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Thoracic Surgery Foundation Research Awards: Leading the Way to Excellence.

Ann Thorac Surg 2021 Apr 18. Epub 2021 Apr 18.

Background: Combining clinical and research excellence has become an increasingly difficult endeavor for thoracic surgeons, with typical success rates for the NHLBI and NCI being 25.1% and 11.3% respectively. Read More

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A Review of Network and Computer Analysis of Epileptiform Discharge Free EEG to Characterize and Detect Epilepsy.

Clin EEG Neurosci 2021 Apr 21:15500594211008285. Epub 2021 Apr 21.

7491Cornwall Partnership NHS Foundation Trust, Truro, UK.

. There is emerging evidence that network/computer analysis of epileptiform discharge free electroencephalograms (EEGs) can be used to detect epilepsy, improve diagnosis and resource use. Such methods are automated and can be performed on shorter recordings of EEG. Read More

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Correlation of supine MRI and standing radiographs for cervical sagittal balance in myelopathy patients: a cross-sectional study.

Eur Spine J 2021 Apr 21. Epub 2021 Apr 21.

Department of Neurosciences, CHU de Québec - Université Laval Research center, Quebec, QC, Canada.

Purpose: Cervical sagittal alignment is correlated with myelopathy severity and used by spinal surgeons for surgical planification. Magnetic resonance imaging (MRI) is the gold standard for the evaluation of cervical myelopathy but may not be for the assessment of cervical sagittal balance compared to X-rays. The objective of this study was to assess the correlation of cervical alignment between supine MRI and standing radiographs in patients with cervical spondylotic myelopathy (CSM). Read More

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A characteristic occipital epileptiform EEG pattern in ADCK3-related mitochondrial disease.

Epileptic Disord 2021 Apr 21. Epub 2021 Apr 21.

Department of Neurology and Clinical Neurophysiology, St. Olavs Hospital, Trondheim University Hospital, Norway, Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.

Objective: ADCK3-related disease is a mitochondrial disorder associated with an abnormality of coenzyme Q metabolism. Ataxia and epilepsy are common, and the phenotype overlaps with other mitochondrial encephalopathies, particularly POLG-related disease. CoQ supplementation may be beneficial. Read More

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Syncope and electrocardiogram.

Minerva Med 2021 Apr 21. Epub 2021 Apr 21.

Cardiology Division, San Giuseppe Hospital, Empoli, Firenze, Italy -

Introduction: Suspected transient loss of consciousness (T-LOC) and syncope are common causes of hospitalization in older patients. Arrhythmias are the most common cardiac causes of syncope. Although a number of instrumental diagnostic procedures are usually routinely performed in patients with suspected syncope, a 12 leads electrocardiogram (ECG) is the only instrumental test recommended for the initial evaluation of these patients. Read More

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Impact of coronaphobia on treatment and follow-up compliance of cancer patients.

Future Oncol 2021 Apr 21. Epub 2021 Apr 21.

Department of Pulmonology, Erzincan Binali Yıldrıım University Medical School, Erzincan, 24000, Turkey.

The aim of this study was to assess the impact of coronaphobia on treatment and follow-up compliance in cancer patients. The records of 230 cancer patients were reviewed. Coronaphobia was assessed via the validated COVID-19 Phobia Scale (C19P-S). Read More

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Effect of music therapy on improving sleep quality in older adults: A systematic review and meta-analysis.

J Am Geriatr Soc 2021 Apr 20. Epub 2021 Apr 20.

Department of Nursing, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

Objectives: Poor sleep quality is a common issue among older adults; it can lead to a poor quality of life and impairments in cognitive function and physical health. This study aimed to conduct a systematic review and meta-analysis of the effect of listening to music on sleep quality in older adults.

Design: Systematic review and meta-analyses. Read More

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Real-World Evidence for Control of Chronic Migraine Patients Receiving CGRP Monoclonal Antibody Therapy Added to OnabotulinumtoxinA: A Retrospective Chart Review.

Pain Ther 2021 Apr 21. Epub 2021 Apr 21.

Allergan, an AbbVie Company, Irvine, CA, USA.

Introduction: Combination use of onabotulinumtoxinA and calcitonin gene-related peptide (CGRP) monoclonal antibodies (mAbs) has the potential to be more effective than either therapy alone for migraine prevention.

Methods: This retrospective, longitudinal chart review included adults with chronic migraine treated at one clinical site with ≥ 2 consecutive cycles of onabotulinumtoxinA and ≥ 1 month of subsequent combination treatment with CGRP mAbs. Charts at time of mAb prescription (baseline) and up to four visits ~ 3, 6, 9, and 12 months post-baseline were reviewed for safety, tolerability, and outcome measures (monthly headache days [MHDs], headache intensity, and migraine-related disability [MIDAS]). Read More

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Ultrasound-guided transthoracic needle biopsy of the lung: sensitivity and safety variables.

