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Efficacy and safety of sacubitril/valsartan in the treatment of heart failure: protocol for a systematic review incorporating unpublished clinical study reports.

HRB Open Res 2020 10;3. Epub 2020 Feb 10.

Department of General Practice and HRB Centre for Primary Care Research, Royal College of Surgeons in Ireland, Dublin 2, Ireland.

Sacubitril/valsartan is a first-in-class angiotensin-receptor neprilysin inhibitor used to treat heart failure with reduced ejection fraction. The evidence base for this novel medication is largely based on one pivotal phase III trial which was stopped early due to significant clinical benefits being shown. However potential limitations in the trial design have been highlighted in recent medical literature, necessitating a thorough review of the evidence base for sacubitril/valsartan. Read More

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February 2020

Trauma mechanism and patient reported outcome in tibial plateau fractures with posterior involvement.

Knee 2021 Apr 10;30:41-50. Epub 2021 Apr 10.

Dept. Trauma Surgery, University Hospital Leuven, KU Leuven - University of Leuven, Leuven, Belgium. Electronic address:

Introduction: Posterior tibial plateau fractures (PTPF) have a high impact on functional outcome and the optimal treatment strategy is not well established. The goal of this study was to assess the relationship between trauma mechanism, fracture morphology and functional outcome in a large multicenter cohort and define possible strategies to improve the outcome.

Methods: An international retrospective cohort study was conducted in five level-1 trauma centers. Read More

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Efficacy of cognitive behavioral therapy on mood and quality of life for patients with COVID-19: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 Apr;100(15):e25512

Department of Psychiatry.

Background: There is no study that has conducted a review or meta-analysis investigating a cognitive behavioral therapy (CBT) intervention to patients with COVID19, with the aim of improving their psychological health. Therefore, in order to provide new evidence-based medical evidence for clinical treatment, we undertook a systematic review and meta-analysis to assess the effectiveness of CBT in relieving patients' psychological distress and improving quality of life during the COVID-19 epidemic.

Methods: Seven electronic databases including Web of Science, Embase, PubMed, Wanfang Data, Scopus, Science Direct, Cochrane Library will be searched in April 2021 by 2 independent reviewers. Read More

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External treatment of traditional Chinese medicine for myasthenia gravis: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 Apr;100(15):e25475

Chengdu Eighth People's Hospital (Geriatric Hospital of Chengdu Medical College).

Background: Myasthenia gravis (MG) is an archetypal autoimmune disorder. The conventional treatments for this disease are drugs, plasma exchange, surgical, and so on. However, this disease is difficult to cure. Read More

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