149,990 results match your criteria rheumatoid

Fibromyalgianess and glucocorticoid persistence among patients with rheumatoid arthritis.

Rheumatology (Oxford) 2021 Jul 22. Epub 2021 Jul 22.

Internal Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Objectives: Over 1/3 of patients with rheumatoid arthritis (RA) exhibit evidence of fibromyalgianess, which is associated with higher rates of disability and inadequate responsiveness to RA treatment. Patients with RA often remain on glucocorticoids long-term, despite the known risk of dose-dependent morbidity. We undertook this study to examine the relationship between fibromyalgianess and glucocorticoid persistence among RA patients. Read More

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Validating the Michigan Hand Outcomes Questionnaire in patients with rheumatoid arthritis using Rasch analysis.

PLoS One 2021 22;16(7):e0254984. Epub 2021 Jul 22.

Section of Plastic Surgery, Michigan Medicine, Ann Arbor, Michigan, United States of America.

Introduction: The Michigan Hand Outcomes Questionnaire (MHQ) is a patient-reported outcome measure previously validated in patients with rheumatoid arthritis (RA) using classical test theory. Rasch analysis is a more rigorous method of questionnaire validation that has not been used to test the psychometric properties of the MHQ in patients with RA. The objective of this study is to evaluate the validity and reliability of the MHQ for measuring outcomes in patients with RA with metacarpophalangeal joint deformities. Read More

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Alopecia Areata Treatment Patterns, Healthcare Resource Utilization, and Comorbidities in the US Population Using Insurance Claims.

Adv Ther 2021 Jul 22. Epub 2021 Jul 22.

Yale School of Medicine, New Haven, CT, USA.

Introduction: Alopecia areata (AA) is an autoimmune disorder causing sudden, non-scarring hair loss. There are currently no drugs approved for AA treatment. This study assessed prevalence of comorbidities, treatments, and healthcare costs and resource utilization among patients with AA in the USA. Read More

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An m-Health Intervention for Rheumatoid Arthritis in China ("Rheumatism Center" app): Study Protocol for a Prospective Randomized Controlled Trial.

Nurs Open 2021 Jul 22. Epub 2021 Jul 22.

Rheumatology Department, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.

Aim: To study the feasibility and effectiveness of a m-Health app in improving the management of rheumatoid arthritis.

Design: Randomized controlled trial.

Methods: Sixty rheumatoid arthritis participants will be recruited for a 6-month feasibility study. Read More

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A double-blind placebo-controlled randomized trial of oral saffron in the treatment of rheumatoid arthritis.

Avicenna J Phytomed 2021 Jul-Aug;11(4):332-342

Rheumatic Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Objective: Recently, saffron ( L. from the Iridaceae family) has been characterized by its antioxidant, anti-inflammatory and analgesic effects. This study aimed to evaluate the effect of saffron on disease activity in patients with rheumatoid arthritis (RA). Read More

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December 2019

Fatigue assessment by FACIT-F scale in Pakistani cohort with Rheumatoid Arthritis (FAF-RA) study.

Pak J Med Sci 2021 Jul-Aug;37(4):1025-1030

Dr. Taimoor Zafar, MBBS. Postgraduate Trainee, Central Park Medical College Lahore, Lahore, Pakistan.

Objective: To fine out fatigue frequency and severity by FACIT-F scale in Pakistani cohort with rheumatoid arthritis.

Methods: This study was conducted at department of Medicine division of rheumatology CPMC Lahore. After the approval of IRB, 192 patients of RA were recruited. Read More

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September 2020

Diagnostic and therapeutic delay in Rheumatoid Arthritis patients: Impact on disease outcome.

Pak J Med Sci 2021 Jul-Aug;37(4):1001-1007

Sumaira Farman, FRCP, FACP, FACR, SCE Rheumatology (UK) Graduate Certificate Paediatric Rheumatology (Australia) Professor, Division of Rheumatology, FMH, Consultant Rheumatologist, National Hospital and Medical Center, Lahore, Pakistan.

Objective: To identify factors causing diagnostic and therapeutic delay in patients with rheumatoid arthritis, and to evaluate relationship of diagnostic and therapeutic delay with disease outcome.

Methods: This cross-sectional study was conducted in Rheumatology Department, Fatima Memorial Hospital, Lahore, Pakistan, from May 2018 to July 2018. In this study 102 patients fulfilling ACR/EULAR criteria 2010 were enrolled. Read More

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Potential Privilege of Maltodextrin-α-Tocopherol Nano-Micelles in Seizing Tacrolimus Renal Toxicity, Managing Rheumatoid Arthritis and Accelerating Bone Regeneration.

Int J Nanomedicine 2021 14;16:4781-4803. Epub 2021 Jul 14.

Department of Industrial Pharmacy, Faculty of Pharmacy, Alexandria University, Alexandria, 21521, Egypt.

