14,865 results match your criteria reviewed leading


The effect of remote peer support on stigma in patients after breast cancer surgery during the COVID-19 pandemic: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 Jun;100(24):e26332

Institute of Business, School of Business, Henan University, Jinming Avenue, Kaifeng, Henan, China.

Background: Patients after breast cancer surgery have a high sense of stigma due to the formation of surgical scars, loss of breast shape or other reasons, leading to anxiety, depression, and other adverse mental health problems, thus reducing their quality of life. Remote peer support intervention based on telephone, internet or email is low-cost and easy to spread, and protects patients' privacy, solves the barriers to access that many patients face when attending face-to-face programs. Therefore, remote peer support may be an effective way to reduce stigma and improve mental health in patients after breast cancer surgery during the coronavirus disease 2019 (COVID-19) pandemic. Read More

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DIAPH1 Variants in Non-East Asian Patients With Sporadic Moyamoya Disease.

JAMA Neurol 2021 Jun 14. Epub 2021 Jun 14.

Yale Center for Genome Analysis, West Haven, Connecticut.

Importance: Moyamoya disease (MMD), a progressive vasculopathy leading to narrowing and ultimate occlusion of the intracranial internal carotid arteries, is a cause of childhood stroke. The cause of MMD is poorly understood, but genetic factors play a role. Several familial forms of MMD have been identified, but the cause of most cases remains elusive, especially among non-East Asian individuals. Read More

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Causes and Circumstances of Death in Portopulmonary Hypertension.

Transplant Direct 2021 Jul 8;7(7):e710. Epub 2021 Jun 8.

Inflammation and Immunity Department, Lerner Research Institute, Cleveland Clinic, Cleveland, OH.

The causes and circumstances surrounding death are poorly studied in patients with portopulmonary hypertension (PoPH). We sought to determine the specific reasons for dying and characteristics surrounding this process in patients with PoPH.

Methods: All deaths of patients with PoPH followed in the Cleveland Clinic Pulmonary Vascular Program were prospectively reviewed by the pulmonary hypertension team between 1996 and 2020. Read More

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Early Prediction of Sepsis in the ICU Using Machine Learning: A Systematic Review.

Front Med (Lausanne) 2021 28;8:607952. Epub 2021 May 28.

Machine Learning and Computational Biology Lab, Department of Biosystems Science and Engineering, Eidgenössische Technische Hochschule Zürich (ETH Zurich), Basel, Switzerland.

Sepsis is among the leading causes of death in intensive care units (ICUs) worldwide and its recognition, particularly in the early stages of the disease, remains a medical challenge. The advent of an affluence of available digital health data has created a setting in which machine learning can be used for digital biomarker discovery, with the ultimate goal to advance the early recognition of sepsis. To systematically review and evaluate studies employing machine learning for the prediction of sepsis in the ICU. Read More

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Factors associated with the development of ocular candidiasis and ocular prognosis with echinocandin therapy for candidemia.

J Ophthalmic Inflamm Infect 2021 Jun 14;11(1):17. Epub 2021 Jun 14.

Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.

Purpose: To evaluate the factors associated with the development of ocular candidiasis (OC) and ocular prognosis with echinocandin therapy for candidemia.

Methods: The medical records of 56 consecutive patients with a positive blood culture for Candida species between November 2016 and October 2019 were retrospectively reviewed. Information on patient characteristics, isolated Candida species, treatment details for candidemia, and ocular findings were extracted to identify factors associated with OC development. Read More

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Video case review for quality improvement during cardiac arrest resuscitation in the emergency department.

Int J Clin Pract 2021 Jun 13:e14525. Epub 2021 Jun 13.

Department of Emergency Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC, United States.

Background: Out-of-Hospital-Cardiac-Arrests (OHCA) are a leading global cause of mortality. The American Heart Association (AHA) promotes several important strategies associated with improved cardiac arrest outcomes, including decreasing pulse check time and maintaining a chest compression fraction (CCF) > 0.80. Read More

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Metabolic reprogramming by traditional Chinese medicine and its role in effective cancer therapy.

Pharmacol Res 2021 Jun 10:105728. Epub 2021 Jun 10.

