411,087 results match your criteria review systematic

Comparative Safety and Efficacy of Therapeutic Options in Resectable and Advanced/Metastatic Pancreatic Cancer: A Systematic Review and Indirect Comparison.

Oncol Res Treat 2021 Jul 27:1-9. Epub 2021 Jul 27.

Department of Pharmacotherapy, College of Pharmacy, University of Utah, Salt Lake City, Utah, USA.

Objectives: FOLFIRINOX, gemcitabine/nab-paclitaxel (gem-nab/P), and gemcitabine-capecitabine (gem-cap) demonstrated superiority over gemcitabine monotherapy for pancreatic cancer (PC). It is still unclear which chemotherapy regimen is the most optimal. This study aimed to conduct a systematic review (SR) and indirect comparison to compare safety and efficacy of FOLFIRINOX versus gem-nab/P and gem-cap in PC. Read More

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Sarcopenia Is Associated with Mortality in Adults: A Systematic Review and Meta-Analysis.

Gerontology 2021 Jul 27:1-16. Epub 2021 Jul 27.

Department of Medicine and Aged Care, @AgeMelbourne, The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia.

Background: Sarcopenia can predispose individuals to falls, fractures, hospitalization, and mortality. The prevalence of sarcopenia depends on the population studied and the definition used for the diagnosis.

Objective: This systematic review and meta-analysis aimed to investigate the association between sarcopenia and mortality and if it is dependent on the population and sarcopenia definition. Read More

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Stepped care for the treatment of depression: a systematic review and meta-analysis.

J Affect Disord 2021 Jul 18;294:391-409. Epub 2021 Jul 18.

Health Services Research on Chronic Patients Network (REDISSEC). Tenerife, Spain; Evaluation Unit (SESCS), Canary Islands Health Service (SCS), Tenerife, Spain.

Background: The Stepped Care Model (SCM) proposes a sequential approach in the treatment of depression, applying interventions of increasing intensity according to the level of severity of the individual.

Methods: A systematic review was carried out until January 2020 in eight electronic databases. We included randomized (RCT) and non-randomized controlled trials comparing the SCM to usual non-sequential care. Read More

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Current state of knowledge on immunotherapy in ECOG PS 2 patients. A systematic review.

Adv Med Sci 2021 Jul 24;66(2):381-387. Epub 2021 Jul 24.

2nd Department of Lung Diseases and Tuberculosis, Medical University of Bialystok, Bialystok, Poland.

Background: Patients with Eastern Cooperative Oncology Group Performance Status 2 (ECOG PS 2) are not included in most randomized clinical trials and registry studies. Nevertheless, immune checkpoint inhibitors are registered in the USA and Europe regardless of the performance status. Evidence regarding the effectiveness and safety of such treatment in this cohort is sparse. Read More

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INR and COVID-19 severity and mortality: A systematic review with meta-analysis and meta-regression.

Adv Med Sci 2021 Jul 21;66(2):372-380. Epub 2021 Jul 21.

Discipline of Clinical Pharmacology, College of Medicine and Public Health, Flinders University, Adelaide, Australia; Department of Clinical Pharmacology, Flinders Medical Centre, Southern Adelaide Local Health Network, Adelaide, Australia. Electronic address:

Objectives: D-dimer elevations, suggesting a pro-thrombotic state and coagulopathy, predict adverse outcomes in coronavirus disease 2019 (COVID-19). However, the clinical significance of other coagulation markers, particularly the international normalized ratio (INR), is not well established. We conducted a systematic review and meta-analysis of the INR in COVID-19. Read More

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Questionnaires used in complex trauma intervention evaluations and consideration of their utility for autistic adults with mild intellectual disability: A systematic review.

Res Dev Disabil 2021 Jul 24;117:104039. Epub 2021 Jul 24.

Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, NE1 4LP, United Kingdom.

Introduction: Research suggests some trauma symptoms e.g. avoidance are difficult to recognise in autistic people with intellectual disability while arousal/emotional and interpersonal difficulties may be useful signals. Read More

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Chronic subdural hematoma-induced parkinsonism: A systematic review.

Clin Neurol Neurosurg 2021 Jul 21;208:106826. Epub 2021 Jul 21.

