3,678 results match your criteria ring-opening polymerization

Ultrasensitive electrochemical detection of CYFRA 21-1 via in-situ initiated ROP signal amplification strategy.

Anal Chim Acta 2021 Oct 27;1180:338889. Epub 2021 Jul 27.

Department of Endocrinology, The First Affiliated Hospital, Henan University of Chinese Medicine, Zhengzhou, 450000, PR China. Electronic address:

The cytokeratin19 fragment (CYFRA 21-1) is an essential biomarker for non-small cell lung cancer (NSCLC). This work proposed a novel electrochemical immunosensor with a high selective and sensitive detection of CYFRA 21-1via the ring-opening polymerization (ROP) signal amplification strategy. Specifically, 3-mercaptopropionic (MPA) was employed as a cross-linking agent to immobilize cAb on the electrode surface for subsequent specific capture of CYFRA 21-1. Read More

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October 2021

Elucidating the anticancer activities of guanidinium-functionalized amphiphilic random copolymers by varying the structure and composition in the hydrophobic monomer.

Theranostics 2021 21;11(18):8977-8992. Epub 2021 Aug 21.

Institute of Bioengineering and Bioimaging, 31 Biopolis Way, The Nanos, Singapore 138669, Singapore.

Use of traditional anticancer chemotherapeutics has been hindered by the multifactorial nature of multi-drug resistance (MDR) development and metastasis. Recently, cationic polycarbonates were reported as novel unconventional anticancer agents that mitigated MDR and inhibited metastasis. The aim of this study is to explore structure-anticancer activity relationship. Read More

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Design and construction of a hydrophilic coating on macroporous adsorbent resins for enrichment of glycopeptides.

Anal Methods 2021 Sep 13. Epub 2021 Sep 13.

School of Chemistry and Chemical Engineering, Key Laboratory for Chemical Engineering and Technology, State Ethnic Affairs Commission, North Minzu University, Yinchuan, 750021, China.

Although macroporous adsorbent resins (MARs) have been commercialized and widely applied in industrial and life fields, it is still of necessity to develop simple approaches to functionalize MARs. One of the most widely used methods to realize excellent fouling resistance performance is surface modification of hydrophilic polymers on substrates to fabricate an anti-biofouling coating. Herein, three kinds of hydrophilic poly(glycidyl methacrylate--ethylene glycol dimethacrylate) MAR were designed and facilely prepared by coating a layer of porous organic polymers (POPs) either an epoxy-amine ring-opening polymerization or amine-aldehyde condensation reaction using isophthalaldehyde (IPA), 1,4,7,10-tetraazacyclododecane (cyclen), melamine and 1,3,5-triglycidyl isocyanurate (TGIC) as precursors. Read More

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September 2021

Tuning Net Charge in Aliphatic Polycarbonates Alters Solubility and Protein Complexation Behavior.

ACS Omega 2021 Sep 26;6(35):22589-22602. Epub 2021 Aug 26.

Materials Science and Engineering Division, Material Measurement Laboratory, National Institute of Standards and Technology, 100 Bureau Drive, Gaithersburg, Maryland 20899, United States.

A synthetic strategy yielded polyelectrolytes and polyampholytes with tunable net charge for complexation and protein binding. Organocatalytic ring-opening polymerizations yielded aliphatic polycarbonates that were functionalized with both carboxylate and ammonium side chains in a post-polymerization, radical-mediated thiol-ene reaction. Incorporating net charge into the polymer architecture altered the chain dimensions in phosphate buffered solution in a manner consistent with self-complexation and complexation behavior with model proteins. Read More

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September 2021

Development of Biodegradable Polymer Blends Based on Chitosan and Polylactide and Study of Their Properties.

Materials (Basel) 2021 Aug 28;14(17). Epub 2021 Aug 28.

Chemistry Department, National Research Lobachevsky State University of Nizhny Novgorod, 23 Gagarin Ave, 603022 Nizhny Novgorod, Russia.

Composite materials of various compositions based on chitosan and polylactide were obtained in the form of films or porous bulk samples. Preliminarily, poly-d,l-lactide was synthesized by ring-opening polymerization of lactide in the presence of Ti(OPr). Polylactide obtained at components molar ratio [lactide]:[Ti(OPr)] = 3:1 had the best molecular weight characteristics at a high product yield. Read More

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Overcoming the Low Driving Force in Forming Depolymerizable Polymers through Monomer Isomerization.