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Integration of Chinese and Western Medicine, Peking University Cancer Hospital and Institute, Beijing 100142, PR China. Electronic address:

Metabolic reprogramming, characterized by alterations of cellular metabolic patterns, is fundamentally important in supporting the malignant behaviors of cancer cells. It is considered as a promising therapeutic target against cancer. Traditional Chinese medicine (TCM) and its bioactive components have been used in cancer therapy for an extended period, and they are well-known for their multi-target pharmacological functions and fewer side effects. Read More

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Retrospective Survey of Amphibian Pathology Cases at Texas A&M University System (2016-2020).

J Comp Pathol 2021 May 28;185:87-95. Epub 2021 May 28.

Texas A&M Veterinary Medical Diagnostic Laboratory, College Station, Texas, USA. Electronic address:

Dramatic declines in amphibians worldwide highlight the need for a better understanding of diseases affecting these species. To delineate the health issues of amphibians submitted to Texas A&M University System (2016-2020), the databases were queried on the basis of defined selection criteria. A total of 502 anurans (157 frogs [44 species] and 345 toads [10 species]) and 30 caudatans (23 salamanders [6 species] and 7 newts [4 species]) were reviewed. Read More

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Bioinspired Solid-State Nanochannel Sensors: From Ionic Current Signals, Current, and Fluorescence Dual Signals to Faraday Current Signals.

Small 2021 Jun 12:e2100495. Epub 2021 Jun 12.

Cancer Centre and Centre of Reproduction, Development and Aging, Faculty of Health Sciences, University of Macau, Macau, SAR, 999078, China.

Inspired from bioprotein channels of living organisms, constructing "abiotic" analogues, solid-state nanochannels, to achieve "smart" sensing towards various targets, is highly seductive. When encountered with certain stimuli, dynamic switch of terminal modified probes in terms of surface charge, conformation, fluorescence property, electric potential as well as wettability can be monitored via transmembrane ionic current, fluorescence intensity, faraday current signals of nanochannels and so on. Herein, the modification methodologies of nanochannels and targets-detecting application are summarized in ions, small molecules, as well as biomolecules, and systematically reviewed are the nanochannel-based detection means including 1) by transmembrane current signals; 2) by the coordination of current- and fluorescence-dual signals; 3) by faraday current signals from nanochannel-based electrode. Read More

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Pharmacological Inhibition of the Nod-Like Receptor Family Pyrin Domain Containing 3 Inflammasome with MCC950.

Pharmacol Rev 2021 Jul;73(3):968-1000

Trinity College Dublin, Dublin, Ireland (S.E.C.); Inflazome, D6 Grain House, Mill Court, Great Shelford, Cambridge, United Kingdom (R.H., M.A.C.); and Institute for Molecular Bioscience, University of Queensland, Queensland, Australia (M.A.C.)

Activation of the Nod-like receptor family pyrin domain containing 3 (NLRP3) inflammasome drives release of the proinflammatory cytokines interleukin (IL)-1 and IL-18 and induces pyroptosis (lytic cell death). These events drive chronic inflammation, and as such, NLRP3 has been implicated in a large number of human diseases. These range from autoimmune conditions, the simplest of which is NLRP3 gain-of-function mutations leading to an orphan disease, cryopyrin-associated period syndrome, to large disease burden indications, such as atherosclerosis, heart failure, stroke, neurodegeneration, asthma, ulcerative colitis, and arthritis. Read More

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Partial Arthroscopic Trapeziectomy and Stabilisation by Ligamentoplasty: Outcomes in Patients Younger than 60 Years.

Orthop Traumatol Surg Res 2021 Jun 8:102983. Epub 2021 Jun 8.

Service de chirurgie orthopédique et traumatologique, centre hospitalier de Versailles, 78150 Le Chesnay, France.

Background: Thumb carpo-metacarpal joint (TCMJ) osteoarthritis is the fourth leading cause of referral to elective hand surgery. None of the available techniques has proved superior over the others. Some techniques carry unacceptable risks for younger patients, such as loss of strength and shortening of the thumb column after total trapeziectomy, or wear and loosening after total arthroplasty. Read More

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Correlation between body mass index and prostate volume in benign prostatic hyperplasia patients undergoing holmium enucleation of the prostate surgery.

BMC Urol 2021 Jun 10;21(1):88. Epub 2021 Jun 10.

Department of Urology, The University of Arizona, 1501 N Campbell Ave, PO Box 245077, Tucson, AZ, 85724-5077, USA.