Department of Neurosurgery, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Dr. Soetomo General Academic Hospital, Surabaya, Indonesia.

Background: Chronic subdural hematoma (CSDH) is one of the most common neurosurgical cases, especially in elderly individuals. Secondary parkinsonism due to CSDH is a rare entity. The mechanism of parkinsonism symptoms in chronic subdural hematoma has been suggested to include direct mechanical compression of the basal ganglia due to hematoma or indirectly through brain structure changes due to space lesions and vascular disorders. Read More

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Global sagittal balance of spine in asymptomatic controls: A systematic review and meta-analysis.

World Neurosurg 2021 Jul 24. Epub 2021 Jul 24.

Mental Health Research Group, Health Metrics Research Centre, Iranian Institute for Health Sciences Research, ACECR, Tehran, Iran.

Objective: The purpose of this study was to assess the global sagittal balance of spine (GSBS) in asymptomatic controls.

Methods: PubMed, Scopus, Cochrane library, and Web of Science searched up to July 2020. Studies were screened for the GSB parameters including T1 pelvic angle (TPA), spinosacral angle (SSA), sagittal vertical axis (SVA), C7/ sacrofemoral distance ratio (Barrey index), odontoid hip axis (OD-HA) and Full Balance Index (FBI) as measured in asymptomatic participants. Read More

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Traditional uses, phytochemistry, pharmacology, toxicology and formulation aspects of Glycosmis species: A systematic review.

Phytochemistry 2021 Jul 23;190:112865. Epub 2021 Jul 23.

National Institute of Pharmaceutical Education and Research-Ahmedabad (NIPER-A), An Institute of National Importance, Government of India, Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Opp. Air Force Station, Palaj, Gandhinagar, 382355, Gujarat, India. Electronic address:

The present article is a systematic and constructive review of the traditional medicinal uses, chemistry, pharmacology, toxicology, and formulation aspects of Glycosmis species. The genus Glycosmis comprise 51 accepted species broadly distributed in Australia, China, India, and South-East Asia. Traditionally, Glycosmis species are used in folk medicines to treat cancer, anaemia, rheumatism, fever, cough, liver-related problems, skin ailments, intestinal worm infections, wounds, and facial inflammation. Read More

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Rectus femoris surgery for the correction of stiff knee gait in cerebral palsy: a systematic review and meta-analysis.

Orthop Traumatol Surg Res 2021 Jul 24:103022. Epub 2021 Jul 24.

Service de Chirurgie Pédiatrique, 2 Avenue Foch, 29200 Brest, France.

Introduction: Rectus femoris (RF) transfer was long the gold-standard treatment for stiff knee gait (SKG), but efficacy now seems less than that of distal RF release. The aim of the present study was to compare efficacy between the two. The study hypothesis was that both significantly improve 4 knee kinematic parameters at 1 year. Read More

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A commentary on "The association between serum vitamin D, fertility and semen quality: A systematic review and meta-analysis" (Int J Surg 2019; 71:101-109).

Int J Surg 2021 Jul 24:106034. Epub 2021 Jul 24.

Reproductive Medicine Center, Hangzhou Women's Hospital, Zhejiang, 310008, China. Electronic address:

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Effect and feasibility of wearable physical activity trackers and pedometers for increasing physical activity and improving health outcomes in cancer survivors: A systematic review and meta-analysis.

J Sport Health Sci 2021 Jul 24. Epub 2021 Jul 24.

Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia.

Background: The purpose of this systematic review and meta-analysis was to evaluate the effect of wearable devices for improving physical activity and health-related outcomes in cancer survivors.

Methods: CINAHL, Cochrane, Ebscohost, MEDLINE, Pubmed, ProQuest Health and Medical Complete, ProQuest Nursing and Allied Health Source, ScienceDirect, and SPORTDiscus databases were searched for randomized controlled trials published before September 1, 2020, that evaluated interventions involving wearable devices in cancer survivors. Standardized mean differences (SMDs) were calculated to assess effects on physical activity and health-related outcomes. Read More

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Evaluating the quality of HIV epidemiologic evidence for populations in the absence of a reliable sampling frame: a modified quality assessment tool.