Angew Chem Int Ed Engl 2021 Sep 9. Epub 2021 Sep 9.

University of Akron, School of Polymer Science and Polymer Engineering, 170 University Ave., GDYR 529, 44325, Akron, UNITED STATES.

While depolymerizable polymers have been intensely pursued as a potential solution to address the challenges in polymer sustainability, most depolymerization systems are characterized by a low driving force in polymerization, which poses difficulties for accessing diverse functionalities and architectures of polymers. Here, we address this challenge by using a cyclooctene-based depolymerization system, in which the cis -to- trans alkene isomerization significantly increases the ring strain energy to enable living ring-opening metathesis polymerization at monomer concentrations ≥ 0.025 M. Read More

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September 2021

The Green toxicology approach: Insight towards the eco-toxicologically safe development of benign catalysts.

J Hazard Mater 2021 08 15;416:125889. Epub 2021 Apr 15.

Department of Evolutionary Ecology and Environmental Toxicology, Goethe University Frankfurt, Max-von-Laue-Str. 13, 60438 Frankfurt am Main, Germany; Department of Ecosystem Analysis, Institute for Environmental Research, ABBt - Aachen Biology and Biotechnology, RWTH Aachen University, Worringerweg 1, 52074 Aachen, Germany; LOEWE Centre for Translational Biodiversity Genomics (LOEWE-TBG), 60325 Frankfurt am Main, Germany. Electronic address:

Green toxicology is a novel approach increasingly applied for the development of materials and chemicals that are more benign to the environment and human health than their conventional counterparts. It includes predictive eco-toxicological assessments of chemicals during the early developmental process to exclude adverse effects. In the present study, two guanidine zinc catalysts for the ring-opening polymerization of lactide were investigated using eco-toxicological tools. Read More

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Unique Carbonate-Based Single Ion Conducting Block Copolymers Enabling High-Voltage, All-Solid-State Lithium Metal Batteries.

Macromolecules 2021 Jul 14;54(14):6911-6924. Epub 2021 Jul 14.

GAME Lab, Department of Applied Science and Technology (DISAT), Politecnico di Torino, Corso Duca degli Abruzzi 24, Torino 10129, Italy.

Safety and high-voltage operation are key metrics for advanced, solid-state energy storage devices to power low- or zero-emission HEV or EV vehicles. In this study, we propose the modification of single-ion conducting polyelectrolytes by designing novel block copolymers, which combine one block responsible for high ionic conductivity and the second block for improved mechanical properties and outstanding electrochemical stability. To synthesize such block copolymers, the ring opening polymerization (ROP) of trimethylene carbonate (TMC) monomer by the RAFT-agent having a terminal hydroxyl group is used. Read More

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A GAP Replacement: Improved Synthesis of 3-Azidooxetane and Its Homopolymer Based on Sulfonic Acid Esters of Oxetan-3-ol.

J Org Chem 2021 Sep 1;86(18):12607-12614. Epub 2021 Sep 1.

Department of Chemistry and Biochemistry, Energetic Materials Research, Ludwig-Maximilian University, Butenandtstrasse 5-13 (D), 81377 Munich, Germany.

In the field of energetic binders, only hydroxy-terminated glycidyl azide polymer (GAP) has found widespread application and prevailed in the market. However, oxiranes such as glycidyl azide (GA) allow two ring-opening modes during polymerization and thus lead to polymers of different termination causing inhomogeneous curing results. An elegant solution is the polymerization of 3-azidooxetane as only terminating primary hydroxyl groups are formed. Read More

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September 2021

Crucial Impact of Residue Chirality on the Gelation Process and Biodegradability of Thermoresponsive Polypeptide Hydrogels.

Biomacromolecules 2021 Sep 17;22(9):3992-4003. Epub 2021 Aug 17.

CAS Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, Jilin, P. R. China.

Thermosensitive polypeptide hydrogels have gained considerable attention in potential biomedical applications, of which the polymer structure may be tuned by residue chirality. In this study, polypeptide-based block copolymers with different chiralities were synthesized by ring-opening polymerization of γ-ethyl-l-glutamate -carboxyanhydride and/or γ-ethyl-d-glutamate -carboxyanhydride using amino-terminated monomethoxy poly(ethylene glycol) as a macroinitiator. All mPEG-polypeptide copolymers underwent sol-gel transition with an increase in temperature. Read More

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September 2021

Polyether-Based Diblock Terpolymer Micelles with Pendant Anthracene Units-Light-Induced Crosslinking and Limitations Regarding Reversibility.