Background: Benign prostatic obstruction (BPO) due to benign prostatic hyperplasia (BPH) is a leading cause of morbidity in men over the age of 40. This study examined whether there was an association between body mass index (BMI) and pre-operative prostate volume and whether expression of two genes, alpha-2-macroglobulin (A2M) and transforming growth factor beta 3 (TGFB3), was correlated with BMI, pre-operative prostate volume, and age at surgery.

Methods: Medical records of patients who underwent holmium enucleation of the prostate surgery for treatment of BPO were retrospectively reviewed. Read More

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Updates in Magnetic Resonance Venous Imaging.

Semin Intervent Radiol 2021 Jun 3;38(2):202-208. Epub 2021 Jun 3.

Department of Radiology, NorthShore University HealthSystem, Chicago, Illinois.

For years, magnetic resonance angiography (MRA) has been a leading imaging modality in the assessment of venous disease involving the pelvis and lower extremities. Current advancement in noncontrast MRA techniques enables imaging of a larger subset of patients previously excluded due to allergy or renal insufficiency, allowing for preintervention assessment and planning. In this article, the current status of MR venography, with a focus on current advancements, will be presented. Read More

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How can human-centered design build a story-based video intervention that addresses vaccine hesitancy and bolsters vaccine confidence in the Philippines? A mixedmethod protocol for project SALUBONG.

BMJ Open 2021 06 9;11(6):e046814. Epub 2021 Jun 9.

Heidelberg Institute of Global Health, Ruprecht Karls Universität Heidelberg, Heidelberg, Germany

Introduction: Since the onset of a dengue vaccine controversy in late 2017, vaccine confidence has plummeted in the Philippines, leading to measles and polio outbreaks in early 2019. This protocol outlines a human-centered design (HCD) approach to co-create and test an intervention that addresses vaccine hesitancy (VH) via narrative and empathy with and among families and healthcare workers. METHODS AND ANALYSIS: 'Salubong' is a Filipino term that means to welcome someone back into one's life, reinforcing notions of family ties and friendships. Read More

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Response to: 'Effectiveness of allopurinol on reducing mortality: Time-related biases in observational studies'.

Arthritis Rheumatol 2021 Jun 8. Epub 2021 Jun 8.

Department of Medicine, University of Toronto, Toronto, ON, Canada.

We read with great interest the manuscript by Suissa et al that reviewed observational studies of the association between allopurinol and mortality in individuals with gout (1). Suissa describes immeasurable time bias as time periods during which prescription medication records are not available (e.g. Read More

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Gene expression studies in Depression development and treatment: an overview of the underlying molecular mechanisms and biological processes to identify biomarkers.

Transl Psychiatry 2021 Jun 8;11(1):354. Epub 2021 Jun 8.

IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Biological Psychiatry Laboratory, Brescia, Italy.

A combination of different risk factors, such as genetic, environmental and psychological factors, together with immune system, stress response, brain neuroplasticity and the regulation of neurotransmitters, is thought to lead to the development of major depressive disorder (MDD). A growing number of studies have tried to investigate the underlying mechanisms of MDD by analysing the expression levels of genes involved in such biological processes. These studies have shown that MDD is not just a brain disorder, but also a body disorder, and this is mainly due to the interplay between the periphery and the Central Nervous System (CNS). Read More

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Feasibility of mHealth interventions for depressive symptoms in Latin America: a systematic review.

Int Rev Psychiatry 2021 Jun 9:1-12. Epub 2021 Jun 9.

Bipolar and Depressive Disorders Unit, Hospital Clinic de Barcelona, Institute of Neuroscience, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain.

Depression is a prevalent disorder and leading cause of disability in Latin America, where the mental health treatment gap is still above 50%. We sought to synthesise and assess the quality of the evidence on the feasibility of mHealth-based interventions for depression in Latin America. We conducted a literature search of studies published in 2007 and after using four electronic databases. Read More

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Toxic metals in East African agro-ecosystems: Key risks for sustainable food production.

J Environ Manage 2021 Jun 5;294:112973. Epub 2021 Jun 5.

School of Geography, Earth and Environmental Science, University of Plymouth, Drake Circus, PL4 8AA, UK. Electronic address:

The dramatic increase in world population underpins current escalating food demand, which requires increased productivity in the available arable land through agricultural intensification. Agricultural intensification involves increased agrochemicals use to increase land productivity. Increased uses of agrochemicals pose environmental and ecological risks such as contamination and water eutrophication. Read More

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Revisional Adjustable Gastric Band in Roux-en-Y Gastric Bypass-Is It Worth It?