Background: Tacrolimus (TAC) is a powerful immunosuppressive agent whose therapeutic applicability is confined owing to its systemic side effects.

Objective: Herein, we harnessed a natural polymer based bioconjugate composed of maltodextrin and α-tocopherol (MD-α-TOC) to encapsulate TAC as an attempt to overcome its biological limitations while enhancing its therapeutic anti-rheumatic efficacy.

Methods: The designed TAC loaded maltodextrin-α-tocopherol nano-micelles ([email protected]α-TOC) were assessed for their physical properties, safety, toxicological behavior, their ability to combat arthritis and assist bone/cartilage formation. Read More

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Comment on "Urinary sodium-to-potassium ratio associates with hypertension and current disease activity in patients with rheumatoid arthritis: a cross-sectional study": authors' reply.

Arthritis Res Ther 2021 Jul 21;23(1):195. Epub 2021 Jul 21.

Department of Advanced Medicine for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, 54 Shogoin, Kawahara-cho, Sakyo-ku, Kyoto-shi, Kyoto, 606-8507, Japan.

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A pair of gout-like hands.

W Li X Man

Clin Exp Dermatol 2021 Jul 20. Epub 2021 Jul 20.

Department of Dermatology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

A 65-year-old man presented to our hospital with a 1-year history of multiple nodules on his arms and hands without itching or pain. He is suffering from autoimmune thrombocytopenia for more than 20 years and taking long-term oral glucocorticoids. He also had history of diabetes, hypertension and hyperthyroidism. Read More

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Treatment of Moderate Rheumatoid Arthritis.

Frank McKenna

Rheumatology (Oxford) 2021 Jul 20. Epub 2021 Jul 20.

Manchester University NHS Trust, Dept of Rheumatology, Trafford General Hospital, Moorside Rd, Davyhulme, Manchester, M41 5SL.

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Inhibition of lipid phosphatase SHIP1 expands myeloid-derived suppressor cells and attenuates rheumatoid arthritis in mice.

Am J Physiol Cell Physiol 2021 07 21. Epub 2021 Jul 21.

Division of Hematology/Oncology, Department of Medicine, Rhode Island Hospital, Warren Alpert Medical School, Brown University, Providence, Rhode Island, United States.

Rheumatoid arthritis (RA) is a debilitating autoimmune disease of unknown cause, characterized by infiltration and accumulation of activated immune cells in the synovial joints where cartilage and bone destructions occur. Myeloid-derived suppressor cells (MDSCs) are of myeloid origin and are able to suppress T cell responses. Src homology 2 domain containing inositol polyphosphate 5-phosphatase 1 (SHIP1) was shown to be involved in the regulation of MDSC differentiation. Read More

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The Development of the Rheumatology Informatics System for Effectiveness Learning Collaborative for Improving Patient-Reported Outcome Collection and Patient-Centered Communication in Adult Rheumatology.

ACR Open Rheumatol 2021 Jul 20. Epub 2021 Jul 20.

Zuckerberg San Francisco General Hospital, San Francisco, California.

Objective: Patient-reported outcomes (PROs) are an integral part of treat-to-target approaches in managing rheumatoid arthritis (RA). In clinical practice, however, routine collection, documentation, and discussion of PROs with patients are highly variable. The RISE LC (Rheumatology Informatics System for Effectiveness Learning Collaborative) was established to develop and share best practices in PRO collection and use across adult rheumatology practices in the United States METHODS: The goals of the RISE LC were developed through site surveys and in-person meetings. Read More

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Perioperative Glucocorticoids in Patients With Rheumatoid Arthritis Having Total Joint Replacements: Help or Harm?

ACR Open Rheumatol 2021 Jul 20. Epub 2021 Jul 20.

Weill Cornell Medicine and New York Presbyterian Hospital and Hospital for Special Surgery, New York.

Objective: The optimal strategy for perioperative glucocorticoid (GC) management in patients with rheumatoid arthritis (RA) on chronic GCs is unknown. Although there is a concern for hypotension if inadequate doses are used, higher GC exposure may increase perioperative complications. We aimed to investigate the relationships between perioperative GCs with hemodynamic instability and short-term postoperative complications following total hip arthroplasty (THA) and total knee arthroplasty (TKA) in patients with RA. Read More

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Combinations of Anticyclic Citrullinated Protein Antibody, Rheumatoid Factor, and Serum Calprotectin Positivity Are Associated With the Diagnosis of Rheumatoid Arthritis Within 3 Years.

ACR Open Rheumatol 2021 Jul 20. Epub 2021 Jul 20.

University of Colorado, Aurora, Colorado.

Objective: To evaluate the prevalence of elevations of anti-cyclic citrullinated peptide-3 (anti-CCP3) antibody, rheumatoid factor IgM (RF-IgM) and serum calprotectin (sCP) in pre-rheumatoid arthritis (RA) as well as the diagnostic accuracies of these biomarkers for the timing of diagnosis of future RA.