Eur Radiol 2021 Apr 21. Epub 2021 Apr 21.

Québec Heart and Lung Institute Research Center, Université Laval, Québec City, Québec, Canada.

Objectives: Variables affecting the performance of ultrasound-guided transthoracic needle biopsy (US-TTNB) are not well established. We examined clinical and imaging variables affecting the sensitivity and the complication rates of US-TTNB.

Methods: We retrospectively reviewed a consecutive series of 528 US-TTNBs performed from 2008 to 2017. Read More

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A systematic review of quantitative bias analysis applied to epidemiological research.

Int J Epidemiol 2021 Apr 20. Epub 2021 Apr 20.

Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA.

Background: Quantitative bias analysis (QBA) measures study errors in terms of direction, magnitude and uncertainty. This systematic review aimed to describe how QBA has been applied in epidemiological research in 2006-19.

Methods: We searched PubMed for English peer-reviewed studies applying QBA to real-data applications. Read More

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Leisure and Productivity in Older Adults with Cancer: A Systematic Review.

Occup Ther Int 2021 3;2021:8886193. Epub 2021 Apr 3.

Univ Paris Est Creteil, INSERM, IMRB, F-94010 Creteil, France.

Introduction: Self-care, leisure, and productivity are important occupational domains for older adults' quality of life, which might be affected by cancer and its treatment. A great number of publications about older adults focus on function or self-care, so we aimed to analyse how cancer and its treatments affect leisure and productivity. Secondary objectives were to identify whether particular clinical and/or sociodemographic factors were associated with occupational disruptions and to assess the impact of rehabilitation approaches on leisure and productivity in this population. Read More

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Safety and Outcomes of Laparoscopic Sleeve Gastrectomy in a General Surgery Residency Program.

JSLS 2021 Jan-Mar;25(1)

Obesity Unit, Department of Surgery, University of Rome Tor Vergata, Roma, Italy.

Background: With the escalation of surgical treatment of morbid obesity, there is a growing interest in the training of bariatric surgeons. Laparoscopic sleeve gastrectomy (LSG) gained popularity both as a first-stage approach and as a stand-alone procedure.

Objectives: The aim of this study was to assess detectable differences in LSG with intra-operative resident involvement. Read More

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Assessment of prescription pattern at primary healthcare centres in Khartoum locality, Sudan.

Sudan J Paediatr 2021 ;21(1):23-29

Department of pediatrics and Child health, Faculty of Medicine, National University, Khartoum, Sudan.

To promote rational drug use in developing countries, it is important to assess drug use pattern, using the World Health Organisation (WHO) drug indicators. The aim of this study was to assess the prescription patterns at the primary healthcare centres in Khartoum locality, compare prescription habits between consultants and medical officers and identify polypharmacy and its effect on prescription quality using WHO drug indicators. The study was descriptive and cross-sectional. Read More

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January 2021

Subsequent attendance in a breast cancer screening program after a false-positive result in the Local Health Authority of Bologna (Italy).

Sci Rep 2021 Apr 20;11(1):8530. Epub 2021 Apr 20.

Department of Public Health, LHA Bologna, Via Boldrini, 12, 40121, Bologna, Italy.

We conducted a cross-sectional study to assess the likelihood of returning for routine breast cancer screening among women who have experienced a false-positive result (FPR) and to describe the possible individual and organizational factors that could influence subsequent attendance to the screening program. Several information were collected on demographic and clinical characteristics data. Electronic data from 2014 to 2016 related to breast screening program of the Local Health Authority (LHA) of Bologna (Italy) of women between 45 and 74 years old were reviewed. Read More

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Identification and validation of a risk signature based on extracellular matrix-related genes in gliomas.

Authors:
Jia Liu Guilin Li

Medicine (Baltimore) 2021 Apr;100(16):e25603

Queen Mary School, Medical School of Nanchang University, Nanchang, Jiangxi, PR China.

Abstract: Gliomas have the highest incidence among primary brain tumors, and the extracellular matrix (ECM) plays a vital role in tumor progression. We constructed a risk signature using ECM-related genes to predict the prognosis of patients with gliomas.mRNA and clinical data from glioma patients were downloaded from The Cancer Genome Atlas (TCGA), Genotype-Tissue Expression (GTEx) and Chinese Glioma Genome Atlas (CGGA) databases. Read More

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Acupoint catgut embedding for the treatment of peptic ulcers: A protocol for systematic review and meta analysis.