J Gastrointest Surg 2021 Jun 7. Epub 2021 Jun 7.

Clarunis, Department of Visceral Surgery, University Centre for Gastrointestinal and Liver Diseases, St. Clara Hospital and University Hospital Basel, 4002, Basel, Switzerland.

Purpose: A subset of patients undergoing Roux-en-Y gastric bypass (RYGB) presents with either insufficient weight loss or weight regain. Data on the revisional restrictive options including laparoscopic adjustable gastric band (LAGB) is scarce. This study analyzes the mid-term efficacy and safety of LAGB as a revisional procedure after RYGB. Read More

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The role of MRI and CT of the brain in first episodes of psychosis and behavioural abnormality.

Clin Radiol 2021 Jun 4. Epub 2021 Jun 4.

Department of Neuroradiology, Sheffield Teaching Hospitals, Sheffield, UK.

Aim: To investigate whether computed tomography (CT)/magnetic resonance imaging (MRI) brain imaging is associated with detection of structural causes of a first episode of psychosis (FEP) or first episode of behavioural abnormality (FEB) in the paediatric population, as this has not been previously documented in the literature.

Materials And Methods: Individuals with FEP/FEB but no neurological signs referred to a tertiary children's centre for cerebral MRI or CT were reviewed retrospectively. Individuals were evaluated independently with one technique (CT or MRI) only. Read More

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Disclosure to social network members among abortion-seeking women in low- and middle-income countries with restrictive access: a systematic review.

Reprod Health 2021 Jun 7;18(1):114. Epub 2021 Jun 7.

UNDP-UNFPA-UNICEF-WHO-World Bank Special Programme of Research, Development and Research Training in Human Reproduction (HRP), World Health Organization, Geneva, Switzerland.

Background: Health care for stigmatized reproductive practices in low- and middle-income countries (LMICs) often remains illegal; when legal, it is often inadequate, difficult to find and / or stigmatizing, which results in women deferring care or turning to informal information sources and providers. Women seeking an induced abortion in LMICs often face obstacles of this kind, leading to unsafe abortions. A growing number of studies have shown that abortion seekers confide in social network members when searching for formal or informal care. Read More

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"It could potentially be dangerous... but nothing else has seemed to help me.": Patient and clinician perspectives on benzodiazepine use in opioid agonist treatment.

J Subst Abuse Treat 2021 Apr 30;131:108455. Epub 2021 Apr 30.

Department of Medicine, Section of Infectious Diseases, Boston University School of Medicine, United States of America; Center for Implementation and Improvement Sciences, Department of Medicine, Boston University School of Medicine, United States of America; Department of Health Law, Policy & Management, Boston University School of Public Health, United States of America.

Background: Benzodiazepine use among patients receiving opioid agonist treatment (OAT) presents a conundrum: benzodiazepines increase overdose risk, yet can treat anxiety and insomnia. How best to balance the risks and benefits of benzodiazepines among OAT patients is unclear. Using qualitative methods, we examined patient motivations for benzodiazepine use and understanding of risks, and the context in which benzodiazepine use and prescribing occurs. Read More

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Alpelisib-Induced Diabetic Ketoacidosis: A Case Report and Review of Literature.

AACE Clin Case Rep 2021 Mar-Apr;7(2):127-131. Epub 2020 Dec 28.

Scripps Clinic Medical Group, Division of Diabetes and Endocrinology, La Jolla, California.

Objective: To report the first case of diabetic ketoacidosis (DKA) and its management in a patient with diet-controlled prediabetes and metastatic breast cancer treated with alpelisib, a PI3K (phosphatidylinosiotol-3-kinase) inhibitor.

Methods: Literature on the topic is reviewed. The case is that of a 66-year-old female with diet-controlled prediabetes and metastatic breast carcinoma who had initiated alpelisib 2 weeks prior to being admitted for diabetic ketoacidosis. Read More

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December 2020

Cervical Cancer Prevention Efforts in India.

Indian J Gynecol Oncol 2021 2;19(3):41. Epub 2021 Jun 2.

Department of Gynaecologic Oncology, Cancer Institute (WIA) Adyar, Chennai, Tamil Nadu 600020 India.