Ann Epidemiol 2021 Jul 24. Epub 2021 Jul 24.

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe St, Baltimore, MD, 21205, USA.

Background: Sampling frames rarely exist for key populations at highest risk for HIV, such as sex workers, men who have sex with men, people who use drugs, and transgender populations. Without reliable sampling frames, most data collection relies on non-probability sampling approaches including network-based methods (e.g. Read More

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EVAR Conversion is an Increasingly Common Indication for Open AAA Repair.

J Vasc Surg 2021 Jul 24. Epub 2021 Jul 24.

Division of Vascular Surgery and Endovascular Therapy, University of Florida, Gainesville.

Objective: Although EVAR re-intervention is common, conversion to open repair(EVAR-c) occurs less frequently but can be associated with significant technical complexity and perioperative risk. There is a paucity of data highlighting the evolution of peri-procedural results surrounding EVAR-c and change in practice patterns, especially for referral centers that increasingly manage EVAR failures. The purpose of this analysis was to perform a temporal analysis of our EVAR-c experience and describe changes in patient selection, operative details and outcomes. Read More

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Amyloidosis of the urinary bladder: a systematic review and a proposed management algorithm.

Urology 2021 Jul 24. Epub 2021 Jul 24.

Urology Department, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Greece; Urology Department, The Pennine Acute Hospitals NHS Trust, Manchester, UK.

Objective: To propose an algorithm for the management of bladder amyloidosis based on a systematic review of the literature, given that the bladder is the second most commonly affected organ of the urinary tract in the course of systemic or localized amyloidosis.

Methods: We searched PubMed, Cochrane Library and Scopus databases utilizing PRISMA methodology from inception to November 30, 2020 (PROSPERO: CRD42020207855).

Results: We included 76 studies with 184 patients (9 case series and 67 case reports). Read More

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Fear conditioning and extinction in obsessive-compulsive disorder: A systematic review.

Neurosci Biobehav Rev 2021 Jul 24. Epub 2021 Jul 24.

Department of Psychiatry and Behavioral Sciences, University of Texas at Austin, Austin, TX, 78712, USA. Electronic address:

Laboratory experiments using fear conditioning and extinction protocols help lay the groundwork for designing, testing, and optimizing innovative treatments for anxiety-related disorders. Yet, there is limited basic research on fear conditioning and extinction in obsessive-compulsive disorder (OCD). This is surprising because exposure-based treatments based on associative learning principles are among the most popular and effective treatment options for OCD. Read More

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Public Health Effects of Travel-Related Policies on the COVID-19 Pandemic: A Mixed-Methods Systematic Review.

J Infect 2021 Jul 24. Epub 2021 Jul 24.

Evidence-Based Public Health Unit, Center for International Health Protection, Robert Koch Institute, Nordufer. 20 13353 Berlin, Germany. Electronic address:

Objectives: To map travel policies implemented due to COVID-19 during 2020, and conduct a mixed-methods systematic review of health effects of such policies, and related contextual factors.

Design: Policy mapping and systematic review DATA SOURCES AND ELIGIBILITY CRITERIA: for the policy mapping, we searched websites of relevant government bodies and used data from the Oxford COVID-19 Government Response Tracker for a convenient sample of 31 countries across different regions. For the systematic review, we searched Medline (Ovid), PubMed, EMBASE, the Cochrane Central Register of Controlled Trials and COVID-19 specific databases. Read More

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Decision Making in People With Dementia or Mild Cognitive Impairment: A Narrative Review of Decision-Making Tools.

J Am Med Dir Assoc 2021 Jul 24. Epub 2021 Jul 24.

School of Nursing, University of Wollongong, Wollongong, New South Wales, Australia.

Objectives: This review summarized the applicability of various decision-making tools for helping people with dementia or mild cognitive impairment (MCI) and their families make decisions.

Design: This study was a narrative literature review. The protocol of this review was registered in the International Prospective Register of Systematic Reviews (PROSPERO ID: CRD XXXX). Read More

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Empowerment Approaches in Childhood Weight Management: A Systematic Review.

Child Obes 2021 Jul 26. Epub 2021 Jul 26.