Methods: A total of 215 RA cases, each with approximately three pre-RA diagnoses and one post-RA diagnosis serum sample, and controls were identified from the Department of Defense Serum Repository. All case samples and a single sample from each control subject were tested for anti-CCP3 (IgG), RF-IgM, and sCP. Read More

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The immunosuppressive activity of artemisinin-type drugs towards inflammatory and autoimmune diseases.

Med Res Rev 2021 Jul 21. Epub 2021 Jul 21.

Oesch-Tox Toxicological Consulting and Expert Opinions, Ingelheim, Germany and Institute of Toxicology,  Johannes Gutenberg University of Mainz, Mainz, Germany.

The sesquiterpene lactone artemisinin from Artemisia annua L. is well established for malaria therapy, but its bioactivity spectrum is much broader. In this review, we give a comprehensive and timely overview of the literature regarding the immunosuppressive activity of artemisinin-type compounds toward inflammatory and autoimmune diseases. Read More

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J Cell Physiol 2021 Jul 20. Epub 2021 Jul 20.

Retraction: "Downregulated microRNA-135a ameliorates rheumatoid arthritis by inactivation of the phosphatidylinositol 3-kinase/AKT signaling pathway via phosphatidylinositol 3-kinase regulatory subunit 2," by Yuan Qu, Yu-Ping Zhang, Jing Wu, Li-Gang Jie, Jia-Xin Deng, Dong-Bao Zhao, Qing-Hong Yu, J Cell Physiol. 2019; 17663-17676: The above article, published online on 25 March 2019 in Wiley Online Library (https://onlinelibrary.wiley. Read More

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Corticosteroid injections in the temporomandibular joint temporarily alleviate pain and improve function in rheumatoid arthritis.

Clin Rheumatol 2021 Jul 21. Epub 2021 Jul 21.

Scandinavian Center for Orofacial Neurosciences (SCON), Malmö, Sweden.

Objectives: To evaluate the effect of corticosteroid injections in the painful temporomandibular joint (TMJ) of patients with rheumatoid arthritis (RA) in relation to systemic inflammatory activity.

Method: Examination of 35 patients (median age 54 years; 89% female) included maximum mouth opening capacity, degree of anterior open bite (AOB), TMJ pain intensity at rest, and crepitus. Serum levels of rheumatoid factor (RF), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), serotonin, and plasma levels of interleukine-1β (IL-1β) were determined. Read More

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Polyautoimmunity in systemic lupus erythematosus: secondary Sjogren syndrome.

Z Rheumatol 2021 Jul 21. Epub 2021 Jul 21.

Rheumatology Department, Complejo Asistencial Universitario de León, Calle Altos de nava, s/n, 24001, León, Spain.

Background: Sjogren's syndrome (SS) is a chronic autoimmune disease characterized by lymphocytic infiltration of the exocrine glands. It can be associated with other connective tissue diseases, including systemic lupus erythematosus (SLE).

Objective: This study aimed to determine the incidence of secondary SS (sSS) in patients diagnosed with SLE (SLE-SS) and compare the clinical and serological features of SLE-SS to SLE only. Read More

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Adalimumab-Induced Rhupus Syndrome in a Female Patient Affected with Anti-Citrullinated Protein Antibody (ACPA)-Positive Rheumatoid Arthritis (RA): A Case Report and Review of Literature.

Clin Pract 2021 Jul 1;11(3):404-409. Epub 2021 Jul 1.

Primary Care Department, Casa Della Salute "Chiaravalle Centrale", Fragility Outpatient Clinic, Azienda Sanitaria Provinciale di Ca-tanzaro, Chiaravalle, 88064 Catanzaro, Italy.

We report a 38-year-old female patient affected with anti-citrullinated protein antibody (ACPA)-positive rheumatoid arthritis (RA) who developed mild hemolytic anemia (Hb = 10.5 vs. >12 gr/dL), indolent oral ulceration, ANA (1:1280, homogeneous pattern), and anti-dsDNA antibody positivity following 8 months of therapy with an adalimumab biosimilar (GP2017). Read More

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[Seroprevalence of infections among patients with autoimmune diseases].

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 2020 Jun;33(3):305-307

Department of Laboratory Medicine, First People's Hospital of Yuhang District, Yuhang Branch of The Second Affiliated Hospital of Zhejiang University Medical School, Hangzhou 311100, China.

Objective: To understand the seroprevalence of infections among patients with autoimmune diseases, so as to provide the scientific evidence for the management of toxoplasmosis in patients with autoimmune diseases.