Macromol Rapid Commun 2021 Aug 31:e2100485. Epub 2021 Aug 31.

Institute of Organic Chemistry and Macromolecular Chemistry, Friedrich Schiller University Jena, Humboldtstraße 10, Jena, D-07743, Germany.

The synthesis of 9-methylanthracenyl glycidyl ether (AnthGE) as a crosslinkable monomer that can be applied in anionic ring opening polymerization is reported. Diblock terpolymers of the composition methoxy-poly(ethylene oxide)-block-poly(2-ethylhexyl glycidyl ether-co-9-methylanthracenyl glycidyl ether) (mPEO-b-P(EHGE-co-AnthGE) with 10 to 24 wt% of AnthGE are synthesized and characterized. Their micellization behavior, as well as their light-induced core-crosslinking via irradiation with UV light (λ = 365 nm) is studied. Read More

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Poly(butylene succinate--ε-caprolactone) Copolyesters: Enzymatic Synthesis in Bulk and Thermal Properties.

Polymers (Basel) 2021 Aug 11;13(16). Epub 2021 Aug 11.

Departament d'Enginyeria Química, Universitat Politècnica de Catalunya, ETSEIB, Diagonal 647, 08028 Barcelona, Spain.

This work explores for the first time the enzymatic synthesis of poly(butylene--ε-caprolactone) (PBSCL) copolyesters in bulk using commercially available monomers (dimethyl succinate (DMS), 1,4-butanediol (BD), and ε-caprolactone (CL)). A preliminary kinetic study was carried out which demonstrated the higher reactivity of DMS over CL in the condensation/ring opening polymerization reaction, catalyzed by lipase B. PBSCL copolyesters were obtained with high molecular weights and a random microstructure, as determined by C NMR. Read More

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Aminated Graphene-Graft-Oligo(Glutamic Acid) /Poly(ε-Caprolactone) Composites: Preparation, Characterization and Biological Evaluation.

Polymers (Basel) 2021 Aug 7;13(16). Epub 2021 Aug 7.

Institute of Macromolecular Compounds, Russian Academy of Sciences, 199004 St. Petersburg, Russia.

Biodegradable and biocompatible composites are of great interest as biomedical materials for various regeneration processes such as the regeneration of bones, cartilage and soft tissues. Modification of the filler surface can improve its compatibility with the polymer matrix, and, as a result, the characteristics and properties of composite materials. This work is devoted to the synthesis and modification of aminated graphene with oligomers of glutamic acid and their use for the preparation of composite materials based on poly(ε-caprolactone). Read More

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Non-metal with metal behavior: metal-free coordination-insertion ring-opening polymerization.

Chem Sci 2021 Aug 15;12(32):10732-10741. Epub 2021 Jun 15.

State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University 30 Puzhu Road South Nanjing 211816 China

The "coordination-insertion" ring-opening polymerization (ROP) mechanism has so far been the monopoly of metal catalysts. In this work, we present a metal-free "coordination-insertion" ROP of trimethylene carbonate (TMC) and -caprolactone (ε-CL), as well as their sequential block copolymerization, with -trimethylsilyl-bis (trifluoromethanesulfonyl)imide (TMSNTf) as the non-metallic initiator/catalyst. TMSNTf was proposed to work through an unprecedented metal-free "coordination-insertion" mechanism, which involves the coordination of monomer to the Si atom of TMSNTf, the nucleophilic attack of the -NTf group on the coordinated monomer, and the cleavage of the acyl-oxygen bond of the monomer. Read More

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Reversible redox controlled acids for cationic ring-opening polymerization.

Chem Sci 2021 Aug 6;12(31):10544-10549. Epub 2021 Jul 6.

