PDF

Dietary patterns and risk of nasopharyngeal carcinoma: a population-based case-control study in southern China.

Am J Clin Nutr 2021 May 8. Epub 2021 May 8.

Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.

Background: Dietary factors, such as consumption of preserved foods, fresh vegetables, and fruits, have been linked to the risk of nasopharyngeal carcinoma (NPC). However, little is known about associations between dietary patterns and the risk of NPC in NPC-endemic areas.

Objectives: We aimed to evaluate whether dietary patterns are associated with NPC risk. Read More

View Article and Full-Text PDF

Habitual flavonoid intake and ischemic stroke incidence in the Danish Diet, Cancer, and Health Cohort.

Am J Clin Nutr 2021 May 8. Epub 2021 May 8.

School of Biomedical Sciences, University of Western Australia, Royal Perth Hospital, Perth, Australia.

Background: Flavonoid-rich foods have antiinflammatory, antiatherogenic, and antithrombotic properties that may contribute to a lower risk of ischemic stroke.

Objectives: We aimed to investigate the relationship between habitual flavonoid consumption and incidence of ischemic stroke in participants from the Danish Diet, Cancer and Health Study.

Design: In this prospective cohort study, 55,169 Danish residents without a prior ischemic stroke [median (IQR) age at enrolment of 56 y (52-60)], were followed for 21 y (20-22). Read More

View Article and Full-Text PDF

Treating high-risk moderate acute malnutrition using therapeutic food compared with nutrition counseling (Hi-MAM Study): a cluster-randomized controlled trial.

Am J Clin Nutr 2021 May 8. Epub 2021 May 8.

Project Peanut Butter, Freetown, Sierra Leone.

Background: There is a lack of consensus on what is the most appropriate treatment of moderate acute malnutrition (MAM).

Objectives: We aimed to determine if provision of ready-to-use-therapeutic food (RUTF) and antibiotics to "high-risk" MAM (HR-MAM) children in addition to nutritional counseling would result in higher recovery and less deterioration than nutrition counseling alone.

Methods: At the 11 intervention clinics, HR-MAM children were given RUTF and amoxicillin along with standard nutrition counseling, for 2-12 wk. Read More

View Article and Full-Text PDF

[Establishment of naive Bayes classifier-based risk prediction model for chemotherapyinduced nausea and vomiting].

Authors:
Z Cao X Xiong Q Yang

Nan Fang Yi Ke Da Xue Xue Bao 2021 Apr;41(4):607-612

Clinical Nursing Teaching and Research Section of the Second XiangYa Hospital of Central South University, Changsha 410011, China.

Objective: To establish a risk prediction model of chemotherapy-induced nausea and vomiting based on naive Bayes classifier.

Objective: We collected the basic information, treatment protocols and follow-up data from 300 patients receiving chemotherapy in the Oncology Department of Second Xiangya Hospital from July to September, 2020. Correlation analysis was carried out between the potential factors related to nausea and vomiting in the treatment plan and the individual characteristics of the patients. Read More

View Article and Full-Text PDF

Use of a Tumor Bed Boost in the Radiotherapy after Oncoplastic Breast Conserving Surgery.

Chirurgia (Bucur) 2021 Mar-Apr;116(2 Suppl):110-119

Aim Of The Study: Use of a radiotherapy (RT) tumor bed boost in addition to whole breast irradiation (WBI) after oncoplastic breast conserving surgery (OBCS) can be very challenging due to the massive tissue displacements. The aim of our study is to present relevant RT data regarding the use of a boost RT in patients who underwent OBCS and received adjuvant RT at Neolife Medical Center Bucharest. 12 patients treated with intensity modulated radiotherapy (IMRT), after OBCS, using conventional or hypofractionated schedules, between 10/2018 and 12/2020 were included in the study. Read More

View Article and Full-Text PDF

Contralateral Prophylactic Mastectomy in Patients with Breast Cancer.