School of Human Movement and Nutrition Sciences, The University of Queensland, St Lucia, Queensland, Australia.

Empowerment interventions facilitate individuals, organizations, and communities to gain better control over their health. They are distinctly different from traditional behavior change models and encourage participants to set their own health priorities and agenda. Current evidence suggests empowerment interventions are efficacious for smoking, sexual, and mental health outcomes. Read More

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Can Tai Chi Improve Cognitive Function? A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

J Altern Complement Med 2021 Jul 26. Epub 2021 Jul 26.

Nursing College, Fujian University of Traditional Chinese Medicine, Fuzhou, China.

Tai Chi (TC) is a traditional Chinese martial art with demonstrated beneficial effects on physical and mental health. In this study, the authors performed a systematic review to assess the efficiency of TC in different populations' cognitive function improvement. The present systematic review utilized the Chinese National Knowledge Infrastructure (1915-), Wanfang (1998-), VIP (1989-), Chinese Biomedicine databases (1978-), PubMed (1950-), Web of Science (1900-), Cochrane Library (1948-), Embase (1974-), EBSCOhost (1922-), and OVID (1996-) databases to search and identify relevant articles published in English and Chinese from the beginning of coverage through October 17, 2020. Read More

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An umbrella systematic review of drain fluid analysis in colorectal surgery for the detection of anastomotic leak: not yet ready to translate research studies into clinical practice.

Colorectal Dis 2021 Jul 27. Epub 2021 Jul 27.

Faculty of Medicine and Health, Central Clinical School, The University of Sydney, Sydney, Australia.

Aim: Anastomotic leak (AL) is the most important complication of intestinal surgery with an anastomosis. Whilst a number of studies have defined risk factors for AL, frustratingly, low-risk patients still develop AL. Studies have looked at drain fluid analysis for detection of AL, but these findings have failed to translate into routine clinical practice. Read More

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Ultrasound versus routine care before instrumental vaginal delivery: a systematic review and meta-analysis.

Acta Obstet Gynecol Scand 2021 Jul 27. Epub 2021 Jul 27.

Department of Obstetrics and Gynecology, University of Chieti, Chieti, Italy.

Introduction: The objective was to report the role of ultrasound in affecting maternal and perinatal outcome in women undergoing instrumental vaginal delivery.

Material And Methods: MEDLINE, Embase, CINAHL, Google Scholar and ClinicalTrial.gov databases were searched. Read More

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Epigenetics and postsurgical pain: A scoping review.

Pain Med 2021 Jul 27. Epub 2021 Jul 27.

Medical Research Unit in Reproductive Medicine, Unidad Médica de Alta Especialidad, Hospital de Gineco Obstetricia No. 4, "Luis Castelazo Ayala", Instituto Mexicano del Seguro Social, Mexico City, Mexico.

Objective: Multiple factors are involved in the physiology and variability of postsurgical pain, a great part of which can be explained by genetic and environmental factors and their interaction. Epigenetics refers to the mechanism by which the environment alters the stability and expression of genes. We conducted a scoping review to examine the available evidence in both animal models and clinical studies on epigenetic mechanisms involved in regulation of postsurgical and chronic postsurgical pain. Read More

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The burden of scrub typhus in India: A systematic review.

PLoS Negl Trop Dis 2021 Jul 27;15(7):e0009619. Epub 2021 Jul 27.

Department of Infectious Diseases, Christian Medical College, Vellore, Tamil Nadu, India.

Background: Scrub typhus, a vector-borne zoonotic infection caused by the bacteria Orientia tsutsugamushi, is one of the most common and clinically important rickettsial infections worldwide. An estimated one million cases occur annually with a high case fatality rate. Although scrub typhus is a major public health threat in India, the burden and distribution remains unclear. Read More

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Efficacy and Safety of Thalidomide in Patients with Complicated Central Nervous System Tuberculosis: A Systematic Review and Meta-Analysis.

Am J Trop Med Hyg 2021 Jul 27. Epub 2021 Jul 27.

Pediatric Neurology Division, Department of Pediatrics, All India Institute of Medical Sciences, Rishikesh, India.