Department of Chemistry and Chemical Biology, Cornell University Ithaca New York 14853 USA

Advancements in externally controlled polymerization methodologies have enabled the synthesis of novel polymeric structures and architectures, and they have been pivotal to the development of new photocontrolled lithographic and 3D printing technologies. In particular, the development of externally controlled ring-opening polymerization (ROP) methodologies is of great interest, as these methods provide access to novel biocompatible and biodegradable block polymer structures. Although ROPs mediated by photoacid generators have made significant contributions to the fields of lithography and microelectronics development, these methodologies rely upon catalysts with poor stability and thus poor temporal control. Read More

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Copolymerization of Ring-Opening Oxaspiro Comonomer with Denture Base Acrylic Resin by Free-Radical/Cationic Hybrid Polymerization.

J Pharm Bioallied Sci 2021 Jun 5;13(Suppl 1):S527-S531. Epub 2021 Jun 5.

Department of Prosthodontics and Crown and Bridge, Vinayaka Missions Sankarachariyar Dental College and Hospital, Salem, Tamil Nadu, India.

Background: Polymerization shrinkage is an innate characteristic of thermo-polymerized denture base acrylic resin. Volumetric shrinkage is still a problem, although myriad material modifications. Ring-opening oxaspiro monomers have promising volumetric expansions of about 7%. Read More

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Synthesis and Characterization of a Ring-Opening Oxaspiro Comonomer by a Novel Catalytic Method for Denture Base Resins.

J Pharm Bioallied Sci 2021 Jun 5;13(Suppl 1):S521-S526. Epub 2021 Jun 5.

Department of Prosthodontics and Crown and Bridge, JKK Nattraja Dental College and Hospital, Komarapalayam, Tamil Nadu, India.

Background: 3,9-Dimethylene-1,5,7,11-tetraoxaspiro[5,5]undecane (DMTOSU) is a double ring-opening monomer that exhibits expansion upon polymerization and may be used as a denture base resin's comonomer to offset or minimize polymerization shrinkage. It's synthesis by transesterification reaction (TE) catalyzed by distannoxane is not reported in the literature. The synthesis became the prime concern because this monomer is hardly available commercially. Read More

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Star-Shaped Poly(furfuryl glycidyl ether)-Block-Poly(glyceryl glycerol ether) as an Efficient Agent for the Enhancement of Nifuratel Solubility and for the Formation of Injectable and Self-Healable Hydrogel Platforms for the Gynaecological Therapies.

Int J Mol Sci 2021 Aug 4;22(16). Epub 2021 Aug 4.

Department of General Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, 141/143 Pomorska Street, 90-236 Lodz, Poland.

In this paper, we present novel well-defined unimolecular micelles constructed a on poly(furfuryl glycidyl ether) core and highly hydrophilic poly(glyceryl glycerol ether) shell, PFGE-b-PGGE. The copolymer was synthesized via anionic ring-opening polymerization of furfuryl glycidyl ether and (1,2-isopropylidene glyceryl) glycidyl ether, respectively. MTT assay revealed that the copolymer is non-cytotoxic against human cervical cancer endothelial (HeLa) cells. Read More

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Towards Advances in Molecular Understanding of Boric Acid Biocatalyzed Ring-Opening (Co)Polymerization of δ-Valerolactone in the Presence of Ethylene Glycol as an Initiator.

Molecules 2021 Aug 11;26(16). Epub 2021 Aug 11.

Centre of Polymer and Carbon Materials, Polish Academy of Sciences, 34, M. Curie-Sklodowska St., 41-819 Zabrze, Poland.

Following our previous studies on the molecular level structure of (co)oligoesters obtained via anionic homo- and co-polymerization of novel β-substituted β-lactones, prepared by the atmospheric pressure carbonylation reaction of respective epoxides, the boric acid biocatalyzed ring-opening (co)polymerization of δ-valerolactone has been studied. As a co-monomer the 6-methy-ε-caprolactone, prepared by the one-pot oxidation of respective alcohol, and ethylene glycol as polymerization initiator were used. The obtained copolymers were characterized by H-NMR, GPC and ESI-MS, respectively in order to confirm their chemical structures and identity. Read More

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High Antibacterial Activity and Selectivity of the Versatile Polysulfoniums that Combat Drug Resistance.

Adv Mater 2021 Aug 26:e2104402. Epub 2021 Aug 26.

State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun, 130012, China.