Purpose: Cervical cancer is one of the leading cancers among women in India. Its prevention and control require a concerted effort to improve awareness among women regarding primary and secondary prevention strategies as well as access to care for treatment and palliation. A focused strategy is important to reach the World Health Organization's targets for cervical cancer elimination, due to be completed by 2030. Read More

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Leveraging the Electronic Health Record to Address the COVID-19 Pandemic.

Mayo Clin Proc 2021 06 21;96(6):1592-1608. Epub 2021 Apr 21.

Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN; Gonda Vascular Center, Mayo Clinic, Rochester, MN. Electronic address:

The coronavirus disease 2019 (COVID-19) pandemic continues its global spread. Coordinated effort on a vast scale is required to halt its progression and to save lives. Electronic health record (EHR) data are a valuable resource to mitigate the COVID-19 pandemic. Read More

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MicroRNA-182 is a potential biomarker for prognosis of gastric cancer: A protocol for meta-analysis and bioinformatics analysis.

Medicine (Baltimore) 2021 Jun;100(22):e25830

Department of Gastroenterological Surgery, Yongchuan Hospital of Chongqing Medical University, Chongqing, China.

Background: Being the second leading cause of cancer death in the world, gastric cancer is a common malignant tumor in digestive system. Most patients were diagnosed in advanced stage and had poor prognosis. In recent years, related studies have displayed that MicroRNA-182 (miRNA-182) can promote the proliferation, infiltration, metastasis and drug resistance of tumor cells, so it can be used as a new molecular marker for the early diagnosis, prognosis, and treatment of tumors. Read More

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Pediatric trauma at a single center in the Qassim region of Saudi Arabia.

Ann Saudi Med 2021 May-Jun;41(3):165-170. Epub 2021 Jun 1.

From the Department of Surgery, College of Medicine, Qassim University, Buraidah, Qassim, Saudi Arabia.

Background: Trauma is one of the leading causes of pediatric mortality so the prevention of pediatric trauma is an important goal of any healthcare system. There are only a few studies on pediatric trauma in Saudi Arabia. The availability of data is vital for healthcare leaders in planning for healthcare services. Read More

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Impact of the COVID-19 pandemic on paediatric patients with cancer in low-income, middle-income and high-income countries: protocol for a multicentre, international, observational cohort study.

BMJ Open 2021 06 2;11(6):e045679. Epub 2021 Jun 2.

Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.

Introduction: Childhood cancers are a leading cause of non-communicable disease deaths for children around the world. The COVID-19 pandemic may have impacted on global children's cancer services, which can have consequences for childhood cancer outcomes. The Global Health Research Group on Children's Non-Communicable Diseases is currently undertaking the first international cohort study to determine the variation in paediatric cancer management during the COVID-19 pandemic, and the short-term to medium-term impacts on childhood cancer outcomes. Read More

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A retrospective evaluation of point of care ultrasound for acute cholecystitis in a tertiary academic hospital setting.

Ultrasound J 2021 Jun 3;13(1):28. Epub 2021 Jun 3.

Department of Emergency Medicine, Virginia Commonwealth School of Medicine, Main Hospital 2nd floor, room 606, Suite 600, 1250 East Marshal St, PO BOX 980401, Richmond, VA, 23298-0401, USA.

Background: In 2008 the Council of Emergency Medicine Residency Directors delineated consensus recommendations for training in biliary ultrasound for the "detection of biliary pathology".

Objectives: While studies have looked at the accuracy of emergency provider performed clinical ultrasound (ECUS), we sought to evaluated if ECUS could be diagnostic for acute cholecystitis and thus obviate the need for follow-up imaging.

Method: We reviewed all ECUS performed between 2012 and 2017 that had a matching radiology performed ultrasound (RADUS) and a discharge diagnosis. Read More

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Contemporary management considerations of urinary tract infections for women with spina bifida.

Int Urogynecol J 2021 Jun 3. Epub 2021 Jun 3.

Houston Methodist Hospital, Department of Urology, Neurourology and Transitional Urology Clinic, Weill Cornell Medical College, Houston, TX, 77030, USA.

Introduction And Hypothesis: Urinary tract infections (UTIs) are one of the leading health concerns and causes of hospitalization for adults with spina bifida (SB). The risk factors, evaluation, management, and prevention of UTIs in women with SB must take into consideration their unique pelvic anatomy and function as well as the desire for pregnancy or the occurrence UTI during pregnancy. This article reviews published literature regarding this topic and offers recommendations for UTI evaluation, management, and prevention in the context of the unique pelvic floor health needs of women with SB. Read More

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