Medicine (Baltimore) 2021 Apr;100(16):e25562

Jiangxi University of Traditional Chinese Medicine.

Background: Peptic ulcer (PU) is a common clinical disease of the digestive system, which can occur in all ages, gastric and duodenal ulcers are the most commonly seen PUs in clinical practice. The main manifestations are chronic and periodic rhythmic upper abdominal pain, accompanied by indigestion symptoms such as pantothenic acid, belching, and nausea. Serious complications such as bleeding, perforation, obstruction and canceration are easy to occur, endangering the life safety of patients. Read More

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Prognostic value of long noncoding RNA urothelial carcinoma-associated 1 in esophageal carcinoma: A protocol for meta-analysis, TCGA data and bioinformatics analysis.

Medicine (Baltimore) 2021 Apr;100(16):e25452

Department of Thoracic Surgery, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, 401120, China.

Background: Currently, an increasing number of long noncoding RNAs (LncRNAs) have been reported to be abnormally expressed in human carcinomas and play a vital role in tumourigenesis. Some studies have been carried out to investigate the influence of the expression of LncRNA human urothelial carcinoma associated 1 (UCA1) on prognosis and clinical significance in patients with esophageal cancer, but the results are contradictory and uncertain. A meta-analysis and was conducted with controversial data to accurately assess the issue. Read More

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Effectiveness and safety of traditional Chinese medicine in the treatment of senile hypotension: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 Apr;100(16):e25385

The Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine.

Background: Senile hypotension refers to those whose blood pressure (BP) is lower than 90/60 mm Hg. The consequences can not only cause insufficient cardio-cerebral perfusion, but severe cases may also cause angina pectoris and stroke. At present, Western medicine has no ideal therapeutic drugs for senile hypotension. Read More

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Influence of tendon injuries on the clinical outcome of ankle and hindfoot fractures.

Foot Ankle Surg 2021 Apr 15. Epub 2021 Apr 15.

Hospital Beatriz Ângelo, Portugal.

Background: Associations of tendon injuries with ankle and hindfoot fractures is a current concern and recent research has linked specific fractures with specific tendon injuries, despite its functional impact being unknown. The purpose of this study is to assess that impact.

Methods: Computed tomography scans of patients with ankle and hindfoot fractures were reviewed for tendon injuries. Read More

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Validation of the Activities' Scale in Higher Education Students' Personal Learning Environments.

Psicothema 2021 May;33(2):320-327

Universidad Nacional (Costa Rica), Universidad de A Coruña.

Background: Personal learning environments are the networks of tools, activities, and connections that each person uses for their learning. Although there have been increasing numbers of studies, measurement instruments in this regard are still limited. The aim of this study is to construct and validate a scale to assess the activities that make up Personal Learning Environments. Read More

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Toxicological investigations in a death involving 2-MAPB.

Forensic Sci Med Pathol 2021 Apr 20. Epub 2021 Apr 20.

Governmental Institute of Legal Medicine and Forensic Sciences, Turmstraße 21, 10559, Berlin, Germany.

New psychoactive substances are becoming increasingly popular. However, there is a lack of mass spectral information on parent substances and their corresponding metabolites as well as fatal concentrations in body liquids and tissues. Only very few clinical reports and user reports exist. Read More

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Unicompartmental knee arthroplasty: all-poly versus metal-backed tibial component-a long-term follow-up study.

Int Orthop 2021 Apr 20. Epub 2021 Apr 20.

S. Giovanni Calibita Fatebenefratelli Hospital, Isola Tiberina, 00186, Rome, Italy.

Introduction: While considered a satisfactory solution, unicompartmental knee arthroplasty (UKA) still raises concerns in regard to its durability. These concerns particularly focus on the tibial component. This study aims to compare two different cemented tibial components belonging to the same UKA design: all polyethylene (AP) versus metal backed (MB), at a long-term follow-up. Read More

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Systematic review of factors associated with hope in family carers of persons living with chronic illness.

J Adv Nurs 2021 Apr 20. Epub 2021 Apr 20.

School of Nursing, McMaster University, Hamilton, ON, Canada.

Aims: To identify factors associated with hope in family carers of persons living with chronic illness.

Design: A systematic review of quantitative and mixed method studies on hope in carers of persons living with chronic illness.

Data Sources: Five electronic databases (Medline, Cumulative Index to Nursing and Allied Health Literature, Web of Science, ProQuest Dissertations and PsycINFO) were searched from inception to 13 July 2020. Read More

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A Retrospective Multi-Site Academic Center Analysis of Pneumothorax and Associated Risk Factors after CT-Guided Percutaneous Lung Biopsy.