Sulfonium-ion-containing polymers exhibit significant potential benefits for various applications. An efficient strategy to synthesize a type of antibacterial sulfonium-ion-bearing polypeptoids via a combination of ring-opening polymerization and a post-polymerization functionalization with various functional epoxides is presented. A systematic investigation is further performed in order to explore the influence of the overall hydrophobic/hydrophilic balance on the antimicrobial activity and selectivity of the prepared polysulfoniums. Read More

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O-to-S Substitution Enables Dovetailing Conflicting Cyclizability, Polymerizability, and Recyclability: Dithiolactone vs. Dilactone.

Angew Chem Int Ed Engl 2021 Aug 23. Epub 2021 Aug 23.

Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China.

Developing chemically recyclable polymers represents a greener alternative to landfill and incineration and offers a closed-loop strategy toward a circular materials economy. However, the synthesis of chemically recyclable polymers is still plagued with certain fundamental limitations, including trade-offs between the monomer's cyclizability and polymerizability, as well as between polymer's depolymerizability and properties. Here we describe the subtle O-to-S substitution, dithiolactone monomers derived from abundant feedstock α-amino acids can demonstrate appealing chemical properties different from those of dilactone, including accelerated ring closure, augmented kinetics polymerizability, high depolymerizability and selectivity, and thus constitute a unique class of polythioester materials exhibiting controlled molecular weight (up to 100. Read More

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Immobilization of trypsin onto porous methacrylate-based monolith for flow-through protein digestion and its potential application to chiral separation using liquid chromatography.

Heliyon 2021 Aug 2;7(8):e07707. Epub 2021 Aug 2.

Department of Chemistry, Faculty of Science, Brawijaya University, Malang, 65154, Indonesia.

Monolithic columns for analytical applications have attracted the researcher's attention. In this work, the laboratory-made organic-polymer monolithic column is modified with trypsin and further applied as a nanobiocatalyst microreactor and a stationary phase for separating chiral compounds by liquid chromatography. The monolith was synthesized by in-situ copolymerization of glycidyl methacrylate (GMA) and ethylene glycol dimethacrylate (EDMA) or trimethylolpropane trimethacrylate (TRIM) as a crosslinking agent, with porogen of 1,4-butanediol/propanol/water (4:7:1 v/v) and AIBN as the radical polymerization initiator inside PEEK and silicosteel tubings (1. Read More

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On the Origin of -Selectivity in the Ring-Opening Metathesis Polymerization with Molybdenum Imido Alkylidene Heterocyclic Carbene Complexes.

Organometallics 2021 Aug 9;40(15):2478-2488. Epub 2021 Jul 9.

Institute of Polymer Chemistry, University of Stuttgart, Pfaffenwaldring 55, D-70569 Stuttgart, Germany.

The understanding and control of stereoselectivity is a central aspect in ring-opening metathesis polymerization (ROMP). Herein, we report detailed quantum chemical studies on the reaction mechanism of -selective ROMP of norborn-2-ene (NBE) with Mo(-2,6-Me-CH)(CHCMe)(IMes)(OTf) (, IMes = 1,3-dimesitylimidazol-2-ylidene) as a first step to stereoselective polymerization. Four different reaction pathways based on an ene or ene approach of NBE to either the - or -isomer of the neutral precatalyst have been studied. Read More

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Chemically recyclable thermoplastics from reversible-deactivation polymerization of cyclic acetals.

Science 2021 08;373(6556):783-789

Department of Chemistry and Chemical Biology and Joint Center for Energy Storage Research, Baker Laboratory, Cornell University, Ithaca, NY 14853, USA.

Identifying plastics capable of chemical recycling to monomer (CRM) is the foremost challenge in creating a sustainable circular plastic economy. Polyacetals are promising candidates for CRM but lack useful tensile strengths owing to the low molecular weights produced using current uncontrolled cationic ring-opening polymerization (CROP) methods. Here, we present reversible-deactivation CROP of cyclic acetals using a commercial halomethyl ether initiator and an indium(III) bromide catalyst. Read More

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Photocleavable core cross-linked polymeric micelles of polypept(o)ides and ruthenium(II) complexes.

J Mater Chem B 2021 Aug 10. Epub 2021 Aug 10.

Leiden Academic Centre for Drug Research (LACDR), Leiden University, Einsteinweg 55, 2333CC Leiden, The Netherlands. and Department of Chemistry, Johannes Gutenberg University Mainz, Duesbergweg 10-14, 55128 Mainz, Germany.