Thalidomide, an anti-inflammatory and immunomodulatory agent, has a potential role in cases with central nervous system tuberculosis (CNS-TB) with paradoxical reactions. Although several articles have described the use of thalidomide in CNS-TB, no systematic review has been performed in this regard. Different electronic databases were searched for articles describing the use of thalidomide in patients with CNS-TB. Read More

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Subsyndromal generalised anxiety disorder: operationalisation and epidemiology - a systematic literature survey.

Int J Psychiatry Clin Pract 2021 Jul 27:1-10. Epub 2021 Jul 27.

Department of Psychiatry, Psychotherapy, and Psychosomatics, Psychiatric Hospital, University of Zürich, Zürich, Switzerland.

The diagnosis of anxiety disorders, like other psychiatric disorders also, is operationalised since the introduction of diagnostic manuals. The diagnostic criteria of Generalised Anxiety Disorder (GAD) have been tightened in the last decades. This leads to the exclusion of patients with a high level of anxiety, but not fulfilling certain of the GAD-criteria, from effective treatment. Read More

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A Systematic Review on Infliximab Biosimilar SB2: From Pre-Clinical Data to Real-World Evidence.

Expert Opin Biol Ther 2021 Jul 27. Epub 2021 Jul 27.

Gastroenterologist, Inflammatory Bowel Disease Unit, "Villa Sofia-Cervello" Hospital, Strasburgo 233, 90146 Palermo, Italy.

Introduction: The infliximab biosimilar SB2 was approved in the EU (2016, Flixabi®) and the US (2017, Renflexis®) for the same indications as the reference product (Remicade®) based on a robust analytical and clinical data package.

Areas Covered: This systematic literature review summarizes available analytical and clinical data on SB2, including randomized controlled clinical trials and real-world evidence studies. Overall, 184 articles and congress abstracts were identified (excluding duplicates), whereof 5 reports on analytical data, four reports on two randomized controlled trials and 13 reports of real-world evidence studies were included. Read More

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Trends and Application of Chemometric Pattern Recognition Techniques in Medicinal Plants Analysis.

Crit Rev Anal Chem 2021 Jul 27:1-13. Epub 2021 Jul 27.

Laboratório de Química Analítica e Quimiometria, Universidade Estadual da Paraíba, Campina Grande, Brasil.

Medicinal plants have been used and studied for ages, from very old registers to modern ethnopharmacology, which encompasses analytical chemistry, foods, and pharmacy. Based on international norms and governmental organizations of health, phytomedicine-for example, herbal drugs-needs to guarantee the quality control of products and identify contaminants, biomarkers, and chemical profiles, among other issues. In this sense, is necessary to develop advanced analytical methods that show interesting possibilities and obtain a great amount of data. Read More

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Effect of Oral Motor Intervention on Oral Feeding in Preterm Infants: A Systematic Review and Meta-Analysis.

Am J Speech Lang Pathol 2021 Jul 27:1-11. Epub 2021 Jul 27.

Department of Rehabilitation Medicine, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.

Objective This review article aimed to explore the effect of oral motor intervention on oral feeding in preterm infants through a meta-analysis. Method Eligible studies were retrieved from four databases (PubMed, Embase, Cochrane Library, and Web of Science) up to July 2020 and screened based on established selection criteria. Thereafter, relevant data were extracted and heterogeneity tests were conducted to select appropriate effect models according to the chi-square test and statistics. Read More

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Early versus Late Surgical Decompression for Traumatic Spinal Cord Injury on Neurological Recovery: A Systematic Review and Meta-analysis.

J Neurotrauma 2021 Jul 27. Epub 2021 Jul 27.

National Taiwan University Hospital, 38006, Department of Emergency Medicine, Taipei, Taiwan.

This study aimed to investigate whether early surgical decompression was associated with favourable neurological recovery in patients with traumatic spinal cord injury (tSCI). We searched PubMed and Embase from the database inception through December 2020 and selected studies comparing the impact of early versus late surgical decompression on neurological recovery as assessed by American Spinal Injury Association Impairment Scale (AIS) for adult patients sustaining tSCI. We pooled the effect estimates in random-effects models and quantified the heterogeneity by the I2 statistics. Read More

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