Chirurgia (Bucur) 2021 Mar-Apr;116(2 Suppl):73-83

The rate of contralateral prophylactic mastectomy (CPM) increased within the recent years. The main reasons are: genetic testing, availability of breast reconstruction, more often use of preoperative breast MRI, improvement of postoperative aesthetic results and reimbursement of breast reconstruction. The purpose of this study was to analyze the indication of CPM, it's evolution and the surgical techniques used for this type of surgery. Read More

View Article and Full-Text PDF

Risk Factor Analysis for Flap and Donor Site Related Complications in 1274 DIEP Flaps - Retrospective Single Center Study.

Chirurgia (Bucur) 2021 Mar-Apr;116(2 Suppl):5-15

Breast cancer is the most common cancer affecting women worldwide. In Germany, in almost 70% of cases, women require a complete mastectomy and wish for breast reconstruction which is especially difficult when the breast was previously irradiated. The DIEP flap is then the gold standard for autologous breast reconstruction and shows an overall low complication rate. Read More

View Article and Full-Text PDF

Post-Liver Transplant Acute Kidney Injury.

Liver Transpl 2021 May 8. Epub 2021 May 8.

Division of Gastroenterology (Liver Unit), University of Alberta, Edmonton, Canada.

Acute kidney injury (AKI) is a common condition following liver transplantation (LT). It negatively impacts patient outcomes by increasing the chances of developing chronic kidney disease (CKD) and reducing graft and patient survival. Multiple definitions of AKI have been proposed and utilized throughout the years with the International Club of Ascites (ICA) definition being the most widely used now for cirrhosis patients. Read More

View Article and Full-Text PDF

Predicting QT interval prolongation in patients diagnosed with the 2019 novel coronavirus infection.

Ann Noninvasive Electrocardiol 2021 May 7:e12853. Epub 2021 May 7.

Department of Internal Medicine, Ascension St. John Hospital, Detroit, MI, USA.

Introduction: 2019 novel coronavirus (COVID-19) patients frequently develop QT interval prolongation that predisposes them to Torsades de Pointes and sudden cardiac death. Continuous cardiac monitoring has been recommended for any COVID-19 patient with a Tisdale Score of seven or more. This recommendation, however, has not been validated. Read More

View Article and Full-Text PDF

Neighborhood Poverty and Incident Heart Failure: an Analysis of Electronic Health Records from 2005 to 2018.

J Gen Intern Med 2021 May 7. Epub 2021 May 7.

Department of Preventive Medicine, Northwestern University, Chicago, IL, USA.

Background: Neighborhood-level characteristics, such as poverty, have been associated with risk factors for heart failure (HF), including hypertension and diabetes mellitus. However, the independent association between neighborhood poverty and incident HF remains understudied.

Objective: To evaluate the association between neighborhood poverty and incident HF using a "real-world" clinical cohort. Read More

View Article and Full-Text PDF

Applicability of the PAINESD risk score for 30-day mortality prediction post ventricular tachycardia catheter ablation in Chagas disease.

J Interv Card Electrophysiol 2021 May 8. Epub 2021 May 8.

Instituto do Coração FMUSP, São Paulo, Brazil.

Purpose: The PAINESD risk score was developed in 2015 as a tool to stratify the risk of acute hemodynamic decompensation during ventricular tachycardia (VT) ablation in structural heart disease patients and further then used for post procedure 30-day mortality prediction. The original cohort however did not include Chagas disease (ChD) patients. We aim to evaluate the relevance of the score in a ChD population. Read More

View Article and Full-Text PDF

Haematological and biochemical abnormalities in hunting dogs infected with Acanthocheilonema reconditum, associated risk factors, and a European overview.

Parasitol Res 2021 May 8. Epub 2021 May 8.

Department of Veterinary Medicine and Animal Productions, Università degli Studi di Napoli "Federico II", Via F. Delpino 1, 80137, Naples, Italy.

Acanthocheilonema reconditum is a filarial parasite transmitted by arthropods (fleas, lice, and ticks) that infect dogs. There is minimal published data available to date on potential haematological and biochemical changes associated with this parasitic infection. Study aims were (i) provide an overview of A. Read More

View Article and Full-Text PDF