Core cross-linking of polymeric micelles has been demonstrated to contribute to enhanced stability that can improve the therapeutic efficacy. Photochemistry has the potential to provide spatial resolution and on-demand drug release. In this study, light-sensitive polypyridyl-ruthenium(ii) complexes were combined with polypept(o)ides for photocleavable core cross-linked polymeric micelles. Read More

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Photochromic Polyamide 6 Based on Spiropyran Synthesized via Hydrolyzed Ring-Opening Polymerization.

Polymers (Basel) 2021 Jul 28;13(15). Epub 2021 Jul 28.

Key Laboratory of Textile Fiber and Products (Wuhan Textile University), Ministry of Education, Wuhan 430200, China.

We report photochromic polyamide 6 (PA6) which was synthesized by hydrolyzed ring-opening polymerization of ε-caprolactam with spiropyran (SP) embedded in the polymer chains. It indicated that crystallinity degree of the resulting copolymers was decreased since only PA6 segments can crystallize with increasing content of SP modifier. Meanwhile, toughness of photochromic PA6 was decreased. Read More

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Acetal-Based Functional Epoxide Monomers: Polymerizations and Applications.

Macromol Biosci 2021 Aug 8:e2100251. Epub 2021 Aug 8.

Department of Chemistry, Yonsei University, Seoul, 03722, Republic of Korea.

Protecting group chemistry is essential for various organic transformation and polymerization processes. In particular, conventional anionic ring-opening polymerization (AROP) often requires proper protecting group chemistry because it is typically incompatible with most functional groups due to the highly basic and nucleophilic conditions. In this context, many functional epoxide monomers with proper protecting groups are developed, including the acetal group as a representative example. Read More

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Cationic Polymerization of Hexamethylcyclotrisiloxane in Excess Water.

Molecules 2021 Jul 21;26(15). Epub 2021 Jul 21.

Ingénierie des Matériaux Polymères, CNRS UMR 5223, INSA-Lyon, Univ Lyon, F-69621 Villeurbanne, France.

Ring-opening ionic polymerization of cyclosiloxanes in dispersed media has long been discovered, and is nowadays both fundamentally studied and practically used. In this short communication, we show some preliminary results on the cationic ring-opening polymerization of hexamethylcyclotrisiloxane (D), a crystalline strained cycle, in water. Depending on the catalyst or/and surfactants used, polymers of various molar masses are prepared in a straightforward way. Read More

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Photocurable Epoxy Acrylate Coatings Preparation by Dual Cationic and Radical Photocrosslinking.

Materials (Basel) 2021 Jul 26;14(15). Epub 2021 Jul 26.

Department of Chemical Organic Technology and Polymeric Materials, Faculty of Chemical Technology and Engineering, West Pomeranian University of Technology in Szczecin, Piastów Ave. 42, 71-065 Szczecin, Poland.

In this work, epoxy acrylate resin (EA) based on the industrial-grade bisphenol A-based epoxy resin (Ep6) and acrylic acid (AA) has been synthesized in order to develop hybrid resin comprising both epoxide group and reactive, terminal unsaturation. Obtained epoxy acrylate prepolymer was employed to formulate photocurable coating compositions containing, besides the EA binder, also cationic or radical photoinitiators. Hence, when cationic photoinitiators were applied, polyether-type polymer chains with pending acrylate groups were formed. Read More

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Synthesis and Characterization of New Biodegradable Injectable Thermosensitive Smart Hydrogels for 5-Fluorouracil Delivery.

Int J Mol Sci 2021 Aug 3;22(15). Epub 2021 Aug 3.

Department of Biomaterials Chemistry, Chair of Analytical Chemistry and Biomaterials, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha St., 02-097 Warsaw, Poland.

In this paper, injectable, thermosensitive smart hydrogel local drug delivery systems (LDDSs) releasing the model antitumour drug 5-fluorouracil (5-FU) were developed. The systems were based on biodegradable triblock copolymers synthesized via ring opening polymerization (ROP) of ε-caprolactone (CL) in the presence of poly(ethylene glycol) (PEG) and zirconium(IV) acetylacetonate (Zr(acac)), as co-initiator and catalyst, respectively. The structure, molecular weight (M) and molecular weight distribution () of the synthesized materials was studied in detail using nuclear magnetic resonance (NMR) and gel permeation chromatography (GPC) techniques; the optimal synthesis conditions were determined. Read More

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