Methods: A total of 237 patients with definitive diagnosis of autoimmune disease were selected as the study subjects, including 79 cases with systemic lupus erythematosus, 71 cases with rheumatoid arthritis and 87 cases with inflammatory bowel disease, while 237 healthy volunteers served as controls. The serum anti- IgG antibody was detected using enzyme-linked immunosorbent assay (ELISA) in patients with autoimmune diseases and healthy controls, and the detection of serum IgG antibody against was compared between the autoimmune disease patients and healthy controls. Read More

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Inferior outcomes of primary total knee arthroplasty in patients with rheumatoid arthritis compared to patients with osteoarthritis.

Knee Surg Sports Traumatol Arthrosc 2021 Jul 20. Epub 2021 Jul 20.

Joint and Arthritis Research, Department of Orthopaedic Surgery, Himchan Hospital, 120, Sinmok-ro, Yangcheon-gu, Seoul, Republic of Korea.

Purpose: The purpose of this study was to compare the functional outcomes, activity levels, mortalities, implant survival rates, and complications of total knee arthroplasty (TKA) in patients with rheumatoid arthritis (RA) with those in patients with osteoarthritis (OA) over a minimum 10-year follow-up period.

Methods: Between January 2007 and December 2009, 90 TKAs performed in 57 patients with RA (RA group) were retrospectively reviewed and matched with a control group of 180 TKAs performed in 114 patients with OA. The functional outcomes (Knee Society Score), activity levels (Koval grade), mortalities, implant survival rates, and complications were compared between the two groups with a minimum 10-year follow-up period. Read More

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Bilateral septic arthritis with rapid progressive destruction of the femoral head after joint injection in rheumatoid arthritis.

J Bone Jt Infect 2021 7;6(7):255-256. Epub 2021 Jul 7.

Department of Trauma Surgery, Regensburg University Medical Center, 93042 Regensburg, Germany.

This report is on a 61-year-old patient with steroid therapy for rheumatoid arthritis and pain in the groin on both sides who got injections with hyaluronic acid in both hip joints. After 12 weeks the X-ray of the pelvis showed rapid progressive destruction of both hip joints. Read More

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The Importance of Outcome Measures in the Management of Inflammatory Rheumatic Diseases.

Open Access Rheumatol 2021 12;13:191-200. Epub 2021 Jul 12.

Department of Rheumatology, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

Rheumatic inflammatory diseases include a diverse and heterogeneous group of multifaceted disorders in which clinical history and physical examination are essential to make treatment choices and for optimizing outcomes. Composite outcome measures have become very relevant in rheumatology to evaluate disease activity as they capture the most important dimensions of the disease into one single measure. Most outcome measures may include disease manifestations, laboratory data, physician examination as well as the patient perspective as different outcome dimensions of the disease into a simple index. Read More

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Prevalence and Characteristics of Rheumatoid-Associated Autoantibodies in Patients with COVID-19.

J Inflamm Res 2021 12;14:3123-3128. Epub 2021 Jul 12.

Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.

Objective: Patients with rheumatic immune diseases were more likely to develop severe or critical COVID-19. We aimed to determine whether rheumatoid factor antibodies were present in COVID patients and the level and type of rheumatoid factor antibodies produced in COVID-19 patients were related to the degree of the patient's condition. The study also aimed to determine the prevalence and characteristics of rheumatoid factor antibodies in patients with COVID-19. Read More

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Determining in which pre-arthritis stage HLA-shared epitope alleles and smoking exert their effect on the development of rheumatoid arthritis.

Ann Rheum Dis 2021 Jul 20. Epub 2021 Jul 20.

Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.

Objectives: The human leukocyte antigen-shared epitope (HLA-SE) alleles and smoking are the most prominent genetic and environmental risk factors for rheumatoid arthritis (RA). However, at which pre-arthritis stage (asymptomatic/symptomatic) they exert their effect is unknown. We aimed to determine whether HLA-SE and smoking are involved in the onset of autoantibody positivity, symptoms (clinically suspect arthralgia (CSA)) and/or progression to clinical arthritis. Read More

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Antibodies against citrullinated proteins in relation to periodontitis with or without rheumatoid arthritis: a cross-sectional study.

BMC Oral Health 2021 Jul 20;21(1):360. Epub 2021 Jul 20.

Department of Restorative Dentistry, Faculty of Dentistry, University of Malaya, 50603, Kuala Lumpur, Malaysia.

Background: Previous studies have reported conflicting findings between serum anti-citrullinated protein antibodies (ACPA) levels in rheumatoid arthritis (RA) participants with and without periodontitis (Pd). This study aimed to analyse possible correlations between serum ACPA levels and clinical parameters in Pd and RA participants.

Methods: Full mouth periodontal examination (probing pocket depth, clinical attachment levels, gingival bleeding index, visual plaque index) was conducted and serum samples obtained from 80 participants comprising RA, Pd, both RA and Pd (RAPd) and healthy individuals (HC). Read More

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