Lung 2021 Apr 19. Epub 2021 Apr 19.

Department of Radiology, Montefiore Medical Center, 111 East 210th Street, Bronx, NY, 10467, USA.

Purpose: To assess the risk factors, incidence and significance of pneumothorax in patients undergoing CT-guided lung biopsy.

Methods: Patients who underwent a CT-guided lung biopsy between August 10, 2010 and September 19, 2016 were retrospectively identified. Imaging was assessed for immediate and delayed pneumothorax. Read More

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Free Graft Augmentation Urethroplasty for Bulbar Urethral Strictures: Which Technique Is Best? A Systematic Review.

Eur Urol 2021 Apr 16. Epub 2021 Apr 16.

Division of Urology, Gent University Hospital, Gent, Belgium.

Context: Four techniques for graft placement in one-stage bulbar urethroplasty have been reported: dorsal onlay (DO), ventral onlay (VO), dorsolateral onlay (DLO), and dorsal inlay (DI). There is currently no systematic review in the literature comparing these techniques.

Objective: To assess if stricture recurrence and secondary outcomes vary between the four techniques and to assess if one technique is superior to any other. Read More

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Trends in measles incidence and measles vaccination coverage in Nigeria, 2008-2018.

Vaccine 2021 Apr 17. Epub 2021 Apr 17.

Groningen Research Institute of Pharmacy, University of Groningen, Groningen, the Netherlands.

Introduction: All WHO regions have set measles elimination objective for 2020. To address the specific needs of achieving measles elimination, Nigeria is using a strategy focusing on improving vaccination coverage with the first routine dose of (monovalent) measles (MCV1) at 9 months, providing measles vaccine through supplemental immunization activities (children 9-59 months), and intensified measles case-based surveillance system.

Methods: We reviewed measles immunization coverage from population-based surveys conducted in 2010, 2013 and 2017-18. Read More

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Does Immobilization Post Injection Reduce Contrast Extravasation in MR Arthrography of the Shoulder?

Can Assoc Radiol J 2021 Apr 20:8465371211005147. Epub 2021 Apr 20.

Department of Radiology, 60201Universitair Ziekenhuis Brussel, Jette, Belgium.

Background: Contrast leakage after arthrography is common. We sought to investigate if immobilization could prevent it.

Purpose: The purpose of this study was to determine the effects on contrast extravasation and image quality produced by strict immobilization of the shoulder between arthrography puncture and subsequent MR imaging. Read More

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DeepGRAI (Deep Gray Rating via Artificial Intelligence): Fast, feasible, and clinically relevant thalamic atrophy measurement on clinical quality T2-FLAIR MRI in multiple sclerosis.

Neuroimage Clin 2021 Mar 29;30:102652. Epub 2021 Mar 29.

Buffalo Neuroimaging Analysis Center, Department of Neurology, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA; Jacobs MS Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA.

Background: Thalamic volume loss is a key marker of neurodegeneration in multiple sclerosis (MS). T2-FLAIR MRI is a common denominator in clinical routine MS imaging, but current methods for thalamic volumetry are not applicable to it.

Objective: To develop and validate a robust algorithm to measure thalamic volume using clinical routine T2-FLAIR MRI. Read More

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Single center experience of inferior vena cava filter retrieval in trauma patients: contrast-enhanced CT-based retrieval within hospital stay.

Clin Imaging 2021 Apr 13;79:43-47. Epub 2021 Apr 13.

Department of Orthopedic Surgery, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, Republic of Korea. Electronic address:

Purpose: To assess the safety and retrieval rate of a predischarge inferior vena cava (IVC) filter retrieval strategy based on contrast computed tomography (CT).

Methods: IVC filter insertion for trauma patients from 2010 to 2018 were reviewed. An active filter retrieval strategy was established in March 2017. Read More

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Early and mid-term results of transcatheter aortic valve implantation and valve durability assessment.

Heart Vessels 2021 Apr 19. Epub 2021 Apr 19.

Department of Cardiovascular Surgery, Saitama Medical University International Medical Center, 1397-1 Yamane, Saitama, Hidaka, 350-1298, Japan.

This study aimed to evaluate the early and mid-term outcomes of transcatheter aortic valve implantation (TAVI) and to assess valve durability. A total of 146 consecutive patients who underwent TAVI for severe aortic stenosis between October 2013 and August 2018 were retrospectively reviewed. All patients (mean age, 84 ± 6 years; age range 53-98 years; 42 males [28. Read More

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