Chemistry 2021 Apr 16;27(24):7168-7175. Epub 2021 Mar 16.
Department of Chemistry, Portland State University, Portland, Oregon, 97201, USA.
Herein, the synthesis of 1,2,3,4-tetrasubstituted benzenoid rings, motifs found in pharmaceutical, agrochemical, and natural products, is described. In the past, the regioselective syntheses of such compounds have been a significant challenge. This work reports a method using substituted arynes derived from aryl(Mes)iodonium salts to access a range of densely functionalized 1,2,3,4-tetrasubstituted benzenoid rings. Read More